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Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease. J Hepatol. 2026 Jun; 84(6):1045-1061.
Fondevila MF, Kreimeyer H, Hsu CL, Tamargo-Azpilicueta J, Day LZ, Gritsenko M, Attah K, Cabré N, Harberts A, Tonetti FR, Yang Y, Yamazaki T, Schöler D, Eguileor A, Blasio C, Meijnikman AS, Zhang X, Garcia-Carbonell R, Hook V, Zhou E, Sun Z, Jacobs JM, Turner JR, Llorente C, Glass CK, Stärkel P, Reinheckel T, Diaz-Moreno I, Gonzalez DJ, Schnabl B. PMID: 41654223; PMCID: PMC13197211.
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HumansAnimalsCells
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ATF4 drives regulatory T cell functional specification in homeostasis and obesity. Sci Immunol. 2025 03 14; 10(105):eadp7193.
Wang K, Farrell A, Zhou E, Qin H, Zeng Z, Zhou K, Cunha E Rocha K, Zhang D, Wang G, Atakilit A, Sheppard D, Lu LF, Jin C, Ying W. PMID: 40085690.
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PubMed Mentions:
4 Fields:
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AnimalsCells
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DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice. iScience. 2024 Jun 21; 27(6):109830.
Ge X, Slütter B, Lambooij JM, Zhou E, Ying Z, Agirman C, Heijink M, Rimbert A, Guigas B, Kuiper J, Müller C, Bracher F, Giera M, Kooijman S, Rensen PCN, Wang Y, Schönke M. PMID: 38770137; PMCID: PMC11103367.
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5
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Nat Immunol. 2023 11; 24(11):1825-1838.
Bennett H, Troutman TD, Zhou E, Spann NJ, Link VM, Seidman JS, Nickl CK, Abe Y, Sakai M, Pasillas MP, Marlman JM, Guzman C, Hosseini M, Schnabl B, Glass CK. PMID: 37735593; PMCID: PMC10602851.
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11 Fields:
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AnimalsCells
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Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation. EMBO Mol Med. 2023 08 07; 15(8):e16845.
Zhou E, Ge X, Nakashima H, Li R, van der Zande HJP, Liu C, Li Z, Müller C, Bracher F, Mohammed Y, de Boer JF, Kuipers F, Guigas B, Glass CK, Rensen PCN, Giera M, Wang Y. PMID: 37357756; PMCID: PMC10405065.
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22 Fields:
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HumansAnimals
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Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4. JCI Insight. 2023 02 22; 8(4).
Li Z, Zhou E, Liu C, Wicks H, Yildiz S, Razack F, Ying Z, Kooijman S, Koonen DPY, Heijink M, Kostidis S, Giera M, Sanders IMJG, Kuijper EJ, Smits WK, van Dijk KW, Rensen PCN, Wang Y. PMID: 36810253; PMCID: PMC9977501.
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28 Fields:
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HumansAnimals
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FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis. Elife. 2023 01 17; 12.
Liu C, Schönke M, Spoorenberg B, Lambooij JM, van der Zande HJP, Zhou E, Tushuizen ME, Andreasson AC, Park A, Oldham S, Uhrbom M, Ahlstedt I, Ikeda Y, Wallenius K, Peng XR, Guigas B, Boon MR, Wang Y, Rensen PCN. PMID: 36648330; PMCID: PMC9928421.
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32 Fields:
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HumansAnimals
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A Systems Analysis of Phenotype Heterogeneity in APOE*3Leiden.CETP Mice Induced by Long-Term High-Fat High-Cholesterol Diet Feeding. Nutrients. 2022 Nov 21; 14(22).
Paalvast Y, Zhou E, Rozendaal YJW, Wang Y, Gerding A, van Dijk TH, de Boer JF, Rensen PCN, van Dijk KW, Kuivenhoven JA, Bakker BM, van Riel NAW, Groen AK. PMID: 36432620; PMCID: PMC9698005.
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PubMed Mentions:
1 Fields:
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Animals
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Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. Cardiovasc Res. 2022 01 29; 118(2):489-502.
Liu C, Schönke M, Zhou E, Li Z, Kooijman S, Boon MR, Larsson M, Wallenius K, Dekker N, Barlind L, Peng XR, Wang Y, Rensen PCN. PMID: 33693480; PMCID: PMC8803070.
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PubMed Mentions:
40 Fields:
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Animals
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Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice. Pharmacol Res. 2021 05; 167:105524.
Zhou E, Li Z, Nakashima H, Choukoud A, Kooijman S, Berbée JFP, Rensen PCN, Wang Y. PMID: 33667684.
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7 Fields:
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HumansAnimals
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Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice. Arterioscler Thromb Vasc Biol. 2021 04; 41(4):1474-1486.
Zhou E, Li Z, Nakashima H, Liu C, Ying Z, Foks AC, Berbée JFP, van Dijk KW, Rensen PCN, Wang Y. PMID: 33567866.
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PubMed Mentions:
3 Fields:
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HumansAnimalsCells
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Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development. Cardiovasc Res. 2020 08 01; 116(10):1710-1720.
Zhou E, Hoeke G, Li Z, Eibergen AC, Schonk AW, Koehorst M, Boverhof R, Havinga R, Kuipers F, Coskun T, Boon MR, Groen AK, Rensen PCN, Berbée JFP, Wang Y. PMID: 31589318; PMCID: PMC7643538.
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PubMed Mentions:
14 Fields:
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Animals
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Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions. Diab Vasc Dis Res. 2020 Jan-Feb; 17(1):1479164119892140.
Thiem K, Hoeke G, Zhou E, Hijmans A, Houben T, Boels MG, Mol IM, Lutgens E, Shiri-Sverdlov R, Bussink J, Kanneganti TD, Boon MR, Stienstra R, Tack CJ, Rensen PC, Netea MG, Berbée JF, van Diepen JA. PMID: 31868000; PMCID: PMC7510497.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20623-20634.
Körner A, Zhou E, Müller C, Mohammed Y, Herceg S, Bracher F, Rensen PCN, Wang Y, Mirakaj V, Giera M. PMID: 31548397; PMCID: PMC6789642.
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PubMed Mentions:
36 Fields:
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HumansAnimalsCells
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Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice. Sci Rep. 2019 03 13; 9(1):4337.
Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, Mol IM, Mouktaroudi M, Bussink J, Kanneganti TD, Lutgens E, Stienstra R, Tack CJ, Netea MG, Rensen PCN, Berbée JFP, van Diepen JA. PMID: 30867470; PMCID: PMC6416398.
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PubMed Mentions:
7 Fields:
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Animals
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Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut. 2018 07; 67(7):1269-1279.
Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JFP, Heijink M, Giera M, Willems van Dijk K, Groen AK, Rensen PCN, Wang Y. PMID: 29101261.
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323 Fields:
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Animals
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Oxidized low-density lipoprotein-induced microparticles promote endothelial monocyte adhesion via intercellular adhesion molecule 1. Am J Physiol Cell Physiol. 2017 Nov 01; 313(5):C567-C574.
Fu Z, Zhou E, Wang X, Tian M, Kong J, Li J, Ji L, Niu C, Shen H, Dong S, Liu C, Vermorken A, Willard B, Zu L, Zheng L. PMID: 28814403.
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21 Fields:
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HumansAnimalsCells
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Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration. Lipids Health Dis. 2017 Jan 10; 16(1):3.
Zhou B, Zu L, Chen Y, Zheng X, Wang Y, Pan B, Dong M, Zhou E, Zhao M, Zhang Y, Zheng L, Gao W. PMID: 28069011; PMCID: PMC5223295.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion. J Am Heart Assoc. 2016 10 17; 5(10).
Niu C, Wang X, Zhao M, Cai T, Liu P, Li J, Willard B, Zu L, Zhou E, Li Y, Pan B, Yang F, Zheng L. PMID: 27792649; PMCID: PMC5121506.
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85 Fields:
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HumansCells
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Time course of various cell origin circulating microparticles in ST-segment elevation myocardial infarction patients undergoing percutaneous transluminal coronary intervention. Exp Ther Med. 2016 Apr; 11(4):1481-1486.
Zhou B, Li J, Chen S, Zhou E, Zheng L, Zu L, Gao W. PMID: 27073469; PMCID: PMC4812389.
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4
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Association of endothelial microparticle with NO, eNOS, ET-1, and fractional flow reserve in patients with coronary intermediate lesions. Biomarkers. 2015; 20(6-7):429-35.
Song R, Chou YI, Kong J, Li J, Pan B, Cui M, Zhou E, Zhang Y, Zheng L. PMID: 26554436.
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PubMed Mentions:
7 Fields:
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HumansCells
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Endothelial microparticles after antihypertensive and lipid-lowering therapy inhibit the adhesion of monocytes to endothelial cells. Int J Cardiol. 2016 Jan 01; 202:756-9.
Zu L, Ren C, Pan B, Zhou B, Zhou E, Niu C, Wang X, Zhao M, Gao W, Guo L, Zheng L. PMID: 26476027.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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High density lipoprotein promotes proliferation of adipose-derived stem cells via S1P1 receptor and Akt, ERK1/2 signal pathways. Stem Cell Res Ther. 2015 May 15; 6:95.
Shen H, Zhou E, Wei X, Fu Z, Niu C, Li Y, Pan B, Mathew AV, Wang X, Pennathur S, Zheng L, Wang Y. PMID: 25976318; PMCID: PMC4453044.
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PubMed Mentions:
20 Fields:
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HumansAnimalsCells