Andres Leschziner

InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0694
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    West/Midwest Consortium for High-Resolution Cryo Electron Microscopy
    NIH/NIGMS U24GM116792Jul 11, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein
    NIH/NIGMS R01GM107214Jun 10, 2014 - Feb 28, 2018
    Role: Principal Investigator
    A comparative structural study of ATP-dependent chromatin remodeling complexes
    NIH/NIGMS R01GM092895Apr 1, 2011 - Jul 31, 2022
    Role: Principal Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cianfrocco MA, Lahiri I, DiMaio F, Leschziner AE. cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. J Struct Biol. 2018 Jun 01. PMID: 29864529.
      View in: PubMed
    2. Turegun B, Baker RW, Leschziner AE, Dominguez R. Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Commun Biol. 2018; 1. PMID: 29809203.
      View in: PubMed
    3. Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 11 30; 551(7682):653-657. PMID: 29168508.
      View in: PubMed
    4. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. PMID: 28886386.
      View in: PubMed
    5. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 04 22; 6. PMID: 28432788.
      View in: PubMed
    6. Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. PMID: 26436706; PMCID: PMC4644480 [Available on 11/13/16].
    7. Cianfrocco MA, Leschziner AE. Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Elife. 2015 May 08; 4. PMID: 25955969; PMCID: PMC4440898.
    8. Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 2014 Nov 07; 3. PMID: 25380312; PMCID: PMC4359366.
    9. Cianfrocco MA, Leschziner AE. Traffic control: adaptor proteins guide dynein-cargo takeoff. EMBO J. 2014 Sep 01; 33(17):1845-6. PMID: 25061224; PMCID: PMC4195778.
    10. Nguyen VQ, Ranjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 2013 Sep 12; 154(6):1220-31. PMID: 24034246; PMCID: PMC3776929.
    11. Derr ND, Goodman BS, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science. 2012 Nov 02; 338(6107):662-5. PMID: 23065903; PMCID: PMC3840815.
    12. Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. Structural basis for microtubule binding and release by dynein. Science. 2012 Sep 21; 337(6101):1532-1536. PMID: 22997337; PMCID: PMC3919166.
    13. Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Aug 31; 150(5):975-86. PMID: 22939623; PMCID: PMC3438448.
    14. Leschziner AE. Electron microscopy studies of nucleosome remodelers. Curr Opin Struct Biol. 2011 Dec; 21(6):709-18. PMID: 22040801; PMCID: PMC3241934.
    15. Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner AE. Validation of the orthogonal tilt reconstruction method with a biological test sample. J Struct Biol. 2011 Jul; 175(1):85-96. PMID: 21536134.
      View in: PubMed
    16. Norville JE, Derda R, Gupta S, Drinkwater KA, Belcher AM, Leschziner AE, Knight TF. Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. J Biol Eng. 2010 Dec 20; 4:17. PMID: 21172029; PMCID: PMC3022552.
    17. Leschziner A. The orthogonal tilt reconstruction method. Methods Enzymol. 2010; 482:237-62. PMID: 20888964.
      View in: PubMed
    18. Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. A dimeric structure for archaeal box C/D small ribonucleoproteins. Science. 2009 Sep 11; 325(5946):1384-7. PMID: 19745151; PMCID: PMC2975540.
    19. Wang HW, Ramey VH, Westermann S, Leschziner AE, Welburn JP, Nakajima Y, Drubin DG, Barnes G, Nogales E. Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol. 2007 Aug; 14(8):721-6. PMID: 17643123.
      View in: PubMed
    20. Leschziner AE, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4913-8. PMID: 17360331; PMCID: PMC1820885.
    21. Leschziner AE, Nogales E. Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct. 2007; 36:43-62. PMID: 17201674.
      View in: PubMed
    22. Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol. 2006 Aug; 13(8):684-90. PMID: 16829958.
      View in: PubMed
    23. Leschziner AE, Nogales E. The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol. 2006 Mar; 153(3):284-99. PMID: 16431136.
      View in: PubMed
    24. Leschziner AE, Lemon B, Tjian R, Nogales E. Structural studies of the human PBAF chromatin-remodeling complex. Structure. 2005 Feb; 13(2):267-75. PMID: 15698570.
      View in: PubMed
    25. Leschziner AE, Grindley ND. The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Mol Cell. 2003 Sep; 12(3):775-81. PMID: 14527421.
      View in: PubMed
    26. Sarkis GJ, Murley LL, Leschziner AE, Boocock MR, Stark WM, Grindley ND. A model for the gamma delta resolvase synaptic complex. Mol Cell. 2001 Sep; 8(3):623-31. PMID: 11583624.
      View in: PubMed
    27. Xu Y, Potapova O, Leschziner AE, Grindley ND, Joyce CM. Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. J Biol Chem. 2001 Aug 10; 276(32):30167-77. PMID: 11349126.
      View in: PubMed
    28. Griffin TJ, Parsons L, Leschziner AE, DeVost J, Derbyshire KM, Grindley ND. In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic Acids Res. 1999 Oct 01; 27(19):3859-65. PMID: 10481025; PMCID: PMC148649.
    29. Leschziner AE, Griffin TJ, Grindley ND. Tn552 transposase catalyzes concerted strand transfer in vitro. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7345-50. PMID: 9636151; PMCID: PMC22612.
    30. Grindley ND, Leschziner AE. DNA transposition: from a black box to a color monitor. Cell. 1995 Dec 29; 83(7):1063-6. PMID: 8548793.
      View in: PubMed
    31. Leschziner AE, Boocock MR, Grindley ND. The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Mol Microbiol. 1995 Mar; 15(5):865-70. PMID: 7596288.
      View in: PubMed