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Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat Struct Mol Biol. 2023 09; 30(9):1357-1364.
Karasmanis EP, Reimer JM, Kendrick AA, Nguyen KHV, Rodriguez JA, Truong JB, Lahiri I, Reck-Peterson SL, Leschziner AE. PMID: 37620585; PMCID: PMC10497415.
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PubMed Mentions:
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Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife. 2023 01 24; 12.
Reimer JM, DeSantis ME, Reck-Peterson SL, Leschziner AE. PMID: 36692009; PMCID: PMC9889085.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nat Struct Mol Biol. 2022 12; 29(12):1196-1207.
Snead DM, Matyszewski M, Dickey AM, Lin YX, Leschziner AE, Reck-Peterson SL. PMID: 36510024; PMCID: PMC9758056.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Structural basis for cytoplasmic dynein-1 regulation by Lis1. Elife. 2022 01 07; 11.
Gillies JP, Reimer JM, Karasmanis EP, Lahiri I, Htet ZM, Leschziner AE, Reck-Peterson SL. PMID: 34994688; PMCID: PMC8824474.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
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Structure Analysis of Proteins and Peptides by Difference Circular Dichroism Spectroscopy. Protein J. 2021 12; 40(6):867-875.
Arakawa T, Tokunaga M, Kita Y, Niikura T, Baker RW, Reimer JM, Leschziner AE. PMID: 34709521.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
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Structural Biology of LRRK2 and its Interaction with Microtubules. Mov Disord. 2021 11; 36(11):2494-2504.
Leschziner AE, Reck-Peterson SL. PMID: 34423856; PMCID: PMC9290818.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Structures and function of the amino acid polymerase cyanophycin synthetase. Nat Chem Biol. 2021 10; 17(10):1101-1110.
Sharon I, Haque AS, Grogg M, Lahiri I, Seebach D, Leschziner AE, Hilvert D, Schmeing TM. PMID: 34385683.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
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Structural insights into assembly and function of the RSC chromatin remodeling complex. Nat Struct Mol Biol. 2021 01; 28(1):71-80.
Baker RW, Reimer JM, Carman PJ, Turegun B, Arakawa T, Dominguez R, Leschziner AE. PMID: 33288924; PMCID: PMC7855068.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25486-25493.
Xu J, Wang W, Xu L, Chen JY, Chong J, Oh J, Leschziner AE, Fu XD, Wang D. PMID: 32989164; PMCID: PMC7568279.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature. 2020 12; 588(7837):344-349.
Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE. PMID: 32814344; PMCID: PMC7726071.
View in:
PubMed Mentions:
71 Fields:
Translation:
HumansCells
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Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun. 2020 06 08; 11(1):2866.
Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. PMID: 32513959; PMCID: PMC7280518.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nat Cell Biol. 2020 05; 22(5):518-525.
Htet ZM, Gillies JP, Baker RW, Leschziner AE, DeSantis ME, Reck-Peterson SL. PMID: 32341549; PMCID: PMC7271980.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. Elife. 2019 08 29; 8.
Partlow EA, Baker RW, Beacham GM, Chappie JS, Leschziner AE, Hollopeter G. PMID: 31464684; PMCID: PMC6739873.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
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3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. J Struct Biol. 2019 09 01; 207(3):270-278.
Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. PMID: 31200019; PMCID: PMC6711803.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. J Struct Biol. 2018 09; 203(3):230-235.
Cianfrocco MA, Lahiri I, DiMaio F, Leschziner AE. PMID: 29864529; PMCID: PMC6091888.
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PubMed Mentions:
11 Fields:
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Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Commun Biol. 2018; 1:1.
Turegun B, Baker RW, Leschziner AE, Dominguez R. PMID: 29809203; PMCID: PMC5969521.
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PubMed Mentions:
7
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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 11 30; 551(7682):653-657.
Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. PMID: 29168508; PMCID: PMC5907806.
View in:
PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12.
DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. PMID: 28886386; PMCID: PMC5625841.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 04 22; 6.
Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. PMID: 28432788; PMCID: PMC5413348.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108.
Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. PMID: 26436706; PMCID: PMC4644480.
View in:
PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Elife. 2015 May 08; 4.
Cianfrocco MA, Leschziner AE. PMID: 25955969; PMCID: PMC4440898.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 2014 Nov 07; 3.
Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. PMID: 25380312; PMCID: PMC4359366.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Traffic control: adaptor proteins guide dynein-cargo takeoff. EMBO J. 2014 Sep 01; 33(17):1845-6.
Cianfrocco MA, Leschziner AE. PMID: 25061224; PMCID: PMC4195778.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 2013 Sep 12; 154(6):1220-31.
Nguyen VQ, Ranjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. PMID: 24034246; PMCID: PMC3776929.
View in:
PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
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Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science. 2012 Nov 02; 338(6107):662-5.
Derr ND, Goodman BS, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. PMID: 23065903; PMCID: PMC3840815.
View in:
PubMed Mentions:
148 Fields:
Translation:
Cells
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Structural basis for microtubule binding and release by dynein. Science. 2012 Sep 21; 337(6101):1532-1536.
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. PMID: 22997337; PMCID: PMC3919166.
View in:
PubMed Mentions:
93 Fields:
Translation:
Cells
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Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Aug 31; 150(5):975-86.
Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. PMID: 22939623; PMCID: PMC3438448.
View in:
PubMed Mentions:
126 Fields:
Translation:
HumansAnimalsCells
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Electron microscopy studies of nucleosome remodelers. Curr Opin Struct Biol. 2011 Dec; 21(6):709-18.
Leschziner AE. PMID: 22040801; PMCID: PMC3241934.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Validation of the orthogonal tilt reconstruction method with a biological test sample. J Struct Biol. 2011 Jul; 175(1):85-96.
Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner AE. PMID: 21536134.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. J Biol Eng. 2010 Dec 20; 4:17.
Norville JE, Derda R, Gupta S, Drinkwater KA, Belcher AM, Leschziner AE, Knight TF. PMID: 21172029; PMCID: PMC3022552.
View in:
PubMed Mentions:
9
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The orthogonal tilt reconstruction method. Methods Enzymol. 2010; 482:237-62.
Leschziner A. PMID: 20888964.
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PubMed Mentions:
3 Fields:
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A dimeric structure for archaeal box C/D small ribonucleoproteins. Science. 2009 Sep 11; 325(5946):1384-7.
Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. PMID: 19745151; PMCID: PMC2975540.
View in:
PubMed Mentions:
33 Fields:
Translation:
Cells
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Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol. 2007 Aug; 14(8):721-6.
Wang HW, Ramey VH, Westermann S, Leschziner AE, Welburn JP, Nakajima Y, Drubin DG, Barnes G, Nogales E. PMID: 17643123.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4913-8.
Leschziner AE, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. PMID: 17360331; PMCID: PMC1820885.
View in:
PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct. 2007; 36:43-62.
Leschziner AE, Nogales E. PMID: 17201674.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol. 2006 Aug; 13(8):684-90.
Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M. PMID: 16829958.
View in:
PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol. 2006 Mar; 153(3):284-99.
Leschziner AE, Nogales E. PMID: 16431136.
View in:
PubMed Mentions:
40 Fields:
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Structural studies of the human PBAF chromatin-remodeling complex. Structure. 2005 Feb; 13(2):267-75.
Leschziner AE, Lemon B, Tjian R, Nogales E. PMID: 15698570.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Mol Cell. 2003 Sep; 12(3):775-81.
Leschziner AE, Grindley ND. PMID: 14527421.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
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Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. J Biol Chem. 2001 Aug 10; 276(32):30167-77.
Xu Y, Potapova O, Leschziner AE, Grindley ND, Joyce CM. PMID: 11349126.
View in:
PubMed Mentions:
23 Fields:
Translation:
Cells
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Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. J Neurochem. 2000 Jan; 74(1):70-80.
Leschziner A, Moukhles H, Lindenbaum M, Gee SH, Butterworth J, Campbell KP, Carbonetto S. PMID: 10617107.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic Acids Res. 1999 Oct 01; 27(19):3859-65.
Griffin TJ, Parsons L, Leschziner AE, DeVost J, Derbyshire KM, Grindley ND. PMID: 10481025; PMCID: PMC148649.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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Tn552 transposase catalyzes concerted strand transfer in vitro. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7345-50.
Leschziner AE, Griffin TJ, Grindley ND. PMID: 9636151; PMCID: PMC22612.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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DNA transposition: from a black box to a color monitor. Cell. 1995 Dec 29; 83(7):1063-6.
Grindley ND, Leschziner AE. PMID: 8548793.
View in:
PubMed Mentions:
19 Fields:
Translation:
Cells
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The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Mol Microbiol. 1995 Mar; 15(5):865-70.
Leschziner AE, Boocock MR, Grindley ND. PMID: 7596288.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells