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Deborah Yelon

TitleResearcher
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0380
La Jolla CA 92093
Phone858-534-1822
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    Collapse Research 
    Collapse Research Activities and Funding
    Modulating Morphogenesis: Genetic Regulation of Cardiac Cell Movement in Zebrafish
    NIH/NHLBI R01HL133166Aug 15, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Genetic Regulation of Outflow Tract Formation in Zebrafish
    NIH/NHLBI R01HL108599Apr 1, 2011 - Mar 31, 2020
    Role: Principal Investigator
    Regulation of cardiac chamber morphogenesis in zebrafish
    NIH/NHLBI R01HL081911Jul 1, 2005 - May 31, 2010
    Role: Principal Investigator
    Comparative genetics of cardiac chamber formation
    NIH/NICHD R21HD047858Dec 5, 2004 - Nov 30, 2007
    Role: Principal Investigator
    Genetic Regulation of Cardiac Patterning in Zebrafish
    NIH/NHLBI R01HL069594Jul 1, 2002 - Jan 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB. Guidelines for morpholino use in zebrafish. PLoS Genet. 2017 10; 13(10):e1007000. PMID: 29049395.
      View in: PubMed
    2. Pradhan A, Zeng XI, Sidhwani P, Marques SR, George V, Targoff KL, Chi NC, Yelon D. FGF signaling enforces cardiac chamber identity in the developing ventricle. Development. 2017 04 01; 144(7):1328-1338. PMID: 28232600.
      View in: PubMed
    3. Iklé JM, Tavares AL, King M, Ding H, Colombo S, Firulli BA, Firulli AB, Targoff KL, Yelon D, Clouthier DE. Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis. 2017 03; 55(3). PMID: 28109039.
      View in: PubMed
    4. Bloomekatz J, Singh R, Prall OW, Dunn AC, Vaughan M, Loo CS, Harvey RP, Yelon D. Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. Elife. 2017 Jan 18; 6. PMID: 28098558.
      View in: PubMed
    5. Perens EA, Garavito-Aguilar ZV, Guio-Vega GP, Peña KT, Schindler YL, Yelon D. Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. Elife. 2016 11 02; 5. PMID: 27805568.
      View in: PubMed
    6. Ryckebüsch L, Hernandez L, Wang C, Phan J, Yelon D. Tmem2 regulates cell-matrix interactions that are essential for muscle fiber attachment. Development. 2016 08 15; 143(16):2965-72. PMID: 27471259; PMCID: PMC5004884 [Available on 08/15/17].
    7. Andrew DJ, Yelon D. Editorial overview: Developmental mechanisms, patterning and organogenesis. Curr Opin Genet Dev. 2015 Jun; 32:v-viii. PMID: 26051229; PMCID: PMC4750389.
    8. Schindler YL, Garske KM, Wang J, Firulli BA, Firulli AB, Poss KD, Yelon D. Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development. 2014 Aug; 141(16):3112-22. PMID: 25038045; PMCID: PMC4197543.
    9. Zeng XX, Yelon D. Cadm4 restricts the production of cardiac outflow tract progenitor cells. Cell Rep. 2014 May 22; 7(4):951-60. PMID: 24813897; PMCID: PMC4147860.
    10. Schumacher JA, Bloomekatz J, Garavito-Aguilar ZV, Yelon D. tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Dev Biol. 2013 Nov 15; 383(2):214-26. PMID: 24075907; PMCID: PMC3932745.
    11. Targoff KL, Colombo S, George V, Schell T, Kim SH, Solnica-Krezel L, Yelon D. Nkx genes are essential for maintenance of ventricular identity. Development. 2013 Oct; 140(20):4203-13. PMID: 24026123; PMCID: PMC3787760.
    12. Miura GI, Yelon D. Cardiovascular biology: play it again, Gata4. Curr Biol. 2013 Jul 22; 23(14):R619-21. PMID: 23885880.
      View in: PubMed
    13. Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 2013 Jun 27; 498(7455):497-501. PMID: 23783515; PMCID: PMC4090927.
    14. Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P, Chisholm AD. Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos. Development. 2012 Nov; 139(22):4271-9. PMID: 23052905; PMCID: PMC3478691.
    15. Yelon D. Developmental biology: Heart under construction. Nature. 2012 Apr 25; 484(7395):459-60. PMID: 22538602.
      View in: PubMed
    16. Lin YF, Swinburne I, Yelon D. Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart. Dev Biol. 2012 Feb 15; 362(2):242-53. PMID: 22192888; PMCID: PMC3279915.
    17. Totong R, Schell T, Lescroart F, Ryckebüsch L, Lin YF, Zygmunt T, Herwig L, Krudewig A, Gershoony D, Belting HG, Affolter M, Torres-Vázquez J, Yelon D. The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development. 2011 Oct; 138(19):4199-205. PMID: 21896630; PMCID: PMC3171221.
    18. Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011 Aug; 138(16):3421-30. PMID: 21752928; PMCID: PMC3143562.
    19. Waxman JS, Yelon D. Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Dev Biol. 2011 Apr 01; 352(1):128-40. PMID: 21276787; PMCID: PMC3207040.
    20. Peshkovsky C, Totong R, Yelon D. Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Dev Dyn. 2011 Feb; 240(2):446-56. PMID: 21246662.
      View in: PubMed
    21. Miura GI, Yelon D. A guide to analysis of cardiac phenotypes in the zebrafish embryo. Methods Cell Biol. 2011; 101:161-80. PMID: 21550443; PMCID: PMC3292854.
    22. Evans SM, Yelon D, Conlon FL, Kirby ML. Myocardial lineage development. Circ Res. 2010 Dec 10; 107(12):1428-44. PMID: 21148449; PMCID: PMC3073310.
    23. Sogah VM, Serluca FC, Fishman MC, Yelon D, Macrae CA, Mably JD. Distinct troponin C isoform requirements in cardiac and skeletal muscle. Dev Dyn. 2010 Nov; 239(11):3115-23. PMID: 20925115; PMCID: PMC2965274.
    24. Garavito-Aguilar ZV, Riley HE, Yelon D. Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development. 2010 Oct; 137(19):3215-20. PMID: 20724450; PMCID: PMC2934734.
    25. Mandel EM, Kaltenbrun E, Callis TE, Zeng XX, Marques SR, Yelon D, Wang DZ, Conlon FL. The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development. 2010 Jun; 137(11):1919-29. PMID: 20460370; PMCID: PMC2867324.
    26. de Pater E, Clijsters L, Marques SR, Lin YF, Garavito-Aguilar ZV, Yelon D, Bakkers J. Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development. 2009 May; 136(10):1633-41. PMID: 19395641; PMCID: PMC2673760.
    27. Waxman JS, Yelon D. Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling. Dev Dyn. 2009 May; 238(5):1207-13. PMID: 19384962; PMCID: PMC2739864.
    28. Marques SR, Yelon D. Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Dev Biol. 2009 Apr 15; 328(2):472-82. PMID: 19232521; PMCID: PMC2709526.
    29. Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Dev Biol. 2009 Apr 15; 328(2):342-54. PMID: 19389352; PMCID: PMC2674121.
    30. Osborne N, Brand-Arzamendi K, Ober EA, Jin SW, Verkade H, Holtzman NG, Yelon D, Stainier DY. The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Curr Biol. 2008 Dec 09; 18(23):1882-8. PMID: 19062281; PMCID: PMC2741689.
    31. Waxman JS, Keegan BR, Roberts RW, Poss KD, Yelon D. Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. Dev Cell. 2008 Dec; 15(6):923-34. PMID: 19081079; PMCID: PMC2752051.
    32. de Campos-Baptista MI, Holtzman NG, Yelon D, Schier AF. Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish. Dev Dyn. 2008 Dec; 237(12):3624-33. PMID: 18985714; PMCID: PMC2632806.
    33. Thomas NA, Koudijs M, van Eeden FJ, Joyner AL, Yelon D. Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development. 2008 Nov; 135(22):3789-99. PMID: 18842815; PMCID: PMC4213142.
    34. Linville A, Radtke K, Waxman JS, Yelon D, Schilling TF. Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches. Dev Biol. 2009 Jan 01; 325(1):60-70. PMID: 18929555; PMCID: PMC3045866.
    35. Targoff KL, Schell T, Yelon D. Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Dev Biol. 2008 Oct 15; 322(2):314-21. PMID: 18718462; PMCID: PMC2752039.
    36. Marques SR, Lee Y, Poss KD, Yelon D. Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. Dev Biol. 2008 Sep 15; 321(2):397-406. PMID: 18639539; PMCID: PMC2752040.
    37. Schoenebeck JJ, Keegan BR, Yelon D. Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell. 2007 Aug; 13(2):254-67. PMID: 17681136; PMCID: PMC2709538.
    38. Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, Rohr KB. Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development. 2007 Aug; 134(15):2871-9. PMID: 17611226.
      View in: PubMed
    39. Holtzman NG, Schoenebeck JJ, Tsai HJ, Yelon D. Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development. 2007 Jun; 134(12):2379-86. PMID: 17537802.
      View in: PubMed
    40. Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, Yelon D. Functional modulation of cardiac form through regionally confined cell shape changes. PLoS Biol. 2007 Mar; 5(3):e53. PMID: 17311471; PMCID: PMC1802756.
    41. Waxman JS, Yelon D. Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Dev Dyn. 2007 Feb; 236(2):587-95. PMID: 17195188.
      View in: PubMed
    42. Schoenebeck JJ, Yelon D. Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Semin Cell Dev Biol. 2007 Feb; 18(1):27-35. PMID: 17241801; PMCID: PMC1876688.
    43. Trinh LA, Yelon D, Stainier DY. Hand2 regulates epithelial formation during myocardial diferentiation. Curr Biol. 2005 Mar 08; 15(5):441-6. PMID: 15786591.
      View in: PubMed
    44. Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D. Retinoic acid signaling restricts the cardiac progenitor pool. Science. 2005 Jan 14; 307(5707):247-9. PMID: 15653502.
      View in: PubMed
    45. Keegan BR, Meyer D, Yelon D. Organization of cardiac chamber progenitors in the zebrafish blastula. Development. 2004 Jul; 131(13):3081-91. PMID: 15175246.
      View in: PubMed
    46. Glickman NS, Yelon D. Coordinating morphogenesis: epithelial integrity during heart tube assembly. Dev Cell. 2004 Mar; 6(3):311-2. PMID: 15030750.
      View in: PubMed
    47. Auman HJ, Yelon D. Vertebrate organogenesis: getting the heart into shape. Curr Biol. 2004 Feb 17; 14(4):R152-3. PMID: 15027466.
      View in: PubMed
    48. O'Brien EK, d'Alençon C, Bonde G, Li W, Schoenebeck J, Allende ML, Gelb BD, Yelon D, Eisen JS, Cornell RA. Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Dev Biol. 2004 Jan 01; 265(1):246-61. PMID: 14697367.
      View in: PubMed
    49. Berdougo E, Coleman H, Lee DH, Stainier DY, Yelon D. Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development. 2003 Dec; 130(24):6121-9. PMID: 14573521.
      View in: PubMed
    50. Miller CT, Yelon D, Stainier DY, Kimmel CB. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development. 2003 Apr; 130(7):1353-65. PMID: 12588851.
      View in: PubMed
    51. Glickman NS, Yelon D. Cardiac development in zebrafish: coordination of form and function. Semin Cell Dev Biol. 2002 Dec; 13(6):507-13. PMID: 12468254.
      View in: PubMed
    52. Yelon D, Stainier DY. Pattern formation: swimming in retinoic acid. Curr Biol. 2002 Oct 15; 12(20):R707-9. PMID: 12401191.
      View in: PubMed
    53. Keegan BR, Feldman JL, Lee DH, Koos DS, Ho RK, Stainier DY, Yelon D. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development. 2002 Apr; 129(7):1623-32. PMID: 11923199.
      View in: PubMed
    54. Yelon D, Weinstein BM, Fishman MC. Cardiovascular system. Results Probl Cell Differ. 2002; 40:298-321. PMID: 12353483.
      View in: PubMed
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