Terence Hwa

Title(s)Professor, Molecular Biology
SchoolAcademic Aff
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Training Program in Quantitative Integrative Biology
    NIH/NIGMS T32GM127235Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Quantitative studies of metabolic switches in enteric bacteria
    NIH/NIGMS R01GM109069Feb 17, 2014 - Jan 31, 2018
    Role: Principal Investigator
    Quantitative Studies of Bacterial Growth Physiology
    NIH/NIGMS R01GM095903Aug 1, 2011 - Aug 31, 2019
    Role: Principal Investigator
    Quantitative Characterization &Modeling of sRNA-Mediated Gene Regulation
    NIH/NIGMS R01GM077298May 1, 2007 - Apr 30, 2012
    Role: Principal Investigator
    Combinational Transcription Control in Bacteria
    NIH/NIGMS R21GM070915Apr 1, 2004 - Sep 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Warren MR, Sun H, Yan Y, Cremer J, Li B, Hwa T. Spatiotemporal establishment of dense bacterial colonies growing on hard agar. Elife. 2019 Mar 11; 8. PMID: 30855227.
      View in: PubMed
    2. Arnoldini M, Cremer J, Hwa T. Bacterial growth, flow, and mixing shape human gut microbiota density and composition. Gut Microbes. 2018 11 02; 9(6):559-566. PMID: 29533125.
      View in: PubMed
    3. Dai X, Zhu M, Warren M, Balakrishnan R, Okano H, Williamson JR, Fredrick K, Hwa T. Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress. MBio. 2018 02 13; 9(1). PMID: 29440576.
      View in: PubMed
    4. Mori M, Schink S, Erickson DW, Gerland U, Hwa T. Quantifying the benefit of a proteome reserve in fluctuating environments. Nat Commun. 2017 10 31; 8(1):1225. PMID: 29089487.
      View in: PubMed
    5. Erickson DW, Schink SJ, Patsalo V, Williamson JR, Gerland U, Hwa T. A global resource allocation strategy governs growth transition kinetics of Escherichia coli. Nature. 2017 11 02; 551(7678):119-123. PMID: 29072300.
      View in: PubMed
    6. Cremer J, Arnoldini M, Hwa T. Effect of water flow and chemical environment on microbiota growth and composition in the human colon. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):6438-6443. PMID: 28588144.
      View in: PubMed
    7. Dai X, Zhu M, Warren M, Balakrishnan R, Patsalo V, Okano H, Williamson JR, Fredrick K, Wang YP, Hwa T. Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nat Microbiol. 2016 Dec 12; 2:16231. PMID: 27941827.
      View in: PubMed
    8. Cremer J, Segota I, Yang CY, Arnoldini M, Sauls JT, Zhang Z, Gutierrez E, Groisman A, Hwa T. Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11414-11419. PMID: 27681630.
      View in: PubMed
    9. Basan M, Zhu M, Dai X, Warren M, Sévin D, Wang YP, Hwa T. Inflating bacterial cells by increased protein synthesis. Mol Syst Biol. 2015 Oct 30; 11(10):836. PMID: 26519362; PMCID: PMC4631207.
    10. Hermsen R, Okano H, You C, Werner N, Hwa T. A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates. Mol Syst Biol. 2015 Apr 09; 11(4):801. PMID: 25862745; PMCID: PMC4422558.
    11. Hui S, Silverman JM, Chen SS, Erickson DW, Basan M, Wang J, Hwa T, Williamson JR. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol Syst Biol. 2015 Feb 12; 11(1):784. PMID: 25678603; PMCID: PMC4358657.
    12. Deris JB, Kim M, Zhang Z, Okano H, Hermsen R, Groisman A, Hwa T. The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria. Science. 2013 Nov 29; 342(6162):1237435. PMID: 24288338; PMCID: PMC4059556.
    13. You C, Okano H, Hui S, Zhang Z, Kim M, Gunderson CW, Wang YP, Lenz P, Yan D, Hwa T. Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature. 2013 Aug 15; 500(7462):301-6. PMID: 23925119; PMCID: PMC4038431.
    14. Hermsen R, Deris JB, Hwa T. On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10775-80. PMID: 22711808; PMCID: PMC3390829.
    15. Sulkowska JI, Morcos F, Weigt M, Hwa T, Onuchic JN. Genomics-aided structure prediction. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10340-5. PMID: 22691493; PMCID: PMC3387073.
    16. Kim M, Zhang Z, Okano H, Yan D, Groisman A, Hwa T. Need-based activation of ammonium uptake in Escherichia coli. Mol Syst Biol. 2012; 8:616. PMID: 23010999; PMCID: PMC3472687.
    17. Morcos F, Pagnani A, Lunt B, Bertolino A, Marks DS, Sander C, Zecchina R, Onuchic JN, Hwa T, Weigt M. Direct-coupling analysis of residue coevolution captures native contacts across many protein families. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):E1293-301. PMID: 22106262; PMCID: PMC3241805.
    18. Hermsen R, Erickson DW, Hwa T. Speed, sensitivity, and bistability in auto-activating signaling circuits. PLoS Comput Biol. 2011 Nov; 7(11):e1002265. PMID: 22125482; PMCID: PMC3219618.
    19. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. PMID: 21920356; PMCID: PMC3661008.
    20. Hermsen R, Hwa T. Sources and sinks: a stochastic model of evolution in heterogeneous environments. Phys Rev Lett. 2010 Dec 10; 105(24):248104. PMID: 21231560; PMCID: PMC4038430.
    21. Scott M, Gunderson CW, Mateescu EM, Zhang Z, Hwa T. Interdependence of cell growth and gene expression: origins and consequences. Science. 2010 Nov 19; 330(6007):1099-102. PMID: 21097934.
      View in: PubMed
    22. Schug A, Weigt M, Hoch JA, Onuchic JN, Hwa T, Szurmant H. Computational modeling of phosphotransfer complexes in two-component signaling. Methods Enzymol. 2010; 471:43-58. PMID: 20946841.
      View in: PubMed
    23. Klumpp S, Zhang Z, Hwa T. Growth rate-dependent global effects on gene expression in bacteria. Cell. 2009 Dec 24; 139(7):1366-75. PMID: 20064380; PMCID: PMC2818994.
    24. Schug A, Weigt M, Onuchic JN, Hwa T, Szurmant H. High-resolution protein complexes from integrating genomic information with molecular simulation. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22124-9. PMID: 20018738; PMCID: PMC2799721.
    25. Klumpp S, Hwa T. Traffic patrol in the transcription of ribosomal RNA. RNA Biol. 2009 Sep-Oct; 6(4):392-4. PMID: 19502817; PMCID: PMC2859892.
    26. Weigt M, White RA, Szurmant H, Hoch JA, Hwa T. Identification of direct residue contacts in protein-protein interaction by message passing. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):67-72. PMID: 19116270; PMCID: PMC2629192.
    27. Klumpp S, Hwa T. Growth-rate-dependent partitioning of RNA polymerases in bacteria. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20245-50. PMID: 19073937; PMCID: PMC2629260.
    28. Levine E, Hwa T. Small RNAs establish gene expression thresholds. Curr Opin Microbiol. 2008 Dec; 11(6):574-9. PMID: 18935980; PMCID: PMC2613760.
    29. Klumpp S, Hwa T. Stochasticity and traffic jams in the transcription of ribosomal RNA: Intriguing role of termination and antitermination. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18159-64. PMID: 19017803; PMCID: PMC2587539.
    30. Liu J, Desai A, Onuchic JN, Hwa T. An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13752-7. PMID: 18780795; PMCID: PMC2544526.
    31. Liu J, Desai A, Onuchic JN, Hwa T. A mechanobiochemical mechanism for monooriented chromosome oscillation in mitosis. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16104-9. PMID: 17911248; PMCID: PMC2042169.
    32. Levine E, Zhang Z, Kuhlman T, Hwa T. Quantitative characteristics of gene regulation by small RNA. PLoS Biol. 2007 Sep; 5(9):e229. PMID: 17713988; PMCID: PMC1994261.
    33. Levine E, Hwa T. Stochastic fluctuations in metabolic pathways. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9224-9. PMID: 17517669; PMCID: PMC1890476.
    34. Scott M, Hwa T, Ingalls B. Deterministic characterization of stochastic genetic circuits. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7402-7. PMID: 17446275; PMCID: PMC1863463.
    35. Kuhlman T, Zhang Z, Saier MH, Hwa T. Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):6043-8. PMID: 17376875; PMCID: PMC1851613.
    36. Gerland U, Bundschuh R, Hwa T. Translocation of structured polynucleotides through nanopores. Phys Biol. 2004 Jun; 1(1-2):19-26. PMID: 16204818.
      View in: PubMed
    37. Peng W, Levine H, Hwa T, Kessler DA. Analytical study of the effect of recombination on evolution via DNA shuffling. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 May; 69(5 Pt 1):051911. PMID: 15244851.
      View in: PubMed
    38. Arndt PF, Petrov DA, Hwa T. Distinct changes of genomic biases in nucleotide substitution at the time of Mammalian radiation. Mol Biol Evol. 2003 Nov; 20(11):1887-96. PMID: 12885958.
      View in: PubMed
    39. Gerland U, Bundschuh R, Hwa T. Mechanically probing the folding pathway of single RNA molecules. Biophys J. 2003 May; 84(5):2831-40. PMID: 12719217; PMCID: PMC1302848.
    40. Buchler NE, Gerland U, Hwa T. On schemes of combinatorial transcription logic. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5136-41. PMID: 12702751; PMCID: PMC404558.
    41. Hwa T, Marinari E, Sneppen K, Tang LH. Localization of denaturation bubbles in random DNA sequences. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4411-6. PMID: 12672955; PMCID: PMC404689.
    42. Peng W, Gerland U, Hwa T, Levine H. Dynamics of competitive evolution on a smooth landscape. Phys Rev Lett. 2003 Feb 28; 90(8):088103. PMID: 12633464.
      View in: PubMed
    43. Arndt PF, Burge CB, Hwa T. DNA sequence evolution with neighbor-dependent mutation. J Comput Biol. 2003; 10(3-4):313-22. PMID: 12935330.
      View in: PubMed
    44. Gerland U, Hwa T. On the selection and evolution of regulatory DNA motifs. J Mol Evol. 2002 Oct; 55(4):386-400. PMID: 12355260.
      View in: PubMed
    45. Gerland U, Moroz JD, Hwa T. Physical constraints and functional characteristics of transcription factor-DNA interaction. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12015-20. PMID: 12218191; PMCID: PMC129390.