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Amy Jak

Title(s)Associate Professor In Residence, Psychiatry
SchoolHealth Sciences
Phone858-642-3742
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    Biography

    Dr. Jak received her doctorate in Clinical Psychology, with specialization in neuropsychology, from the University of Cincinnati (2004). She completed a postdoctoral fellowship in neuropsychology at the VA San Diego Healthcare System/Veteran’s Medical Research Foundation from 2004-2007. Currently, she is an Assistant Professor (In Residence) of Psychiatry at UCSD and a Staff Neurosychologist and Director, TBI Cognitive Rehabilitation Clinic, at the Veterans Affairs San Diego Healthcare System. Dr. Jak’s research interests are in novel treatments for mild TBI as well as in cognitive aging and mild cognitive impairment.

    Research Interests

    Dr. Jak’s research focuses on neuropsychology and neuroimaging in normal aging and mild cognitive impairment. Specifically, her current research examines how protective behavioral factors (e.g., physically and mentally active lifestyles) impact cognition and brain structural integrity. Additionally, her research examines the potential for activity levels to modify genetic risk for cognitive decline. Other research interests center on the neuropsychological presentation of mild cognitive impairment, mild traumatic brain injury, and post-traumatic stress disorder.

    Clinical Focus

    Dr. Jak is the Director of Traumatic Brain Injury Cognitive Rehabilitation at the VA San Diego Healthcare system and provides psychoeducation and training in compensatory strategies to veterans with mild to moderate TBI. She is also a Clinical Neuropsychologist within the Department's private practice plan (UCSD Neuropsychological Associates). She conducts clinical neuropsychological evaluations of adults with a wide range of neurologic and psychiatric disorders, with particular emphasis on dementia and traumatic brain injury.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Eglit GML, Jurick SM, Delis DC, Filoteo JV, Bondi MW, Jak AJ. Utility of the D-KEFS Color Word Interference Test as an embedded measure of performance validity. Clin Neuropsychol. 2019 Jul 27; 1-21. PMID: 31352854.
      View in: PubMed
    2. Crocker LD, Jurick SM, Thomas KR, Keller AV, Sanderson-Cimino M, Hoffman SN, Boyd B, Rodgers C, Norman SB, Lang AJ, Twamley EW, Jak AJ. Mild traumatic brain injury characteristics do not negatively influence cognitive processing therapy attendance or outcomes. J Psychiatr Res. 2019 Sep; 116:7-13. PMID: 31174014.
      View in: PubMed
    3. Merritt VC, Jurick SM, Crocker LD, Hoffman SN, Keller AV, DeFord N, Jak AJ. Evaluation of objective and subjective clinical outcomes in combat veterans with and without mild TBI and PTSD: A four-group design. J Clin Exp Neuropsychol. 2019 Sep; 41(7):665-679. PMID: 31084252.
      View in: PubMed
    4. Thomas KR, Eppig JS, Weigand AJ, Edmonds EC, Wong CG, Jak AJ, Delano-Wood L, Galasko DR, Salmon DP, Edland SD, Bondi MW. Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement. 2019 Jan 11. PMID: 30610833.
      View in: PubMed
    5. Merritt VC, Padgett CR, Jak AJ. A systematic review of sex differences in concussion outcome: what do we know? Clin Neuropsychol. 2019 Jan 08; 1-28. PMID: 30618335.
      View in: PubMed
    6. Church HR, Seewald PM, Clark JMR, Jak AJ, Twamley EW. Predictors of work outcomes following supported employment in veterans with a history of traumatic brain injury. NeuroRehabilitation. 2019; 44(3):333-339. PMID: 31177239.
      View in: PubMed
    7. Jak AJ, Jurick S, Crocker LD, Sanderson-Cimino M, Aupperle R, Rodgers CS, Thomas KR, Boyd B, Norman SB, Lang AJ, Keller AV, Schiehser DM, Twamley EW. SMART-CPT for veterans with comorbid post-traumatic stress disorder and history of traumatic brain injury: a randomised controlled trial. J Neurol Neurosurg Psychiatry. 2019 Mar; 90(3):333-341. PMID: 30554135.
      View in: PubMed
    8. Merritt VC, Lapira KM, Clark AL, Sorg SF, Werhane ML, Jak AJ, Bondi MW, Schiehser DM, Delano-Wood L. APOE-e4 Genotype is Associated with Elevated Post-Concussion Symptoms in Military Veterans with a Remote History of Mild Traumatic Brain Injury. Arch Clin Neuropsychol. 2018 Dec 06. PMID: 30521018.
      View in: PubMed
    9. Hoffman SN, Herbert MS, Crocker LD, DeFord NE, Keller AV, Jurick SM, Sanderson-Cimino M, Jak AJ. The Role of Pain Catastrophizing in Cognitive Functioning Among Veterans With a History of Mild Traumatic Brain Injury. J Head Trauma Rehabil. 2018 Nov 28. PMID: 30499934.
      View in: PubMed
    10. Twamley EW, Hays CC, Van Patten R, Seewald PM, Orff HJ, Depp CA, Olsen DC, Jak AJ. Neurocognition, psychiatric symptoms, and lifetime homelessness among veterans with a history of traumatic brain injury. Psychiatry Res. 2019 01; 271:167-170. PMID: 30481694.
      View in: PubMed
    11. Crocker LD, Keller AV, Jurick SM, Bomyea J, Hays CC, Twamley EW, Jak AJ. Mild Traumatic Brain Injury Burden Moderates the Relationship Between Cognitive Functioning and Suicidality in Iraq/Afghanistan-Era Veterans. J Int Neuropsychol Soc. 2019 Jan; 25(1):79-89. PMID: 30444208.
      View in: PubMed
    12. Wong CG, Thomas KR, Edmonds EC, Weigand AJ, Bangen KJ, Eppig JS, Jak AJ, Devine SA, Delano-Wood L, Libon DJ, Edland SD, Au R, Bondi MW. Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old. Dement Geriatr Cogn Disord. 2018; 46(5-6):253-265. PMID: 30391953.
      View in: PubMed
    13. Bomyea J, Jurick SM, Keller AV, Hays CC, Twamley EW, Jak AJ. Neurobehavioral symptom validity and performance validity in veterans: Evidence for distinct outcomes across data types. Appl Neuropsychol Adult. 2018 Sep 05; 1-11. PMID: 30183368.
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    14. Crocker LD, Jurick SM, Thomas KR, Keller AV, Sanderson-Cimino M, Boyd B, Rodgers C, Twamley EW, Jak AJ. Worse baseline executive functioning is associated with dropout and poorer response to trauma-focused treatment for veterans with PTSD and comorbid traumatic brain injury. Behav Res Ther. 2018 Sep; 108:68-77. PMID: 30031369.
      View in: PubMed
    15. Jurick SM, Crocker LD, Keller AV, Hoffman SN, Bomyea J, Jacobson MW, Jak AJ. The Minnesota Multiphasic Personality Inventory-2-RF in Treatment-Seeking Veterans with History of Mild Traumatic Brain Injury. Arch Clin Neuropsychol. 2018 May 30. PMID: 29850866.
      View in: PubMed
    16. Elman JA, Jak AJ, Panizzon MS, Tu XM, Chen T, Reynolds CA, Gustavson DE, Franz CE, Hatton SN, Jacobson KC, Toomey R, McKenzie R, Xian H, Lyons MJ, Kremen WS. Underdiagnosis of mild cognitive impairment: A consequence of ignoring practice effects. Alzheimers Dement (Amst). 2018; 10:372-381. PMID: 30003138.
      View in: PubMed
    17. Jurick SM, Weissberger GH, Clark LR, Wierenga CE, Chang YL, Schiehser DM, Han SD, Jak AJ, Dev SI, Bondi MW. Faulty Adaptation to Repeated Face-Name Associative Pairs in Mild Cognitive Impairment is Predictive of Cognitive Decline. Arch Clin Neuropsychol. 2018 Mar 01; 33(2):168-183. PMID: 28655152.
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    18. Jurick SM, Crocker LD, Sanderson-Cimino M, Keller AV, Trenova LS, Boyd BL, Twamley EW, Rodgers CS, Schiehser DM, Aupperle RL, Jak AJ. Contributions to Executive Dysfunction in Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury. J Head Trauma Rehabil. 2018 Mar/Apr; 33(2):E41-E52. PMID: 28520663.
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    19. Olsen DC, Hays CC, Orff HJ, Jak AJ, Twamley EW. Correlates of employment and postsecondary education enrolment in Afghanistan and Iraq veterans with traumatic brain injuries. Brain Inj. 2018; 32(5):544-549. PMID: 29370539.
      View in: PubMed
    20. Emrani S, Libon DJ, Lamar M, Price CC, Jefferson AL, Gifford KA, Hohman TJ, Nation DA, Delano-Wood L, Jak A, Bangen KJ, Bondi MW, Brickman AM, Manly J, Swenson R, Au R. Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. J Alzheimers Dis. 2018; 61(3):917-928. PMID: 29254087.
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    21. Jurick SM, Hoffman SN, Sorg S, Keller AV, Evangelista ND, DeFord NE, Sanderson-Cimino M, Bangen KJ, Delano-Wood L, Deoni S, Jak AJ. Pilot investigation of a novel white matter imaging technique in Veterans with and without history of mild traumatic brain injury. Brain Inj. 2018; 32(10):1256-1265. PMID: 30169992.
      View in: PubMed
    22. Jak AJ, Crocker LD, Aupperle RL, Clausen A, Bomyea J. Neurocognition in PTSD: Treatment Insights and Implications. Curr Top Behav Neurosci. 2018; 38:93-116. PMID: 28025811.
      View in: PubMed
    23. Granholm EL, Panizzon MS, Elman JA, Jak AJ, Hauger RL, Bondi MW, Lyons MJ, Franz CE, Kremen WS. Pupillary Responses as a Biomarker of Early Risk for Alzheimer's Disease. J Alzheimers Dis. 2017; 56(4):1419-1428. PMID: 28157098.
      View in: PubMed
    24. Storzbach D, Twamley EW, Roost MS, Golshan S, Williams RM, O'Neil M, Jak AJ, Turner AP, Kowalski HM, Pagulayan KF, Huckans M. Compensatory Cognitive Training for Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn Veterans With Mild Traumatic Brain Injury. J Head Trauma Rehabil. 2017 Jan/Feb; 32(1):16-24. PMID: 27022961.
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    25. Clark AL, Sorg SF, Schiehser DM, Bigler ED, Bondi MW, Jacobson MW, Jak AJ, Delano-Wood L. White Matter Associations With Performance Validity Testing in Veterans With Mild Traumatic Brain Injury: The Utility of Biomarkers in Complicated Assessment. J Head Trauma Rehabil. 2016 Sep-Oct; 31(5):346-59. PMID: 26360002.
      View in: PubMed
    26. Schiehser DM, Delano-Wood L, Jak AJ, Hanson KL, Sorg SF, Orff H, Clark AL. Predictors of cognitive and physical fatigue in post-acute mild-moderate traumatic brain injury. Neuropsychol Rehabil. 2017 Oct; 27(7):1031-1046. PMID: 27535726.
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    27. Hanson KL, Schiehser DM, Clark AL, Sorg SF, Kim RT, Jacobson MW, Werhane ML, Jak AJ, Twamley EW, Delano-Wood L. Problem alcohol use in veterans with mild traumatic brain injury: Associations with cognitive performance and psychiatric symptoms. J Clin Exp Neuropsychol. 2016 12; 38(10):1115-30. PMID: 27430280.
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    28. Jak AJ, Preis SR, Beiser AS, Seshadri S, Wolf PA, Bondi MW, Au R. Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study. J Int Neuropsychol Soc. 2016 10; 22(9):937-943. PMID: 27029348.
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    29. Edmonds EC, Delano-Wood L, Jak AJ, Galasko DR, Salmon DP, Bondi MW. "Missed" Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria. J Alzheimers Dis. 2016 03 31; 52(2):685-91. PMID: 27031477; PMCID: PMC4879874.
    30. Bomyea J, Lang AJ, Delano-Wood L, Jak A, Hanson KL, Sorg S, Clark AL, Schiehser DM. Neuropsychiatric Predictors of Post-Injury Headache After Mild-Moderate Traumatic Brain Injury in Veterans. Headache. 2016 Apr; 56(4):699-710. PMID: 27028095.
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    31. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Franz CE, Jak AJ, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. Is bigger always better? The importance of cortical configuration with respect to cognitive ability. Neuroimage. 2016 Apr 01; 129:356-366. PMID: 26827810; PMCID: PMC4838639 [Available on 04/01/17].
    32. Jurick SM, Bangen KJ, Evangelista ND, Sanderson-Cimino M, Delano-Wood L, Jak AJ. Advanced neuroimaging to quantify myelin in vivo: Application to mild TBI. Brain Inj. 2016; 30(12):1452-1457. PMID: 27834545.
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    33. Jurick SM, Twamley EW, Crocker LD, Hays CC, Orff HJ, Golshan S, Jak AJ. Postconcussive symptom overreporting in Iraq/Afghanistan Veterans with mild traumatic brain injury. J Rehabil Res Dev. 2016; 53(5):571-584. PMID: 27898153.
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    34. Leung A, Shukla S, Fallah A, Song D, Lin L, Golshan S, Tsai A, Jak A, Polston G, Lee R. Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches. Neuromodulation. 2016 Feb; 19(2):133-41. PMID: 26555886.
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    35. Twamley EW, Thomas KR, Gregory AM, Jak AJ, Bondi MW, Delis DC, Lohr JB. CogSMART Compensatory Cognitive Training for Traumatic Brain Injury: Effects Over 1 Year. J Head Trauma Rehabil. 2015 Nov-Dec; 30(6):391-401. PMID: 25033034.
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    36. Jak AJ, Aupperle R, Rodgers CS, Lang AJ, Schiehser DM, Norman SB, Twamley EW. Evaluation of a hybrid treatment for Veterans with comorbid traumatic brain injury and posttraumatic stress disorder: Study protocol for a randomized controlled trial. Contemp Clin Trials. 2015 Nov; 45(Pt B):210-216. PMID: 26500169.
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    37. Ahmed S, Brennan L, Eppig J, Price CC, Lamar M, Delano-Wood L, Bangen KJ, Edmonds EC, Clark L, Nation DA, Jak A, Au R, Swenson R, Bondi MW, Libon DJ. Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment. Appl Neuropsychol Adult. 2016; 23(1):43-52. PMID: 26397732.
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    38. Walter KH, Jak AJ, Twamley EW. Psychiatric comorbidity effects on compensatory cognitive training outcomes for veterans with traumatic brain injuries. Rehabil Psychol. 2015 Aug; 60(3):303-8. PMID: 26147236.
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    39. Schiehser DM, Twamley EW, Liu L, Matevosyan A, Filoteo JV, Jak AJ, Orff HJ, Hanson KL, Sorg SF, Delano-Wood L. The Relationship Between Postconcussive Symptoms and Quality of Life in Veterans With Mild to Moderate Traumatic Brain Injury. J Head Trauma Rehabil. 2015 Jul-Aug; 30(4):E21-8. PMID: 24922041.
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    40. Jak AJ, Gregory A, Orff HJ, Colón C, Steele N, Schiehser DM, Delano-Wood L, Jurick SM, Twamley EW. Neuropsychological performance in treatment-seeking Operation Enduring Freedom/Operation Iraqi Freedom Veterans with a history of mild traumatic brain injury. J Clin Exp Neuropsychol. 2015; 37(4):379-88. PMID: 25850338.
      View in: PubMed
    41. Schiehser DM, Delano-Wood L, Jak AJ, Matthews SC, Simmons AN, Jacobson MW, Filoteo JV, Bondi MW, Orff HJ, Liu L. Validation of the Modified Fatigue Impact Scale in mild to moderate traumatic brain injury. J Head Trauma Rehabil. 2015 Mar-Apr; 30(2):116-21. PMID: 24413076.
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    42. Docherty AR, Hagler DJ, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Jak A, Lyons MJ, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability? Neuroimage. 2015 Feb 01; 106:154-60. PMID: 25433211; PMCID: PMC4313767.
    43. Jak AJ, Panizzon MS, Spoon KM, Fennema-Notestine C, Franz CE, Thompson WK, Jacobson KC, Xian H, Eyler LT, Vuoksimaa E, Toomey R, Lyons MJ, Neale MC, Tsuang MT, Dale AM, Kremen WS. Hippocampal atrophy varies by neuropsychologically defined MCI among men in their 50s. Am J Geriatr Psychiatry. 2015 May; 23(5):456-65. PMID: 25306196; PMCID: PMC4345132.
    44. Edmonds EC, Delano-Wood L, Clark LR, Jak AJ, Nation DA, McDonald CR, Libon DJ, Au R, Galasko D, Salmon DP, Bondi MW. Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors. Alzheimers Dement. 2015 Apr; 11(4):415-24. PMID: 24857234.
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    45. Kremen WS, Jak AJ, Panizzon MS, Spoon KM, Franz CE, Thompson WK, Jacobson KC, Vasilopoulos T, Vuoksimaa E, Xian H, Toomey R, Lyons MJ. Authors' response to: commentary by Johnson et al. Int J Epidemiol. 2014 Apr; 43(2):612-3. PMID: 24760875; PMCID: PMC3997381.
    46. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Fischl B, Franz CE, Jak A, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness. Cereb Cortex. 2015 Aug; 25(8):2127-37. PMID: 24554725.
      View in: PubMed
    47. Sorg SF, Delano-Wood L, Luc N, Schiehser DM, Hanson KL, Nation DA, Lanni E, Jak AJ, Lu K, Meloy MJ, Frank LR, Lohr JB, Bondi MW. White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):21-32. PMID: 23640539; PMCID: PMC4300196.
    48. Twamley EW, Jak AJ, Delis DC, Bondi MW, Lohr JB. Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) for veterans with traumatic brain injury: pilot randomized controlled trial. J Rehabil Res Dev. 2014; 51(1):59-70. PMID: 24805894.
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    49. Bondi MW, Edmonds EC, Jak AJ, Clark LR, Delano-Wood L, McDonald CR, Nation DA, Libon DJ, Au R, Galasko D, Salmon DP. Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. J Alzheimers Dis. 2014; 42(1):275-89. PMID: 24844687; PMCID: PMC4133291.
    50. Zlatar ZZ, Wierenga CE, Bangen KJ, Liu TT, Jak AJ. Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer's disease. J Alzheimers Dis. 2014; 41(3):809-17. PMID: 24685629; PMCID: PMC4259215.
    51. Kremen WS, Jak AJ, Panizzon MS, Spoon KM, Franz CE, Thompson WK, Jacobson KC, Vasilopoulos T, Vuoksimaa E, Xian H, Toomey R, Lyons MJ. Early identification and heritability of mild cognitive impairment. Int J Epidemiol. 2014 Apr; 43(2):600-10. PMID: 24370560; PMCID: PMC3997374.
    52. Eyler LT, Vuoksimaa E, Panizzon MS, Fennema-Notestine C, Neale MC, Chen CH, Jak A, Franz CE, Lyons MJ, Thompson WK, Spoon KM, Fischl B, Dale AM, Kremen WS. Conceptual and data-based investigation of genetic influences and brain asymmetry: a twin study of multiple structural phenotypes. J Cogn Neurosci. 2014 May; 26(5):1100-17. PMID: 24283492; PMCID: PMC3999438.
    53. Clark LR, Delano-Wood L, Libon DJ, McDonald CR, Nation DA, Bangen KJ, Jak AJ, Au R, Salmon DP, Bondi MW. Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? J Int Neuropsychol Soc. 2013 Jul; 19(6):635-45. PMID: 23552486; PMCID: PMC3742806.
    54. Vuoksimaa E, Panizzon MS, Chen CH, Eyler LT, Fennema-Notestine C, Fiecas MJ, Fischl B, Franz CE, Grant MD, Jak AJ, Lyons MJ, Neale MC, Thompson WK, Tsuang MT, Xian H, Dale AM, Kremen WS. Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia. 2013 May; 51(6):1124-31. PMID: 23499725; PMCID: PMC3660613.
    55. Huckans M, Hutson L, Twamley E, Jak A, Kaye J, Storzbach D. Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions. Neuropsychol Rev. 2013 Mar; 23(1):63-80. PMID: 23471631; PMCID: PMC3640648.
    56. Jak AJ, Seelye AM, Jurick SM. Crosswords to computers: a critical review of popular approaches to cognitive enhancement. Neuropsychol Rev. 2013 Mar; 23(1):13-26. PMID: 23423553.
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    57. Nation DA, Wierenga CE, Clark LR, Dev SI, Stricker NH, Jak AJ, Salmon DP, Delano-Wood L, Bangen KJ, Rissman RA, Liu TT, Bondi MW. Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2013; 36(4):689-98. PMID: 23666173.
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    58. Eyler LT, Chen CH, Panizzon MS, Fennema-Notestine C, Neale MC, Jak A, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Prom-Wormley E, Seidman LJ, Tsuang MT, Fiecas MJ, Dale AM, Kremen WS. A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study. Twin Res Hum Genet. 2012 Jun; 15(3):304-14. PMID: 22856366; PMCID: PMC3549553.
    59. Kubarych TS, Prom-Wormley EC, Franz CE, Panizzon MS, Dale AM, Fischl B, Eyler LT, Fennema-Notestine C, Grant MD, Hauger RL, Hellhammer DH, Jak AJ, Jernigan TL, Lupien SJ, Lyons MJ, Mendoza SP, Neale MC, Seidman LJ, Tsuang MT, Kremen WS. A multivariate twin study of hippocampal volume, self-esteem and well-being in middle-aged men. Genes Brain Behav. 2012 Jul; 11(5):539-44. PMID: 22471516; PMCID: PMC3389179.
    60. Wierenga CE, Dev SI, Shin DD, Clark LR, Bangen KJ, Jak AJ, Rissman RA, Liu TT, Salmon DP, Bondi MW. Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition. J Cereb Blood Flow Metab. 2012 Aug; 32(8):1589-99. PMID: 22549621.
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    61. Chen CH, Gutierrez ED, Thompson W, Panizzon MS, Jernigan TL, Eyler LT, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. Hierarchical genetic organization of human cortical surface area. Science. 2012 Mar 30; 335(6076):1634-6. PMID: 22461613; PMCID: PMC3690329.
    62. Panizzon MS, Fennema-Notestine C, Kubarych TS, Chen CH, Eyler LT, Fischl B, Franz CE, Grant MD, Hamza S, Jak A, Jernigan TL, Lyons MJ, Neale MC, Prom-Wormley EC, Seidman L, Tsuang MT, Wu H, Xian H, Dale AM, Kremen WS. Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics? Neuroimage. 2012 Apr 15; 60(3):1686-95. PMID: 22500923; PMCID: PMC3328105.
    63. Delano-Wood L, Stricker NH, Sorg SF, Nation DA, Jak AJ, Woods SP, Libon DJ, Delis DC, Frank LR, Bondi MW. Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment. J Alzheimers Dis. 2012; 29(3):589-603. PMID: 22466061; PMCID: PMC3341099.
    64. Nation DA, Delano-Wood L, Bangen KJ, Wierenga CE, Jak AJ, Hansen LA, Galasko DR, Salmon DP, Bondi MW. Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease. J Alzheimers Dis. 2012; 30(3):595-603. PMID: 22451309.
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    65. Jak AJ. The impact of physical and mental activity on cognitive aging. Curr Top Behav Neurosci. 2012; 10:273-91. PMID: 21818703.
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    66. Bangen KJ, Restom K, Liu TT, Wierenga CE, Jak AJ, Salmon DP, Bondi MW. Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study. J Alzheimers Dis. 2012; 31 Suppl 3:S59-74. PMID: 22531427.
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    67. Chen CH, Panizzon MS, Eyler LT, Jernigan TL, Thompson W, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Hamza S, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. Genetic influences on cortical regionalization in the human brain. Neuron. 2011 Nov 17; 72(4):537-44. PMID: 22099457; PMCID: PMC3222857.
    68. Panizzon MS, Hauger RL, Eaves LJ, Chen CH, Dale AM, Eyler LT, Fischl B, Fennema-Notestine C, Franz CE, Grant MD, Jacobson KC, Jak AJ, Lyons MJ, Mendoza SP, Neale MC, Prom-Wormley E, Seidman LJ, Tsuang MT, Xian H, Kremen WS. Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men. Neuroimage. 2012 Jan 16; 59(2):1123-31. PMID: 21983185; PMCID: PMC3230702.
    69. Schiehser DM, Delis DC, Filoteo JV, Delano-Wood L, Han SD, Jak AJ, Drake AI, Bondi MW. Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? J Clin Exp Neuropsychol. 2011 Jul; 33(6):704-14. PMID: 21958432.
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    70. Nation DA, Hong S, Jak AJ, Delano-Wood L, Mills PJ, Bondi MW, Dimsdale JE. Stress, exercise, and Alzheimer's disease: a neurovascular pathway. Med Hypotheses. 2011 Jun; 76(6):847-54. PMID: 21398043; PMCID: PMC3094492.
    71. Eyler LT, Prom-Wormley E, Panizzon MS, Kaup AR, Fennema-Notestine C, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Stevens A, Pacheco J, Perry ME, Schmitt JE, Seidman LJ, Thermenos HW, Tsuang MT, Chen CH, Thompson WK, Jak A, Dale AM, Kremen WS. Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study. Cereb Cortex. 2011 Oct; 21(10):2313-21. PMID: 21378112; PMCID: PMC3169660.
    72. Fennema-Notestine C, Panizzon MS, Thompson WR, Chen CH, Eyler LT, Fischl B, Franz CE, Grant MD, Jak AJ, Jernigan TL, Lyons MJ, Neale MC, Seidman LJ, Tsuang MT, Xian H, Dale AM, Kremen WS. Presence of ApoE e4 allele associated with thinner frontal cortex in middle age. J Alzheimers Dis. 2011; 26 Suppl 3:49-60. PMID: 21971450; PMCID: PMC3302177.
    73. Wierenga CE, Stricker NH, McCauley A, Simmons A, Jak AJ, Chang YL, Nation DA, Bangen KJ, Salmon DP, Bondi MW. Altered brain response for semantic knowledge in Alzheimer's disease. Neuropsychologia. 2011 Feb; 49(3):392-404. PMID: 21163275; PMCID: PMC3058793.
    74. Panizzon MS, Hauger R, Dale AM, Eaves LJ, Eyler LT, Fischl B, Fennema-Notestine C, Franz CE, Grant MD, Jak AJ, Jacobson KC, Lyons MJ, Mendoza SP, Neale MC, Prom-Wormley EC, Seidman LJ, Tsuang MT, Xian H, Kremen WS. Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology. 2010 Sep 07; 75(10):874-80. PMID: 20819998; PMCID: PMC2938973.
    75. Nation DA, Wierenga CE, Delano-Wood L, Jak AJ, Delis DC, Salmon DP, Bondi MW. Elevated pulse pressure is associated with age-related decline in language ability. J Int Neuropsychol Soc. 2010 Sep; 16(5):933-8. PMID: 20663268; PMCID: PMC3008594.
    76. Han SD, Suzuki H, Jak AJ, Chang YL, Salmon DP, Bondi MW. Hierarchical cognitive and psychosocial predictors of amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2010 Jul; 16(4):721-9. PMID: 20561399.
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    87. Fine EM, Delis DC, Wetter SR, Jacobson MW, Jak AJ, McDonald CR, Braga JC, Thal LJ, Salmon DP, Bondi MW. Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study. Am J Geriatr Psychiatry. 2008 May; 16(5):366-74. PMID: 18448849; PMCID: PMC3050584.
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    93. Fleck DE, Shear PK, Zimmerman ME, Getz GE, Corey KB, Jak A, Lebowitz BK, Strakowski SM. Verbal memory in mania: effects of clinical state and task requirements. Bipolar Disord. 2003 Oct; 5(5):375-80. PMID: 14525560.
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    94. Meiron L, Jak A, Shoshana C, Maria Z, Aron Z. Intrapartum maternal fever and neonatal outcome. Pediatrics. 2001 Sep; 108(3):818. PMID: 11548758.
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    95. Cohen JA, Cutter GR, Fischer JS, Goodman AD, Heidenreich FR, Jak AJ, Kniker JE, Kooijmans MF, Lull JM, Sandrock AW, Simon JH, Simonian NA, Whitaker JN. Use of the multiple sclerosis functional composite as an outcome measure in a phase 3 clinical trial. Arch Neurol. 2001 Jun; 58(6):961-7. PMID: 11405811.
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    96. Cohen JA, Fischer JS, Bolibrush DM, Jak AJ, Kniker JE, Mertz LA, Skaramagas TT, Cutter GR. Intrarater and interrater reliability of the MS functional composite outcome measure. Neurology. 2000 Feb 22; 54(4):802-6. PMID: 10690966.
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