Michael David

Title(s)Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse education and training
    Div. of Cytokine Biology, CBER/FDA06/1996Interferons; Cytokines
    Univ. of Vienna, Vienna, AustriaPh.D.06/1991Pharmacology/Pharmacognosy
    Univ. of Vienna, Vienna, AustriaPharmD02/1989Pharmacy
    Collapse awards and honors
    National Multiple Sclerosis Society2014  - 2017National Multiple Sclerosis Research Award
    National Multiple Sclerosis Society2007  - 2010National Multiple Sclerosis Research Award
    National Multiple Sclerosis Society2002  - 2005National Multiple Sclerosis Research Award
    Sidney Kimmel Foundation for Cancer Research1997  - 1998Sidney Kimmel Scholar Award
    NIH1993  - 1996Fogarty Scholar Award
    Austrian Science Foundation1991  - 1992Schroedinger Award

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Translational inhibition by Schlafen proteins during the DNA damage response
    NIH R01GM128155Mar 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Generation and characterization of IRF7 conditional knockout animals
    NIH R03AI133243Jun 8, 2017 - May 31, 2021
    Role: Principal Investigator
    The IRF-type I interferon system during gestation
    NIH R21AI126191Mar 15, 2017 - Feb 29, 2020
    Role: Principal Investigator
    Role of TLR3 pathway in HIV infection
    NIH R21AI127297Jun 17, 2016 - May 31, 2019
    Role: Principal Investigator
    DNA structure modification by the Schlafen protein family
    NIH R21AI124199Mar 7, 2016 - Feb 28, 2019
    Role: Principal Investigator
    The IRF - type I interferon system in T cell-mediated immune tolerance
    NIH R21AI105722Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Antiviral host defense through selective translational inhibition
    NIH R01GM101982Jun 1, 2012 - May 31, 2017
    Role: Principal Investigator
    Global innate immune responses to HIV-1 infection
    NIH P01AI090935Aug 15, 2010 - Jul 31, 2015
    Role: Co-Investigator
    Slfn proteins in innate immunity
    NIH R21AI088490May 5, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Interferon modulation of cellular microRNAs in the Hepatitis C antiviral defense
    NIH R01DK078857Jul 1, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Interferon actions and autoimmune disorders
    NIH R01AI071233Feb 15, 2007 - Jul 19, 2011
    Role: Principal Investigator
    Activation of Interferon Regulated Genes
    NIH R56AI047182Apr 1, 2000 - Feb 28, 2007
    Role: Principal Investigator
    ACTIVATION OF INTERFERON REGULATED GENES
    NIH R01AI047182Apr 1, 2000 - Feb 28, 2006
    Role: Principal Investigator
    Intracellular Signaling by Interferons
    NIH R01CA080105Jun 29, 1999 - Jun 30, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response. J Biol Chem. 2019 10 04; 294(40):14674-14685. Malone D, Lardelli RM, Li M, David M. PMID: 31395656; PMCID: PMC6779438.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    2. DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs. Nat Struct Mol Biol. 2018 11; 25(11):1047-1058. Li M, Kao E, Malone D, Gao X, Wang JYJ, David M. PMID: 30374083; PMCID: PMC6579113.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    3. Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. PLoS Pathog. 2016 Dec; 12(12):e1006066. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. PMID: 28027315; PMCID: PMC5189954.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    4. B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel. Blood. 2016 Mar 10; 127(10):1276-86. Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A. PMID: 26773039; PMCID: PMC4786837.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    5. IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling. J Immunol. 2015 Jun 01; 194(11):5120-8. Otero DC, Fares-Frederickson NJ, Xiao M, Baker DP, David M. PMID: 25888642; PMCID: PMC4433809.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014 Dec; 2(12):1199-208. Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H. PMID: 25300859; PMCID: PMC4258479.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    7. Unconventional post-translational modifications in immunological signaling. Nat Immunol. 2014 Jun; 15(6):512-20. Mowen KA, David M. PMID: 24840982.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    8. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013 Oct 16; 10:106. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. PMID: 24131498; PMCID: PMC3827935.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    9. IRF7-dependent IFN-β production in response to RANKL promotes medullary thymic epithelial cell development. J Immunol. 2013 Apr 01; 190(7):3289-98. Otero DC, Baker DP, David M. PMID: 23440417; PMCID: PMC3608802.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    10. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012 Nov 01; 491(7422):125-8. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. PMID: 23000900; PMCID: PMC3705913.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansCells
    11. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Jan 06; 12(2):125-35. González-Navajas JM, Lee J, David M, Raz E. PMID: 22222875; PMCID: PMC3727154.
      View in: PubMed   Mentions: 480     Fields:    Translation:Humans
    12. Phospholipase Cγ-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation. J Biol Chem. 2012 Feb 03; 287(6):3704-9. Chiang CY, Veckman V, Limmer K, David M. PMID: 22158869; PMCID: PMC3281733.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    13. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One. 2011; 6(9):e24972. Moro H, Otero DC, Tanabe Y, David M. PMID: 21949815; PMCID: PMC3176796.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Interferons and microRNAs. J Interferon Cytokine Res. 2010 Nov; 30(11):825-8. David M. PMID: 20939680.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009 Aug; 1(5):288-95. Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. PMID: 19890474; PMCID: PMC2771872.
      View in: PubMed   Mentions: 97     Fields:    
    16. MicroRNAs in the immune response. Cytokine. 2008 Sep; 43(3):391-4. Pedersen I, David M. PMID: 18701320; PMCID: PMC3642994.
      View in: PubMed   Mentions: 56  
    17. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature. 2007 Oct 18; 449(7164):919-22. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M. PMID: 17943132; PMCID: PMC2748825.
      View in: PubMed   Mentions: 367     Fields:    
    18. Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One. 2007 Oct 17; 2(10):e1044. Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC. PMID: 17940608; PMCID: PMC2001179.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007 Sep 15; 179(6):3402-6. Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. PMID: 17785772; PMCID: PMC2770724.
      View in: PubMed   Mentions: 26     Fields:    
    20. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol. 2006 Nov 15; 177(10):6593-7. Otero DC, Poli V, David M, Rickert RC. PMID: 17082570; PMCID: PMC2770730.
      View in: PubMed   Mentions: 21     Fields:    
    21. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol. 2006 May 15; 176(10):5720-4. Chiang E, Dang O, Anderson K, Matsuzawa A, Ichijo H, David M. PMID: 16670275; PMCID: PMC2749679.
      View in: PubMed   Mentions: 28     Fields:    
    22. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 09; 122(5):707-21. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. PMID: 16143103; PMCID: PMC1430687.
      View in: PubMed   Mentions: 209     Fields:    Translation:AnimalsCells
    23. Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes. J Immunol. 2005 Jan 15; 174(2):609-13. Tanabe Y, Nishibori T, Su L, Arduini RM, Baker DP, David M. PMID: 15634877.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    24. Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA. Mol Ther. 2005 Jan; 11(1):112-9. Li S, Wilkinson M, Xia X, David M, Xu L, Purkel-Sutton A, Bhardwaj A. PMID: 15585412.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell. 2004 Aug 27; 15(4):559-71. Mowen KA, Schurter BT, Fathman JW, David M, Glimcher LH. PMID: 15327772.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    26. Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes. Shock. 2004 May; 21(5):470-5. Dang O, Navarro L, David M. PMID: 15087825; PMCID: PMC1282467.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Arsenic inhibition of the JAK-STAT pathway. Oncogene. 2004 Apr 29; 23(20):3603-12. Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW. PMID: 15116095.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    28. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004 May 28; 279(22):22795-8. Smith WA, Schurter BT, Wong-Staal F, David M. PMID: 15084609.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    29. Cutting edge: anthrax lethal toxin inhibits activation of IFN-regulatory factor 3 by lipopolysaccharide. J Immunol. 2004 Jan 15; 172(2):747-51. Dang O, Navarro L, Anderson K, David M. PMID: 14707042.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    30. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med. 2004 Jan 05; 199(1):25-34. Nishibori T, Tanabe Y, Su L, David M. PMID: 14699080; PMCID: PMC1193645.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    31. The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression. J Virol. 2003 Mar; 77(6):3690-701. Ruvolo V, Navarro L, Sample CE, David M, Sung S, Swaminathan S. PMID: 12610144; PMCID: PMC149524.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    32. Signal transduction by type I interferons. Biotechniques. 2002 Oct; Suppl:58-65. David M. PMID: 12395928.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    33. Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem. 2002 Sep 27; 277(39):35787-90. Zhu W, Mustelin T, David M. PMID: 12171910.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    34. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug; 22(16):5662-8. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. PMID: 12138178; PMCID: PMC133976.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    35. Regulation of STAT protein synthesis by c-Cbl. Oncogene. 2001 Nov 01; 20(50):7326-33. Blesofsky WA, Mowen K, Arduini RM, Baker DP, Murphy MA, Bowtell DD, David M. PMID: 11704862.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Analysis of protein arginine methylation and protein arginine-methyltransferase activity. Sci STKE. 2001 Jul 31; 2001(93):pl1. Mowen KA, David M. PMID: 11752667.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    37. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001 Mar 09; 104(5):731-41. Mowen KA, Tang J, Zhu W, Schurter BT, Shuai K, Herschman HR, David M. PMID: 11257227.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    38. Cytokine activation of transcription. Genet Eng (N Y). 2001; 23:35-44. Mowen KA, David M. PMID: 11570105.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    39. Regulation of STAT1 nuclear export by Jak1. Mol Cell Biol. 2000 Oct; 20(19):7273-81. Mowen K, David M. PMID: 10982844; PMCID: PMC86281.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    40. Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem. 2000 Apr 28; 275(17):12661-6. Su L, David M. PMID: 10777558.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    41. p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J Biol Chem. 1999 Dec 10; 274(50):35535-8. Navarro L, David M. PMID: 10585427.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    42. Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J Biol Chem. 1999 Nov 05; 274(45):31770-4. Su L, Rickert RC, David M. PMID: 10542198; PMCID: PMC2772110.
      View in: PubMed   Mentions: 16     Fields:    
    43. Inhibition of B cell receptor-mediated apoptosis by IFN. J Immunol. 1999 Jun 01; 162(11):6317-21. Su L, David M. PMID: 10352242.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J Biol Chem. 1998 Nov 13; 273(46):30073-6. Mowen K, David M. PMID: 9804758.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol. 1998 Jul; 18(7):3796-802. Navarro L, Mowen K, Rodems S, Weaver B, Reich N, Spector D, David M. PMID: 9632763; PMCID: PMC108963.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
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