Eric Granholm

Title(s)Professor In Residence, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-2040-7951 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los Angeles, Los Angeles, CAPh.D.12/1991Clinical Psychology

    Collapse Overview 
    Collapse Overview

    Dr. Granholm is Professor, Vice Chair for Clinical Research, and Director of the Center for Mental Health Technology in the Department of Psychiatry at UC San Diego. He received his Ph.D. in Clinical Psychology from the University of California, Los Angeles in 1991, and completed a postdoctoral fellowship at the UCLA Semel Institute for Neuroscience and Human Behavior. At UCLA, he conducted research on neuropsychology, pupillometry, social skills training and family therapy for schizophrenia and bipolar disorder. Since joining the faculty at UCSD in 1993, Dr. Granholm has been an active basic and clinical researcher in the areas of neuropsychology, pupillometry, ecological momentary assessment, mobile interventions and cognitive behavior therapy in schizophrenia and Alzheimer’s disease. He developed Cognitive-Behavioral Social Skills Training (CBSST) for schizophrenia and has conducted several CBSST clinical trials.

    Research Interests

    Dr. Granholm’s recent research has primarily focused on (1) clinical trials of interventions to improve functioning and recovery outcomes in schizophrenia; and (2) early detection of risk and prevention of Alzheimer’s disease. He developed an intervention called Cognitive-Behavioral Social Skills Training (CBSST), which combines two evidence-based psychotherapy interventions, cognitive-behavior therapy and social skills training, and has conducted several clinical trials demonstrating the efficacy of CBSST for improving negative symptoms and functioning in schizophrenia. His mobile interventions research, uses ecological momentary assessment (EMA) and interventions (EMI), which involve smartphone delivery of assessment questionnaires and cognitive-behavioral interventions in real time, real world contexts to improve motivation and functioning, and reduce social isolation and loneliness in schizophrenia and Alzheimer’s disease.

    Dr. Granholm’s basic neurocognitive and psychophysiology research has focused on the broad investigation of the relationships between neurocognition and aging, symptoms, and community functioning in schizophrenia and Alzheimer’s disease. His current basic research examines (1) associations between dysfunctional attitudes, amotivation, and goal-directed task effort, using pupillary responses as an index of task effort allocation; (2) early detection of risk for age-related cognitive decline; and (3) relationships between dysfunctional attitudes, motivation, neurocognition, and functioning in schizophrenia and Alzheimer’s disease.

    Clinical Focus

    Dr. Granholm worked as a clinical psychologist at psychosocial rehabilitation programs for serious mental illness the VA San Diego Healthcare System for over 30 years. His primary clinical focus is on cognitive-behavioral and social skills training interventions and neuropsychological assessment for serious mental illness. He is also an active clinical supervisor and teacher of psychology interns, clinical psychology practicum students, psychiatry residents, post-graduate fellows and community providers from multiple disciplines (psychology, social work, vocational rehabilitation, occupational therapy, psychiatric nursing, and psychiatry).

    Collapse Research 
    Collapse Research Activities and Funding
    Evaluating the Use of Peer Specialists to Deliver Cognitive Behavioral Social Skills Training
    VA I01HX002344May 1, 2018 - Apr 30, 2022
    Role: Co-Principal Investigator
    Pupillary Responses as a Risk and Staging Biomarker of Preclinical Alzheimer's Disease
    NIH/NIA R01AG054509May 15, 2017 - Apr 30, 2021
    Role: Principal Investigator
    Pupillary Responses as a Risk and Staging Biomarker of Preclinical Alzheimer's Disease
    NIH RF1AG054509May 15, 2017 - Apr 30, 2021
    Role: Principal Investigator
    Mobile-Assisted Cognitive Behavior Therapy for Negative Symptoms in Schizophrenia
    NIH/NIMH R33MH110019Aug 15, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Mobile-Assisted Cognitive Behavior Therapy for Negative Symptoms in Schizophrenia
    NIH/NIMH R61MH110019Aug 15, 2016 - May 31, 2018
    Role: Principal Investigator
    Improving Negative Symptoms of Psychosis In Real-World Environments - INSPIRE
    NIH R34MH101250Sep 26, 2013 - Aug 31, 2017
    Role: Principal Investigator
    2/2-Combined Oxytocin and CBSST for Social Function in People with Schizophrenia
    NIH/NIMH R34MH100410Jun 20, 2013 - Mar 31, 2016
    Role: Principal Investigator
    Ecological Momentary Assessment of Functioning in Schizophrenia
    VA I01CX000810Apr 1, 2013 - Sep 30, 2016
    Role: Principal Investigator
    Enhancing Assertive Community Treatment with CBT and SST for Schizophrenia
    NIH/NIMH R01MH091057May 18, 2011 - Feb 29, 2016
    Role: Principal Investigator
    Cognitive Behavioral Skills Training for Schizophrenia
    NIH/NIMH R01MH071410Jun 1, 2005 - Mar 31, 2011
    Role: Principal Investigator
    NIH/NIMH R01MH061381Jul 1, 2000 - Jun 30, 2005
    Role: Principal Investigator
    NIH/NIMH R03MH056014Aug 1, 1996 - Jul 31, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Enhancing assertive community treatment with cognitive behavioral social skills training for schizophrenia: study protocol for a randomized controlled trial. Trials. 2015 Sep 30; 16:438. Granholm E, Holden JL, Sommerfeld D, Rufener C, Perivoliotis D, Mueser K, Aarons GA. PMID: 26424639; PMCID: PMC4590698.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    2. Pupillary Responses as a Biomarker of Diminished Effort Associated With Defeatist Attitudes and Negative Symptoms in Schizophrenia. Biol Psychiatry. 2016 10 15; 80(8):581-8. Granholm E, Ruiz I, Gallegos-Rodriguez Y, Holden J, Link PC. PMID: 26475673; PMCID: PMC4792801.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    3. Ecological Momentary Assessment of social functioning in schizophrenia: impact of performance appraisals and affect on social interactions. Schizophr Res. 2013 Apr; 145(1-3):120-4. Granholm E, Ben-Zeev D, Fulford D, Swendsen J. PMID: 23402693; PMCID: PMC3637048.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    4. Randomized controlled trial of cognitive behavioral social skills training for older consumers with schizophrenia: defeatist performance attitudes and functional outcome. Am J Geriatr Psychiatry. 2013 Mar; 21(3):251-62. Granholm E, Holden J, Link PC, McQuaid JR, Jeste DV. PMID: 23395192; PMCID: PMC3467335.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    5. Mobile Assessment and Treatment for Schizophrenia (MATS): a pilot trial of an interactive text-messaging intervention for medication adherence, socialization, and auditory hallucinations. Schizophr Bull. 2012 May; 38(3):414-25. Granholm E, Ben-Zeev D, Link PC, Bradshaw KR, Holden JL. PMID: 22080492; PMCID: PMC3329971.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    6. Age-related practice effects across longitudinal neuropsychological assessments in older people with schizophrenia. Neuropsychology. 2010 Sep; 24(5):616-24. Granholm E, Link P, Fish S, Kraemer H, Jeste D. PMID: 20804250.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    7. Social disinterest attitudes and group cognitive-behavioral social skills training for functional disability in schizophrenia. Schizophr Bull. 2009 Sep; 35(5):874-83. Granholm E, Ben-Zeev D, Link PC. PMID: 19628761; PMCID: PMC2728822.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    8. Pupillometric measures of attentional allocation to target and mask processing on the backward masking task in schizophrenia. Psychophysiology. 2009 May; 46(3):510-20. Granholm E, Fish SC, Verney SP. PMID: 19496224; PMCID: PMC2734867.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    9. Neuropsychological predictors of functional outcome in Cognitive Behavioral Social Skills Training for older people with schizophrenia. Schizophr Res. 2008 Mar; 100(1-3):133-43. Granholm E, McQuaid JR, Link PC, Fish S, Patterson T, Jeste DV. PMID: 18222648; PMCID: PMC2352154.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    10. Feasibility and validity of computerized ecological momentary assessment in schizophrenia. Schizophr Bull. 2008 May; 34(3):507-14. Granholm E, Loh C, Swendsen J. PMID: 17932087; PMCID: PMC2632427.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    11. Effortful cognitive resource allocation and negative symptom severity in chronic schizophrenia. Schizophr Bull. 2007 May; 33(3):831-42. Granholm E, Verney SP, Perivoliotis D, Miura T. PMID: 16956985; PMCID: PMC2526135.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    12. A randomized, controlled trial of cognitive behavioral social skills training for middle-aged and older outpatients with chronic schizophrenia. Am J Psychiatry. 2005 Mar; 162(3):520-9. Granholm E, McQuaid JR, McClure FS, Auslander LA, Perivoliotis D, Pedrelli P, Patterson T, Jeste DV. PMID: 15741469.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCTClinical Trials
    13. Pupillometric measures of cognitive and emotional processes. Int J Psychophysiol. 2004 Mar; 52(1):1-6. Granholm E, Steinhauer SR. PMID: 15003368.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    14. Pupillary responses and attentional allocation problems on the backward masking task in schizophrenia. Int J Psychophysiol. 2004 Mar; 52(1):37-51. Granholm E, Verney SP. PMID: 15003371.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    15. Brief integrated outpatient dual-diagnosis treatment reduces psychiatric hospitalizations. Am J Addict. 2003 Jul-Sep; 12(4):306-13. Granholm E, Anthenelli R, Monteiro R, Sevcik J, Stoler M. PMID: 14504023.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. Tropicamide effects on pupil size and pupillary light reflexes in Alzheimer's and Parkinson's disease. Int J Psychophysiol. 2003 Feb; 47(2):95-115. Granholm E, Morris S, Galasko D, Shults C, Rogers E, Vukov B. PMID: 12568941.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCTClinical Trials
    17. Lateralized perceptual organization deficits on the global-local task in schizotypal personality disorder. J Abnorm Psychol. 2002 Feb; 111(1):42-52. Granholm E, Cadenhead K, Shafer KM, Filoteo JV. PMID: 11866178.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Accelerated age-related decline in processing resources in schizophrenia: evidence from pupillary responses recorded during the span of apprehension task. J Int Neuropsychol Soc. 2000 Jan; 6(1):30-43. Granholm E, Morris S, Asarnow RF, Chock D, Jeste DV. PMID: 10761365.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    19. Pupillary responses evoked during verbal fluency tasks indicate semantic network dysfunction in schizophrenia. J Clin Exp Neuropsychol. 1998 Dec; 20(6):856-72. Granholm E, Chock D, Morris S. PMID: 10484697.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Pupillary responses index overload of working memory resources in schizophrenia. J Abnorm Psychol. 1997 Aug; 106(3):458-67. Granholm E, Morris SK, Sarkin AJ, Asarnow RF, Jeste DV. PMID: 9241947.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    21. Pupillary responses index cognitive resource limitations. Psychophysiology. 1996 Jul; 33(4):457-61. Granholm E, Asarnow RF, Sarkin AJ, Dykes KL. PMID: 8753946.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCTClinical Trials
    22. Span of apprehension deficits in older outpatients with schizophrenia. Schizophr Res. 1996 May; 20(1-2):51-6. Granholm E, Asarnow RF, Verney SP, Nelson P, Jeste DV. PMID: 8794493.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Display visual angle and attentional scanpaths on the span of apprehension task in schizophrenia. J Abnorm Psychol. 1996 Feb; 105(1):17-24. Granholm E, Asarnow RF, Marder SR. PMID: 8666706.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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