Michael David

SchoolAcademic Aff
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    Collapse Biography 
    Collapse Education and Training
    Div. of Cytokine Biology, CBER/FDA06/1996Interferons; Cytokines
    Univ. of Vienna, Vienna, AustriaPh.D.06/1991Pharmacology/Pharmacognosy
    Univ. of Vienna, Vienna, AustriaPharmD02/1989Pharmacy
    Collapse Awards and Honors
    National Multiple Sclerosis Society2014  - 2017National Multiple Sclerosis Research Award
    National Multiple Sclerosis Society2007  - 2010National Multiple Sclerosis Research Award
    National Multiple Sclerosis Society2002  - 2005National Multiple Sclerosis Research Award
    Sidney Kimmel Foundation for Cancer Research1997  - 1998Sidney Kimmel Scholar Award
    NIH1993  - 1996Fogarty Scholar Award
    Austrian Science Foundation1991  - 1992Schroedinger Award

    Collapse Research 
    Collapse Research Activities and Funding
    Translational inhibition by Schlafen proteins during the DNA damage response
    NIH/NIGMS R01GM128155Mar 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Generation and characterization of IRF7 conditional knockout animals
    NIH/NIAID R03AI133243Jun 8, 2017 - May 31, 2019
    Role: Principal Investigator
    The IRF-type I interferon system during gestation
    NIH/NIAID R21AI126191Mar 15, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Role of TLR3 pathway in HIV infection
    NIH/NIAID R21AI127297Jun 17, 2016 - May 31, 2018
    Role: Principal Investigator
    DNA structure modification by the Schlafen protein family
    NIH/NIAID R21AI124199Mar 7, 2016 - Feb 28, 2018
    Role: Principal Investigator
    The IRF - type I interferon system in T cell-mediated immune tolerance
    NIH/NIAID R21AI105722Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Antiviral host defense through selective translational inhibition
    NIH/NIGMS R01GM101982Jun 1, 2012 - May 31, 2016
    Role: Principal Investigator
    Global innate immune responses to HIV-1 infection
    NIH P01AI090935Aug 15, 2010 - Jul 31, 2015
    Role: Co-Investigator
    Slfn proteins in innate immunity
    NIH/NIAID R21AI088490May 5, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Interferon modulation of cellular microRNAs in the Hepatitis C antiviral defense
    NIH/NIDDK R01DK078857Jul 1, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Interferon actions and autoimmune disorders
    NIH/NIAID R01AI071233Feb 15, 2007 - Jul 19, 2011
    Role: Principal Investigator
    Activation of Interferon Regulated Genes
    NIH/NIAID R56AI047182Apr 1, 2000 - Feb 28, 2007
    Role: Principal Investigator
    NIH/NIAID R01AI047182Apr 1, 2000 - Feb 28, 2006
    Role: Principal Investigator
    Intracellular Signaling by Interferons
    NIH/NCI R01CA080105Jun 29, 1999 - Jun 30, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Malone D, Lardelli RM, Li M, David M. Dephosphorylation activates the interferon-stimulated schlafen family member 11 in the DNA Damage Response. J Biol Chem. 2019 Aug 08. PMID: 31395656.
      View in: PubMed
    2. Li M, Kao E, Malone D, Gao X, Wang JYJ, David M. DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs. Nat Struct Mol Biol. 2018 Nov; 25(11):1047-1058. PMID: 30374083.
      View in: PubMed
    3. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. PLoS Pathog. 2016 Dec; 12(12):e1006066. PMID: 28027315.
      View in: PubMed
    4. Azarian T, Daum RS, Petty LA, Steinbeck JL, Yin Z, Nolan D, Boyle-Vavra S, Hanage WP, Salemi M, David MZ. Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections. J Infect Dis. 2016 09 15; 214(6):895-905. PMID: 27288537.
      View in: PubMed
    5. Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A. B-cell survival and development controlled by the coordination of NF-?B family members RelB and cRel. Blood. 2016 Mar 10; 127(10):1276-86. PMID: 26773039; PMCID: PMC4786837 [Available on 03/10/17].
    6. Hemmige V, McNulty M, Silverman E, David MZ. Recurrent skin and soft tissue infections in HIV-infected patients during a 5-year period: incidence and risk factors in a retrospective cohort study. BMC Infect Dis. 2015 Oct 26; 15:455. PMID: 26503616; PMCID: PMC4620745.
    7. Montgomery CP, David MZ, Daum RS. Host factors that contribute to recurrent staphylococcal skin infection. Curr Opin Infect Dis. 2015 Jun; 28(3):253-8. PMID: 25887613; PMCID: PMC4414914.
    8. Otero DC, Fares-Frederickson NJ, Xiao M, Baker DP, David M. IFN-ß Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling. J Immunol. 2015 Jun 01; 194(11):5120-8. PMID: 25888642; PMCID: PMC4433809.
    9. Miller LG, Eells SJ, David MZ, Ortiz N, Taylor AR, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. Staphylococcus aureus skin infection recurrences among household members: an examination of host, behavioral, and pathogen-level predictors. Clin Infect Dis. 2015 Mar 01; 60(5):753-63. PMID: 25428411; PMCID: PMC4402346.
    10. Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014 Dec; 2(12):1199-208. PMID: 25300859; PMCID: PMC4258479.
    11. Eells SJ, David MZ, Taylor A, Ortiz N, Kumar N, Sieth J, Boyle-Vavra S, Daum RS, Miller LG. Persistent environmental contamination with USA300 methicillin-resistant Staphylococcus aureus and other pathogenic strain types in households with S. aureus skin infections. Infect Control Hosp Epidemiol. 2014 Nov; 35(11):1373-82. PMID: 25333432.
      View in: PubMed
    12. Mowen KA, David M. Unconventional post-translational modifications in immunological signaling. Nat Immunol. 2014 Jun; 15(6):512-20. PMID: 24840982.
      View in: PubMed
    13. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013 Oct 16; 10:106. PMID: 24131498; PMCID: PMC3827935.
    14. Otero DC, Baker DP, David M. IRF7-dependent IFN-ß production in response to RANKL promotes medullary thymic epithelial cell development. J Immunol. 2013 Apr 01; 190(7):3289-98. PMID: 23440417; PMCID: PMC3608802.
    15. Dukic VM, Lauderdale DS, Wilder J, Daum RS, David MZ. Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis. PLoS One. 2013; 8(1):e52722. PMID: 23300988.
      View in: PubMed
    16. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012 Nov 01; 491(7422):125-8. PMID: 23000900; PMCID: PMC3705913.
    17. Miller LG, Eells SJ, Taylor AR, David MZ, Ortiz N, Zychowski D, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. Staphylococcus aureus colonization among household contacts of patients with skin infections: risk factors, strain discordance, and complex ecology. Clin Infect Dis. 2012 Jun; 54(11):1523-35. PMID: 22474221; PMCID: PMC3348950.
    18. González-Navajas JM, Lee J, David M, Raz E. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Jan 06; 12(2):125-35. PMID: 22222875.
      View in: PubMed
    19. Chiang CY, Veckman V, Limmer K, David M. Phospholipase C?-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation. J Biol Chem. 2012 Feb 03; 287(6):3704-9. PMID: 22158869; PMCID: PMC3281733.
    20. Moro H, Otero DC, Tanabe Y, David M. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One. 2011; 6(9):e24972. PMID: 21949815; PMCID: PMC3176796.
    21. David M. Interferons and microRNAs. J Interferon Cytokine Res. 2010 Nov; 30(11):825-8. PMID: 20939680.
      View in: PubMed
    22. Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009 Aug; 1(5):288-95. PMID: 19890474.
      View in: PubMed
    23. Pedersen I, David M. MicroRNAs in the immune response. Cytokine. 2008 Sep; 43(3):391-4. PMID: 18701320; PMCID: PMC3642994.
    24. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature. 2007 Oct 18; 449(7164):919-22. PMID: 17943132; PMCID: PMC2748825.
    25. Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC. Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One. 2007 Oct 17; 2(10):e1044. PMID: 17940608; PMCID: PMC2001179.
    26. Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007 Sep 15; 179(6):3402-6. PMID: 17785772; PMCID: PMC2770724.
    27. Otero DC, Poli V, David M, Rickert RC. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol. 2006 Nov 15; 177(10):6593-7. PMID: 17082570; PMCID: PMC2770730.
    28. Chiang E, Dang O, Anderson K, Matsuzawa A, Ichijo H, David M. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol. 2006 May 15; 176(10):5720-4. PMID: 16670275; PMCID: PMC2749679.
    29. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 09; 122(5):707-21. PMID: 16143103; PMCID: PMC1430687.
    30. Tanabe Y, Nishibori T, Su L, Arduini RM, Baker DP, David M. Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes. J Immunol. 2005 Jan 15; 174(2):609-13. PMID: 15634877.
      View in: PubMed
    31. Li S, Wilkinson M, Xia X, David M, Xu L, Purkel-Sutton A, Bhardwaj A. Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA. Mol Ther. 2005 Jan; 11(1):112-9. PMID: 15585412.
      View in: PubMed
    32. Mowen KA, Schurter BT, Fathman JW, David M, Glimcher LH. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell. 2004 Aug 27; 15(4):559-71. PMID: 15327772.
      View in: PubMed
    33. Dang O, Navarro L, David M. Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes. Shock. 2004 May; 21(5):470-5. PMID: 15087825; PMCID: PMC1282467.
    34. Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW. Arsenic inhibition of the JAK-STAT pathway. Oncogene. 2004 Apr 29; 23(20):3603-12. PMID: 15116095.
      View in: PubMed
    35. Smith WA, Schurter BT, Wong-Staal F, David M. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004 May 28; 279(22):22795-8. PMID: 15084609.
      View in: PubMed
    36. Dang O, Navarro L, Anderson K, David M. Cutting edge: anthrax lethal toxin inhibits activation of IFN-regulatory factor 3 by lipopolysaccharide. J Immunol. 2004 Jan 15; 172(2):747-51. PMID: 14707042.
      View in: PubMed
    37. Nishibori T, Tanabe Y, Su L, David M. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med. 2004 Jan 05; 199(1):25-34. PMID: 14699080; PMCID: PMC1193645.
    38. Ruvolo V, Navarro L, Sample CE, David M, Sung S, Swaminathan S. The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression. J Virol. 2003 Mar; 77(6):3690-701. PMID: 12610144; PMCID: PMC149524.
    39. David M. Signal transduction by type I interferons. Biotechniques. 2002 Oct; Suppl:58-65. PMID: 12395928.
      View in: PubMed
    40. Zhu W, Mustelin T, David M. Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem. 2002 Sep 27; 277(39):35787-90. PMID: 12171910.
      View in: PubMed
    41. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug; 22(16):5662-8. PMID: 12138178; PMCID: PMC133976.
    42. Blesofsky WA, Mowen K, Arduini RM, Baker DP, Murphy MA, Bowtell DD, David M. Regulation of STAT protein synthesis by c-Cbl. Oncogene. 2001 Nov 01; 20(50):7326-33. PMID: 11704862.
      View in: PubMed
    43. Mowen KA, David M. Analysis of protein arginine methylation and protein arginine-methyltransferase activity. Sci STKE. 2001 Jul 31; 2001(93):pl1. PMID: 11752667.
      View in: PubMed
    44. Mowen KA, Tang J, Zhu W, Schurter BT, Shuai K, Herschman HR, David M. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001 Mar 09; 104(5):731-41. PMID: 11257227.
      View in: PubMed
    45. Mowen KA, David M. Cytokine activation of transcription. Genet Eng (N Y). 2001; 23:35-44. PMID: 11570105.
      View in: PubMed
    46. Mowen K, David M. Regulation of STAT1 nuclear export by Jak1. Mol Cell Biol. 2000 Oct; 20(19):7273-81. PMID: 10982844; PMCID: PMC86281.
    47. Su L, David M. Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem. 2000 Apr 28; 275(17):12661-6. PMID: 10777558.
      View in: PubMed
    48. Navarro L, David M. p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J Biol Chem. 1999 Dec 10; 274(50):35535-8. PMID: 10585427.
      View in: PubMed
    49. Su L, Rickert RC, David M. Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J Biol Chem. 1999 Nov 05; 274(45):31770-4. PMID: 10542198; PMCID: PMC2772110.
    50. Su L, David M. Inhibition of B cell receptor-mediated apoptosis by IFN. J Immunol. 1999 Jun 01; 162(11):6317-21. PMID: 10352242.
      View in: PubMed
    51. Mowen K, David M. Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J Biol Chem. 1998 Nov 13; 273(46):30073-6. PMID: 9804758.
      View in: PubMed
    52. Navarro L, Mowen K, Rodems S, Weaver B, Reich N, Spector D, David M. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol. 1998 Jul; 18(7):3796-802. PMID: 9632763; PMCID: PMC108963.