Andres Leschziner

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    West/Midwest Consortium for High-Resolution Cryo Electron Microscopy
    NIH U24GM116792Jul 11, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein
    NIH R01GM107214Jun 10, 2014 - Jul 31, 2022
    Role: Principal Investigator
    A comparative structural study of ATP-dependent chromatin remodeling complexes
    NIH R01GM092895Apr 1, 2011 - Jul 31, 2022
    Role: Principal Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2. bioRxiv. 2024 Oct 31. Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Krämer A, Schwalm MP, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S. PMID: 39554022; PMCID: PMC11565912.
      View in: PubMed   Mentions:
    2. Cryo-EM visualizes multiple steps of dynein activation pathway. bioRxiv. 2024 Oct 13. Kendrick A, Nguyen K, Ma W, Karasmanis E, Amaro RE, Reck-Peterson S, Leschziner A. PMID: 39416051; PMCID: PMC11482813.
      View in: PubMed   Mentions:
    3. Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2. bioRxiv. 2024 Jun 20. Chen S, Basiashvili T, Hutchings J, Murillo MS, Suarez AV, Louro JA, Leschziner AE, Villa E. PMID: 38948781; PMCID: PMC11212993.
      View in: PubMed   Mentions:
    4. A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. J Biol Chem. 2024 Jul; 300(7):107469. Dederer V, Sanz Murillo M, Karasmanis EP, Hatch KS, Chatterjee D, Preuss F, Abdul Azeez KR, Nguyen LV, Galicia C, Dreier B, Plückthun A, Versees W, Mathea S, Leschziner AE, Reck-Peterson SL, Knapp S. PMID: 38876305; PMCID: PMC11284679.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2314245121. Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE. PMID: 38194460; PMCID: PMC10801861.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv. 2023 12; 9(48):eadk6191. Sanz Murillo M, Villagran Suarez A, Dederer V, Chatterjee D, Alegrio Louro J, Knapp S, Mathea S, Leschziner AE. PMID: 38039358; PMCID: PMC10691770.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. Author Correction: Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun. 2023 Nov 17; 14(1):7463. Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. PMID: 37978300; PMCID: PMC10656468.
      View in: PubMed   Mentions:    Fields:    
    8. Structure of LRRK1 and mechanisms of autoinhibition and activation. Nat Struct Mol Biol. 2023 Nov; 30(11):1735-1745. Reimer JM, Dickey AM, Lin YX, Abrisch RG, Mathea S, Chatterjee D, Fay EJ, Knapp S, Daugherty MD, Reck-Peterson SL, Leschziner AE. PMID: 37857821; PMCID: PMC10643122.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat Struct Mol Biol. 2023 09; 30(9):1357-1364. Karasmanis EP, Reimer JM, Kendrick AA, Nguyen KHV, Rodriguez JA, Truong JB, Lahiri I, Reck-Peterson SL, Leschziner AE. PMID: 37620585; PMCID: PMC10497415.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife. 2023 01 24; 12. Reimer JM, DeSantis ME, Reck-Peterson SL, Leschziner AE. PMID: 36692009; PMCID: PMC9889085.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    11. Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nat Struct Mol Biol. 2022 12; 29(12):1196-1207. Snead DM, Matyszewski M, Dickey AM, Lin YX, Leschziner AE, Reck-Peterson SL. PMID: 36510024; PMCID: PMC9758056.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Structural basis for cytoplasmic dynein-1 regulation by Lis1. Elife. 2022 01 07; 11. Gillies JP, Reimer JM, Karasmanis EP, Lahiri I, Htet ZM, Leschziner AE, Reck-Peterson SL. PMID: 34994688; PMCID: PMC8824474.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    13. Structure Analysis of Proteins and Peptides by Difference Circular Dichroism Spectroscopy. Protein J. 2021 12; 40(6):867-875. Arakawa T, Tokunaga M, Kita Y, Niikura T, Baker RW, Reimer JM, Leschziner AE. PMID: 34709521.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Structural Biology of LRRK2 and its Interaction with Microtubules. Mov Disord. 2021 11; 36(11):2494-2504. Leschziner AE, Reck-Peterson SL. PMID: 34423856; PMCID: PMC9290818.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Structures and function of the amino acid polymerase cyanophycin synthetase. Nat Chem Biol. 2021 10; 17(10):1101-1110. Sharon I, Haque AS, Grogg M, Lahiri I, Seebach D, Leschziner AE, Hilvert D, Schmeing TM. PMID: 34385683.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    16. Structural insights into assembly and function of the RSC chromatin remodeling complex. Nat Struct Mol Biol. 2021 01; 28(1):71-80. Baker RW, Reimer JM, Carman PJ, Turegun B, Arakawa T, Dominguez R, Leschziner AE. PMID: 33288924; PMCID: PMC7855068.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25486-25493. Xu J, Wang W, Xu L, Chen JY, Chong J, Oh J, Leschziner AE, Fu XD, Wang D. PMID: 32989164; PMCID: PMC7568279.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature. 2020 12; 588(7837):344-349. Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE. PMID: 32814344; PMCID: PMC7726071.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    19. Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun. 2020 06 08; 11(1):2866. Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. PMID: 32513959; PMCID: PMC7280518.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nat Cell Biol. 2020 05; 22(5):518-525. Htet ZM, Gillies JP, Baker RW, Leschziner AE, DeSantis ME, Reck-Peterson SL. PMID: 32341549; PMCID: PMC7271980.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    21. A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. Elife. 2019 08 29; 8. Partlow EA, Baker RW, Beacham GM, Chappie JS, Leschziner AE, Hollopeter G. PMID: 31464684; PMCID: PMC6739873.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    22. 3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. J Struct Biol. 2019 09 01; 207(3):270-278. Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. PMID: 31200019; PMCID: PMC6711803.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. J Struct Biol. 2018 09; 203(3):230-235. Cianfrocco MA, Lahiri I, DiMaio F, Leschziner AE. PMID: 29864529; PMCID: PMC6091888.
      View in: PubMed   Mentions: 11     Fields:    
    24. Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Commun Biol. 2018; 1:1. Turegun B, Baker RW, Leschziner AE, Dominguez R. PMID: 29809203; PMCID: PMC5969521.
      View in: PubMed   Mentions: 10  
    25. Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 11 30; 551(7682):653-657. Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. PMID: 29168508; PMCID: PMC5907806.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    26. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. PMID: 28886386; PMCID: PMC5625841.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    27. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 04 22; 6. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. PMID: 28432788; PMCID: PMC5413348.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    28. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. PMID: 26436706; PMCID: PMC4644480.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    29. Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Elife. 2015 May 08; 4. Cianfrocco MA, Leschziner AE. PMID: 25955969; PMCID: PMC4440898.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 2014 Nov 07; 3. Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. PMID: 25380312; PMCID: PMC4359366.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    31. Traffic control: adaptor proteins guide dynein-cargo takeoff. EMBO J. 2014 Sep 01; 33(17):1845-6. Cianfrocco MA, Leschziner AE. PMID: 25061224; PMCID: PMC4195778.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    32. Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 2013 Sep 12; 154(6):1220-31. Nguyen VQ, Ranjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. PMID: 24034246; PMCID: PMC3776929.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    33. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science. 2012 Nov 02; 338(6107):662-5. Derr ND, Goodman BS, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. PMID: 23065903; PMCID: PMC3840815.
      View in: PubMed   Mentions: 161     Fields:    Translation:Cells
    34. Structural basis for microtubule binding and release by dynein. Science. 2012 Sep 21; 337(6101):1532-1536. Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. PMID: 22997337; PMCID: PMC3919166.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
    35. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Aug 31; 150(5):975-86. Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. PMID: 22939623; PMCID: PMC3438448.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    36. Electron microscopy studies of nucleosome remodelers. Curr Opin Struct Biol. 2011 Dec; 21(6):709-18. Leschziner AE. PMID: 22040801; PMCID: PMC3241934.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Validation of the orthogonal tilt reconstruction method with a biological test sample. J Struct Biol. 2011 Jul; 175(1):85-96. Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner AE. PMID: 21536134.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. J Biol Eng. 2010 Dec 20; 4:17. Norville JE, Derda R, Gupta S, Drinkwater KA, Belcher AM, Leschziner AE, Knight TF. PMID: 21172029; PMCID: PMC3022552.
      View in: PubMed   Mentions: 9  
    39. The orthogonal tilt reconstruction method. Methods Enzymol. 2010; 482:237-62. Leschziner A. PMID: 20888964.
      View in: PubMed   Mentions: 3     Fields:    
    40. A dimeric structure for archaeal box C/D small ribonucleoproteins. Science. 2009 Sep 11; 325(5946):1384-7. Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. PMID: 19745151; PMCID: PMC2975540.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    41. Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol. 2007 Aug; 14(8):721-6. Wang HW, Ramey VH, Westermann S, Leschziner AE, Welburn JP, Nakajima Y, Drubin DG, Barnes G, Nogales E. PMID: 17643123.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    42. Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4913-8. Leschziner AE, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. PMID: 17360331; PMCID: PMC1820885.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    43. Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct. 2007; 36:43-62. Leschziner AE, Nogales E. PMID: 17201674.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    44. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol. 2006 Aug; 13(8):684-90. Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M. PMID: 16829958.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    45. The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol. 2006 Mar; 153(3):284-99. Leschziner AE, Nogales E. PMID: 16431136.
      View in: PubMed   Mentions: 41     Fields:    
    46. Structural studies of the human PBAF chromatin-remodeling complex. Structure. 2005 Feb; 13(2):267-75. Leschziner AE, Lemon B, Tjian R, Nogales E. PMID: 15698570.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    47. The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Mol Cell. 2003 Sep; 12(3):775-81. Leschziner AE, Grindley ND. PMID: 14527421.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    48. A model for the gamma delta resolvase synaptic complex. Mol Cell. 2001 Sep; 8(3):623-31. Sarkis GJ, Murley LL, Leschziner AE, Boocock MR, Stark WM, Grindley ND. PMID: 11583624.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    49. Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. J Biol Chem. 2001 Aug 10; 276(32):30167-77. Xu Y, Potapova O, Leschziner AE, Grindley ND, Joyce CM. PMID: 11349126.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    50. Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. J Neurochem. 2000 Jan; 74(1):70-80. Leschziner A, Moukhles H, Lindenbaum M, Gee SH, Butterworth J, Campbell KP, Carbonetto S. PMID: 10617107.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    51. In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic Acids Res. 1999 Oct 01; 27(19):3859-65. Griffin TJ, Parsons L, Leschziner AE, DeVost J, Derbyshire KM, Grindley ND. PMID: 10481025; PMCID: PMC148649.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    52. Tn552 transposase catalyzes concerted strand transfer in vitro. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7345-50. Leschziner AE, Griffin TJ, Grindley ND. PMID: 9636151; PMCID: PMC22612.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    53. DNA transposition: from a black box to a color monitor. Cell. 1995 Dec 29; 83(7):1063-6. Grindley ND, Leschziner AE. PMID: 8548793.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    54. The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Mol Microbiol. 1995 Mar; 15(5):865-70. Leschziner AE, Boocock MR, Grindley ND. PMID: 7596288.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
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