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    Yishi Jin

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0368
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Cytoskeletal dynamics in axon regeneration
      NIH/NINDS R01NS093588Jul 15, 2015 - Apr 30, 2019
      Role: Principal Investigator
      Neuroscience Graduate Training Program
      NIH/NINDS T32NS061847Jul 1, 2008 - Jun 30, 2018
      Role: Principal Investigator
      Development of a C.elegans model for axonal regeneration
      NIH/NINDS R56NS057317Dec 1, 2006 - Mar 31, 2015
      Role: Principal Investigator
      GABAergic Neuron Differentiation in C.elegans
      NIH/NINDS R37NS035546Jul 18, 1996 - Mar 31, 2022
      Role: Principal Investigator
      GABAergic Neuron Differentiation in C. elegans
      NIH/NINDS R01NS035546Jul 18, 1996 - Jun 30, 2017
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Noma K, Goncharov A, Ellisman MH, Jin Y. Microtubule-dependent ribosome localization in C. elegans neurons. Elife. 2017 Aug 02; 6. PMID: 28767038.
        View in: PubMed
      2. McCulloch KA, Qi YB, Takayanagi-Kiya S, Jin Y, Cherra SJ. Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans. G3 (Bethesda). 2017 Jul 05; 7(7):2055-2063. PMID: 28468816.
        View in: PubMed
      3. Sharifnia P, Kim KW, Wu Z, Jin Y. Distinct cis elements in the 3' UTR of the C. elegans cebp-1 mRNA mediate its regulation in neuronal development. Dev Biol. 2017 Sep 01; 429(1):240-248. PMID: 28673818.
        View in: PubMed
      4. Kurup N, Yan D, Kono K, Jin Y. Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans. PLoS Genet. 2017 Jun; 13(6):e1006844. PMID: 28636662.
        View in: PubMed
      5. Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore AJ, Saito R, Yoshida K, Ogawa S, Rodewald HR, Lin YC, Kawamoto H, Murre C. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017 May 16; 46(5):818-834.e4. PMID: 28514688.
        View in: PubMed
      6. Knowlton WM, Hubert T, Wu Z, Chisholm AD, Jin Y. A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans. Front Neurosci. 2017; 11:263. PMID: 28539870.
        View in: PubMed
      7. Zhou K, Cherra SJ, Goncharov A, Jin Y. Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal Ca2+ Sensor Protein. Cell Rep. 2017 May 09; 19(6):1117-1129. PMID: 28494862.
        View in: PubMed
      8. Chen F, Chisholm AD, Jin Y. Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development. Development. 2017 Feb 15; 144(4):698-707. PMID: 28087624.
        View in: PubMed
      9. Kim KW, Thakur N, Piggott CA, Omi S, Polanowska J, Jin Y, Pujol N. Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. BMC Biol. 2016 Dec 07; 14(1):104. PMID: 27927209.
        View in: PubMed
      10. Noma K, Jin Y. Optogenetic Random Mutagenesis Using Histone-miniSOG in C. elegans. J Vis Exp. 2016 Nov 14; (117). PMID: 27911392.
        View in: PubMed
      11. Chisholm AD, Hutter H, Jin Y, Wadsworth WG. The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans. Genetics. 2016 Nov; 204(3):849-882. PMID: 28114100.
        View in: PubMed
      12. Takayanagi-Kiya S, Zhou K, Jin Y. Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel. Elife. 2016 Oct 26; 5. PMID: 27782882.
        View in: PubMed
      13. Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci Rep. 2016 Aug 11; 6:31482. PMID: 27511108; PMCID: PMC4980599.
      14. Takayanagi-Kiya S, Jin Y. Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. G3 (Bethesda). 2016 Jul 07; 6(7):2165-71. PMID: 27185401; PMCID: PMC4938669.
      15. Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld MG, Fu XD, Chisholm AD, Jin Y. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife. 2016 Jun 02; 5. PMID: 27253061; PMCID: PMC4946901.
      16. Knowlton WM, Jin Y. Ground Control to Major Tom: The Cell Body Signals Axon Degeneration. Cell. 2016 Feb 25; 164(5):842-4. PMID: 26919423.
        View in: PubMed
      17. Xu S, Wang Z, Kim KW, Jin Y, Chisholm AD. Targeted Mutagenesis of Duplicated Genes in Caenorhabditis elegans Using CRISPR-Cas9. J Genet Genomics. 2016 Feb 20; 43(2):103-6. PMID: 26924693.
        View in: PubMed
      18. Kurup N, Jin Y. Neural circuit rewiring: insights from DD synapse remodeling. Worm. 2016 Jan-Mar; 5(1):e1129486. PMID: 27073734; PMCID: PMC4805360 [Available on 12/10/16].
      19. Noma K, Jin Y. Optogenetic mutagenesis in Caenorhabditis elegans. Nat Commun. 2015 Dec 03; 6:8868. PMID: 26632265; PMCID: PMC4686824.
      20. Jin Y. Erratum to: Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics. Sci China Life Sci. 2015 Dec; 58(12):1306. PMID: 26601665.
        View in: PubMed
      21. Chen F, Zhou Y, Qi YB, Khivansara V, Li H, Chun SY, Kim JK, Fu XD, Jin Y. Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development. Genes Dev. 2015 Nov 15; 29(22):2377-90. PMID: 26588990; PMCID: PMC4691892.
      22. Jin Y. Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics. Sci China Life Sci. 2015 Nov; 58(11):1084-8. PMID: 26563175; PMCID: PMC4696538.
      23. Chen L, Chuang M, Koorman T, Boxem M, Jin Y, Chisholm AD. Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase. Elife. 2015 Sep 04; 4. PMID: 26339988; PMCID: PMC4596636.
      24. Kurup N, Yan D, Goncharov A, Jin Y. Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling. Curr Biol. 2015 Jun 15; 25(12):1594-605. PMID: 26051896; PMCID: PMC4470761.
      25. Kim KW, Jin Y. Neuronal responses to stress and injury in C. elegans. FEBS Lett. 2015 Jun 22; 589(14):1644-52. PMID: 25979176; PMCID: PMC4458507.
      26. Sharifnia P, Jin Y. Regulatory roles of RNA binding proteins in the nervous system of C. elegans. Front Mol Neurosci. 2014; 7:100. PMID: 25628531; PMCID: PMC4290612.
      27. Cherra SJ, Jin Y. Advances in synapse formation: forging connections in the worm. Wiley Interdiscip Rev Dev Biol. 2015 Mar-Apr; 4(2):85-97. PMID: 25472860; PMCID: PMC4339659.
      28. Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm AD. The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. Cell Rep. 2014 Nov 06; 9(3):874-83. PMID: 25437544; PMCID: PMC4250830.
      29. Noma K, Goncharov A, Jin Y. Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans. Genetics. 2014 Nov; 198(3):1101-15. PMID: 25194163; PMCID: PMC4224155.
      30. Hubert T, Wu Z, Chisholm AD, Jin Y. S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans. J Neurosci. 2014 Jan 15; 34(3):758-63. PMID: 24431434; PMCID: PMC3891956.
      31. Zhou K, Stawicki TM, Goncharov A, Jin Y. Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics. Elife. 2013 Nov 12; 2:e01180. PMID: 24220508; PMCID: PMC3821175.
      32. Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 2013 Sep 04; 79(5):903-16. PMID: 24012004; PMCID: PMC3779136.
      33. Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 2013 Jul 24; 79(2):241-53. PMID: 23889931; PMCID: PMC3804158.
      34. Kurup N, Sharifnia P, Jin Y. Spatial and temporal dynamics of neurite regrowth. Curr Opin Neurobiol. 2013 Dec; 23(6):1011-7. PMID: 23856616; PMCID: PMC3833091.
      35. Stawicki TM, Takayanagi-Kiya S, Zhou K, Jin Y. Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. PLoS Genet. 2013 May; 9(5):e1003472. PMID: 23658528; PMCID: PMC3642046.
      36. Yan D, Jin Y. Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform. Neuron. 2012 Nov 08; 76(3):534-48. PMID: 23141066; PMCID: PMC3508676.
      37. Ghosh-Roy A, Goncharov A, Jin Y, Chisholm AD. Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration. Dev Cell. 2012 Oct 16; 23(4):716-28. PMID: 23000142; PMCID: PMC3477258.
      38. Sann SB, Crane MM, Lu H, Jin Y. Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans. PLoS One. 2012; 7(6):e37930. PMID: 22675499; PMCID: PMC3366993.
      39. Qi YB, Garren EJ, Shu X, Tsien RY, Jin Y. Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7499-504. PMID: 22532663; PMCID: PMC3358873.
      40. Yan D, Noma K, Jin Y. Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans. Curr Opin Neurobiol. 2012 Jun; 22(3):431-7. PMID: 22036768; PMCID: PMC3291474.
      41. Chen L, Wang Z, Ghosh-Roy A, Hubert T, Yan D, O'Rourke S, Bowerman B, Wu Z, Jin Y, Chisholm AD. Axon regeneration pathways identified by systematic genetic screening in C. elegans. Neuron. 2011 Sep 22; 71(6):1043-57. PMID: 21943602; PMCID: PMC3183436.
      42. Stawicki TM, Zhou K, Yochem J, Chen L, Jin Y. TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis. Curr Biol. 2011 May 24; 21(10):883-8. PMID: 21549603; PMCID: PMC4034270.
      43. Shu X, Lev-Ram V, Deerinck TJ, Qi Y, Ramko EB, Davidson MW, Jin Y, Ellisman MH, Tsien RY. A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms. PLoS Biol. 2011 Apr; 9(4):e1001041. PMID: 21483721; PMCID: PMC3071375.
      44. Yan D, Jin Y. Molecular and genetic approaches for the analysis of C. elegans neuronal development. Methods Cell Biol. 2011; 106:413-43. PMID: 22118286.
        View in: PubMed
      45. Gotenstein JR, Swale RE, Fukuda T, Wu Z, Giurumescu CA, Goncharov A, Jin Y, Chisholm AD. The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration. Development. 2010 Nov; 137(21):3603-13. PMID: 20876652; PMCID: PMC2964093.
      46. Wang Z, Jin Y. Genetic dissection of axon regeneration. Curr Opin Neurobiol. 2011 Feb; 21(1):189-96. PMID: 20832288; PMCID: PMC3070659.
      47. Van Epps H, Dai Y, Qi Y, Goncharov A, Jin Y. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Development. 2010 Jul; 137(13):2237-50. PMID: 20530551; PMCID: PMC2882140.
      48. Trujillo G, Nakata K, Yan D, Maruyama IN, Jin Y. A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. Genetics. 2010 Sep; 186(1):135-45. PMID: 20592265; PMCID: PMC2940282.
      49. Ghosh-Roy A, Wu Z, Goncharov A, Jin Y, Chisholm AD. Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase. J Neurosci. 2010 Mar 03; 30(9):3175-83. PMID: 20203177; PMCID: PMC2921707.
      50. Yan D, Wu Z, Chisholm AD, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009 Sep 04; 138(5):1005-18. PMID: 19737525; PMCID: PMC2772821.
      51. Sann S, Wang Z, Brown H, Jin Y. Roles of endosomal trafficking in neurite outgrowth and guidance. Trends Cell Biol. 2009 Jul; 19(7):317-24. PMID: 19540123.
        View in: PubMed
      52. Tsai PS, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems. Curr Opin Biotechnol. 2009 Feb; 20(1):90-9. PMID: 19269159; PMCID: PMC3123732.
      53. Jin Y, Garner CC. Molecular mechanisms of presynaptic differentiation. Annu Rev Cell Dev Biol. 2008; 24:237-62. PMID: 18588488.
        View in: PubMed
      54. Wu Z, Ghosh-Roy A, Yanik MF, Zhang JZ, Jin Y, Chisholm AD. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15132-7. PMID: 17848506; PMCID: PMC1975853.
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