Annette Von Drygalski

Photo of Annette Von Drygalski
Title(s)Professor Of Clinical, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9426-6322 Additional info
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    Other Positions
    Title(s)Director, Center for Bleeding and Clotting Disorders


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    Dr. von Drygalski is the Director of the Hemophilia and Thrombosis Treatment Center at UCSD (http://health.ucsd.edu/specialties/hemophilia/Pages/default.aspx) and her research interests involve basic, translational and clinical science in the field of hemostasis and thrombosis, specifically hemophilia.

    Dr. von Drygalski collaborates with Laurent O. Mosnier and John H. Griffin, Ph.D., at The Scripps Research Institute in La Jolla, focusing on the development of novel bypassing treatment strategies, mechanisms of fibrinolysis and joint disease in hemophilia. Dr. von Drygalski maintains a clinical research program studying the aging patient with hemophilia in aspects such as hemophilic arthropathy and the hypertension of hemophilia. She is the primary institutional investigator for several international clinical trials evaluating new treatment options for patients with hemophilia. Dr. von Drygalski was the recent recipient of a National Hemophilia/Novo Nordisk Career Development Award and a Bayer Early Career Development Award.

    Collapse Biography 
    Collapse education and training
    Ludwig Maximilians University, Munich, GermanyMD01/1989Medicine
    Collapse awards and honors
    San Diego County Medical Society2014Physician of Exceptional Excellence Award in Hematology
    National Hemophilia Foundation/Novo Nordisk2013Career Development Award
    Bayer Healthcare2012Early Career Development Award
    American Society of Hematology2010American Society of Hematology Research Training Fellowship Award

    Collapse Research 
    Collapse Clinical Trials

    Collapse Featured Content 

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Characterization of a mouse model to study mechanisms of hemophilia A pain. Blood Adv. 2026 Oct 13; 10(19):6366-6380. Fouda R, Argueta D, Goel Y, Velasco G, O'Daniel K, Peterson K, Zamora Z, Joseph BC, von Drygalski A, Gupta K. PMID: 42295153; PMCID: PMC13631532.
      View in: PubMed   Mentions:    Fields:    
    2. Lack of Inhibitor Development in Previously Treated People With Haemophilia Switching Factor Products-Final Results of Athn 2: Factor Switching Study. Haemophilia. 2026 Aug 04. Cockrell E, Chandler M, Chrisentery-Singleton T, Croteau SE, Daoud N, Guerrera MF, Hirsh MN, Journeycake J, Kulkarni R, Lattimore SU, McGuinn C, Ragni M, Recht M, Reiss UM, Sidonio R, Takemoto CM, Tarantino M, von Drygalski A, Neufeld EJ. PMID: 42549504.
      View in: PubMed   Mentions:    Fields:    
    3. T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers. Pediatr Blood Cancer. 2026 Sep; 73(9):e70518. Garcia J, Hussain T, Dillenbeck J, Hammer M, von Drygalski A, Young G, Zia A. PMID: 42496612.
      View in: PubMed   Mentions:    Fields:    
    4. Advances in Hemophilia: From Joint Health to FVIII Guidelines and the Clinical Integration of Rebalancing Agents. Am J Hematol. 2026 Aug; 101(8):1781-1782. Young G, von Drygalski A, Pipe S, Sidonio R. PMID: 42252525.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The effects of recombinant human activated factor VII and tranexamic acid on traumatic bleeding and mortality in mice. Res Pract Thromb Haemost. 2026 Mar; 10(3):103436. Chumappumkal Joseph B, De Pablo-Moreno JA, Falah N, Wentzel A, Lora Cacho M, Frias-Anaya E, Lopez-Ramirez MA, von Drygalski A. PMID: 42027309; PMCID: PMC13100279.
      View in: PubMed   Mentions: Translation:HumansAnimals
    6. Etranacogene dezaparvovec in people with hemophilia B with preexisting adeno-associated virus 5 neutralizing antibodies: 4-year subgroup results from the HOPE-B trial. Res Pract Thromb Haemost. 2026 Jan; 10(1):103360. Klamroth R, Monahan PE, Van der Valk P, Quon D, Kazmi RS, Coppens M, O'Connell N, Pipe SW, von Drygalski A, Afzal S, Gabriel R, Youssar L, Gill S, Jansen N, Wang F, Le Quellec S, Hermans C. PMID: 41756540; PMCID: PMC12934310.
      View in: PubMed   Mentions:
    7. Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study. J Imaging. 2026 Jan 06; 12(1). Sedaghat S, Park JI, Fu E, von Drygalski A, Ma Y, Chang EY, Du J, Nardo L, Jang H. PMID: 41590913; PMCID: PMC12843048.
      View in: PubMed   Mentions:
    8. Joint tissue plasticity in hemophilia: insights from the Joint Activity and Damage Exam ultrasound protocol. Res Pract Thromb Haemost. 2026 Jan; 10(1):103290. Sheth P, Tong K, Joseph BC, Manon-Jensen T, Glenzer M, Nwi-Mozu I, Aguero P, Steiner B, Bailey C, Quon DV, Kruse-Jarres R, Lee E, Karsdal MA, Liu L, von Drygalski A. PMID: 41552748; PMCID: PMC12805341.
      View in: PubMed   Mentions:
    9. Point-of-care musculoskeletal ultrasound for hemophilic arthropathy: a scoping review of scanning protocols by the Imaging Expert Working Group of the International Prophylaxis Study Group. Res Pract Thromb Haemost. 2025 Oct; 9(7):103185. Nguyen KT, Bakeer N, von Drygalski A, Babyn P, Pergantou H, Dunn A, Lundin B, Strike K. PMID: 41141846; PMCID: PMC12547463.
      View in: PubMed   Mentions:
    10. Perspectives on Selected Hemophilia Research Presented at ISTH 2025: Nonfactor Replacement Therapies. Am J Hematol. 2025 Dec; 100(12):2174. von Drygalski A. PMID: 40954483; PMCID: PMC12603875.
      View in: PubMed   Mentions: 1     Fields:    
    11. Defective lymphangiogenesis and iron removal after hemarthrosis in factor VIII-deficient mice are rectified with therapeutic factor VIII administration-implications for joint health. J Thromb Haemost. 2026 01; 24(1):88-98. Chumappumkal Joseph B, De Pablo-Moreno JA, Falah N, Lora Cacho M, von Drygalski A. PMID: 40907702.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Protein misfolding in hemophilia. Adv Protein Chem Struct Biol. 2025; 148:1-27. Chumappumkal Joseph B, De Pablo-Moreno JA, Falah N, Simmons DH, von Drygalski A. PMID: 41309188.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Completion of phase 2b trial of etranacogene dezaparvovec gene therapy in patients with hemophilia B over 5 years. Blood Adv. 2025 Jul 22; 9(14):3543-3552. von Drygalski A, Gomez E, Giermasz A, Castaman G, Key NS, Lattimore SU, Leebeek FWG, Miesbach WA, Recht M, Monahan PE, Le Quellec S, Pipe SW. PMID: 40188458; PMCID: PMC12275190.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    14. Standardization of Terminology, Definitions, and Outcome Criteria for Bleeding in Hereditary Hemorrhagic Telangiectasia: International Consensus Report. Am J Hematol. 2025 10; 100(10):1813-1827. Al-Samkari H, Kasthuri RS, Mager HJ, Zhou JY, Serra MM, Samuelson-Bannow BT, Van Doren LN, Piccirillo JF, Clancy MS, McCrae KR, Thomas SM, Riera-Mestre A, Pishko AM, Sewaralthahab S, Gossage JR, Iyer VN, Hermans C, Hammill A, Winship I, Mei-Zahav M, von Drygalski A, Olitsky S, Faughnan ME. PMID: 40662351; PMCID: PMC12417758.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Proactive measures to reduce maternal mortality and post-partum hemorrhage in sub-Saharan Africa: the hematology perspective. Expert Rev Hematol. 2025 Oct; 18(10):771-775. Chumappumkal Joseph B, Emenalom EC, Silva P, von Drygalski A. PMID: 40583200.
      View in: PubMed   Mentions:    Fields:    
    16. Acute obstetric coagulopathy: need for innovation. Blood Adv. 2025 Jun 10; 9(11):2781-2782. Chumappumkal Joseph B, von Drygalski A. PMID: 40456021; PMCID: PMC12188218.
      View in: PubMed   Mentions:    Fields:    
    17. Synovial Gene expression after Hemarthrosis differs between FVIII-deficient mice treated with recombinant FVIII or FVIII-Fc Fusion Protein. PLoS One. 2025; 20(5):e0320322. Chumappumkal Joseph B, Whisenant TC, Cooke EJ, Zhou JY, Falah N, De-Pablo Moreno JA, von Drygalski A. PMID: 40388523; PMCID: PMC12088034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Hemosiderin quantification in hemophilic arthropathy using quantitative magnetic resonance imaging. Sci Rep. 2025 Apr 24; 15(1):14353. Sedaghat S, Luck JV, von Drygalski A, Fu E, Park JI, Gehling KG, Ma Y, Ball S, Chang EY, Du J, Jang H. PMID: 40274909; PMCID: PMC12022072.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Perioperative Management With Efanesoctocog Alfa in Patients With Haemophilia A in the Phase 3 XTEND-1 and XTEND-Kids Studies. Haemophilia. 2025 May; 31(3):391-400. Klamroth R, von Drygalski A, Hermans C, Park YS, Chan AKC, Kupesiz A, Alvarez-Román MT, Malec L, Santagostino E, Neill G, Bystrická L, Dumont J, Abad-Franch L, Fetita LS, Khoo L. PMID: 40099428; PMCID: PMC12175115.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    20. Management challenge of a rare concomitant platelet glycoprotein IV/CD36 and IIb/IIIa deficiencies: Case illustration. Transfusion. 2025 Apr; 65(4):767-772. Sekayan T, Allen ES, Kopko P, Stephens LD, Zhao M, Curtis BR, Sullivan MJ, Trapp-Stamborski V, von Drygalski A. PMID: 40033798; PMCID: PMC12005580.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Real-world impact of emicizumab and immunosuppression on acquired hemophilia A: a multicenter US cohort. Blood Adv. 2024 Nov 26; 8(22):5896-5905. Poston JN, Bryan C, von Drygalski A, Al Banaa K, Zhou JY, Parnes A, Chen EC, Khan O, Ellsworth P, Cafuir L, Walsh C, Escobar MA, Wu JF, Malec LM, Kessler CM, Janbain M, Kruse-Jarres R. PMID: 39361769; PMCID: PMC11612364.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Optimizing liver health before and after gene therapy for hemophilia A. Blood Adv. 2024 10 08; 8(19):5203-5212. Ragni MV, Mead H, de Jong YP, Kaczmarek R, Leavitt AD, Long B, Nugent DJ, Sabatino DE, Fong S, von Drygalski A, Walsh CE, Luxon BA. PMID: 38843379; PMCID: PMC11530393.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Evaluating the impact of a year-long external mentorship pilot program in classical hematology. Blood Adv. 2024 09 24; 8(18):4833-4844. Qureshy Z, Nair P, Vesely SK, King AA, Lee AI, Connell NT, von Drygalski A, Wong-Sefidan I, Murphy MC, Mistry RH, Zon RL, Reid EG, Fritz J, Park SJ. PMID: 39087874; PMCID: PMC11416643.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Traumatic bleeding and mortality in mice are intensified by iron deficiency anemia and can be rescued with tranexamic acid. Res Pract Thromb Haemost. 2024 Aug; 8(6):102543. Joseph BC, Sekayan T, Falah N, Barnes RFW, Flood V, De Pablo-Moreno JA, von Drygalski A. PMID: 39286605; PMCID: PMC11403369.
      View in: PubMed   Mentions: 1  
    25. International Prophylaxis Study Group (IPSG) haemophilia joint MRI scale version 2.0. Haemophilia. 2024 May; 30(3):862-864. Lundin B, Bakeer N, Dunn AL, Gibikote S, Keshava SN, Ljung RCR, Papakonstantinou O, Pergantou H, Strike K, Drygalski AV, Zhang N, Babyn P, Dover S, Doria AS. PMID: 38634801.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Three-year outcomes of valoctocogene roxaparvovec gene therapy for hemophilia A. J Thromb Haemost. 2024 07; 22(7):1880-1893. Madan B, Ozelo MC, Raheja P, Symington E, Quon DV, Leavitt AD, Pipe SW, Lowe G, Kenet G, Reding MT, Mason J, Wang M, von Drygalski A, Klamroth R, Shapiro S, Chambost H, Dunn AL, Oldenburg J, Chou SC, Peyvandi F, Millar CM, Osmond D, Yu H, Dashiell-Aje E, Robinson TM, Mahlangu J. PMID: 38614387.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    27. Etranacogene dezaparvovec-drlb gene therapy for patients with hemophilia B (congenital factor IX deficiency). Expert Opin Biol Ther. 2023 Jul-Dec; 23(12):1173-1184. Sekayan T, Simmons DH, von Drygalski A. PMID: 37962325.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. The current challenges faced by people with hemophilia B. Eur J Haematol. 2024 Mar; 112(3):339-349. Miesbach W, von Drygalski A, Smith C, Sivamurthy K, Pinachyan K, Bensen-Kennedy D, Drelich D, Kulkarni R. PMID: 38082533.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Heterozygous congenital Factor VII deficiency with the 9729del4 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male. Blood Cells Mol Dis. 2016 Mar; 57:8-12. Cramer TJ, Anderson K, Navaz K, Brown JM, Mosnier LO, von Drygalski A. PMID: 26852649; PMCID: PMC4874642.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Advances and challenges in hemophilic arthropathy. Semin Hematol. 2016 Jan; 53(1):10-9. Wyseure T, Mosnier LO, von Drygalski A. PMID: 26805902; PMCID: PMC5034876.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    31. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thromb Haemost. 2016 Mar; 115(3):551-61. Bhat V, von Drygalski A, Gale AJ, Griffin JH, Mosnier LO. PMID: 26466980; PMCID: PMC4775351.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    32. Prevalence and risk factors for hypertension in hemophilia. Hypertension. 2013 Jul; 62(1):209-15. von Drygalski A, Kolaitis NA, Bettencourt R, Bergstrom J, Kruse-Jarres R, Quon DV, Wassel C, Li MC, Waalen J, Elias DJ, Mosnier LO, Allison M. PMID: 23630949; PMCID: PMC3850775.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    33. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):769-76. von Drygalski A, Furlan-Freguia C, Ruf W, Griffin JH, Mosnier LO. PMID: 23393392; PMCID: PMC3735365.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    34. Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux. Thromb Haemost. 2012 Nov; 108(5):981-91. von Drygalski A, Furlan-Freguia C, Mosnier LO, Yegneswaran S, Ruf W, Griffin JH. PMID: 23052565; PMCID: PMC3597782.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    35. Iron metabolism in man. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):599-606. von Drygalski A, Adamson JW. PMID: 22968710.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    36. Anemia after bariatric surgery cannot be explained by iron deficiency alone: results of a large cohort study. Surg Obes Relat Dis. 2011 Mar-Apr; 7(2):151-6. von Drygalski A, Andris DA, Nuttleman PR, Jackson S, Klein J, Wallace JR. PMID: 20702143.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    37. Anemia after bariatric surgery: more than just iron deficiency. Nutr Clin Pract. 2009 Apr-May; 24(2):217-26. von Drygalski A, Andris DA. PMID: 19321896.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    38. Anemia in cystic fibrosis: incidence, mechanisms, and association with pulmonary function and vitamin deficiency. Nutr Clin Pract. 2008 Oct-Nov; 23(5):557-63. von Drygalski A, Biller J. PMID: 18849562.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
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