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Andres Leschziner

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    West/Midwest Consortium for High-Resolution Cryo Electron Microscopy
    NIH/NIGMS U24GM116792Jul 11, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein
    NIH/NIGMS R01GM107214Jun 10, 2014 - Jul 31, 2022
    Role: Principal Investigator
    A comparative structural study of ATP-dependent chromatin remodeling complexes
    NIH/NIGMS R01GM092895Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc Natl Acad Sci U S A. 2020 Sep 28. Xu J, Wang W, Xu L, Chen JY, Chong J, Oh J, Leschziner AE, Fu XD, Wang D. PMID: 32989164.
      View in: PubMed   Mentions:    Fields:    
    2. Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature. 2020 Aug 19. Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE. PMID: 32814344.
      View in: PubMed   Mentions: 2     Fields:    
    3. Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun. 2020 06 08; 11(1):2866. Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. PMID: 32513959.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nat Cell Biol. 2020 05; 22(5):518-525. Htet ZM, Gillies JP, Baker RW, Leschziner AE, DeSantis ME, Reck-Peterson SL. PMID: 32341549.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. Elife. 2019 08 29; 8. Partlow EA, Baker RW, Beacham GM, Chappie JS, Leschziner AE, Hollopeter G. PMID: 31464684.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. 3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. J Struct Biol. 2019 09 01; 207(3):270-278. Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. PMID: 31200019.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. J Struct Biol. 2018 09; 203(3):230-235. Cianfrocco MA, Lahiri I, DiMaio F, Leschziner AE. PMID: 29864529.
      View in: PubMed   Mentions: 4     Fields:    
    8. Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Commun Biol. 2018; 1:1. Turegun B, Baker RW, Leschziner AE, Dominguez R. PMID: 29809203.
      View in: PubMed   Mentions:
    9. Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 11 30; 551(7682):653-657. Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. PMID: 29168508.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    10. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. PMID: 28886386.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 04 22; 6. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. PMID: 28432788.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. PMID: 26436706.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    13. Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Elife. 2015 May 08; 4. Cianfrocco MA, Leschziner AE. PMID: 25955969.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 2014 Nov 07; 3. Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. PMID: 25380312.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    15. Traffic control: adaptor proteins guide dynein-cargo takeoff. EMBO J. 2014 Sep 01; 33(17):1845-6. Cianfrocco MA, Leschziner AE. PMID: 25061224.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 2013 Sep 12; 154(6):1220-31. Nguyen VQ, Ranjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. PMID: 24034246.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    17. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science. 2012 Nov 02; 338(6107):662-5. Derr ND, Goodman BS, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. PMID: 23065903.
      View in: PubMed   Mentions: 102     Fields:    Translation:Cells
    18. Structural basis for microtubule binding and release by dynein. Science. 2012 Sep 21; 337(6101):1532-1536. Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. PMID: 22997337.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    19. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Aug 31; 150(5):975-86. Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. PMID: 22939623.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    20. Electron microscopy studies of nucleosome remodelers. Curr Opin Struct Biol. 2011 Dec; 21(6):709-18. Leschziner AE. PMID: 22040801.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Validation of the orthogonal tilt reconstruction method with a biological test sample. J Struct Biol. 2011 Jul; 175(1):85-96. Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner AE. PMID: 21536134.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. J Biol Eng. 2010 Dec 20; 4:17. Norville JE, Derda R, Gupta S, Drinkwater KA, Belcher AM, Leschziner AE, Knight TF. PMID: 21172029.
      View in: PubMed   Mentions:
    23. The orthogonal tilt reconstruction method. Methods Enzymol. 2010; 482:237-62. Leschziner A. PMID: 20888964.
      View in: PubMed   Mentions: 3     Fields:    
    24. A dimeric structure for archaeal box C/D small ribonucleoproteins. Science. 2009 Sep 11; 325(5946):1384-7. Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. PMID: 19745151.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    25. Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol. 2007 Aug; 14(8):721-6. Wang HW, Ramey VH, Westermann S, Leschziner AE, Welburn JP, Nakajima Y, Drubin DG, Barnes G, Nogales E. PMID: 17643123.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    26. Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4913-8. Leschziner AE, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. PMID: 17360331.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    27. Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct. 2007; 36:43-62. Leschziner AE, Nogales E. PMID: 17201674.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    28. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol. 2006 Aug; 13(8):684-90. Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M. PMID: 16829958.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    29. The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol. 2006 Mar; 153(3):284-99. Leschziner AE, Nogales E. PMID: 16431136.
      View in: PubMed   Mentions: 36     Fields:    
    30. Structural studies of the human PBAF chromatin-remodeling complex. Structure. 2005 Feb; 13(2):267-75. Leschziner AE, Lemon B, Tjian R, Nogales E. PMID: 15698570.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    31. The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Mol Cell. 2003 Sep; 12(3):775-81. Leschziner AE, Grindley ND. PMID: 14527421.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    32. A model for the gamma delta resolvase synaptic complex. Mol Cell. 2001 Sep; 8(3):623-31. Sarkis GJ, Murley LL, Leschziner AE, Boocock MR, Stark WM, Grindley ND. PMID: 11583624.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    33. Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. J Biol Chem. 2001 Aug 10; 276(32):30167-77. Xu Y, Potapova O, Leschziner AE, Grindley ND, Joyce CM. PMID: 11349126.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    34. Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. J Neurochem. 2000 Jan; 74(1):70-80. Leschziner A, Moukhles H, Lindenbaum M, Gee SH, Butterworth J, Campbell KP, Carbonetto S. PMID: 10617107.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic Acids Res. 1999 Oct 01; 27(19):3859-65. Griffin TJ, Parsons L, Leschziner AE, DeVost J, Derbyshire KM, Grindley ND. PMID: 10481025.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    36. Tn552 transposase catalyzes concerted strand transfer in vitro. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7345-50. Leschziner AE, Griffin TJ, Grindley ND. PMID: 9636151.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    37. DNA transposition: from a black box to a color monitor. Cell. 1995 Dec 29; 83(7):1063-6. Grindley ND, Leschziner AE. PMID: 8548793.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    38. The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Mol Microbiol. 1995 Mar; 15(5):865-70. Leschziner AE, Boocock MR, Grindley ND. PMID: 7596288.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
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