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Annette Von Drygalski

TitleAssociate Clinical Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0878
San Diego CA 92122
Phone858-657-6028
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    Other Positions
    TitleDirector, Hemophilia and Thrombosis Treatment Center


    Collapse Biography 
    Collapse Awards and Honors
    San Diego County Medical Society2014Physician of Exceptional Excellence Award in Hematology
    National Hemophilia Foundation/Novo Nordisk2013Career Development Award
    Bayer Healthcare2012Early Career Development Award
    American Society of Hematology2010American Society of Hematology Research Training Fellowship Award

    Collapse Overview 
    Collapse Overview
    Dr. von Drygalski is the Director of the Hemophilia and Thrombosis Treatment Center at UCSD (http://health.ucsd.edu/specialties/hemophilia/Pages/default.aspx) and her research interests involve basic, translational and clinical science in the field of hemostasis and thrombosis, specifically hemophilia.

    Dr. von Drygalski collaborates with Laurent O. Mosnier and John H. Griffin, Ph.D., at The Scripps Research Institute in La Jolla, focusing on the development of novel bypassing treatment strategies, mechanisms of fibrinolysis and joint disease in hemophilia. Dr. von Drygalski maintains a clinical research program studying the aging patient with hemophilia in aspects such as hemophilic arthropathy and the hypertension of hemophilia. She is the primary institutional investigator for several international clinical trials evaluating new treatment options for patients with hemophilia. Dr. von Drygalski was the recent recipient of a National Hemophilia/Novo Nordisk Career Development Award and a Bayer Early Career Development Award.


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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cooke EJ, Zhou JY, Wyseure T, Joshi S, Bhat V, Durden DL, Mosnier LO, von Drygalski A. Erratum to: Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice. Thromb Haemost. 2018 Aug 02. PMID: 30071568.
      View in: PubMed
    2. Wyseure T, Cooke EJ, Declerck PJ, Behrendt N, Meijers JCM, von Drygalski A, Mosnier LO. Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding. Blood. 2018 Jul 19. PMID: 30026184.
      View in: PubMed
    3. Sood SL, Cheng D, Ragni M, Kessler CM, Quon D, Shapiro AD, Key NS, Manco-Johnson MJ, Cuker A, Kempton C, Wang TF, Eyster ME, Kuriakose P, von Drygalski A, Gill JC, Wheeler A, Kouides P, Escobar MA, Leissinger C, Galdzicka S, Corson M, Watson C, Konkle BA. A cross-sectional analysis of cardiovascular disease in the hemophilia population. Blood Adv. 2018 Jun 12; 2(11):1325-1333. PMID: 29895623.
      View in: PubMed
    4. von Drygalski A, Moore RE, Nguyen S, Barnes RFW, Volland LM, Hughes TH, Du J, Chang EY. Advanced Hemophilic Arthropathy: Sensitivity of Soft Tissue Discrimination With Musculoskeletal Ultrasound. J Ultrasound Med. 2018 Jan 24. PMID: 29363781.
      View in: PubMed
    5. Lu X, Ma Y, Chang EY, He Q, Searleman A, von Drygalski A, Du J. Simultaneous quantitative susceptibility mapping (QSM) and R2* for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study. Magn Reson Med. 2018 Apr; 79(4):2315-2322. PMID: 29314215.
      View in: PubMed
    6. von Drygalski A, Rappazzo KC, Barnes RFW, Chang EY. Knee Fat Pad Volumes in Patients with Hemophilia and Their Relationship with Osteoarthritis. Arthritis. 2017; 2017:1578623. PMID: 29359047.
      View in: PubMed
    7. Barnes RFW, Cramer TJ, Hughes TH, von Drygalski A. The hypertension of hemophilia is associated with vascular remodeling in the joint. Microcirculation. 2017 Oct; 24(7). PMID: 28627086.
      View in: PubMed
    8. Barnes RF, Cramer TJ, Sait AS, Kruse-Jarres R, Quon DV, von Drygalski A. The Hypertension of Hemophilia Is Not Explained by the Usual Cardiovascular Risk Factors: Results of a Cohort Study. Int J Hypertens. 2016; 2016:2014201. PMID: 27965893.
      View in: PubMed
    9. Huang WT, Cang WC, Derry KL, Lane JR, von Drygalski A. Four-Factor Prothrombin Complex Concentrate for Coagulopathy Reversal in Patients With Liver Disease. Clin Appl Thromb Hemost. 2017 Nov; 23(8):1028-1035. PMID: 27628534.
      View in: PubMed
    10. Kidder W, Chang EY, M Moran C, Rose SC, von Drygalski A. Persistent Vascular Remodeling and Leakiness are Important Components of the Pathobiology of Re-bleeding in Hemophilic Joints: Two Informative Cases. Microcirculation. 2016 07; 23(5):373-8. PMID: 26833634.
      View in: PubMed
    11. Gale AJ, Bhat V, Pellequer JL, Griffin JH, Mosnier LO, Von Drygalski A. Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding. Pharm Res. 2016 06; 33(6):1517-26. PMID: 26960296; PMCID: PMC4854778 [Available on 06/01/17].
    12. Cramer TJ, Anderson K, Navaz K, Brown JM, Mosnier LO, von Drygalski A. Heterozygous congenital Factor VII deficiency with the 9729del4 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male. Blood Cells Mol Dis. 2016 Mar; 57:8-12. PMID: 26852649.
      View in: PubMed
    13. Wyseure T, Mosnier LO, von Drygalski A. Advances and challenges in hemophilic arthropathy. Semin Hematol. 2016 Jan; 53(1):10-9. PMID: 26805902; PMCID: PMC5034876 [Available on 01/01/17].
    14. Bhat V, von Drygalski A, Gale AJ, Griffin JH, Mosnier LO. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thromb Haemost. 2016 Mar; 115(3):551-61. PMID: 26466980; PMCID: PMC4775351 [Available on 02/28/17].
    15. Bhat V, Olmer M, Joshi S, Durden DL, Cramer TJ, Barnes RF, Ball ST, Hughes TH, Silva M, Luck JV, Moore RE, Mosnier LO, von Drygalski A. Vascular remodeling underlies rebleeding in hemophilic arthropathy. Am J Hematol. 2015 Nov; 90(11):1027-35. PMID: 26257191; PMCID: PMC4618067 [Available on 11/01/16].
    16. von Drygalski A, Bhat V, Gale AJ, Burnier L, Cramer TJ, Griffin JH, Mosnier LO. An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C. PLoS One. 2014; 9(8):e104304. PMID: 25127130; PMCID: PMC4134195.
    17. Macauley MS, Pfrengle F, Rademacher C, Nycholat CM, Gale AJ, von Drygalski A, Paulson JC. Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. J Clin Invest. 2013 Jul; 123(7):3074-83. PMID: 23722906; PMCID: PMC3706185.
    18. von Drygalski A, Kolaitis NA, Bettencourt R, Bergstrom J, Kruse-Jarres R, Quon DV, Wassel C, Li MC, Waalen J, Elias DJ, Mosnier LO, Allison M. Prevalence and risk factors for hypertension in hemophilia. Hypertension. 2013 Jul; 62(1):209-15. PMID: 23630949; PMCID: PMC3850775.
    19. von Drygalski A, Furlan-Freguia C, Ruf W, Griffin JH, Mosnier LO. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):769-76. PMID: 23393392; PMCID: PMC3735365.
    20. von Drygalski A, Furlan-Freguia C, Mosnier LO, Yegneswaran S, Ruf W, Griffin JH. Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux. Thromb Haemost. 2012 Nov; 108(5):981-91. PMID: 23052565; PMCID: PMC3597782.
    21. von Drygalski A, Adamson JW. Iron metabolism in man. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):599-606. PMID: 22968710.
      View in: PubMed
    22. von Drygalski A, Adamson JW. Ironing out fatigue. Blood. 2011 Sep 22; 118(12):3191-2. PMID: 21940826.
      View in: PubMed
    23. von Drygalski A, Andris DA, Nuttleman PR, Jackson S, Klein J, Wallace JR. Anemia after bariatric surgery cannot be explained by iron deficiency alone: results of a large cohort study. Surg Obes Relat Dis. 2011 Mar-Apr; 7(2):151-6. PMID: 20702143.
      View in: PubMed
    24. von Drygalski A, Andris DA. Anemia after bariatric surgery: more than just iron deficiency. Nutr Clin Pract. 2009 Apr-May; 24(2):217-26. PMID: 19321896.
      View in: PubMed
    25. von Drygalski A, Biller J. Anemia in cystic fibrosis: incidence, mechanisms, and association with pulmonary function and vitamin deficiency. Nutr Clin Pract. 2008 Oct-Nov; 23(5):557-63. PMID: 18849562.
      View in: PubMed
    26. Von Drygalski A, Curtis BR, Bougie DW, McFarland JG, Ahl S, Limbu I, Baker KR, Aster RH. Vancomycin-induced immune thrombocytopenia. N Engl J Med. 2007 Mar 01; 356(9):904-10. PMID: 17329697.
      View in: PubMed
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