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Omar Akbari

TitleAssistant Professor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0349
La Jolla CA 92093
Phone858-246-0640
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    Developing reciprocal chromosomal translocations for wild population replacement in an important vector of human disease.
    NIH/NIAID R21AI123937Dec 19, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Synthetically engineering population control systems in vectors of human disease
    NIH/NIAID K22AI113060Aug 11, 2015 - Jul 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Buchman A, Marshall JM, Ostrovski D, Yang T, Akbari O. Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii. Proc Natl Acad Sci U S A. 2018 May 01; 115(18):4725-4730. PMID: 29666236.
      View in: PubMed
    2. Buchman AB, Ivy T, Marshall JM, Akbari O, Hay BA. Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila. ACS Synth Biol. 2018 Apr 13. PMID: 29608276.
      View in: PubMed
    3. Raban R, Akbari O. Gene drives may be the next step towards sustainable control of malaria. Pathog Glob Health. 2017 Dec; 111(8):399-400. PMID: 29566584.
      View in: PubMed
    4. Marshall JM, Akbari O. Can CRISPR-Based Gene Drive Be Confined in the Wild? A Question for Molecular and Population Biology. ACS Chem Biol. 2018 Feb 16; 13(2):424-430. PMID: 29370514.
      View in: PubMed
    5. Vinauger C, Lahondère C, Wolff GH, Locke LT, Liaw JE, Parrish JZ, Akbari O, Dickinson MH, Riffell JA. Modulation of Host Learning in Aedes aegypti Mosquitoes. Curr Biol. 2018 Feb 05; 28(3):333-344.e8. PMID: 29395917.
      View in: PubMed
    6. Li M, Akbari O, White BJ. Highly Efficient Site-Specific Mutagenesis in Malaria Mosquitoes Using CRISPR. G3 (Bethesda). 2018 Feb 02; 8(2):653-658. PMID: 29233915.
      View in: PubMed
    7. Li M, Bui M, Akbari O. Embryo Microinjection and Transplantation Technique for Nasonia vitripennis Genome Manipulation. J Vis Exp. 2017 12 25; (130). PMID: 29364231.
      View in: PubMed
    8. Li Y, Jing XA, Aldrich JC, Clifford C, Chen J, Akbari O, Ferree PM. Erratum to: Unique sequence organization and small RNA expression of a "selfish" B chromosome. Chromosoma. 2017 Dec; 126(6):781. PMID: 28821911.
      View in: PubMed
    9. Li M, Bui M, Yang T, Bowman CS, White BJ, Akbari O. Germline Cas9 expression yields highly efficient genome engineering in a major worldwide disease vector, Aedes aegypti. Proc Natl Acad Sci U S A. 2017 Dec 05; 114(49):E10540-E10549. PMID: 29138316.
      View in: PubMed
    10. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 Aug 08; 35(8):716-718. PMID: 28787415.
      View in: PubMed
    11. Li Y, Jing XA, Aldrich JC, Clifford C, Chen J, Akbari O, Ferree PM. Unique sequence organization and small RNA expression of a "selfish" B chromosome. Chromosoma. 2017 Dec; 126(6):753-768. PMID: 28780664.
      View in: PubMed
    12. Marshall JM, Buchman A, Sánchez C HM, Akbari O. Overcoming evolved resistance to population-suppressing homing-based gene drives. Sci Rep. 2017 Jun 19; 7(1):3776. PMID: 28630470.
      View in: PubMed
    13. Li M, Au LYC, Douglah D, Chong A, White BJ, Ferree PM, Akbari O. Generation of heritable germline mutations in the jewel wasp Nasonia vitripennis using CRISPR/Cas9. Sci Rep. 2017 04 19; 7(1):901. PMID: 28424460.
      View in: PubMed
    14. Choi HM, Calvert CR, Husain N, Huss D, Barsi JC, Deverman BE, Hunter RC, Kato M, Lee SM, Abelin AC, Rosenthal AZ, Akbari O, Li Y, Hay BA, Sternberg PW, Patterson PH, Davidson EH, Mazmanian SK, Prober DA, van de Rijn M, Leadbetter JR, Newman DK, Readhead C, Bronner ME, Wold B, Lansford R, Sauka-Spengler T, Fraser SE, Pierce NA. Mapping a multiplexed zoo of mRNA expression. Development. 2016 10 01; 143(19):3632-3637. PMID: 27702788.
      View in: PubMed
    15. Cheng B, Kuppanda N, Aldrich JC, Akbari O, Ferree PM. Male-Killing Spiroplasma Alters Behavior of the Dosage Compensation Complex during Drosophila melanogaster Embryogenesis. Curr Biol. 2016 05 23; 26(10):1339-45. PMID: 27161498.
      View in: PubMed
    16. Hall AB, Papathanos PA, Sharma A, Cheng C, Akbari O, Assour L, Bergman NH, Cagnetti A, Crisanti A, Dottorini T, Fiorentini E, Galizi R, Hnath J, Jiang X, Koren S, Nolan T, Radune D, Sharakhova MV, Steele A, Timoshevskiy VA, Windbichler N, Zhang S, Hahn MW, Phillippy AM, Emrich SJ, Sharakhov IV, Tu ZJ, Besansky NJ. Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):E2114-23. PMID: 27035980; PMCID: PMC4839409.
      View in: PubMed, PubMed Central
    17. Champer J, Buchman A, Akbari O. Cheating evolution: engineering gene drives to manipulate the fate of wild populations. Nat Rev Genet. 2016 Mar; 17(3):146-59. PMID: 26875679.
      View in: PubMed
    18. Ferree PM, Fang C, Mastrodimos M, Hay BA, Amrhein H, Akbari O. Identification of Genes Uniquely Expressed in the Germ-Line Tissues of the Jewel Wasp Nasonia vitripennis. G3 (Bethesda). 2015 Oct 13; 5(12):2647-53. PMID: 26464360; PMCID: PMC4683638.
      View in: PubMed, PubMed Central
    19. Li J, Olvera AI, Akbari O, Moradian A, Sweredoski MJ, Hess S, Hay BA. Vectored antibody gene delivery mediates long-term contraception. Curr Biol. 2015 Oct 05; 25(19):R820-2. PMID: 26439332.
      View in: PubMed
    20. Akbari O, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. PMID: 26229113; PMCID: PMC4692367.
      View in: PubMed, PubMed Central
    21. Akbari O, Papathanos PA, Sandler JE, Kennedy K, Hay BA. Identification of germline transcriptional regulatory elements in Aedes aegypti. Sci Rep. 2014 Feb 04; 4:3954. PMID: 24492376; PMCID: PMC3912481.
      View in: PubMed, PubMed Central
    22. Akbari O, Antoshechkin I, Amrhein H, Williams B, Diloreto R, Sandler J, Hay BA. The developmental transcriptome of the mosquito Aedes aegypti, an invasive species and major arbovirus vector. G3 (Bethesda). 2013 Sep 04; 3(9):1493-509. PMID: 23833213; PMCID: PMC3755910.
      View in: PubMed, PubMed Central
    23. Akbari O, Antoshechkin I, Hay BA, Ferree PM. Transcriptome profiling of Nasonia vitripennis testis reveals novel transcripts expressed from the selfish B chromosome, paternal sex ratio. G3 (Bethesda). 2013 Sep 04; 3(9):1597-605. PMID: 23893741; PMCID: PMC3755920.
      View in: PubMed, PubMed Central
    24. Akbari O, Matzen KD, Marshall JM, Huang H, Ward CM, Hay BA. A synthetic gene drive system for local, reversible modification and suppression of insect populations. Curr Biol. 2013 Apr 22; 23(8):671-7. PMID: 23541732.
      View in: PubMed
    25. Akbari O, Chen CH, Marshall JM, Huang H, Antoshechkin I, Hay BA. Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression. ACS Synth Biol. 2014 Dec 19; 3(12):915-28. PMID: 23654248; PMCID: PMC3742681.
      View in: PubMed, PubMed Central
    26. Ho MC, Schiller BJ, Akbari O, Bae E, Drewell RA. Disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila. PLoS One. 2011 Jan 21; 6(1):e16283. PMID: 21283702; PMCID: PMC3025016.
      View in: PubMed, PubMed Central
    27. Oliver D, Sheehan B, South H, Akbari O, Pai CY. The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. BMC Cell Biol. 2010 Dec 31; 11:101. PMID: 21194420; PMCID: PMC3022720.
      View in: PubMed, PubMed Central
    28. Akbari O, Oliver D, Eyer K, Pai CY. An Entry/Gateway cloning system for general expression of genes with molecular tags in Drosophila melanogaster. BMC Cell Biol. 2009 Jan 29; 10:8. PMID: 19178707; PMCID: PMC2654426.
      View in: PubMed, PubMed Central
    29. Akbari O, Bae E, Johnsen H, Villaluz A, Wong D, Drewell RA. A novel promoter-tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo. Development. 2008 Jan; 135(1):123-31. PMID: 18045839; PMCID: PMC2205987.
      View in: PubMed, PubMed Central
    30. Akbari O, Schiller BJ, Goetz SE, Ho MC, Bae E, Drewell RA. The abdominal-B promoter tethering element mediates promoter-enhancer specificity at the Drosophila bithorax complex. Fly (Austin). 2007 Nov-Dec; 1(6):337-9. PMID: 18504507; PMCID: PMC2394718.
      View in: PubMed, PubMed Central
    31. Akbari O, Bousum A, Bae E, Drewell RA. Unraveling cis-regulatory mechanisms at the abdominal-A and Abdominal-B genes in the Drosophila bithorax complex. Dev Biol. 2006 May 15; 293(2):294-304. PMID: 16545794.
      View in: PubMed
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