Philbert Tsai

Title(s)Lecturer, Physics
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function. Front Physiol. 2019; 10:233. Smith AF, Doyeux V, Berg M, Peyrounette M, Haft-Javaherian M, Larue AE, Slater JH, Lauwers F, Blinder P, Tsai P, Kleinfeld D, Schaffer CB, Nishimura N, Davit Y, Lorthois S. PMID: 30971935; PMCID: PMC6444172.
      View in: PubMed   Mentions: 41  
    2. Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent "Resting-State" Connectivity. Neuron. 2017 Nov 15; 96(4):936-948.e3. Mateo C, Knutsen PM, Tsai PS, Shih AY, Kleinfeld D. PMID: 29107517; PMCID: PMC5851777.
      View in: PubMed   Mentions: 144     Fields:    Translation:Animals
    3. The impact of vessel size, orientation and intravascular contribution on the neurovascular fingerprint of BOLD bSSFP fMRI. Neuroimage. 2017 12; 163:13-23. Báez-Yánez MG, Ehses P, Mirkes C, Tsai PS, Kleinfeld D, Scheffler K. PMID: 28890417; PMCID: PMC5857886.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    4. Depth-dependent flow and pressure characteristics in cortical microvascular networks. PLoS Comput Biol. 2017 02; 13(2):e1005392. Schmid F, Tsai PS, Kleinfeld D, Jenny P, Weber B. PMID: 28196095; PMCID: PMC5347440.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    5. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416. Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. PMID: 28135240; PMCID: PMC5323291.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    6. The capillary bed offers the largest hemodynamic resistance to the cortical blood supply. J Cereb Blood Flow Metab. 2017 01; 37(1):52-68. Gould IG, Tsai P, Kleinfeld D, Linninger A. PMID: 27780904; PMCID: PMC5363755.
      View in: PubMed   Mentions: 110     Fields:    Translation:Animals
    7. Ultra-large field-of-view two-photon microscopy. Opt Express. 2015 Jun 01; 23(11):13833-47. Tsai PS, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D. PMID: 26072755; PMCID: PMC4523368.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    8. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation. 2015 Apr; 22(3):204-218. Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D. PMID: 25705966; PMCID: PMC4393797.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    9. All-optical osteotomy to create windows for transcranial imaging in mice. Opt Express. 2013 Oct 07; 21(20):23160-8. Jeong DC, Tsai PS, Kleinfeld D. PMID: 24104230; PMCID: PMC3971057.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    10. The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nat Neurosci. 2013 Jul; 16(7):889-97. Blinder P, Tsai PS, Kaufhold JP, Knutsen PM, Suhl H, Kleinfeld D. PMID: 23749145; PMCID: PMC4141079.
      View in: PubMed   Mentions: 283     Fields:    Translation:AnimalsCells
    11. All-optical in situ histology of brain tissue with femtosecond laser pulses. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):327-34. Tsai PS, Blinder P, Squier JA, Kleinfeld D. PMID: 23547156.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat Neurosci. 2013 Jan; 16(1):55-63. Shih AY, Blinder P, Tsai PS, Friedman B, Stanley G, Lyden PD, Kleinfeld D. PMID: 23242312; PMCID: PMC3952571.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimals
    13. Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open-ended segments. Med Image Anal. 2012 Aug; 16(6):1241-58. Kaufhold JP, Tsai PS, Blinder P, Kleinfeld D. PMID: 22854035; PMCID: PMC3443315.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    14. A polished and reinforced thinned-skull window for long-term imaging of the mouse brain. J Vis Exp. 2012 Mar 07; (61). Shih AY, Mateo C, Drew PJ, Tsai PS, Kleinfeld D. PMID: 22433225; PMCID: PMC3460568.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    15. Prospect for feedback guided surgery with ultra-short pulsed laser light. Curr Opin Neurobiol. 2012 Feb; 22(1):24-33. Jeong DC, Tsai PS, Kleinfeld D. PMID: 22088392; PMCID: PMC3763077.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    16. Large-scale automated histology in the pursuit of connectomes. J Neurosci. 2011 Nov 09; 31(45):16125-38. Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai PS, Sakmann B. PMID: 22072665; PMCID: PMC3758571.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    17. A guide to delineate the logic of neurovascular signaling in the brain. Front Neuroenergetics. 2011; 3:1. Kleinfeld D, Blinder P, Drew PJ, Driscoll JD, Muller A, Tsai PS, Shih AY. PMID: 21559095; PMCID: PMC3085135.
      View in: PubMed   Mentions: 46  
    18. Chronic optical access through a polished and reinforced thinned skull. Nat Methods. 2010 Dec; 7(12):981-4. Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D. PMID: 20966916; PMCID: PMC3204312.
      View in: PubMed   Mentions: 232     Fields:    
    19. Temporally focused femtosecond laser pulses for low numerical aperture micromachining through optically transparent materials. Opt Express. 2010 Aug 16; 18(17):18086-94. Vitek DN, Adams DE, Johnson A, Tsai PS, Backus S, Durfee CG, Kleinfeld D, Squier JA. PMID: 20721196; PMCID: PMC3408926.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    20. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18; 29(46):14553-70. Tsai PS, Kaufhold JP, Blinder P, Friedman B, Drew PJ, Karten HJ, Lyden PD, Kleinfeld D. PMID: 19923289; PMCID: PMC4972024.
      View in: PubMed   Mentions: 283     Fields:    Translation:AnimalsCells
    21. Severe blood-brain barrier disruption and surrounding tissue injury. Stroke. 2009 Dec; 40(12):e666-74. Chen B, Friedman B, Cheng Q, Tsai P, Schim E, Kleinfeld D, Lyden PD. PMID: 19893002; PMCID: PMC2819286.
      View in: PubMed   Mentions: 63     Fields:    
    22. Acute vascular disruption and aquaporin 4 loss after stroke. Stroke. 2009 Jun; 40(6):2182-90. Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD. PMID: 19372455; PMCID: PMC2753985.
      View in: PubMed   Mentions: 31     Fields:    
    23. Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems. Curr Opin Biotechnol. 2009 Feb; 20(1):90-9. Tsai PS, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. PMID: 19269159; PMCID: PMC3123732.
      View in: PubMed   Mentions: 32     Fields:    
    24. Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood Flow Metab. 2009 Apr; 29(4):738-51. Shih AY, Friedman B, Drew PJ, Tsai PS, Lyden PD, Kleinfeld D. PMID: 19174826; PMCID: PMC2893883.
      View in: PubMed   Mentions: 65     Fields:    
    25. MPScope: a versatile software suite for multiphoton microscopy. J Neurosci Methods. 2006 Sep 30; 156(1-2):351-9. Nguyen QT, Tsai PS, Kleinfeld D. PMID: 16621010.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    26. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006 Feb; 3(2):99-108. Nishimura N, Schaffer CB, Friedman B, Tsai PS, Lyden PD, Kleinfeld D. PMID: 16432519.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    27. Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol. 2006 Feb; 4(2):e22. Schaffer CB, Friedman B, Nishimura N, Schroeder LF, Tsai PS, Ebner FF, Lyden PD, Kleinfeld D. PMID: 16379497; PMCID: PMC1324794.
      View in: PubMed   Mentions: 173     Fields:    Translation:Animals
    28. All-optical histology using ultrashort laser pulses. Neuron. 2003 Jul 03; 39(1):27-41. Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. PMID: 12848930.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
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