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Hiroyuki Okano

Title(s)Associate Project Scientist, Physics
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions. Mol Syst Biol. 2024 Nov; 20(11):1257-1259. Mori M, Zhang Z, Banaei-Esfahani A, Lalanne JB, Okano H, Collins BC, Schmidt A, Schubert OT, Lee DS, Li GW, Aebersold R, Hwa T, Ludwig C. PMID: 39354190; PMCID: PMC11535196.
      View in: PubMed   Mentions:    Fields:    
    2. Functional decomposition of metabolism allows a system-level quantification of fluxes and protein allocation towards specific metabolic functions. Nat Commun. 2023 07 13; 14(1):4161. Mori M, Cheng C, Taylor BR, Okano H, Hwa T. PMID: 37443156; PMCID: PMC10345195.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    3. Efficient integrated production of bioethanol and antiviral glycerolysis lignin from sugarcane trash. Biotechnol Biofuels Bioprod. 2023 May 15; 16(1):82. Khattab SMR, Okano H, Kimura C, Fujita T, Watanabe T. PMID: 37189175; PMCID: PMC10186800.
      View in: PubMed   Mentions: 2  
    4. A Genome-Scale Metabolic Model of Marine Heterotroph Vibrio splendidus Strain 1A01. mSystems. 2023 04 27; 8(2):e0037722. Iffland-Stettner A, Okano H, Gralka M, Guessous G, Amarnath K, Cordero OX, Hwa T, Bonhoeffer S. PMID: 36853050; PMCID: PMC10134806.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Enzyme expression kinetics by Escherichia coli during transition from rich to minimal media depends on proteome reserves. Nat Microbiol. 2023 02; 8(2):347-359. Wu C, Mori M, Abele M, Banaei-Esfahani A, Zhang Z, Okano H, Aebersold R, Ludwig C, Hwa T. PMID: 36737588; PMCID: PMC9994330.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    6. Hierarchical and simultaneous utilization of carbon substrates: mechanistic insights, physiological roles, and ecological consequences. Curr Opin Microbiol. 2021 10; 63:172-178. Okano H, Hermsen R, Hwa T. PMID: 34365153; PMCID: PMC9744632.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    7. From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions. Mol Syst Biol. 2021 05; 17(5):e9536. Mori M, Zhang Z, Banaei-Esfahani A, Lalanne JB, Okano H, Collins BC, Schmidt A, Schubert OT, Lee DS, Li GW, Aebersold R, Hwa T, Ludwig C. PMID: 34032011; PMCID: PMC8144880.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    8. Global coordination of metabolic pathways in Escherichia coli by active and passive regulation. Mol Syst Biol. 2021 04; 17(4):e10064. Kochanowski K, Okano H, Patsalo V, Williamson J, Sauer U, Hwa T. PMID: 33852189; PMCID: PMC8045939.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    9. A universal trade-off between growth and lag in fluctuating environments. Nature. 2020 08; 584(7821):470-474. Basan M, Honda T, Christodoulou D, Hörl M, Chang YF, Leoncini E, Mukherjee A, Okano H, Taylor BR, Silverman JM, Sanchez C, Williamson JR, Paulsson J, Hwa T, Sauer U. PMID: 32669712; PMCID: PMC7442741.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    10. Regulation underlying hierarchical and simultaneous utilization of carbon substrates by flux sensors in Escherichia coli. Nat Microbiol. 2020 01; 5(1):206-215. Okano H, Hermsen R, Kochanowski K, Hwa T. PMID: 31819215; PMCID: PMC6925339.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    11. Accurate fidelity analysis of the reverse transcriptase by a modified next-generation sequencing. Enzyme Microb Technol. 2018 Aug; 115:81-85. Okano H, Baba M, Hidese R, Iida K, Li T, Kojima K, Takita T, Yanagihara I, Fujiwara S, Yasukawa K. PMID: 29859606.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. High sensitive RNA detection by one-step RT-PCR using the genetically engineered variant of DNA polymerase with reverse transcriptase activity from hyperthermophilies. J Biosci Bioeng. 2018 Mar; 125(3):275-281. Okano H, Baba M, Kawato K, Hidese R, Yanagihara I, Kojima K, Takita T, Fujiwara S, Yasukawa K. PMID: 29100684.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    13. Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress. mBio. 2018 02 13; 9(1). Dai X, Zhu M, Warren M, Balakrishnan R, Okano H, Williamson JR, Fredrick K, Hwa T. PMID: 29440576; PMCID: PMC5821080.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    14. Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain. Biochemistry. 2017 11 28; 56(47):6281-6291. Murata D, Okano H, Angkawidjaja C, Akutsu M, Tanaka SI, Kitahara K, Yoshizawa T, Matsumura H, Kado Y, Mizohata E, Inoue T, Sano S, Koga Y, Kanaya S, Takano K. PMID: 29094929.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    15. Next-generation sequencing-based analysis of reverse transcriptase fidelity. Biochem Biophys Res Commun. 2017 10 14; 492(2):147-153. Yasukawa K, Iida K, Okano H, Hidese R, Baba M, Yanagihara I, Kojima K, Takita T, Fujiwara S. PMID: 28778390.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    16. High sensitive one-step RT-PCR using MMLV reverse transcriptase, DNA polymerase with reverse transcriptase activity, and DNA/RNA helicase. Biochem Biophys Res Commun. 2017 05 20; 487(1):128-133. Okano H, Baba M, Yamasaki T, Hidese R, Fujiwara S, Yanagihara I, Ujiiye T, Hayashi T, Kojima K, Takita T, Yasukawa K. PMID: 28400277.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    17. Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nat Microbiol. 2016 Dec 12; 2:16231. Dai X, Zhu M, Warren M, Balakrishnan R, Patsalo V, Okano H, Williamson JR, Fredrick K, Wang YP, Hwa T. PMID: 27941827; PMCID: PMC5346290.
      View in: PubMed   Mentions: 168     Fields:    Translation:Cells
    18. Enhanced detection of RNA by MMLV reverse transcriptase coupled with thermostable DNA polymerase and DNA/RNA helicase. Enzyme Microb Technol. 2017 Jan; 96:111-120. Okano H, Katano Y, Baba M, Fujiwara A, Hidese R, Fujiwara S, Yanagihara I, Hayashi T, Kojima K, Takita T, Yasukawa K. PMID: 27871370.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    19. Expression of moloney murine leukemia virus reverse transcriptase in a cell-free protein expression system. Biotechnol Lett. 2016 Jul; 38(7):1203-11. Katano Y, Hisayoshi T, Kuze I, Okano H, Ito M, Nishigaki K, Takita T, Yasukawa K. PMID: 27053084.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature. 2015 Dec 03; 528(7580):99-104. Basan M, Hui S, Okano H, Zhang Z, Shen Y, Williamson JR, Hwa T. PMID: 26632588; PMCID: PMC4843128.
      View in: PubMed   Mentions: 331     Fields:    Translation:Cells
    21. A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates. Mol Syst Biol. 2015 Apr 09; 11(4):801. Hermsen R, Okano H, You C, Werner N, Hwa T. PMID: 25862745; PMCID: PMC4422558.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    22. Structure, activity, and stability of metagenome-derived glycoside hydrolase family 9 endoglucanase with an N-terminal Ig-like domain. Protein Sci. 2015 Mar; 24(3):408-19. Okano H, Kanaya E, Ozaki M, Angkawidjaja C, Kanaya S. PMID: 25545469; PMCID: PMC4353366.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    23. Structural and biochemical characterization of a metagenome-derived esterase with a long N-terminal extension. Protein Sci. 2015 Jan; 24(1):93-104. Okano H, Hong X, Kanaya E, Angkawidjaja C, Kanaya S. PMID: 25348365; PMCID: PMC4282415.
      View in: PubMed   Mentions: 5     Fields:    Translation:CellsPHPublic Health
    24. Structure and stability of metagenome-derived glycoside hydrolase family 12 cellulase (LC-CelA) a homolog of Cel12A from Rhodothermus marinus. FEBS Open Bio. 2014; 4:936-46. Okano H, Ozaki M, Kanaya E, Kim JJ, Angkawidjaja C, Koga Y, Kanaya S. PMID: 25426413; PMCID: PMC4239480.
      View in: PubMed   Mentions: 8     Fields:    
    25. The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria. Science. 2013 Nov 29; 342(6162):1237435. Deris JB, Kim M, Zhang Z, Okano H, Hermsen R, Groisman A, Hwa T. PMID: 24288338; PMCID: PMC4059556.
      View in: PubMed   Mentions: 101     Fields:    Translation:Cells
    26. Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature. 2013 Aug 15; 500(7462):301-6. You C, Okano H, Hui S, Zhang Z, Kim M, Gunderson CW, Wang YP, Lenz P, Yan D, Hwa T. PMID: 23925119; PMCID: PMC4038431.
      View in: PubMed   Mentions: 210     Fields:    Translation:Cells
    27. Need-based activation of ammonium uptake in Escherichia coli. Mol Syst Biol. 2012; 8:616. Kim M, Zhang Z, Okano H, Yan D, Groisman A, Hwa T. PMID: 23010999; PMCID: PMC3472687.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    28. Reversible adenylylation of glutamine synthetase is dynamically counterbalanced during steady-state growth of Escherichia coli. J Mol Biol. 2010 Dec 03; 404(3):522-36. Okano H, Hwa T, Lenz P, Yan D. PMID: 20887734.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    29. Predictors of gastric myoelectrical activity in type 2 diabetes mellitus. J Clin Gastroenterol. 2009 May-Jun; 43(5):429-36. Hata N, Murata S, Maeda J, Yatani H, Kohno Y, Yokono K, Okano H. PMID: 19564814.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve. J Comp Neurol. 2009 Mar 10; 513(2):237-48. Saito A, Sato T, Okano H, Toyoda K, Bamba H, Kimura S, Bellier JP, Matsuo A, Kimura H, Hisa Y, Tooyama I. PMID: 19137611.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J Biol Chem. 2009 Apr 03; 284(14):9566-77. Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M. PMID: 19088069; PMCID: PMC2666609.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. [A case of elderly onset loss of consciousness due to bacterial meningitis and subsequent vasculitis]. Nihon Ronen Igakkai Zasshi. 2008 Jul; 45(4):434-8. Kameno M, Takata T, Yasuda H, Hara K, Okano H, Sakurai T, Nagata M, Yokono K. PMID: 18753720.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Estimation of the source-by-source effect of autorepression on genetic noise. Biophys J. 2008 Aug; 95(3):1063-74. Okano H, Kobayashi TJ, Tozaki H, Kimura H. PMID: 18390607; PMCID: PMC2479612.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    34. Reconstructing the single-cell-level behavior of a toggle switch from population-level measurements. FEBS Lett. 2008 Apr 02; 582(7):1067-72. Tozaki H, Kobayashi TJ, Okano H, Yamamoto R, Aihara K, Kimura H. PMID: 18325334.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    35. A case of severe dilatation of the parotid duct due to fibrinous sialodochitis. Acta Otolaryngol. 2006 Oct; 126(10):1112-4. Shimada T, Okano H, Hisa Y. PMID: 16923720.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    36. [Group B streptococcal vertebral osteomyelitis following superficial suppurative thrombophlebitis]. Nihon Ronen Igakkai Zasshi. 2006 Sep; 43(5):635-8. Ohji G, Nagata M, Hara K, Matsuzawa T, Hata N, Yasuda H, Sakurai T, Okano H, Yokono K. PMID: 17073295.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. Localization of fibroblast growth factor-1 in cholinergic neurons innervating the rat larynx. J Histochem Cytochem. 2006 Sep; 54(9):1061-71. Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I. PMID: 16735594.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Mathematical description of gene regulatory units. Biophys J. 2006 Aug 15; 91(4):1235-47. Tanaka RJ, Okano H, Kimura H. PMID: 16714341; PMCID: PMC1518624.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. Age-related expression of alpha-gustducin in the rat larynx. Ann Otol Rhinol Laryngol. 2006 May; 115(5):387-93. Nishio T, Koike S, Okano H, Bamba H, Hisa Y. PMID: 16739672.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. Participation of TRPV1 and TRPV2 in the rat laryngeal sensory innervation. Neurosci Lett. 2006 May 29; 400(1-2):35-8. Okano H, Koike S, Bamba H, Toyoda K, Uno T, Hisa Y. PMID: 16517068.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    41. Comparison of FGF1 (aFGF) expression between the dorsal motor nucleus of vagus and the hypoglossal nucleus of rat. Acta Histochem Cytochem. 2006 Mar 02; 39(1):1-7. Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I. PMID: 17460766; PMCID: PMC1831852.
      View in: PubMed   Mentions: 1  
    42. A newborn case of congenital laryngeal cyst complicated with pneumothorax and pneumomediastinum. Auris Nasus Larynx. 2006 Jun; 33(2):207-10. Bamba H, Hirasugi K, Okano H, Nishio T, Uno T, Hisa Y. PMID: 16356675.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Distribution of vanilloid receptors in the rat laryngeal innervation. Acta Otolaryngol. 2004 May; 124(4):515-9. Koike S, Uno T, Bamba H, Shibata T, Okano H, Hisa Y. PMID: 15224886.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. A novel mechanism of intragenic complementation between Phe to Ala calmodulin mutations. J Biochem. 2004 Mar; 135(3):289-95. Okano H, Asakawa M, Ohya Y. PMID: 15113827.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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