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F. Akif Tezcan

Title(s)Professor, Chemistry and Biochemistry
SchoolAcademic Aff
Phone858-534-4862
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of Energy Transduction and Substrate Activation in Biological Nitrogen
    NIH/NIGMS R01GM099813Aug 1, 2012 - Apr 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rutledge HL, Rittle J, Williamson LM, Xu WA, Gagnon DM, Tezcan FA. Redox-Dependent Metastability of the Nitrogenase P-Cluster. J Am Chem Soc. 2019 Jun 26; 141(25):10091-10098. PMID: 31146522.
      View in: PubMed
    2. Rittle J, Field MJ, Green MT, Tezcan FA. An efficient, step-economical strategy for the design of functional metalloproteins. Nat Chem. 2019 05; 11(5):434-441. PMID: 30778140.
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    3. Churchfield LA, Tezcan FA. Design and Construction of Functional Supramolecular Metalloprotein Assemblies. Acc Chem Res. 2019 Feb 19; 52(2):345-355. PMID: 30698941.
      View in: PubMed
    4. Subramanian RH, Smith SJ, Alberstein RG, Bailey JB, Zhang L, Cardone G, Suominen L, Chami M, Stahlberg H, Baker TS, Tezcan FA. Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions. ACS Cent Sci. 2018 Nov 28; 4(11):1578-1586. PMID: 30555911.
      View in: PubMed
    5. Zhang L, Bailey JB, Subramanian RH, Groisman A, Tezcan FA. Author Correction: Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks. Nature. 2018 08; 560(7719):E31. PMID: 29973728.
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    6. Churchfield LA, Alberstein RG, Williamson LM, Tezcan FA. Determining the Structural and Energetic Basis of Allostery in a De Novo Designed Metalloprotein Assembly. J Am Chem Soc. 2018 Aug 08; 140(31):10043-10053. PMID: 29996654.
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    7. Zhang L, Bailey JB, Subramanian RH, Groisman A, Tezcan FA. Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks. Nature. 2018 05; 557(7703):86-91. PMID: 29720635.
      View in: PubMed
    8. Alberstein R, Suzuki Y, Paesani F, Tezcan FA. Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly. Nat Chem. 2018 07; 10(7):732-739. PMID: 29713036.
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    9. Alberstein RG, Tezcan FA. Observations of the birth of crystals. Nature. 2018 04 05; 556(7699):41-42. PMID: 29620750.
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    10. De Meulenaere E, Bailey JB, Tezcan FA, Deheyn DD. First biochemical and crystallographic characterization of a fast-performing ferritin from a marine invertebrate. Biochem J. 2017 12 11; 474(24):4193-4206. PMID: 29127253.
      View in: PubMed
    11. Owens CP, Tezcan FA. Conformationally Gated Electron Transfer in Nitrogenase. Isolation, Purification, and Characterization of Nitrogenase From Gluconacetobacter diazotrophicus. Methods Enzymol. 2018; 599:355-386. PMID: 29746246.
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    12. Song WJ, Yu J, Tezcan FA. Importance of Scaffold Flexibility/Rigidity in the Design and Directed Evolution of Artificial Metallo-ß-lactamases. J Am Chem Soc. 2017 11 22; 139(46):16772-16779. PMID: 28992705.
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    13. Bailey JB, Zhang L, Chiong JA, Ahn S, Tezcan FA. Synthetic Modularity of Protein-Metal-Organic Frameworks. J Am Chem Soc. 2017 06 21; 139(24):8160-8166. PMID: 28590729.
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    14. Chabolla SA, Machan CW, Yin J, Dellamary EA, Sahu S, Gianneschi NC, Gilson MK, Tezcan FA, Kubiak CP. Bio-inspired CO2 reduction by a rhenium tricarbonyl bipyridine-based catalyst appended to amino acids and peptidic platforms: incorporating proton relays and hydrogen-bonding functional groups. Faraday Discuss. 2017 06 02; 198:279-300. PMID: 28374024.
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    15. Churchfield LA, George A, Tezcan FA. Repurposing proteins for new bioinorganic functions. Essays Biochem. 2017 05 09; 61(2):245-258. PMID: 28487401.
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    16. Katz FEH, Shi X, Owens CP, Joseph S, Tezcan FA. Determination of nucleoside triphosphatase activities from measurement of true inorganic phosphate in the presence of labile phosphate compounds. Anal Biochem. 2017 03 01; 520:62-67. PMID: 28017740.
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    17. Churchfield LA, Medina-Morales A, Brodin JD, Perez A, Tezcan FA. De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds. J Am Chem Soc. 2016 10 12; 138(40):13163-13166. PMID: 27649076.
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    18. Owens CP, Katz FE, Carter CH, Oswald VF, Tezcan FA. Tyrosine-Coordinated P-Cluster in G. diazotrophicus Nitrogenase: Evidence for the Importance of O-Based Ligands in Conformationally Gated Electron Transfer. J Am Chem Soc. 2016 08 17; 138(32):10124-7. PMID: 27487256.
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    19. Bailey JB, Subramanian RH, Churchfield LA, Tezcan FA. Metal-Directed Design of Supramolecular Protein Assemblies. Methods Enzymol. 2016; 580:223-50. PMID: 27586336.
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    20. Smith SJ, Radford RJ, Subramanian RH, Barnett BR, Figueroa JS, Tezcan FA. Tunable Helicity, Stability and DNA-Binding Properties of Short Peptides with Hybrid Metal Coordination Motifs. Chem Sci. 2016 Aug 01; 7(8):5453-5461. PMID: 27800151.
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    21. Suzuki Y, Cardone G, Restrepo D, Zavattieri PD, Baker TS, Tezcan FA. Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals. Nature. 2016 05 19; 533(7603):369-73. PMID: 27135928; PMCID: PMC4991361 [Available on 11/02/16].
    22. Owens CP, Katz FE, Carter CH, Luca MA, Tezcan FA. Evidence for Functionally Relevant Encounter Complexes in Nitrogenase Catalysis. J Am Chem Soc. 2015 Oct 07; 137(39):12704-12. PMID: 26360912.
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    23. Sontz PA, Bailey JB, Ahn S, Tezcan FA. A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals. J Am Chem Soc. 2015 Sep 16; 137(36):11598-601. PMID: 26305584.
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    24. Brodin JD, Smith SJ, Carr JR, Tezcan FA. Designed, Helical Protein Nanotubes with Variable Diameters from a Single Building Block. J Am Chem Soc. 2015 Aug 26; 137(33):10468-71. PMID: 26256820.
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    25. Tezcan FA, Kaiser JT, Howard JB, Rees DC. Structural evidence for asymmetrical nucleotide interactions in nitrogenase. J Am Chem Soc. 2015 Jan 14; 137(1):146-9. PMID: 25522159.
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    26. Song WJ, Tezcan FA. A designed supramolecular protein assembly with in vivo enzymatic activity. Science. 2014 Dec 19; 346(6216):1525-8. PMID: 25525249.
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    27. Machan CW, Chabolla SA, Yin J, Gilson MK, Tezcan FA, Kubiak CP. Supramolecular assembly promotes the electrocatalytic reduction of carbon dioxide by Re(I) bipyridine catalysts at a lower overpotential. J Am Chem Soc. 2014 Oct 15; 136(41):14598-607. PMID: 25226161.
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    28. Brodin JD, Carr JR, Sontz PA, Tezcan FA. Exceptionally stable, redox-active supramolecular protein assemblies with emergent properties. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):2897-902. PMID: 24516140.
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    29. Sontz PA, Song WJ, Tezcan FA. Interfacial metal coordination in engineered protein and peptide assemblies. Curr Opin Chem Biol. 2014 Apr; 19:42-9. PMID: 24780278.
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    30. Song WJ, Sontz PA, Ambroggio XI, Tezcan FA. Metals in protein-protein interfaces. Annu Rev Biophys. 2014; 43:409-31. PMID: 24773016.
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    31. Smith SJ, Du K, Radford RJ, Tezcan FA. Functional, metal-based crosslinkers for a-helix induction in short peptides. Chem Sci. 2013 Sep; 4(9):3740-3747. PMID: 24156013.
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    32. Medina-Morales A, Perez A, Brodin JD, Tezcan FA. In vitro and cellular self-assembly of a Zn-binding protein cryptand via templated disulfide bonds. J Am Chem Soc. 2013 Aug 14; 135(32):12013-22. PMID: 23905754.
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    33. Huard DJ, Kane KM, Tezcan FA. Re-engineering protein interfaces yields copper-inducible ferritin cage assembly. Nat Chem Biol. 2013 Mar; 9(3):169-76. PMID: 23340339.
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    34. Roth LE, Tezcan FA. ATP-uncoupled, six-electron photoreduction of hydrogen cyanide to methane by the molybdenum-iron protein. J Am Chem Soc. 2012 May 23; 134(20):8416-9. PMID: 22564208.
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    35. Brodin JD, Ambroggio XI, Tang C, Parent KN, Baker TS, Tezcan FA. Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays. Nat Chem. 2012 Mar 04; 4(5):375-82. PMID: 22522257; PMCID: PMC3335442.
    36. Salgado EN, Brodin JD, To MM, Tezcan FA. Templated construction of a Zn-selective protein dimerization motif. Inorg Chem. 2011 Jul 04; 50(13):6323-9. PMID: 21648390.
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    37. Roth LE, Tezcan FA. X-ray crystallography. Methods Mol Biol. 2011; 766:147-64. PMID: 21833866.
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    38. Roth LE, Nguyen JC, Tezcan FA. ATP- and iron-protein-independent activation of nitrogenase catalysis by light. J Am Chem Soc. 2010 Oct 06; 132(39):13672-4. PMID: 20843032.
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    39. Ni TW, Tezcan FA. Structural characterization of a microperoxidase inside a metal-directed protein cage. Angew Chem Int Ed Engl. 2010 Sep 17; 49(39):7014-8. PMID: 20721993.
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    40. Radford RJ, Lawrenz M, Nguyen PC, McCammon JA, Tezcan FA. Porous protein frameworks with unsaturated metal centers in sterically encumbered coordination sites. Chem Commun (Camb). 2011 Jan 07; 47(1):313-5. PMID: 20740227.
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    41. Radford RJ, Nguyen PC, Tezcan FA. Modular and versatile hybrid coordination motifs on alpha-helical protein surfaces. Inorg Chem. 2010 Aug 02; 49(15):7106-15. PMID: 20617830.
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    42. Brodin JD, Medina-Morales A, Ni T, Salgado EN, Ambroggio XI, Tezcan FA. Evolution of metal selectivity in templated protein interfaces. J Am Chem Soc. 2010 Jun 30; 132(25):8610-7. PMID: 20515031.
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    43. Salgado EN, Radford RJ, Tezcan FA. Metal-directed protein self-assembly. Acc Chem Res. 2010 May 18; 43(5):661-72. PMID: 20192262.
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    44. Radford RJ, Nguyen PC, Ditri TB, Figueroa JS, Tezcan FA. Controlled protein dimerization through hybrid coordination motifs. Inorg Chem. 2010 May 03; 49(9):4362-9. PMID: 20377257; PMCID: PMC2896031.
    45. Salgado EN, Ambroggio XI, Brodin JD, Lewis RA, Kuhlman B, Tezcan FA. Metal templated design of protein interfaces. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):1827-32. PMID: 20080561.
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    46. Radford RJ, Tezcan FA. A superprotein triangle driven by nickel(II) coordination: exploiting non-natural metal ligands in protein self-assembly. J Am Chem Soc. 2009 Jul 08; 131(26):9136-7. PMID: 19527025.
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    47. Salgado EN, Lewis RA, Mossin S, Rheingold AL, Tezcan FA. Control of protein oligomerization symmetry by metal coordination: C2 and C3 symmetrical assemblies through Cu(II) and Ni(II) coordination. Inorg Chem. 2009 Apr 06; 48(7):2726-8. PMID: 19267481; PMCID: PMC2707880.
    48. Salgado EN, Lewis RA, Faraone-Mennella J, Tezcan FA. Metal-mediated self-assembly of protein superstructures: influence of secondary interactions on protein oligomerization and aggregation. J Am Chem Soc. 2008 May 14; 130(19):6082-4. PMID: 18422313.
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    49. Salgado EN, Faraone-Mennella J, Tezcan FA. Controlling protein-protein interactions through metal coordination: assembly of a 16-helix bundle protein. J Am Chem Soc. 2007 Nov 07; 129(44):13374-5. PMID: 17929927.
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    50. Faraone-Mennella J, Tezcan FA, Gray HB, Winkler JR. Stability and folding kinetics of structurally characterized cytochrome c-b562. Biochemistry. 2006 Sep 05; 45(35):10504-11. PMID: 16939202.
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    51. Tezcan FA, Kaiser JT, Mustafi D, Walton MY, Howard JB, Rees DC. Nitrogenase complexes: multiple docking sites for a nucleotide switch protein. Science. 2005 Aug 26; 309(5739):1377-80. PMID: 16123301.
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    52. Corbett MC, Tezcan FA, Einsle O, Walton MY, Rees DC, Latimer MJ, Hedman B, Hodgson KO. Mo K- and L-edge X-ray absorption spectroscopic study of the ADP.AlF4--stabilized nitrogenase complex: comparison with MoFe protein in solution and single crystal. J Synchrotron Radiat. 2005 Jan; 12(Pt 1):28-34. PMID: 15616362.
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    53. Pasaoglu H, Tezcan F, Yesilel OZ, Olmez H, Içbudak H, Büyükgüngör O. Diaquabis(pyridine-2-carboxamide-kappa2N1,O2)nickel(II) disaccharinate tetrahydrate. Acta Crystallogr C. 2004 Jul; 60(Pt 7):m335-7. PMID: 15237152.
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    54. Einsle O, Tezcan FA, Andrade SL, Schmid B, Yoshida M, Howard JB, Rees DC. Nitrogenase MoFe-protein at 1.16 A resolution: a central ligand in the FeMo-cofactor. Science. 2002 Sep 06; 297(5587):1696-700. PMID: 12215645.
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