Radha Ayyagari

Title(s)Professor In Residence, Ophthalmology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Unraveling the molecular pathology of retinal degeneration through single cell genomics
    NIH R01EY031663Jun 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Molecular mechanism underlying late-onset retinal/macular degeneration
    NIH R01EY030591Sep 1, 2020 - Jun 30, 2024
    Role: Principal Investigator
    Molecular Basis of Hereditary Retinal Degenerations
    NIH R01EY021237Sep 1, 2011 - May 31, 2021
    Role: Principal Investigator
    Molecular Mechanisms Underlying Macular Degenerations
    NIH R01EY013198Jun 1, 2000 - May 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Novel Mouse Model for Late-Onset Retinal Degeneration (L-ORD) Develops RPE Abnormalities Due to the Loss of C1qtnf5/Ctrp5. Adv Exp Med Biol. 2023; 1415:335-340. Borooah S, Chekuri A, Pachauri S, Sahu B, Vorochikhina M, Suk JJ, Bartsch DU, Chavali VRM, Jablonski MM, Ayyagari R. PMID: 37440053.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Single cell RNA sequencing confirms retinal microglia activation associated with early onset retinal degeneration. Sci Rep. 2022 Sep 10; 12(1):15273. Kumari A, Ayala-Ramirez R, Zenteno JC, Huffman K, Sasik R, Ayyagari R, Borooah S. PMID: 36088481; PMCID: PMC9464204.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype. Genes (Basel). 2022 08 17; 13(8). Biswas P, Berry AM, Zawaydeh Q, Bartsch DG, Raghavendra PB, Hejtmancik JF, Khan NW, Riazuddin SA, Ayyagari R. PMID: 36011372; PMCID: PMC9408336.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Deciphering the genetic architecture and ethnographic distribution of IRD in three ethnic populations by whole genome sequence analysis. PLoS Genet. 2021 10; 17(10):e1009848. Biswas P, Villanueva AL, Soto-Hermida A, Duncan JL, Matsui H, Borooah S, Kurmanov B, Richard G, Khan SY, Branham K, Huang B, Suk J, Bakall B, Goldberg JL, Gabriel L, Khan NW, Raghavendra PB, Zhou J, Devalaraja S, Huynh A, Alapati A, Zawaydeh Q, Weleber RG, Heckenlively JR, Hejtmancik JF, Riazuddin S, Sieving PA, Riazuddin SA, Frazer KA, Ayyagari R. PMID: 34662339; PMCID: PMC8589175.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Reticular Pseudodrusen in Late-Onset Retinal Degeneration. Ophthalmol Retina. 2021 10; 5(10):1043-1051. Borooah S, Papastavrou V, Lando L, Han J, Lin JH, Ayyagari R, Dhillon B, Browning AC. PMID: 33352318; PMCID: PMC8217414.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    6. Detection and validation of novel mutations in MERTK in a simplex case of retinal degeneration using WGS and hiPSC-RPEs model. Hum Mutat. 2021 02; 42(2):189-199. Biswas P, Borooah S, Matsui H, Voronchikhina M, Zhou J, Zawaydeh Q, Raghavendra PB, Ferreyra H, Riazuddin SA, Wahlin K, Frazer KA, Ayyagari R. PMID: 33252167; PMCID: PMC7878419.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice. Sci Rep. 2020 11 04; 10(1):19013. Baxter SL, Keenan WT, Athanas AJ, Proudfoot JA, Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Patapoutian A, Weinreb RN. PMID: 33149214; PMCID: PMC7643131.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. Late-onset retinal degeneration pathology due to mutations in CTRP5 is mediated through HTRA1. Aging Cell. 2019 12; 18(6):e13011. Chekuri A, Zientara-Rytter K, Soto-Hermida A, Borooah S, Voronchikhina M, Biswas P, Kumar V, Goodsell D, Hayward C, Shaw P, Stanton C, Garland D, Subramani S, Ayyagari R. PMID: 31385385; PMCID: PMC6826137.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    9. Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci. Stem Cell Reports. 2019 06 11; 12(6):1342-1353. Smith EN, D'Antonio-Chronowska A, Greenwald WW, Borja V, Aguiar LR, Pogue R, Matsui H, Benaglio P, Borooah S, D'Antonio M, Ayyagari R, Frazer KA. PMID: 31080113; PMCID: PMC6565613.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    10. Long-Term Effects of Gene Therapy in a Novel Mouse Model of Human MFRP-Associated Retinopathy. Hum Gene Ther. 2019 05; 30(5):632-650. Chekuri A, Sahu B, Chavali VRM, Voronchikhina M, Soto-Hermida A, Suk JJ, Alapati AN, Bartsch DU, Ayala-Ramirez R, Zenteno JC, Dinculescu A, Jablonski MM, Borooah S, Ayyagari R. PMID: 30499344; PMCID: PMC6534092.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis. Hum Genet. 2018 Jul; 137(6-7):447-458. Chekuri A, Guru AA, Biswas P, Branham K, Borooah S, Soto-Hermida A, Hicks M, Khan NW, Matsui H, Alapati A, Raghavendra PB, Roosing S, Sarangapani S, Mathavan S, Telenti A, Heckenlively JR, Riazuddin SA, Frazer KA, Sieving PA, Ayyagari R. PMID: 29978320; PMCID: PMC6150774.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Transcriptome Analysis of Orbital Adipose Tissue in Active Thyroid Eye Disease Using Next Generation RNA Sequencing Technology. Open Ophthalmol J. 2018; 12:41-52. Lee BW, Kumar VB, Biswas P, Ko AC, Alameddine RM, Granet DB, Ayyagari R, Kikkawa DO, Korn BS. PMID: 29760827; PMCID: PMC5906971.
      View in: PubMed   Mentions: 6  
    13. The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data. Ophthalmology. 2019 01; 126(1):156-170. Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, Dirkes KA, Holmann M, Williams-Steppe E, Hammel N, Saunders LJ, Vega S, Sandow K, Roll K, Slight R, Auerbach D, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA, Park SC, Tello C, Cotliar J, Bansal R, Sidoti PA, Cioffi GA, Blumberg D, Ritch R, Bell NP, Blieden LS, Davis G, Medeiros FA, Ng MCY, Das SK, Palmer ND, Divers J, Langefeld CD, Freedman BI, Bowden DW, Christopher MA, Chen YI, Guo X, Taylor KD, Rotter JI, Weinreb RN, African Descent and Glaucoma Evaluation Study III Genomics Study Group. PMID: 29361356; PMCID: PMC6050158.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    14. Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree. Adv Exp Med Biol. 2018; 1074:219-228. Biswas P, Naeem MA, Ali MH, Assir MZ, Khan SN, Riazuddin S, Hejtmancik JF, Riazuddin SA, Ayyagari R. PMID: 29721947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. A mutation in IFT43 causes non-syndromic recessive retinal degeneration. Hum Mol Genet. 2017 12 01; 26(23):4741-4751. Biswas P, Duncan JL, Ali M, Matsui H, Naeem MA, Raghavendra PB, Frazer KA, Arts HH, Riazuddin S, Akram J, Hejtmancik JF, Riazuddin SA, Ayyagari R. PMID: 28973684; PMCID: PMC6075558.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Genetic analysis of 10 pedigrees with inherited retinal degeneration by exome sequencing and phenotype-genotype association. Physiol Genomics. 2017 Apr 01; 49(4):216-229. Biswas P, Duncan JL, Maranhao B, Kozak I, Branham K, Gabriel L, Lin JH, Barteselli G, Navani M, Suk J, Parke M, Schlechter C, Weleber RG, Heckenlively JR, Dagnelie G, Lee P, Riazuddin SA, Ayyagari R. PMID: 28130426; PMCID: PMC5407181.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. A Report on Molecular Diagnostic Testing for Inherited Retinal Dystrophies by Targeted Genetic Analyses. Genet Test Mol Biomarkers. 2017 Feb; 21(2):66-73. Ramkumar HL, Gudiseva HV, Kishaba KT, Suk JJ, Verma R, Tadimeti K, Thorson JA, Ayyagari R. PMID: 28005406; PMCID: PMC5327051.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. LONGITUDINAL STRUCTURAL CHANGES IN LATE-ONSET RETINAL DEGENERATION. Retina. 2016 Dec; 36(12):2348-2356. Cukras C, Flamendorf J, Wong WT, Ayyagari R, Cunningham D, Sieving PA. PMID: 27388725; PMCID: PMC5115976.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    19. A missense mutation in ASRGL1 is involved in causing autosomal recessive retinal degeneration. Hum Mol Genet. 2016 06 15; 25(12):2483-2497. Biswas P, Chavali VR, Agnello G, Stone E, Chakarova C, Duncan JL, Kannabiran C, Homsher M, Bhattacharya SS, Naeem MA, Kimchi A, Sharon D, Iwata T, Riazuddin S, Reddy GB, Hejtmancik JF, Georgiou G, Riazuddin SA, Ayyagari R. PMID: 27106100; PMCID: PMC6086560.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. Mol Vis. 2015; 21:273-84. Sahu B, Chavali VR, Alapati A, Suk J, Bartsch DU, Jablonski MM, Ayyagari R. PMID: 25814825; PMCID: PMC4360165.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Molecular diagnostic testing by eyeGENE: analysis of patients with hereditary retinal dystrophy phenotypes involving central vision loss. Invest Ophthalmol Vis Sci. 2014 Jul 31; 55(9):5510-21. Alapati A, Goetz K, Suk J, Navani M, Al-Tarouti A, Jayasundera T, Tumminia SJ, Lee P, Ayyagari R. PMID: 25082885; PMCID: PMC4152151.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    22. A degenerative retinal process in HIV-associated non-infectious retinopathy. PLoS One. 2013; 8(9):e74712. Kozak I, Sasik R, Freeman WR, Sprague LJ, Gomez ML, Cheng L, El-Emam S, Mojana F, Bartsch DU, Bosten J, Ayyagari R, Hardiman G. PMID: 24069333; PMCID: PMC3775801.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    23. Identification of a novel mutation in the CDHR1 gene in a family with recessive retinal degeneration. Arch Ophthalmol. 2012 Oct; 130(10):1301-8. Duncan JL, Roorda A, Navani M, Vishweswaraiah S, Syed R, Soudry S, Ratnam K, Gudiseva HV, Lee P, Gaasterland T, Ayyagari R. PMID: 23044944; PMCID: PMC3799916.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    24. Silencing the expression of CTRP5/C1QTNF5 and ELOVL4 genes by small interfering RNA. Adv Exp Med Biol. 2012; 723:225-33. Chavali VR, Vasireddy V, Ayyagari R. PMID: 22183337.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    25. Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PLoS One. 2011; 6(6):e21193. Vasireddy V, Chavali VR, Joseph VT, Kadam R, Lin JH, Jamison JA, Kompella UB, Reddy GB, Ayyagari R. PMID: 21738619; PMCID: PMC3126808.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    26. A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration. Hum Mol Genet. 2011 May 15; 20(10):2000-14. Chavali VR, Khan NW, Cukras CA, Bartsch DU, Jablonski MM, Ayyagari R. PMID: 21349921; PMCID: PMC3080610.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    27. Identification of a promoter for the human C1Q-tumor necrosis factor-related protein-5 gene associated with late-onset retinal degeneration. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5499-507. Chavali VR, Sommer JR, Petters RM, Ayyagari R. PMID: 20554618; PMCID: PMC3061496.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Genetics and molecular pathology of Stargardt-like macular degeneration. Prog Retin Eye Res. 2010 May; 29(3):191-207. Vasireddy V, Wong P, Ayyagari R. PMID: 20096366; PMCID: PMC3059896.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    29. AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet. 2010 Feb; 42(2):175-80. Louie CM, Caridi G, Lopes VS, Brancati F, Kispert A, Lancaster MA, Schlossman AM, Otto EA, Leitges M, Gröne HJ, Lopez I, Gudiseva HV, O'Toole JF, Vallespin E, Ayyagari R, Ayuso C, Cremers FP, den Hollander AI, Koenekoop RK, Dallapiccola B, Ghiggeri GM, Hildebrandt F, Valente EM, Williams DS, Gleeson JG. PMID: 20081859; PMCID: PMC2884967.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    30. Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin. Exp Eye Res. 2009 Dec; 89(6):905-12. Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R. PMID: 19682985; PMCID: PMC2783393.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
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