Michael David

Title(s)Professor, Molecular Biology
SchoolAcademic Aff
Address9500 Gilman Drive #0322
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Div. of Cytokine Biology, CBER/FDA06/1996Interferons; Cytokines
    Univ. of Vienna, Vienna, AustriaPh.D.06/1991Pharmacology/Pharmacognosy
    Univ. of Vienna, Vienna, AustriaPharmD02/1989Pharmacy
    Collapse Awards and Honors
    National Multiple Sclerosis Society2014  - 2017National Multiple Sclerosis Research Award
    National Multiple Sclerosis Society2007  - 2010National Multiple Sclerosis Research Award
    National Multiple Sclerosis Society2002  - 2005National Multiple Sclerosis Research Award
    Sidney Kimmel Foundation for Cancer Research1997  - 1998Sidney Kimmel Scholar Award
    NIH1993  - 1996Fogarty Scholar Award
    Austrian Science Foundation1991  - 1992Schroedinger Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Translational inhibition by Schlafen proteins during the DNA damage response
    NIH/NIGMS R01GM128155Mar 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Generation and characterization of IRF7 conditional knockout animals
    NIH/NIAID R03AI133243Jun 8, 2017 - May 31, 2019
    Role: Principal Investigator
    The IRF-type I interferon system during gestation
    NIH/NIAID R21AI126191Mar 15, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Role of TLR3 pathway in HIV infection
    NIH/NIAID R21AI127297Jun 17, 2016 - May 31, 2018
    Role: Principal Investigator
    DNA structure modification by the Schlafen protein family
    NIH/NIAID R21AI124199Mar 7, 2016 - Feb 28, 2018
    Role: Principal Investigator
    The IRF - type I interferon system in T cell-mediated immune tolerance
    NIH/NIAID R21AI105722Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Antiviral host defense through selective translational inhibition
    NIH/NIGMS R01GM101982Jun 1, 2012 - May 31, 2016
    Role: Principal Investigator
    Global innate immune responses to HIV-1 infection
    NIH P01AI090935Aug 15, 2010 - Jul 31, 2015
    Role: Co-Investigator
    Slfn proteins in innate immunity
    NIH/NIAID R21AI088490May 5, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Interferon modulation of cellular microRNAs in the Hepatitis C antiviral defense
    NIH/NIDDK R01DK078857Jul 1, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Interferon actions and autoimmune disorders
    NIH/NIAID R01AI071233Feb 15, 2007 - Jul 19, 2011
    Role: Principal Investigator
    Activation of Interferon Regulated Genes
    NIH/NIAID R56AI047182Apr 1, 2000 - Feb 28, 2007
    Role: Principal Investigator
    NIH/NIAID R01AI047182Apr 1, 2000 - Mar 31, 2005
    Role: Principal Investigator
    Intracellular Signaling by Interferons
    NIH/NCI R01CA080105Jun 29, 1999 - May 31, 2002
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tracking U.S. Pertussis Incidence: Correlation of Public Health Surveillance and Google Search Data Varies by State. Sci Rep. 2019 Dec 24; 9(1):19801. Arehart CH, David MZ, Dukic V. PMID: 31875051.
      View in: PubMed   Mentions:    Fields:    
    2. Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response. J Biol Chem. 2019 10 04; 294(40):14674-14685. Malone D, Lardelli RM, Li M, David M. PMID: 31395656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs. Nat Struct Mol Biol. 2018 11; 25(11):1047-1058. Li M, Kao E, Malone D, Gao X, Wang JYJ, David M. PMID: 30374083.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. PLoS Pathog. 2016 Dec; 12(12):e1006066. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. PMID: 28027315.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    5. Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections. J Infect Dis. 2016 09 15; 214(6):895-905. Azarian T, Daum RS, Petty LA, Steinbeck JL, Yin Z, Nolan D, Boyle-Vavra S, Hanage WP, Salemi M, David MZ. PMID: 27288537.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. B-cell survival and development controlled by the coordination of NF-?B family members RelB and cRel. Blood. 2016 Mar 10; 127(10):1276-86. Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A. PMID: 26773039.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Recurrent skin and soft tissue infections in HIV-infected patients during a 5-year period: incidence and risk factors in a retrospective cohort study. BMC Infect Dis. 2015 Oct 26; 15:455. Hemmige V, McNulty M, Silverman E, David MZ. PMID: 26503616.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Host factors that contribute to recurrent staphylococcal skin infection. Curr Opin Infect Dis. 2015 Jun; 28(3):253-8. Montgomery CP, David MZ, Daum RS. PMID: 25887613.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    9. IFN-ß Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling. J Immunol. 2015 Jun 01; 194(11):5120-8. Otero DC, Fares-Frederickson NJ, Xiao M, Baker DP, David M. PMID: 25888642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Staphylococcus aureus skin infection recurrences among household members: an examination of host, behavioral, and pathogen-level predictors. Clin Infect Dis. 2015 Mar 01; 60(5):753-63. Miller LG, Eells SJ, David MZ, Ortiz N, Taylor AR, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. PMID: 25428411.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    11. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014 Dec; 2(12):1199-208. Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H. PMID: 25300859.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    12. Persistent environmental contamination with USA300 methicillin-resistant Staphylococcus aureus and other pathogenic strain types in households with S. aureus skin infections. Infect Control Hosp Epidemiol. 2014 Nov; 35(11):1373-82. Eells SJ, David MZ, Taylor A, Ortiz N, Kumar N, Sieth J, Boyle-Vavra S, Daum RS, Miller LG. PMID: 25333432.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    13. Predictors of skin and soft tissue infections in HIV-infected outpatients in the community-associated methicillin-resistant Staphylococcus aureus era. Eur J Clin Microbiol Infect Dis. 2015 Feb; 34(2):339-47. Hemmige V, McNulty M, Silverman E, David MZ. PMID: 25213720.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Unconventional post-translational modifications in immunological signaling. Nat Immunol. 2014 Jun; 15(6):512-20. Mowen KA, David M. PMID: 24840982.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013 Oct 16; 10:106. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. PMID: 24131498.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    16. IRF7-dependent IFN-ß production in response to RANKL promotes medullary thymic epithelial cell development. J Immunol. 2013 Apr 01; 190(7):3289-98. Otero DC, Baker DP, David M. PMID: 23440417.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis. PLoS One. 2013; 8(1):e52722. Dukic VM, Lauderdale DS, Wilder J, Daum RS, David MZ. PMID: 23300988.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCellsPHPublic Health
    18. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012 Nov 01; 491(7422):125-8. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. PMID: 23000900.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    19. Staphylococcus aureus colonization among household contacts of patients with skin infections: risk factors, strain discordance, and complex ecology. Clin Infect Dis. 2012 Jun; 54(11):1523-35. Miller LG, Eells SJ, Taylor AR, David MZ, Ortiz N, Zychowski D, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. PMID: 22474221.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    20. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Jan 06; 12(2):125-35. González-Navajas JM, Lee J, David M, Raz E. PMID: 22222875.
      View in: PubMed   Mentions: 283     Fields:    Translation:Humans
    21. Phospholipase C?-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation. J Biol Chem. 2012 Feb 03; 287(6):3704-9. Chiang CY, Veckman V, Limmer K, David M. PMID: 22158869.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    22. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One. 2011; 6(9):e24972. Moro H, Otero DC, Tanabe Y, David M. PMID: 21949815.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Interferons and microRNAs. J Interferon Cytokine Res. 2010 Nov; 30(11):825-8. David M. PMID: 20939680.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    24. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009 Aug; 1(5):288-95. Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. PMID: 19890474.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    25. MicroRNAs in the immune response. Cytokine. 2008 Sep; 43(3):391-4. Pedersen I, David M. PMID: 18701320.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    26. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature. 2007 Oct 18; 449(7164):919-22. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M. PMID: 17943132.
      View in: PubMed   Mentions: 342     Fields:    Translation:HumansAnimalsCells
    27. Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One. 2007 Oct 17; 2(10):e1044. Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC. PMID: 17940608.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    28. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007 Sep 15; 179(6):3402-6. Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. PMID: 17785772.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    29. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol. 2006 Nov 15; 177(10):6593-7. Otero DC, Poli V, David M, Rickert RC. PMID: 17082570.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    30. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol. 2006 May 15; 176(10):5720-4. Chiang E, Dang O, Anderson K, Matsuzawa A, Ichijo H, David M. PMID: 16670275.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    31. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 09; 122(5):707-21. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. PMID: 16143103.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    32. Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes. J Immunol. 2005 Jan 15; 174(2):609-13. Tanabe Y, Nishibori T, Su L, Arduini RM, Baker DP, David M. PMID: 15634877.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    33. Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA. Mol Ther. 2005 Jan; 11(1):112-9. Li S, Wilkinson M, Xia X, David M, Xu L, Purkel-Sutton A, Bhardwaj A. PMID: 15585412.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell. 2004 Aug 27; 15(4):559-71. Mowen KA, Schurter BT, Fathman JW, David M, Glimcher LH. PMID: 15327772.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    35. Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes. Shock. 2004 May; 21(5):470-5. Dang O, Navarro L, David M. PMID: 15087825.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    36. Arsenic inhibition of the JAK-STAT pathway. Oncogene. 2004 Apr 29; 23(20):3603-12. Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW. PMID: 15116095.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    37. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004 May 28; 279(22):22795-8. Smith WA, Schurter BT, Wong-Staal F, David M. PMID: 15084609.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    38. Cutting edge: anthrax lethal toxin inhibits activation of IFN-regulatory factor 3 by lipopolysaccharide. J Immunol. 2004 Jan 15; 172(2):747-51. Dang O, Navarro L, Anderson K, David M. PMID: 14707042.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med. 2004 Jan 05; 199(1):25-34. Nishibori T, Tanabe Y, Su L, David M. PMID: 14699080.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    40. The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression. J Virol. 2003 Mar; 77(6):3690-701. Ruvolo V, Navarro L, Sample CE, David M, Sung S, Swaminathan S. PMID: 12610144.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    41. Signal transduction by type I interferons. Biotechniques. 2002 Oct; Suppl:58-65. David M. PMID: 12395928.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem. 2002 Sep 27; 277(39):35787-90. Zhu W, Mustelin T, David M. PMID: 12171910.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    43. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug; 22(16):5662-8. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. PMID: 12138178.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    44. Regulation of STAT protein synthesis by c-Cbl. Oncogene. 2001 Nov 01; 20(50):7326-33. Blesofsky WA, Mowen K, Arduini RM, Baker DP, Murphy MA, Bowtell DD, David M. PMID: 11704862.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Analysis of protein arginine methylation and protein arginine-methyltransferase activity. Sci STKE. 2001 Jul 31; 2001(93):pl1. Mowen KA, David M. PMID: 11752667.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    46. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001 Mar 09; 104(5):731-41. Mowen KA, Tang J, Zhu W, Schurter BT, Shuai K, Herschman HR, David M. PMID: 11257227.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    47. Cytokine activation of transcription. Genet Eng (N Y). 2001; 23:35-44. Mowen KA, David M. PMID: 11570105.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    48. Regulation of STAT1 nuclear export by Jak1. Mol Cell Biol. 2000 Oct; 20(19):7273-81. Mowen K, David M. PMID: 10982844.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    49. Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem. 2000 Apr 28; 275(17):12661-6. Su L, David M. PMID: 10777558.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    50. p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J Biol Chem. 1999 Dec 10; 274(50):35535-8. Navarro L, David M. PMID: 10585427.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    51. Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J Biol Chem. 1999 Nov 05; 274(45):31770-4. Su L, Rickert RC, David M. PMID: 10542198.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    52. Inhibition of B cell receptor-mediated apoptosis by IFN. J Immunol. 1999 Jun 01; 162(11):6317-21. Su L, David M. PMID: 10352242.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    53. Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J Biol Chem. 1998 Nov 13; 273(46):30073-6. Mowen K, David M. PMID: 9804758.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    54. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol. 1998 Jul; 18(7):3796-802. Navarro L, Mowen K, Rodems S, Weaver B, Reich N, Spector D, David M. PMID: 9632763.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
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