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    Lingyun Cheng

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0946
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Porous Silicon Particles for Sustained Intravitreal Drug Delivery
      NIH/NEI R01EY020617Sep 1, 2011 - Aug 31, 2016
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hou H, Wang C, Nan K, Freeman WR, Sailor MJ, Cheng L. Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):557-66. PMID: 26882530; PMCID: PMC4758302.
      2. Hou H, Nieto A, Belghith A, Nan K, Li Y, Freeman WR, Sailor MJ, Cheng L. A sustained intravitreal drug delivery system with remote real time monitoring capability. Acta Biomater. 2015 Sep; 24:309-21. PMID: 26087110; PMCID: PMC4560601.
      3. Hou H, Huffman K, Rios S, Freeman WR, Sailor MJ, Cheng L. A Novel Approach of Daunorubicin Application on Formation of Proliferative Retinopathy Using a Porous Silicon Controlled Delivery System: Pharmacodynamics. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2755-63. PMID: 25829415; PMCID: PMC4416660.
      4. Camacho N, Barteselli G, Nezgoda JT, El-Emam S, Cheng L, Bartsch DU, Freeman WR. Significance of the hyperautofluorescent ring associated with choroidal neovascularisation in eyes undergoing anti-VEGF therapy for wet age-related macular degeneration. Br J Ophthalmol. 2015 Sep; 99(9):1277-83. PMID: 25777818.
        View in: PubMed
      5. Nieto A, Hou H, Moon SW, Sailor MJ, Freeman WR, Cheng L. Surface engineering of porous silicon microparticles for intravitreal sustained delivery of rapamycin. Invest Ophthalmol Vis Sci. 2015 Jan 22; 56(2):1070-80. PMID: 25613937; PMCID: PMC4329946.
      6. Barteselli G, Amini P, Ezon IC, Nezgoda JT, Cheng L, Freeman WR. Impact on intraocular pressure after 20-mg decanted triamcinolone acetonide (kenalog) injection when using prophylactic antiglaucoma therapy. Retina. 2015 Jan; 35(1):75-81. PMID: 25077534; PMCID: PMC4276472.
      7. Ma F, Nan K, Lee S, Beadle JR, Hou H, Freeman WR, Hostetler KY, Cheng L. Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system. Eur J Pharm Biopharm. 2015 Jan; 89:271-9. PMID: 25513956; PMCID: PMC4355386.
      8. Wang C, Hou H, Nan K, Sailor MJ, Freeman WR, Cheng L. Intravitreal controlled release of dexamethasone from engineered microparticles of porous silicon dioxide. Exp Eye Res. 2014 Dec; 129:74-82. PMID: 25446320; PMCID: PMC4259850.
      9. Kozak I, El-Emam SY, Cheng L, Bartsch DU, Chhablani J, Freeman WR, Arevalo JF. Fluorescein angiography versus optical coherence tomography-guided planning for macular laser photocoagulation in diabetic macular edema. Retina. 2014 Aug; 34(8):1600-5. PMID: 24695064; PMCID: PMC4695978.
      10. Nan K, Ma F, Hou H, Freeman WR, Sailor MJ, Cheng L. Porous silicon oxide-PLGA composite microspheres for sustained ocular delivery of daunorubicin. Acta Biomater. 2014 Aug; 10(8):3505-12. PMID: 24793657; PMCID: PMC4106702.
      11. Barteselli G, Lee SN, El-Emam S, Hou H, Ma F, Chhablani J, Conner L, Cheng L, Bartsch DU, Freeman WR. Macular choroidal volume variations in highly myopic eyes with myopic traction maculopathy and choroidal neovascularization. Retina. 2014 May; 34(5):880-9. PMID: 24217703.
        View in: PubMed
      12. Xue A, Bao F, Zheng L, Wang Q, Cheng L, Qu J. Posterior scleral reinforcement on progressive high myopic young patients. Optom Vis Sci. 2014 Apr; 91(4):412-8. PMID: 24509544.
        View in: PubMed
      13. Ma F, Arcinue CA, Barteselli G, Cheng L, Ezon I, Lee SN, Freeman WR. Optical coherence tomography findings of the vitreoretinal interface in asymptomatic fellow eyes of patients with acute posterior vitreous detachment. Retina. 2014 Mar; 34(3):447-54. PMID: 24136409.
        View in: PubMed
      14. Hou H, Nieto A, Ma F, Freeman WR, Sailor MJ, Cheng L. Tunable sustained intravitreal drug delivery system for daunorubicin using oxidized porous silicon. J Control Release. 2014 Mar 28; 178:46-54. PMID: 24424270; PMCID: PMC3951847.
      15. Wang H, Barteselli G, Freeman WR, Lee SN, Chhablani J, El-Emam S, Cheng L. Temporal pattern of resolution/recurrence of choroidal neovascularization during bevacizumab therapy for wet age-related macular degeneration. Int J Ophthalmol. 2013; 6(5):600-5. PMID: 24195033; PMCID: PMC3808905.
      16. Kozak I, Sasik R, Freeman WR, Sprague LJ, Gomez ML, Cheng L, El-Emam S, Mojana F, Bartsch DU, Bosten J, Ayyagari R, Hardiman G. A degenerative retinal process in HIV-associated non-infectious retinopathy. PLoS One. 2013; 8(9):e74712. PMID: 24069333; PMCID: PMC3775801.
      17. Nieto A, Hou H, Sailor MJ, Freeman WR, Cheng L. Ocular silicon distribution and clearance following intravitreal injection of porous silicon microparticles. Exp Eye Res. 2013 Nov; 116:161-8. PMID: 24036388; PMCID: PMC3873878.
      18. Barteselli G, Chhablani J, Lee SN, Wang H, El Emam S, Kozak I, Cheng L, Bartsch DU, Azen S, Freeman WR. Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography. Retina. 2013 Sep; 33(8):1574-83. PMID: 23584697; PMCID: PMC3804067.
      19. El-Emam S, Chhablani J, Barteselli G, Wang H, Lee SN, Kozak I, Cheng L, Freeman WR. Correlation of spectral domain optical coherence tomography characteristics with visual acuity in eyes with subfoveal scarring after treatment for wet age-related macular degeneration. Retina. 2013 Jun; 33(6):1249-57. PMID: 23446655.
        View in: PubMed
      20. Chhablani J, Bartsch DU, Cheng L, Gomez L, Alshareef RA, Rezeq SS, Garg SJ, Burgansky-Eliash Z, Freeman WR. Segmental reproducibility of retinal blood flow velocity measurements using retinal function imager. Graefes Arch Clin Exp Ophthalmol. 2013 Dec; 251(12):2665-70. PMID: 23700326; PMCID: PMC3865139.
      21. Hartmann KI, Nieto A, Wu EC, Freeman WR, Kim JS, Chhablani J, Sailor MJ, Cheng L. Hydrosilylated porous silicon particles function as an intravitreal drug delivery system for daunorubicin. J Ocul Pharmacol Ther. 2013 Jun; 29(5):493-500. PMID: 23448595; PMCID: PMC3669596.
      22. Chhablani J, Kim JS, Freeman WR, Kozak I, Wang HY, Cheng L. Predictors of visual outcome in eyes with choroidal neovascularization secondary to age related macular degeneration treated with intravitreal bevacizumab monotherapy. Int J Ophthalmol. 2013; 6(1):62-6. PMID: 23549041; PMCID: PMC3580252.
      23. Lee SN, Chhablani J, Chan CK, Wang H, Barteselli G, El-Emam S, Gomez ML, Kozak I, Cheng L, Freeman WR. Characterization of microaneurysm closure after focal laser photocoagulation in diabetic macular edema. Am J Ophthalmol. 2013 May; 155(5):905-12. PMID: 23394906; PMCID: PMC3627831.
      24. Chhablani J, Nieto A, Hou H, Wu EC, Freeman WR, Sailor MJ, Cheng L. Oxidized porous silicon particles covalently grafted with daunorubicin as a sustained intraocular drug delivery system. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):1268-79. PMID: 23322571; PMCID: PMC3576052.
      25. Chhablani J, Barteselli G, Bartsch DU, Kozak I, Wang H, El-Emam S, Doede AL, Cheng L, Freeman WR. Influence of scanning density on macular choroidal volume measurement using spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2013 May; 251(5):1303-9. PMID: 23142990; PMCID: PMC3593737.
      26. Chhablani J, Kozak IR, Mojana F, Cheng L, Morrison VL, Wang H, Kim JS, Dustin L, Azen S, Freeman WR. Fundus autofluorescence not predictive of treatment response to intravitreal bevacizumab in exudative age-related macular degeneration. Retina. 2012 Sep; 32(8):1465-70. PMID: 22466489.
        View in: PubMed
      27. Barteselli G, Chhablani J, El-Emam S, Wang H, Chuang J, Kozak I, Cheng L, Bartsch DU, Freeman WR. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology. 2012 Dec; 119(12):2572-8. PMID: 22921388; PMCID: PMC3514583.
      28. Kim JS, Beadle JR, Freeman WR, Hostetler KY, Hartmann K, Valiaeva N, Kozak I, Conner L, Trahan J, Aldern KA, Cheng L. A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy. Mol Vis. 2012; 18:1907-17. PMID: 22876115; PMCID: PMC3413433.
      29. Chhablani J, Barteselli G, Wang H, El-Emam S, Kozak I, Doede AL, Bartsch DU, Cheng L, Freeman WR. Repeatability and reproducibility of manual choroidal volume measurements using enhanced depth imaging optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2274-80. PMID: 22427584; PMCID: PMC3995568.
      30. Chhablani JK, Kim JS, Cheng L, Kozak I, Freeman W. External limiting membrane as a predictor of visual improvement in diabetic macular edema after pars plana vitrectomy. Graefes Arch Clin Exp Ophthalmol. 2012 Oct; 250(10):1415-20. PMID: 22354371.
        View in: PubMed
      31. Wang H, Chhablani J, Freeman WR, Chan CK, Kozak I, Bartsch DU, Cheng L. Characterization of diabetic microaneurysms by simultaneous fluorescein angiography and spectral-domain optical coherence tomography. Am J Ophthalmol. 2012 May; 153(5):861-867.e1. PMID: 22300473; PMCID: PMC3331899.
      32. Wang H, Chhablani J, Freeman WR, Beadle JR, Hostetler KY, Hartmann K, Conner L, Aldern KA, Pearson L, Cheng L. Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug. Invest Ophthalmol Vis Sci. 2011 Dec 09; 52(13):9391-6. PMID: 22058340; PMCID: PMC3250264.
      33. Kim JS, Chhablani J, Chan CK, Cheng L, Kozak I, Hartmann K, Freeman WR. Retinal adherence and fibrillary surface changes correlate with surgical difficulty of epiretinal membrane removal. Am J Ophthalmol. 2012 Apr; 153(4):692-7, 697.e1-2. PMID: 22137206; PMCID: PMC3297697.
      34. Freeman WR, Kozak I, Yuson RM, Nigam N, Cheng L, Mojana F. Prognosti implications of pigment epithelial detachment in bevacizumab (avastin)-treated eyes with age-related macular degeneration and choroidal neovascularization. Retina. 2011 Oct; 31(9):1812-8. PMID: 21866073.
        View in: PubMed
      35. Hartmann KI, Bartsch DU, Cheng L, Kim JS, Gomez ML, Klein H, Freeman WR. Scanning laser ophthalmoscope imaging stabilized microperimetry in dry age-related macular degeneration. Retina. 2011 Jul-Aug; 31(7):1323-31. PMID: 21540764.
        View in: PubMed
      36. Kim JS, Maheshwary AS, Bartsch DU, Cheng L, Gomez ML, Hartmann K, Freeman WR. The microperimetry of resolved cotton-wool spots in eyes of patients with hypertension and diabetes mellitus. Arch Ophthalmol. 2011 Jul; 129(7):879-84. PMID: 21746978.
        View in: PubMed
      37. Cheng L, Beadle JR, Tammewar A, Hostetler KY, Hoh C, Freeman WR. Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis. J Ocul Pharmacol Ther. 2011 Apr; 27(2):157-62. PMID: 21351867; PMCID: PMC3078534.
      38. Mojana F, Brar M, Cheng L, Bartsch DU, Freeman WR. Long-term SD-OCT/SLO imaging of neuroretina and retinal pigment epithelium after subthreshold infrared laser treatment of drusen. Retina. 2011 Feb; 31(2):235-42. PMID: 21157398; PMCID: PMC3530923.
      39. Wu EC, Andrew JS, Cheng L, Freeman WR, Pearson L, Sailor MJ. Real-time monitoring of sustained drug release using the optical properties of porous silicon photonic crystal particles. Biomaterials. 2011 Mar; 32(7):1957-66. PMID: 21122914; PMCID: PMC3025697.
      40. Brar M, Cheng L, Yuson R, Mojana F, Freeman WR, Gill PS. Ocular safety profile and intraocular pharmacokinetics of an antagonist of EphB4/EphrinB2 signalling. Br J Ophthalmol. 2010 Dec; 94(12):1668-73. PMID: 20934994.
        View in: PubMed
      41. Andrew JS, Anglin EJ, Wu EC, Chen MY, Cheng L, Freeman WR, Sailor MJ. Sustained Release of a Monoclonal Antibody from Electrochemically Prepared Mesoporous Silicon Oxide. Adv Funct Mater. 2010 Sep 08; 20(23):4168-4174. PMID: 21274422.
        View in: PubMed
      42. Maheshwary AS, Oster SF, Yuson RM, Cheng L, Mojana F, Freeman WR. The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema. Am J Ophthalmol. 2010 Jul; 150(1):63-67.e1. PMID: 20451897; PMCID: PMC2900476.
      43. Oster SF, Mojana F, Brar M, Yuson RM, Cheng L, Freeman WR. Disruption of the photoreceptor inner segment/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes. Retina. 2010 May; 30(5):713-8. PMID: 20038861.
        View in: PubMed
      44. Freeman SR, Kozak I, Cheng L, Bartsch DU, Mojana F, Nigam N, Brar M, Yuson R, Freeman WR. Optical coherence tomography-raster scanning and manual segmentation in determining drusen volume in age-related macular degeneration. Retina. 2010 Mar; 30(3):431-5. PMID: 19952989.
        View in: PubMed
      45. Brar M, Yuson R, Kozak I, Mojana F, Cheng L, Bartsch DU, Oster SF, Freeman WR. Correlation between morphologic features on spectral-domain optical coherence tomography and angiographic leakage patterns in macular edema. Retina. 2010 Mar; 30(3):383-9. PMID: 20216291; PMCID: PMC2870721.
      46. Mojana F, Kozak I, Oster SF, Cheng L, Bartsch DU, Brar M, Yuson RM, Freeman WR. Observations by spectral-domain optical coherence tomography combined with simultaneous scanning laser ophthalmoscopy: imaging of the vitreous. Am J Ophthalmol. 2010 Apr; 149(4):641-50. PMID: 20138610.
        View in: PubMed
      47. Nigam N, Bartsch DU, Cheng L, Brar M, Yuson RM, Kozak I, Mojana F, Freeman WR. Spectral domain optical coherence tomography for imaging ERM, retinal edema, and vitreomacular interface. Retina. 2010 Feb; 30(2):246-53. PMID: 19940804.
        View in: PubMed
      48. Lee BR, Bartsch DU, Kozak I, Cheng L, Freeman WR. Comparison of a novel confocal scanning laser ophthalmoscopy algorithm with optical coherence tomography in measurement of macular thickness and volume. Retina. 2009 Oct; 29(9):1328-34. PMID: 19934823.
        View in: PubMed
      49. Bessho K, Bartsch DU, Gomez L, Cheng L, Koh HJ, Freeman WR. Ocular wavefront aberrations in patients with macular diseases. Retina. 2009 Oct; 29(9):1356-63. PMID: 19574950; PMCID: PMC3711882.
      50. Cheng L, Hostetler K, Valiaeva N, Tammewar A, Freeman WR, Beadle J, Bartsch DU, Aldern K, Falkenstein I. Intravitreal crystalline drug delivery for intraocular proliferation diseases. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):474-81. PMID: 19696179; PMCID: PMC2869063.
      51. Pathak S, Tolentino R, Nguyen K, D'Amico L, Barron E, Cheng L, Freeman WR, Silva GA. Quantum dot labeling and imaging of glial fibrillary acidic protein intermediate filaments and gliosis in the rat neural retina and dissociated astrocytes. J Nanosci Nanotechnol. 2009 Aug; 9(8):5047-54. PMID: 19928184.
        View in: PubMed
      52. Brar M, Kozak I, Cheng L, Bartsch DU, Yuson R, Nigam N, Oster SF, Mojana F, Freeman WR. Correlation between spectral-domain optical coherence tomography and fundus autofluorescence at the margins of geographic atrophy. Am J Ophthalmol. 2009 Sep; 148(3):439-44. PMID: 19541290; PMCID: PMC2731819.
      53. Cheng L, Banker AS, Martin M, Kozak I, Freeman WR. Triamcinolone acetonide concentration of aqueous humor after decanted 20-mg intravitreal injection. Ophthalmology. 2009 Jul; 116(7):1356-9. PMID: 19450879.
        View in: PubMed
      54. Tantayakom T, Lim JN, Purcell TL, Nalgirkar A, Cheng L, Schanzlin DJ. Visual outcomes after wavefront-guided laser in situ keratomileusis with and without iris registration. J Cataract Refract Surg. 2008 Sep; 34(9):1532-7. PMID: 18721715.
        View in: PubMed
      55. Falkenstein IA, Cheng L, Wong-Staal F, Tammewar AM, Barron EC, Silva GA, Li QX, Yu D, Hysell M, Liu G, Ke N, Macdonald JE, Freeman WR. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul; 33(7):599-609. PMID: 18600493; PMCID: PMC2664073.
      56. Mojana F, Cheng L, Bartsch DU, Silva GA, Kozak I, Nigam N, Freeman WR. The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol. 2008 Aug; 146(2):218-227. PMID: 18538742; PMCID: PMC2735863.
      57. Anglin EJ, Cheng L, Freeman WR, Sailor MJ. Porous silicon in drug delivery devices and materials. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1266-77. PMID: 18508154; PMCID: PMC2710886.
      58. Kozak I, Cheng L, Silva GA, Freeman WR. Testing of intraocular drugs for clinical use. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):4861-3. PMID: 17962431.
        View in: PubMed
      59. Kozak I, Bartsch DU, Cheng L, McCutchan A, Weinreb RN, Freeman WR. Scanning laser polarimetry demonstration of retinal nerve fiber layer damage in human immunodeficiency virus-positive patients without infectious retinitis. Retina. 2007 Nov-Dec; 27(9):1267-73. PMID: 18046236.
        View in: PubMed
      60. Tammewar AM, Cheng L, Hostetler KY, Falkenstein I, Beadle JR, Barron EC, Kozak I, Freeman WR. Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig. J Ocul Pharmacol Ther. 2007 Oct; 23(5):433-44. PMID: 17900229.
        View in: PubMed
      61. Falkenstein IA, Cheng L, Morrison VL, Kozak I, Tammewar AM, Freeman WR. Standardized visual acuity results associated with primary versus secondary bevacizumab (avastin) treatment for choroidal neovascularization in age-related macular degeneration. Retina. 2007 Jul-Aug; 27(6):701-6. PMID: 17621178; PMCID: PMC2752060.
      62. Koh HJ, Cheng L, Kosobucki B, Freeman WR. Prophylactic intraoperative 360 degrees laser retinopexy for prevention of retinal detachment. Retina. 2007 Jul-Aug; 27(6):744-9. PMID: 17621184.
        View in: PubMed
      63. Kozak I, Bartsch DU, Cheng L, Freeman WR. Hyperreflective sign in resolved cotton wool spots using high-resolution optical coherence tomography and optical coherence tomography ophthalmoscopy. Ophthalmology. 2007 Mar; 114(3):537-43. PMID: 17324696.
        View in: PubMed
      64. Kozak I, Cheng L, Falkenstein I, Tammewar AM, Freeman WR. Evaluation of subretinal triamcinolone acetonide in patients with exudative age-related macular degeneration. J Ocul Pharmacol Ther. 2007 Feb; 23(1):46-53. PMID: 17341150.
        View in: PubMed
      65. Falkenstein I, Kozak I, Kayikcioglu O, Cheng L, Bartsch DU, Azen SP, Labree LD, Freeman WR. Assessment of retinal function in patients with HIV without infectious retinitis by multifocal electroretinogram and automated perimetry. Retina. 2006 Oct; 26(8):928-34. PMID: 17031295.
        View in: PubMed
      66. Kozak I, Kayikcioglu OR, Cheng L, Falkenstein I, Silva GA, Yu DX, Freeman WR. The effect of recombinant human hyaluronidase on dexamethasone penetration into the posterior segment of the eye after sub-Tenon's injection. J Ocul Pharmacol Ther. 2006 Oct; 22(5):362-9. PMID: 17076631.
        View in: PubMed
      67. Kozak I, Cheng L, Mendez T, Davidson MC, Freeman WR. Evaluation of the toxicity of subretinal triamcinolone acetonide in the rabbit. Retina. 2006 Sep; 26(7):811-7. PMID: 16963856.
        View in: PubMed
      68. Kozak I, Bartsch DU, Cheng L, Freeman WR. In vivo histology of cotton-wool spots using high-resolution optical coherence tomography. Am J Ophthalmol. 2006 Apr; 141(4):748-50. PMID: 16564817.
        View in: PubMed
      69. Morrison VL, Koh HJ, Cheng L, Bessho K, Davidson MC, Freeman WR. Intravitreal toxicity of the kenalog vehicle (benzyl alcohol) in rabbits. Retina. 2006 Mar; 26(3):339-44. PMID: 16508436.
        View in: PubMed
      70. Kozak I, LaBree L, Azen SP, Cheng L, Reagan NL, Freeman WR. Long-term study of intraocular pressure changes in patients with human immunodeficiency virus treated with highly active antiretroviral therapy. Ophthalmology. 2006 Mar; 113(3):451-5. PMID: 16513459.
        View in: PubMed
      71. Bessho K, Rodanant N, Bartsch DU, Cheng L, Koh HJ, Freeman WR. Effect of subthreshold infrared laser treatment for drusen regression on macular autofluorescence in patients with age-related macular degeneration. Retina. 2005 Dec; 25(8):981-8. PMID: 16340527.
        View in: PubMed
      72. Kozak I, Cheng L, Freeman WR. Lidocaine gel anesthesia for intravitreal drug administration. Retina. 2005 Dec; 25(8):994-8. PMID: 16340529.
        View in: PubMed
      73. Lu S, Cheng L, Hostetler KY, Koh HJ, Beadle JR, Davidson MC, Freeman WR. Intraocular properties of hexadecyloxypropyl-cyclic-cidofovir in Guinea pigs. J Ocul Pharmacol Ther. 2005 Jun; 21(3):205-9. PMID: 15969637.
        View in: PubMed
      74. Cheng L, Toyoguchi M, Looney DJ, Lee J, Davidson MC, Freeman WR. Efficient gene transfer to retinal pigment epithelium cells with long-term expression. Retina. 2005 Feb-Mar; 25(2):193-201. PMID: 15689811; PMCID: PMC1382166.
      75. Kozak I, Bartsch DU, Cheng L, Kosobucki BR, Freeman WR. Objective analysis of retinal damage in HIV-positive patients in the HAART era using OCT. Am J Ophthalmol. 2005 Feb; 139(2):295-301. PMID: 15733991; PMCID: PMC3757251.
      76. Cheng L, Hostetler KY, Lee J, Koh HJ, Beadle JR, Bessho K, Toyoguchi M, Aldern K, Bovet JM, Freeman WR. Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4138-44. PMID: 15505067; PMCID: PMC2666013.
      77. Koh HJ, Cheng L, Bessho K, Jones TR, Davidson MC, Freeman WR. Intraocular properties of urokinase-derived antiangiogenic A6 peptide in rabbits. J Ocul Pharmacol Ther. 2004 Oct; 20(5):439-49. PMID: 15650519.
        View in: PubMed
      78. El-Bradey MH, Cheng L, Bartsch DU, Niessman M, El-Musharaf A, Freeman WR. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinase, on a new animal model of epiretinal membrane. Retina. 2004 Oct; 24(5):783-9. PMID: 15492635.
        View in: PubMed
      79. El Bradey M, Cheng L, Bartsch DU, Appelt K, Rodanant N, Bergeron-Lynn G, Freeman WR. Preventive versus treatment effect of AG3340, a potent matrix metalloproteinase inhibitor in a rat model of choroidal neovascularization. J Ocul Pharmacol Ther. 2004 Jun; 20(3):217-36. PMID: 15279727; PMCID: PMC1360230.
      80. Kosobucki BR, Goldberg DE, Bessho K, Koh HJ, Rodanant N, Labree L, Cheng L, Schrier RD, Azen SP, Freeman WR. Valganciclovir therapy for immune recovery uveitis complicated by macular edema. Am J Ophthalmol. 2004 Apr; 137(4):636-8. PMID: 15059701.
        View in: PubMed
      81. Koh HJ, Bessho K, Cheng L, Bartsch DU, Jones TR, Bergeron-Lynn G, Freeman WR. Inhibition of choroidal neovascularization in rats by the urokinase-derived peptide A6. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):635-40. PMID: 14744908; PMCID: PMC1378117.
      82. Song MK, Azen SP, Buley A, Torriani F, Cheng L, Chaidhawangul S, Ozerdem U, Scholz B, Freeman WR. Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis. Am J Ophthalmol. 2003 Oct; 136(4):696-702. PMID: 14516810.
        View in: PubMed
      83. Bartsch DU, Aurora A, Rodanant N, Cheng L, Freeman WR. Volumetric analysis of macular edema by scanning laser tomography in immune recovery uveitis. Arch Ophthalmol. 2003 Sep; 121(9):1246-51. PMID: 12963607.
        View in: PubMed
      84. Cheng L, Hostetler KY, Toyoguchi M, Beadle JR, Rodanant N, Gardner MF, Aldern KA, Bergeron-Lynn G, Freeman WR. Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir. J Ocul Pharmacol Ther. 2003 Apr; 19(2):161-9. PMID: 12804061.
        View in: PubMed
      85. Rodanant N, Friberg TR, Cheng L, Aurora A, Bartsch D, Toyoguchi M, Corbin PS, El-Bradey MH, Freeman WR. Predictors of drusen reduction after subthreshold infrared (810 nm) diode laser macular grid photocoagulation for nonexudative age-related macular degeneration. Am J Ophthalmol. 2002 Oct; 134(4):577-85. PMID: 12383815.
        View in: PubMed
      86. Cheng L, Azen SP, El-Bradey MH, Toyoguchi M, Chaidhawangul S, Rivero ME, Scholz BM, Freeman WR. Effects of preoperative and postoperative epiretinal membranes on macular hole closure and visual restoration. Ophthalmology. 2002 Aug; 109(8):1514-20. PMID: 12153804.
        View in: PubMed
      87. Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar; 24(3):196-201. PMID: 12221527.
        View in: PubMed
      88. Cheng L, Hostetler KY, Chaidhawangul S, Gardner MF, Beadle JR, Toyoguchi M, Bergeron-Lynn G, Freeman WR. Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):515-21. PMID: 11818399.
        View in: PubMed
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