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Emmanuel Theodorakis

Photo of Emmanuel Theodorakis
Title(s)Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
Emailetheodorakis@ucsd.edu
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    Collapse Biography 
    Collapse education and training
    University of Athens, Greece, Athens, GreeceB.Sc.07/1987Chemistry
    Paris XI University, FranceM.Sc.07/1989Organic Chemistry
    Texas A&M University, Texas, USAPhD research04/1993Organic Chemistry
    Paris XI University, FrancePh.D.04/1993Organic Chemistry
    The Scripps Research Institute, CA, UCAPost-Doc06/1995Organic Synthesis

    Collapse Overview 
    Collapse overview
    Synthesis, medicinal chemistry, chemical biology, natural products, neurodegeneration, fluorescent sensors,
    Collapse webpage

    Collapse Research 
    Collapse research activities and funding
    Chemical design of amyloid targeting fluorescent probes
    NIH/NIA RF1AG062362Aug 15, 2018 - Jun 30, 2023
    Role: PI
    Chemical design of amyloid targeting fluorescent probes
    NIH/NIA R01AG062362Aug 15, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Chemical design of amyloid targeting fluorescent probes
    NIH/NIA RF1AG062362Aug 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Chemical Biology of Caged Garcinia Xanthones
    NIH/NCI R01CA133002Sep 11, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Synthesis of Bioactive Marine Natural Products
    NIH/NIGMS R01GM081484Jul 1, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Total Synthesis of Bioactive Natural Products
    NIH/NCI R01CA086079Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator
    TOPOISOMERASE II POISONING AND ANTICANCER DRUG DESIGN
    NIH/NCI R01CA085600Feb 2, 2001 - Jan 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Excited State Rotational Freedom Impacts Viscosity Sensitivity in Arylcyanoamide Fluorescent Molecular Rotor Dyes. J Phys Chem B. 2024 Apr 25; 128(16):3946-3952. Ehrlich RS, Dasgupta S, Jessup RE, Teppang KL, Shiao AL, Jeoung KY, Su X, Shivkumar A, Theodorakis EA, Paesani F, Yang J. PMID: 38624216; PMCID: PMC11951057.
      View in: PubMed   Mentions: 3     Fields:    
    2. Fluorescent molecular rotors as versatile in situ sensors for protein quantitation. Sci Rep. 2023 11 22; 13(1):20529. Daus K, Tharamak S, Pluempanupat W, Galie PA, Theodoraki MA, Theodorakis EA, Alpaugh ML. PMID: 37993476; PMCID: PMC10665405.
      View in: PubMed   Mentions: 1     Fields:    
    3. Electrochemical potential enables dormant spores to integrate environmental signals. Science. 2022 10 07; 378(6615):43-49. Kikuchi K, Galera-Laporta L, Weatherwax C, Lam JY, Moon EC, Theodorakis EA, Garcia-Ojalvo J, Süel GM. PMID: 36201591; PMCID: PMC10593254.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    4. Gambogic acid: Multi-gram scale isolation, stereochemical erosion toward epi-gambogic acid and biological profile. Front Nat Prod. 2022; 1. Arevalo GE, Frank MK, Decker KS, Theodoraki MA, Theodorakis EA. PMID: 39211297; PMCID: PMC11361287.
      View in: PubMed   Mentions: 1  
    5. Exploring the Effect of Aliphatic Substituents on Aryl Cyano Amides on Enhancement of Fluorescence upon Binding to Amyloid-β Aggregates. ACS Chem Neurosci. 2021 08 04; 12(15):2946-2952. Ehrlich RS, Shiao AL, Li M, Teppang KL, Jeoung KY, Theodorakis EA, Yang J. PMID: 34270227; PMCID: PMC10246476.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes. Bioorg Chem. 2019 12; 93:103303. Chantarasriwong O, Dorwart TJ, Morales TH, Maggio SF, Settle AL, Milcarek AT, Alpaugh ML, Theodoraki MA, Theodorakis EA. PMID: 31585264.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery. Mar Drugs. 2019 Apr 19; 17(4). Braddock AA, Theodorakis EA. PMID: 31010150; PMCID: PMC6521127.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    8. Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer. Eur J Med Chem. 2019 Apr 15; 168:405-413. Chantarasriwong O, Milcarek AT, Morales TH, Settle AL, Rezende CO, Althufairi BD, Theodoraki MA, Alpaugh ML, Theodorakis EA. PMID: 30831408.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids. Sci Rep. 2018 05 03; 8(1):6950. Cao KJ, Elbel KM, Cifelli JL, Cirera J, Sigurdson CJ, Paesani F, Theodorakis EA, Yang J. PMID: 29725045; PMCID: PMC5934448.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity. Antimicrob Agents Chemother. 2017 01; 61(1). Ke H, Morrisey JM, Qu S, Chantarasriwong O, Mather MW, Theodorakis EA, Vaidya AB. PMID: 27799215; PMCID: PMC5192125.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4801-9. Yim KH, Prince TL, Qu S, Bai F, Jennings PA, Onuchic JN, Theodorakis EA, Neckers L. PMID: 27466407; PMCID: PMC4995996.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    12. Ratiometric mechanosensitive fluorescent dyes: Design and applications. J Mater Chem C Mater. 2016 Apr 14; 4(14):2707-2718. Haidekker MA, Theodorakis EA. PMID: 27127631; PMCID: PMC4844075.
      View in: PubMed   Mentions: 16  
    13. Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening. Oncotarget. 2015 Aug 28; 6(25):21255-67. Theodoraki MA, Rezende CO, Chantarasriwong O, Corben AD, Theodorakis EA, Alpaugh ML. PMID: 26101913; PMCID: PMC4673263.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. ACS Chem Neurosci. 2015 Sep 16; 6(9):1503-8. Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis EA, Walsh DM, Yang J, Shah JV. PMID: 26212450; PMCID: PMC4814290.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    15. Total Synthesis and Structural Revision of Antibiotic CJ-16,264. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9203-8. Nicolaou KC, Shah AA, Korman H, Khan T, Shi L, Worawalai W, Theodorakis EA. PMID: 26096055; PMCID: PMC4530996.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    16. Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates. Org Chem Front. 2015 Apr 01; 2(4):388-393. Lacoske MH, Xu J, Mansour N, Gao C, Theodorakis EA. PMID: 26257916; PMCID: PMC4527581.
      View in: PubMed   Mentions: 2  
    17. Cyclopenta[b]naphthalene cyanoacrylate dyes: synthesis and evaluation as fluorescent molecular rotors. Org Biomol Chem. 2015 Mar 14; 13(10):2965-73. Kocsis LS, Elbel KM, Hardigree BA, Brummond KM, Haidekker MA, Theodorakis EA. PMID: 25614187; PMCID: PMC4339457.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3698-703. Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis EA, Jennings PA, Onuchic JN, Mittler R, Nechushtai R. PMID: 25762074; PMCID: PMC4378444.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    19. 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem. 2015 Feb 12; 58(3):1524-43. Papakyriakou A, Zervoudi E, Tsoukalidou S, Mauvais FX, Sfyroera G, Mastellos DC, van Endert P, Theodorakis EA, Vourloumis D, Stratikos E. PMID: 25635706.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. Erratum: renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res. 2014 Dec 05; 33:95. Williams RT, Yu AL, Diccianni MB, Theodorakis EA, Batova A. PMID: 25480670; PMCID: PMC4272799.
      View in: PubMed   Mentions:    Fields:    
    21. Spirotetronate polyketides as leads in drug discovery. J Nat Prod. 2015 Mar 27; 78(3):562-75. Lacoske MH, Theodorakis EA. PMID: 25434976; PMCID: PMC4380204.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    22. Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB. Chem Biol. 2014 Aug 14; 21(8):955-66. Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L. PMID: 25065531.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors. Org Chem Front. 2014 Apr 01; 1(2):135-139. Caro-Diaz EJ, Aung A, Xu J, Varghese S, Theodorakis EA. PMID: 24910777; PMCID: PMC4043345.
      View in: PubMed   Mentions: 3  
    24. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis EA, Gianneschi NC, Vecchio KS, Chien S, Lee OK, Varghese S. PMID: 24395775; PMCID: PMC3903237.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansCells
    25. Neurotrophic natural products: chemistry and biology. Angew Chem Int Ed Engl. 2014 Jan 20; 53(4):956-87. Xu J, Lacoske MH, Theodorakis EA. PMID: 24353244; PMCID: PMC3945720.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    26. Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res. 2013 Aug 20; 32:57. Williams RT, Yu AL, Diccianni MB, Theodorakis EA, Batova A. PMID: 23958461; PMCID: PMC3765946.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    27. Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 01; 23(17):4832-6. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. PMID: 23916253.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation. Beilstein J Org Chem. 2013; 9:1135-40. Trzoss L, Xu J, Lacoske MH, Theodorakis EA. PMID: 23843905; PMCID: PMC3701413.
      View in: PubMed   Mentions: 2  
    29. A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones. Org Biomol Chem. 2013 May 28; 11(20):3341-8. Elbel KM, Guizzunti G, Theodoraki MA, Xu J, Batova A, Dakanali M, Theodorakis EA. PMID: 23563530; PMCID: PMC3654788.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Synthesis of a highly functionalized core of verrillin. Org Lett. 2013 May 17; 15(10):2410-3. Saitman A, Theodorakis EA. PMID: 23627293; PMCID: PMC3766406.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    31. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10; 19(20):6398-408. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. PMID: 23526661; PMCID: PMC3875175.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    32. A strategy toward the synthesis of C13-oxidized cembrenolides. Tetrahedron Lett. 2013 Mar 20; 54(12):1612-1615. Saitman A, Sullivan SD, Theodorakis EA. PMID: 23626379; PMCID: PMC3634613.
      View in: PubMed   Mentions: 5     Fields:    
    33. Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides. Bioorg Med Chem. 2012 Dec 01; 20(23):6885-93. Martínez-Montero S, Fernández S, Sanghvi YS, Theodorakis EA, Detorio MA, McBrayer TR, Whitaker T, Schinazi RF, Gotor V, Ferrero M. PMID: 23085031; PMCID: PMC3489957.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    34. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-β and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J. PMID: 22866977; PMCID: PMC3480552.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    35. Self-calibrating viscosity probes: design and subcellular localization. Bioorg Med Chem. 2012 Jul 15; 20(14):4443-50. Dakanali M, Do TH, Horn A, Chongchivivat A, Jarusreni T, Lichlyter D, Guizzunti G, Haidekker MA, Theodorakis EA. PMID: 22698784; PMCID: PMC3390230.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    36. Subcellular localization and activity of gambogic acid. Chembiochem. 2012 May 29; 13(8):1191-8. Guizzunti G, Batova A, Chantarasriwong O, Dakanali M, Theodorakis EA. PMID: 22532297; PMCID: PMC3359389.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    37. Formal synthesis of (-)-englerin A and cytotoxicity studies of truncated englerins. Chem Asian J. 2012 May; 7(5):1052-60. Xu J, Caro-Diaz EJ, Batova A, Sullivan SD, Theodorakis EA. PMID: 22415793; PMCID: PMC3338859.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. Nature-inspired total synthesis of (-)-fusarisetin A. J Am Chem Soc. 2012 Mar 21; 134(11):5072-5. Xu J, Caro-Diaz EJ, Trzoss L, Theodorakis EA. PMID: 22390338; PMCID: PMC3310296.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    39. Fusarisetin A: Scalable Total Synthesis and Related Studies. Chem Sci. 2012 Jan 01; 3(12):3378-3386. Xu J, Caro-Diaz EJ, Lacoske MH, Hung CI, Jamora C, Theodorakis EA. PMID: 23227303; PMCID: PMC3513937.
      View in: PubMed   Mentions: 13  
    40. Total synthesis of norcembrenolide B and scabrolide D. Org Lett. 2011 Nov 04; 13(21):5854-7. Saitman A, Rulliere P, Sullivan SD, Theodorakis EA. PMID: 21973225; PMCID: PMC3204162.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    41. Intrinsic and extrinsic temperature-dependency of viscosity-sensitive fluorescent molecular rotors. J Fluoresc. 2012 Jan; 22(1):457-65. Howell S, Dakanali M, Theodorakis EA, Haidekker MA. PMID: 21947609; PMCID: PMC3272777.
      View in: PubMed   Mentions: 9     Fields:    
    42. Intramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids. Tetrahedron Lett. 2011 Sep 21; 52(38):4920-4923. Fischer D, Nguyen TX, Trzoss L, Dakanali M, Theodorakis EA. PMID: 21857757; PMCID: PMC3157960.
      View in: PubMed   Mentions: 2     Fields:    
    43. Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance? Invest New Drugs. 2012 Oct; 30(5):1841-8. Guizzunti G, Theodorakis EA, Yu AL, Zurzolo C, Batova A. PMID: 21898184; PMCID: PMC3405192.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett. 2011 Sep 02; 13(17):4554-7. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. PMID: 21812392; PMCID: PMC3163030.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    45. Enantioselective synthesis of the ABC ring motif of norzoanthamine based on asymmetric Robinson annulation reactions. Org Lett. 2011 Jul 01; 13(13):3308-11. Nguyen TX, Dakanali M, Trzoss L, Theodorakis EA. PMID: 21615125; PMCID: PMC3153989.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    46. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. Chang WM, Dakanali M, Capule CC, Sigurdson CJ, Yang J, Theodorakis EA. PMID: 21743829; PMCID: PMC3129977.
      View in: PubMed   Mentions: 32     Fields:    
    47. Synthesis of (-)-callicarpenal, a potent arthropod-repellent. Tetrahedron. 2011 Apr 29; 67(17):3023-3029. Ling T, Xu J, Smith R, Ali A, Cantrell CL, Theodorakis EA. PMID: 21643472; PMCID: PMC3105892.
      View in: PubMed   Mentions: 5     Fields:    
    48. Synthesis and evaluation of self-calibrating ratiometric viscosity sensors. Org Biomol Chem. 2011 May 07; 9(9):3530-40. Yoon HJ, Dakanali M, Lichlyter D, Chang WM, Nguyen KA, Nipper ME, Haidekker MA, Theodorakis EA. PMID: 21437318; PMCID: PMC3157677.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    49. Enantioselective total synthesis of (-)-jiadifenolide. Angew Chem Int Ed Engl. 2011 Apr 11; 50(16):3672-6. Xu J, Trzoss L, Chang WK, Theodorakis EA. PMID: 21400650; PMCID: PMC3159889.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    50. Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors. Biochimie. 2011 Jun; 93(6):988-94. Nipper ME, Dakanali M, Theodorakis E, Haidekker MA. PMID: 21354253; PMCID: PMC3095221.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    51. The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity. Mol Cancer Ther. 2010 Nov; 9(11):2869-78. Batova A, Altomare D, Chantarasriwong O, Ohlsen KL, Creek KE, Lin YC, Messersmith A, Yu AL, Yu J, Theodorakis EA. PMID: 20881270; PMCID: PMC2978789.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    52. Environment-sensitive behavior of fluorescent molecular rotors. J Biol Eng. 2010 Sep 15; 4:11. Haidekker MA, Theodorakis EA. PMID: 20843326; PMCID: PMC2949793.
      View in: PubMed   Mentions: 76  
    53. Chemistry and biology of the caged Garcinia xanthones. Chemistry. 2010 Sep 03; 16(33):9944-62. Chantarasriwong O, Batova A, Chavasiri W, Theodorakis EA. PMID: 20648491; PMCID: PMC3144150.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    54. Enantioselective formal synthesis of (-)-englerin A via a Rh-catalyzed [4 + 3] cycloaddition reaction. Org Lett. 2010 Aug 20; 12(16):3708-11. Xu J, Caro-Diaz EJ, Theodorakis EA. PMID: 20669919; PMCID: PMC2927118.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    55. Imaging of flow patterns with fluorescent molecular rotors. J Fluoresc. 2010 Sep; 20(5):1087-98. Mustafic A, Huang HM, Theodorakis EA, Haidekker MA. PMID: 20405175; PMCID: PMC2937142.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    56. Molecular rotors: Synthesis and evaluation as viscosity sensors. Tetrahedron. 2010 Apr 03; 66(14):2582-2588. Sutharsan J, Lichlyter D, Wright NE, Dakanali M, Haidekker MA, Theodorakis EA. PMID: 20694175; PMCID: PMC2915462.
      View in: PubMed   Mentions: 21     Fields:    
    57. Chemical biology studies on norrisolide. Bioorg Med Chem. 2010 Mar 15; 18(6):2115-2122. Guizzunti G, Brady TP, Fischer D, Malhotra V, Theodorakis EA. PMID: 20189813; PMCID: PMC2838712.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    58. Rational design of amyloid binding agents based on the molecular rotor motif. ChemMedChem. 2010 Jan; 5(1):56-60. Sutharsan J, Dakanali M, Capule CC, Haidekker MA, Yang J, Theodorakis EA. PMID: 20024978; PMCID: PMC2837554.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    59. Evaluation of the pharmacophoric motif of the caged Garcinia xanthones. Org Biomol Chem. 2009 Dec 07; 7(23):4886-94. Chantarasriwong O, Cho WC, Batova A, Chavasiri W, Moore C, Rheingold AL, Theodorakis EA. PMID: 19907779; PMCID: PMC2927871.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    60. Hexachloroethane: a highly efficient reagent for the synthesis of chlorosilanes from hydrosilanes. Tetrahedron Lett. 2009 Sep 09; 50(36):5080-5082. Pongkittiphan V, Theodorakis EA, Chavasiri W. PMID: 20360997; PMCID: PMC2847782.
      View in: PubMed   Mentions:    Fields:    
    61. Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs. Org Biomol Chem. 2009 Apr 07; 7(7):1415-23. Díaz-Rodríguez A, Sanghvi YS, Fernández S, Schinazi RF, Theodorakis EA, Ferrero M, Gotor V. PMID: 19300828; PMCID: PMC7733237.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    62. Characterization of changes in the viscosity of lipid membranes with the molecular rotor FCVJ. Biochim Biophys Acta. 2008 Apr; 1778(4):1148-53. Nipper ME, Majd S, Mayer M, Lee JC, Theodorakis EA, Haidekker MA. PMID: 18258179.
      View in: PubMed   Mentions: 29     Fields:    
    63. Synthesis of 2',3'-cyclohexene bicyclic nucleoside analogues as antiviral compounds. Nucleic Acids Symp Ser (Oxf). 2008; (52):99-100. Díaz-Rodríguez A, Fernández S, Sanghvi YS, Theodorakis EA, Gotor V, Ferrero M. PMID: 18776272.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    64. Molecular rotors--fluorescent biosensors for viscosity and flow. Org Biomol Chem. 2007 Jun 07; 5(11):1669-78. Haidekker MA, Theodorakis EA. PMID: 17520133.
      View in: PubMed   Mentions: 107     Fields:    
    65. Selective activation of liver X receptors by acanthoic acid-related diterpenes. Mol Pharmacol. 2007 Jun; 71(6):1545-53. Traves PG, Hortelano S, Zeini M, Chao TH, Lam T, Neuteboom ST, Theodorakis EA, Palladino MA, Castrillo A, Bosca L. PMID: 17329499.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    66. Synthesis and use of an in-solution ratiometric fluorescent viscosity sensor. Nat Protoc. 2007; 2(1):227-36. Fischer D, Theodorakis EA, Haidekker MA. PMID: 17401358.
      View in: PubMed   Mentions: 10     Fields:    
    67. Synthesis and evaluation of caged Garcinia xanthones. Org Biomol Chem. 2007 Feb 07; 5(3):494-500. Batova A, Lam T, Wascholowski V, Yu AL, Giannis A, Theodorakis EA. PMID: 17252132.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    68. Trifunctional norrisolide probes for the study of Golgi vesiculation. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):320-5. Guizzunti G, Brady TP, Malhotra V, Theodorakis EA. PMID: 17110104; PMCID: PMC1853282.
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    69. Optical fiber-based fluorescent viscosity sensor. Opt Lett. 2006 Sep 01; 31(17):2529-31. Haidekker MA, Akers WJ, Fischer D, Theodorakis EA. PMID: 16902608.
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    70. Chemical analysis of norrisolide-induced Golgi vesiculation. J Am Chem Soc. 2006 Apr 05; 128(13):4190-1. Guizzunti G, Brady TP, Malhotra V, Theodorakis EA. PMID: 16568969.
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    71. A central strategy for converting natural products into fluorescent probes. Chembiochem. 2006 Mar; 7(3):409-16. Alexander MD, Burkart MD, Leonard MS, Portonovo P, Liang B, Ding X, Joullié MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong BG, Brady TP, Theodorakis EA, La Clair JJ. PMID: 16432909.
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    72. A ratiometric fluorescent viscosity sensor. J Am Chem Soc. 2006 Jan 18; 128(2):398-9. Haidekker MA, Brady TP, Lichlyter D, Theodorakis EA. PMID: 16402812.
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    73. Norrisolide: total synthesis and related studies. Chemistry. 2005 Dec 09; 11(24):7175-90. Brady TP, Kim SH, Wen K, Kim C, Theodorakis EA. PMID: 16163770.
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    74. Effects of solvent polarity and solvent viscosity on the fluorescent properties of molecular rotors and related probes. Bioorg Chem. 2005 Dec; 33(6):415-25. Haidekker MA, Brady TP, Lichlyter D, Theodorakis EA. PMID: 16182338.
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    75. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest. 2005 Jul; 115(7):1806-15. Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS. PMID: 16007254; PMCID: PMC1159132.
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    76. Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants. Bioorg Med Chem Lett. 2005 Jun 02; 15(11):2745-8. Lee H, Lee K, Jung JK, Cho J, Theodorakis EA. PMID: 15911250.
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    77. A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation. Chembiochem. 2005 Jan; 6(1):133-44. Chao TH, Lam T, Vong BG, Través PG, Hortelano S, Chowdhury C, Bahjat FR, Lloyd GK, Moldawer LL, Boscá L, Palladino MA, Theodorakis EA. PMID: 15540220.
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    78. Fragmentation of Golgi membranes by norrisolide and designed analogues. Bioorg Med Chem Lett. 2004 Oct 18; 14(20):5035-9. Brady TP, Wallace EK, Kim SH, Guizzunti G, Malhotra V, Theodorakis EA. PMID: 15380194.
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    79. Hydrophilic molecular rotor derivatives-synthesis and characterization. Bioorg Chem. 2004 Aug; 32(4):274-89. Haidekker MA, Brady TP, Chalian SH, Akers W, Lichlyter D, Theodorakis EA. PMID: 15210341.
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    80. Stereoselective total synthesis of (-)-borrelidin. Angew Chem Int Ed Engl. 2004 Jul 26; 43(30):3947-51. Vong BG, Kim SH, Abraham S, Theodorakis EA. PMID: 15274222.
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    81. Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels-Alder/Claisen rearrangement. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12030-5. Tisdale EJ, Slobodov I, Theodorakis EA. PMID: 15210986; PMCID: PMC514429.
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    82. 3,3(')-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3241-4. Oka N, Sanghvi YS, Theodorakis EA. PMID: 15149683.
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    83. Stereoselective synthesis of the ABC ring system of norzoanthamine. Org Lett. 2004 Mar 18; 6(6):941-4. Ghosh S, Rivas F, Fischer D, González MA, Theodorakis EA. PMID: 15012070.
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    84. Stereoselective total synthesis of (+)-norrisolide. Angew Chem Int Ed Engl. 2004 Jan 30; 43(6):739-42. Brady TP, Kim SH, Wen K, Theodorakis EA. PMID: 14755708.
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    85. Biomimetic total synthesis of forbesione and desoxymorellin utilizing a tandem Claisen/Diels--Alder/Claisen rearrangement. Org Biomol Chem. 2003 Dec 21; 1(24):4418-22. Tisdale EJ, Slobodov I, Theodorakis EA. PMID: 14727628.
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    86. Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorg Med Chem Lett. 2003 Oct 06; 13(19):3217-21. Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis EA. PMID: 12951096.
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    87. Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov. 2003 Sep; 2(9):736-46. Palladino MA, Bahjat FR, Theodorakis EA, Moldawer LL. PMID: 12951580.
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    88. Novel synthesis of 2'-O-methylguanosine. Bioorg Med Chem Lett. 2003 May 19; 13(10):1631-4. Chow S, Wen K, Sanghvi YS, Theodorakis EA. PMID: 12729629.
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    89. Synthetic studies on borrelidin: enantioselective synthesis of the C1-C12 fragment. Org Lett. 2003 May 15; 5(10):1617-20. Vong BG, Abraham S, Xiang AX, Theodorakis EA. PMID: 12735735.
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    90. Regioselective synthesis of the tricyclic core of lateriflorone. Org Lett. 2003 May 01; 5(9):1491-4. Tisdale EJ, Li H, Vong BG, Kim SH, Theodorakis EA. PMID: 12713306.
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    91. MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):583-7. Chow S, Wen K, Sanghvi YS, Theodorakis EA. PMID: 14565233.
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    92. Synthesis of 2'-O-methoxyethylguanosine using a novel silicon-based protecting group. J Org Chem. 2002 Nov 01; 67(22):7887-9. Wen K, Chow S, Sanghvi YS, Theodorakis EA. PMID: 12398522.
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    93. Phospholipid-bound molecular rotors: synthesis and characterization. Bioorg Med Chem. 2002 Nov; 10(11):3627-36. Haidekker MA, Brady T, Wen K, Okada C, Stevens HY, Snell JM, Frangos JA, Theodorakis EA. PMID: 12213479.
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    94. Unified synthesis of quinone sesquiterpenes based on a radical decarboxylation and quinone addition reaction. J Am Chem Soc. 2002 Oct 16; 124(41):12261-7. Ling T, Poupon E, Rueden EJ, Kim SH, Theodorakis EA. PMID: 12371868.
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    95. A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1609-14. Haidekker MA, Tsai AG, Brady T, Stevens HY, Frangos JA, Theodorakis E, Intaglietta M. PMID: 11959622.
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    96. Regioselective synthesis of the bridged tricyclic core of Garcinia natural products via intramolecular aryl acrylate cycloadditions. Org Lett. 2002 Mar 21; 4(6):909-12. Tisdale EJ, Chowdhury C, Vong BG, Li H, Theodorakis EA. PMID: 11893183.
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    97. Synthesis of (-)-ilimaquinone via a radical decarboxylation and quinone addition reaction. Org Lett. 2002 Mar 07; 4(5):819-22. Ling T, Poupon E, Rueden EJ, Theodorakis EA. PMID: 11869136.
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    98. Enantioselective synthesis of the antiinflammatory agent (-)-acanthoic acid. J Org Chem. 2001 Dec 28; 66(26):8843-53. Ling T, Chowdhury C, Kramer BA, Vong BG, Palladino MA, Theodorakis EA. PMID: 11749614.
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    99. Investigation of the biological mode of action of clerocidin using whole cell assays. Bioorg Med Chem. 2001 Jun; 9(6):1365-70. Jamora C, Theodoraki MA, Malhotra V, Theodorakis EA. PMID: 11408157.
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    100. New fluorescent probes for the measurement of cell membrane viscosity. Chem Biol. 2001 Feb; 8(2):123-31. Haidekker MA, Ling T, Anglo M, Stevens HY, Frangos JA, Theodorakis EA. PMID: 11251287.
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    101. Stereoselective synthesis of (-)-acanthoic acid. Org Lett. 2000 Jul 13; 2(14):2073-6. Ling T, Kramer BA, Palladino MA, Theodorakis EA. PMID: 10891233.
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    102. Stereoselective total synthesis of reveromycin B and C19-epi-reveromycin B. Chemistry. 2000 Jun 02; 6(11):1987-2001. Drouet KE, Theodorakis EA. PMID: 10894398.
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    103. Enantioselective synthesis of the [6,6] spiroketal core of reveromycin A. Org Lett. 2000 Jan 27; 2(2):207-10. Drouet KE, Ling T, Tran HV, Theodorakis EA. PMID: 10814283.
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    104. Design, synthesis, and evaluation of N-aroyloxy-2-thiopyridones as DNA photocleaving reagents. Bioorg Med Chem. 1999 May; 7(5):727-36. Blom P, Xiang AX, Kao D, Theodorakis EA. PMID: 10400326.
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    105. Total Synthesis of Clerocidin via a Novel, Enantioselective Homoallenylboration Methodology. J Org Chem. 1998 Oct 02; 63(20):6774-6775. Xiang AX, Watson DA, Ling T, Theodorakis EA. PMID: 11672290.
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    106. Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):940-4. Liu C, Smith BM, Ajito K, Komatsu H, Gomez-Paloma L, Li T, Theodorakis EA, Nicolaou KC, Vogt PK. PMID: 8570664; PMCID: PMC40163.
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    107. The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol. 1995 Aug; 2(8):533-41. Gawley RE, Rein KS, Jeglitsch G, Adams DJ, Theodorakis EA, Tiebes J, Nicolaou KC, Baden DG. PMID: 9383457.
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    108. Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis. Chem Biol. 1994 Sep; 1(1):57-66. Nicolaou KC, Pitsinos EN, Theodorakis EA, Saimoto H, Wrasidlo W. PMID: 9383371.
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