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Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function. Front Physiol. 2019; 10:233.
Smith AF, Doyeux V, Berg M, Peyrounette M, Haft-Javaherian M, Larue AE, Slater JH, Lauwers F, Blinder P, Tsai P, Kleinfeld D, Schaffer CB, Nishimura N, Davit Y, Lorthois S. PMID: 30971935.
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Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent "Resting-State" Connectivity. Neuron. 2017 Nov 15; 96(4):936-948.e3.
Mateo C, Knutsen PM, Tsai PS, Shih AY, Kleinfeld D. PMID: 29107517.
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59 Fields:
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Animals
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The impact of vessel size, orientation and intravascular contribution on the neurovascular fingerprint of BOLD bSSFP fMRI. Neuroimage. 2017 12; 163:13-23.
Báez-Yánez MG, Ehses P, Mirkes C, Tsai PS, Kleinfeld D, Scheffler K. PMID: 28890417.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Depth-dependent flow and pressure characteristics in cortical microvascular networks. PLoS Comput Biol. 2017 02; 13(2):e1005392.
Schmid F, Tsai PS, Kleinfeld D, Jenny P, Weber B. PMID: 28196095.
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PubMed Mentions:
22 Fields:
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AnimalsCells
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Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416.
Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. PMID: 28135240.
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123 Fields:
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AnimalsCells
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The capillary bed offers the largest hemodynamic resistance to the cortical blood supply. J Cereb Blood Flow Metab. 2017 01; 37(1):52-68.
Gould IG, Tsai P, Kleinfeld D, Linninger A. PMID: 27780904.
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51 Fields:
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Animals
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Ultra-large field-of-view two-photon microscopy. Opt Express. 2015 Jun 01; 23(11):13833-47.
Tsai PS, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D. PMID: 26072755.
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34 Fields:
Translation:
Animals
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Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation. 2015 Apr; 22(3):204-218.
Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D. PMID: 25705966.
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33 Fields:
Translation:
HumansAnimalsCells
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All-optical osteotomy to create windows for transcranial imaging in mice. Opt Express. 2013 Oct 07; 21(20):23160-8.
Jeong DC, Tsai PS, Kleinfeld D. PMID: 24104230.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nat Neurosci. 2013 Jul; 16(7):889-97.
Blinder P, Tsai PS, Kaufhold JP, Knutsen PM, Suhl H, Kleinfeld D. PMID: 23749145.
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174 Fields:
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AnimalsCells
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All-optical in situ histology of brain tissue with femtosecond laser pulses. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):327-34.
Tsai PS, Blinder P, Squier JA, Kleinfeld D. PMID: 23547156.
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Animals
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The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat Neurosci. 2013 Jan; 16(1):55-63.
Shih AY, Blinder P, Tsai PS, Friedman B, Stanley G, Lyden PD, Kleinfeld D. PMID: 23242312.
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111 Fields:
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HumansAnimals
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Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open-ended segments. Med Image Anal. 2012 Aug; 16(6):1241-58.
Kaufhold JP, Tsai PS, Blinder P, Kleinfeld D. PMID: 22854035.
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PubMed Mentions:
11 Fields:
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HumansAnimals
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A polished and reinforced thinned-skull window for long-term imaging of the mouse brain. J Vis Exp. 2012 Mar 07; (61).
Shih AY, Mateo C, Drew PJ, Tsai PS, Kleinfeld D. PMID: 22433225.
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PubMed Mentions:
59 Fields:
Translation:
Animals
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Prospect for feedback guided surgery with ultra-short pulsed laser light. Curr Opin Neurobiol. 2012 Feb; 22(1):24-33.
Jeong DC, Tsai PS, Kleinfeld D. PMID: 22088392.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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Large-scale automated histology in the pursuit of connectomes. J Neurosci. 2011 Nov 09; 31(45):16125-38.
Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai PS, Sakmann B. PMID: 22072665.
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70 Fields:
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HumansAnimalsCells
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A guide to delineate the logic of neurovascular signaling in the brain. Front Neuroenergetics. 2011; 3:1.
Kleinfeld D, Blinder P, Drew PJ, Driscoll JD, Muller A, Tsai PS, Shih AY. PMID: 21559095.
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Chronic optical access through a polished and reinforced thinned skull. Nat Methods. 2010 Dec; 7(12):981-4.
Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D. PMID: 20966916.
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PubMed Mentions:
171 Fields:
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Animals
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Temporally focused femtosecond laser pulses for low numerical aperture micromachining through optically transparent materials. Opt Express. 2010 Aug 16; 18(17):18086-94.
Vitek DN, Adams DE, Johnson A, Tsai PS, Backus S, Durfee CG, Kleinfeld D, Squier JA. PMID: 20721196.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18; 29(46):14553-70.
Tsai PS, Kaufhold JP, Blinder P, Friedman B, Drew PJ, Karten HJ, Lyden PD, Kleinfeld D. PMID: 19923289.
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203 Fields:
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AnimalsCells
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Acute vascular disruption and aquaporin 4 loss after stroke. Stroke. 2009 Jun; 40(6):2182-90.
Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD. PMID: 19372455.
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29 Fields:
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AnimalsCells
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Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems. Curr Opin Biotechnol. 2009 Feb; 20(1):90-9.
Tsai PS, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. PMID: 19269159.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood Flow Metab. 2009 Apr; 29(4):738-51.
Shih AY, Friedman B, Drew PJ, Tsai PS, Lyden PD, Kleinfeld D. PMID: 19174826.
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48 Fields:
Translation:
AnimalsCells
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MPScope: a versatile software suite for multiphoton microscopy. J Neurosci Methods. 2006 Sep 30; 156(1-2):351-9.
Nguyen QT, Tsai PS, Kleinfeld D. PMID: 16621010.
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52 Fields:
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Animals
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Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006 Feb; 3(2):99-108.
Nishimura N, Schaffer CB, Friedman B, Tsai PS, Lyden PD, Kleinfeld D. PMID: 16432519.
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114 Fields:
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AnimalsCells
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Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol. 2006 Feb; 4(2):e22.
Schaffer CB, Friedman B, Nishimura N, Schroeder LF, Tsai PS, Ebner FF, Lyden PD, Kleinfeld D. PMID: 16379497.
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145 Fields:
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Animals
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All-optical histology using ultrashort laser pulses. Neuron. 2003 Jul 03; 39(1):27-41.
Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. PMID: 12848930.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells