Loading...

Omar Akbari

Title(s)Associate Professor, Cell and Developmental Biology
SchoolAcademic Aff
Address9500 Gilman Drive #0335
La Jolla CA 92093
Phone858-246-0640
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Precision guided SIT for the control of vector-borne disease
    NIH/NIAID R01AI151004Jan 23, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Transcriptome engineering technologies for the development of antiviral effectors in mosquitoes
    NIH/NIAID R21AI149161Jan 23, 2020 - Dec 31, 2021
    Role: Principal Investigator
    Development of synthetic viral circuitry to regulate viruses in mosquito disease vectors
    NIH/NIAID DP2AI152071Sep 30, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Developing reciprocal chromosomal translocations for wild population replacement in an important vector of human disease.
    NIH/NIAID R21AI123937Dec 19, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Synthetically engineering population control systems in vectors of human disease
    NIH/NIAID K22AI113060Aug 11, 2015 - Jul 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Embryo Microinjection Techniques for Efficient Site-Specific Mutagenesis in Culex quinquefasciatus. J Vis Exp. 2020 May 24; (159). Bui M, Li M, Raban RR, Liu N, Akbari OS. PMID: 32510506.
      View in: PubMed   Mentions:    Fields:    
    2. Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations. BMC Biol. 2020 May 12; 18(1):50. Sánchez C HM, Bennett JB, Wu SL, Rašic G, Akbari OS, Marshall JM. PMID: 32398005.
      View in: PubMed   Mentions:    Fields:    
    3. A drug-inducible sex-separation technique for insects. Nat Commun. 2020 Apr 30; 11(1):2106. Kandul NP, Liu J, Hsu AD, Hay BA, Akbari OS. PMID: 32355156.
      View in: PubMed   Mentions:    Fields:    
    4. Correction: Broad dengue neutralization in mosquitoes expressing an engineered antibody. PLoS Pathog. 2020 Apr; 16(4):e1008545. Buchman A, Gamez S, Li M, Antoshechkin I, Li HH, Wang HW, Chen CH, Klein MJ, Duchemin JB, Crowe JE, Paradkar PN, Akbari OS. PMID: 32348355.
      View in: PubMed   Mentions:    Fields:    
    5. Genome elimination mediated by gene expression from a selfish chromosome. Sci Adv. 2020 04; 6(14):eaaz9808. Dalla Benetta E, Antoshechkin I, Yang T, Nguyen HQM, Ferree PM, Akbari OS. PMID: 32284986.
      View in: PubMed   Mentions:    Fields:    
    6. The Developmental Transcriptome of Aedes albopictus, a Major Worldwide Human Disease Vector. G3 (Bethesda). 2020 Mar 05; 10(3):1051-1062. Gamez S, Antoshechkin I, Mendez-Sanchez SC, Akbari OS. PMID: 31964684.
      View in: PubMed   Mentions:    Fields:    
    7. Progress towards engineering gene drives for population control. J Exp Biol. 2020 Feb 07; 223(Pt Suppl 1). Raban RR, Marshall JM, Akbari OS. PMID: 32034041.
      View in: PubMed   Mentions:    Fields:    
    8. Assessment of a Split Homing Based Gene Drive for Efficient Knockout of Multiple Genes. G3 (Bethesda). 2020 02 06; 10(2):827-837. Kandul NP, Liu J, Buchman A, Gantz VM, Bier E, Akbari OS. PMID: 31882406.
      View in: PubMed   Mentions:    Fields:    
    9. Development of a confinable gene drive system in the human disease vector Aedes aegypti. Elife. 2020 Jan 21; 9. Li M, Yang T, Kandul NP, Bui M, Gamez S, Raban R, Bennett J, Sánchez C HM, Lanzaro GC, Schmidt H, Lee Y, Marshall JM, Akbari OS. PMID: 31960794.
      View in: PubMed   Mentions: 3     Fields:    
    10. Broad dengue neutralization in mosquitoes expressing an engineered antibody. PLoS Pathog. 2020 01; 16(1):e1008103. Buchman A, Gamez S, Li M, Antoshechkin I, Li HH, Wang HW, Chen CH, Klein MJ, Duchemin JB, Crowe JE, Paradkar PN, Akbari OS. PMID: 31945137.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. The olfactory basis of orchid pollination by mosquitoes. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):708-716. Lahondère C, Vinauger C, Okubo RP, Wolff GH, Chan JK, Akbari OS, Riffell JA. PMID: 31871198.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. A typology of community and stakeholder engagement based on documented examples in the field of novel vector control. PLoS Negl Trop Dis. 2019 11; 13(11):e0007863. Schairer CE, Taitingfong R, Akbari OS, Bloss CS. PMID: 31765377.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    13. Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies. Front Genet. 2019; 10:1072. Marshall JM, Raban RR, Kandul NP, Edula JR, León TM, Akbari OS. PMID: 31737050.
      View in: PubMed   Mentions:
    14. Malaria eradication within a generation: ambitious, achievable, and necessary. Lancet. 2019 09 21; 394(10203):1056-1112. Feachem RGA, Chen I, Akbari O, Bertozzi-Villa A, Bhatt S, Binka F, Boni MF, Buckee C, Dieleman J, Dondorp A, Eapen A, Sekhri Feachem N, Filler S, Gething P, Gosling R, Haakenstad A, Harvard K, Hatefi A, Jamison D, Jones KE, Karema C, Kamwi RN, Lal A, Larson E, Lees M, Lobo NF, Micah AE, Moonen B, Newby G, Ning X, Pate M, Quiñones M, Roh M, Rolfe B, Shanks D, Singh B, Staley K, Tulloch J, Wegbreit J, Woo HJ, Mpanju-Shumbusho W. PMID: 31511196.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    15. Reply to 'Concerns about the feasibility of using "precision guided sterile males" to control insects'. Nat Commun. 2019 09 02; 10(1):3955. Kandul NP, Liu J, Sanchez C HM, Wu SL, Marshall JM, Akbari OS. PMID: 31477702.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    16. Visual-Olfactory Integration in the Human Disease Vector Mosquito Aedes aegypti. Curr Biol. 2019 08 05; 29(15):2509-2516.e5. Vinauger C, Van Breugel F, Locke LT, Tobin KKS, Dickinson MH, Fairhall AL, Akbari OS, Riffell JA. PMID: 31327719.
      View in: PubMed   Mentions:    Fields:    
    17. Live calcium imaging of Aedes aegypti neuronal tissues reveals differential importance of chemosensory systems for life-history-specific foraging strategies. BMC Neurosci. 2019 06 17; 20(1):27. Bui M, Shyong J, Lutz EK, Yang T, Li M, Truong K, Arvidson R, Buchman A, Riffell JA, Akbari OS. PMID: 31208328.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Sequence Expression of Supernumerary B Chromosomes: Function or Fluff? Genes (Basel). 2019 02 08; 10(2). Dalla Benetta E, Akbari OS, Ferree PM. PMID: 30744010.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3656-3661. Buchman A, Gamez S, Li M, Antoshechkin I, Li HH, Wang HW, Chen CH, Klein MJ, Duchemin JB, Paradkar PN, Akbari OS. PMID: 30723148.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Transforming insect population control with precision guided sterile males with demonstration in flies. Nat Commun. 2019 01 08; 10(1):84. Kandul NP, Liu J, Sanchez C HM, Wu SL, Marshall JM, Akbari OS. PMID: 30622266.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    21. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 2018 11; 563(7732):501-507. Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipovic I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG, Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Rašic G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB. PMID: 30429615.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Gene editing technologies and applications for insects. Curr Opin Insect Sci. 2018 08; 28:66-72. Gantz VM, Akbari OS. PMID: 30551769.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    23. Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):4725-4730. Buchman A, Marshall JM, Ostrovski D, Yang T, Akbari OS. PMID: 29666236.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    24. Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila. ACS Synth Biol. 2018 05 18; 7(5):1359-1370. Buchman AB, Ivy T, Marshall JM, Akbari OS, Hay BA. PMID: 29608276.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Gene drives may be the next step towards sustainable control of malaria. Pathog Glob Health. 2017 12; 111(8):399-400. Raban R, Akbari OS. PMID: 29566584.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    26. Can CRISPR-Based Gene Drive Be Confined in the Wild? A Question for Molecular and Population Biology. ACS Chem Biol. 2018 02 16; 13(2):424-430. Marshall JM, Akbari OS. PMID: 29370514.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    27. Modulation of Host Learning in Aedes aegypti Mosquitoes. Curr Biol. 2018 02 05; 28(3):333-344.e8. Vinauger C, Lahondère C, Wolff GH, Locke LT, Liaw JE, Parrish JZ, Akbari OS, Dickinson MH, Riffell JA. PMID: 29395917.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    28. Highly Efficient Site-Specific Mutagenesis in Malaria Mosquitoes Using CRISPR. G3 (Bethesda). 2018 02 02; 8(2):653-658. Li M, Akbari OS, White BJ. PMID: 29233915.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    29. Embryo Microinjection and Transplantation Technique for Nasonia vitripennis Genome Manipulation. J Vis Exp. 2017 12 25; (130). Li M, Bui M, Akbari OS. PMID: 29364231.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Erratum to: Unique sequence organization and small RNA expression of a "selfish" B chromosome. Chromosoma. 2017 12; 126(6):781. Li Y, Jing XA, Aldrich JC, Clifford C, Chen J, Akbari OS, Ferree PM. PMID: 28821911.
      View in: PubMed   Mentions:    Fields:    
    31. Germline Cas9 expression yields highly efficient genome engineering in a major worldwide disease vector, Aedes aegypti. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):E10540-E10549. Li M, Bui M, Yang T, Bowman CS, White BJ, Akbari OS. PMID: 29138316.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 08 08; 35(8):716-718. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. PMID: 28787415.
      View in: PubMed   Mentions: 7     Fields:    
    33. Unique sequence organization and small RNA expression of a "selfish" B chromosome. Chromosoma. 2017 Dec; 126(6):753-768. Li Y, Jing XA, Aldrich JC, Clifford C, Chen J, Akbari OS, Ferree PM. PMID: 28780664.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Overcoming evolved resistance to population-suppressing homing-based gene drives. Sci Rep. 2017 06 19; 7(1):3776. Marshall JM, Buchman A, Sánchez C HM, Akbari OS. PMID: 28630470.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    35. Generation of heritable germline mutations in the jewel wasp Nasonia vitripennis using CRISPR/Cas9. Sci Rep. 2017 04 19; 7(1):901. Li M, Au LYC, Douglah D, Chong A, White BJ, Ferree PM, Akbari OS. PMID: 28424460.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    36. Mapping a multiplexed zoo of mRNA expression. Development. 2016 10 01; 143(19):3632-3637. Choi HM, Calvert CR, Husain N, Huss D, Barsi JC, Deverman BE, Hunter RC, Kato M, Lee SM, Abelin AC, Rosenthal AZ, Akbari OS, Li Y, Hay BA, Sternberg PW, Patterson PH, Davidson EH, Mazmanian SK, Prober DA, van de Rijn M, Leadbetter JR, Newman DK, Readhead C, Bronner ME, Wold B, Lansford R, Sauka-Spengler T, Fraser SE, Pierce NA. PMID: 27702788.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    37. Male-Killing Spiroplasma Alters Behavior of the Dosage Compensation Complex during Drosophila melanogaster Embryogenesis. Curr Biol. 2016 05 23; 26(10):1339-45. Cheng B, Kuppanda N, Aldrich JC, Akbari OS, Ferree PM. PMID: 27161498.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):E2114-23. Hall AB, Papathanos PA, Sharma A, Cheng C, Akbari OS, Assour L, Bergman NH, Cagnetti A, Crisanti A, Dottorini T, Fiorentini E, Galizi R, Hnath J, Jiang X, Koren S, Nolan T, Radune D, Sharakhova MV, Steele A, Timoshevskiy VA, Windbichler N, Zhang S, Hahn MW, Phillippy AM, Emrich SJ, Sharakhov IV, Tu ZJ, Besansky NJ. PMID: 27035980.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. Cheating evolution: engineering gene drives to manipulate the fate of wild populations. Nat Rev Genet. 2016 Mar; 17(3):146-59. Champer J, Buchman A, Akbari OS. PMID: 26875679.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    40. Identification of Genes Uniquely Expressed in the Germ-Line Tissues of the Jewel Wasp Nasonia vitripennis. G3 (Bethesda). 2015 Oct 13; 5(12):2647-53. Ferree PM, Fang C, Mastrodimos M, Hay BA, Amrhein H, Akbari OS. PMID: 26464360.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    41. Vectored antibody gene delivery mediates long-term contraception. Curr Biol. 2015 Oct 05; 25(19):R820-2. Li J, Olvera AI, Akbari OS, Moradian A, Sweredoski MJ, Hess S, Hay BA. PMID: 26439332.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. PMID: 26229113.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    43. Identification of germline transcriptional regulatory elements in Aedes aegypti. Sci Rep. 2014 Feb 04; 4:3954. Akbari OS, Papathanos PA, Sandler JE, Kennedy K, Hay BA. PMID: 24492376.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. The developmental transcriptome of the mosquito Aedes aegypti, an invasive species and major arbovirus vector. G3 (Bethesda). 2013 Sep 04; 3(9):1493-509. Akbari OS, Antoshechkin I, Amrhein H, Williams B, Diloreto R, Sandler J, Hay BA. PMID: 23833213.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    45. Transcriptome profiling of Nasonia vitripennis testis reveals novel transcripts expressed from the selfish B chromosome, paternal sex ratio. G3 (Bethesda). 2013 Sep 04; 3(9):1597-605. Akbari OS, Antoshechkin I, Hay BA, Ferree PM. PMID: 23893741.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    46. A synthetic gene drive system for local, reversible modification and suppression of insect populations. Curr Biol. 2013 Apr 22; 23(8):671-7. Akbari OS, Matzen KD, Marshall JM, Huang H, Ward CM, Hay BA. PMID: 23541732.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    47. Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression. ACS Synth Biol. 2014 Dec 19; 3(12):915-28. Akbari OS, Chen CH, Marshall JM, Huang H, Antoshechkin I, Hay BA. PMID: 23654248.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    48. Disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila. PLoS One. 2011 Jan 21; 6(1):e16283. Ho MC, Schiller BJ, Akbari OS, Bae E, Drewell RA. PMID: 21283702.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    49. The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. BMC Cell Biol. 2010 Dec 31; 11:101. Oliver D, Sheehan B, South H, Akbari O, Pai CY. PMID: 21194420.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    50. An Entry/Gateway cloning system for general expression of genes with molecular tags in Drosophila melanogaster. BMC Cell Biol. 2009 Jan 29; 10:8. Akbari OS, Oliver D, Eyer K, Pai CY. PMID: 19178707.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    51. A novel promoter-tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo. Development. 2008 Jan; 135(1):123-31. Akbari OS, Bae E, Johnsen H, Villaluz A, Wong D, Drewell RA. PMID: 18045839.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    52. The abdominal-B promoter tethering element mediates promoter-enhancer specificity at the Drosophila bithorax complex. Fly (Austin). 2007 Nov-Dec; 1(6):337-9. Akbari OS, Schiller BJ, Goetz SE, Ho MC, Bae E, Drewell RA. PMID: 18504507.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Unraveling cis-regulatory mechanisms at the abdominal-A and Abdominal-B genes in the Drosophila bithorax complex. Dev Biol. 2006 May 15; 293(2):294-304. Akbari OS, Bousum A, Bae E, Drewell RA. PMID: 16545794.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    Omar's Networks
    Concepts (211)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (17)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _
    ↑