Juan Lasheras

Title(s)	Professor, Mechanical and Aerospace Engineering
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Development of patient-specific mathematical models for the transport of solute molecules in the cerebrospinal fluid (CSF) along the spinal canal
NIH R01NS120343Sep 30, 2020 - Aug 31, 2025
Role: Principal Investigator

Bio-Mechanics of Directional Migration of Leukocytes
NIH R01GM084227Sep 30, 2010 - Jun 30, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation. PLoS Pathog. 2022 03; 18(3):e1010309. Yeh YT, Skinner DE, Criado-Hidalgo E, Chen NS, Garcia-De Herreros A, El-Sakkary N, Liu L, Zhang S, Kandasamy A, Chien S, Lasheras JC, Del Álamo JC, Caffrey CR. PMID: 35316298; PMCID: PMC8939816.

View in: PubMed Mentions: 1 Fields:
Mic Microbiology
Translation:Humans Animals Cells
Transmantle Pressure Computed from MR Imaging Measurements of Aqueduct Flow and Dimensions. AJNR Am J Neuroradiol. 2021 10; 42(10):1815-1821. Sincomb SJ, Coenen W, Criado-Hidalgo E, Wei K, King K, Borzage M, Haughton V, Sánchez AL, Lasheras JC. PMID: 34385144; PMCID: PMC8562736.

View in: PubMed Mentions: 2 Fields:
Neu Neurology Rad Radiology
Translation:Humans
The interplay between matrix deformation and the coordination of turning events governs directed neutrophil migration in 3D matrices. Sci Adv. 2021 Jul; 7(29). François J, Kandasamy A, Yeh YT, Schwartz A, Ayala C, Meili R, Chien S, Lasheras JC, Del Álamo JC. PMID: 34261650; PMCID: PMC8279509.

View in: PubMed Mentions: 4 Fields:
Sci Science
Elucidating the Biomechanics of Leukocyte Transendothelial Migration by Quantitative Imaging. Front Cell Dev Biol. 2021; 9:635263. Schwartz AB, Campos OA, Criado-Hidalgo E, Chien S, Del Álamo JC, Lasheras JC, Yeh YT. PMID: 33855018; PMCID: PMC8039384.

View in: PubMed Mentions: 6
Interaction of a Migrating Cell Monolayer with a Flexible Fiber. Biophys J. 2021 02 02; 120(3):539-546. Valencia L, López-Llorente V, Lasheras JC, Jorcano JL, Rodríguez-Rodríguez J. PMID: 33359462; PMCID: PMC7895989.

View in: PubMed Mentions: Fields:
Bio Biophysics
Translation:Cells
Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020922118. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. PMID: 32489641; PMCID: PMC7238833.

View in: PubMed Mentions: 1
Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery. AJNR Am J Neuroradiol. 2019 07; 40(7):1242-1249. Coenen W, Gutiérrez-Montes C, Sincomb S, Criado-Hidalgo E, Wei K, King K, Haughton V, Martínez-Bazán C, Sánchez AL, Lasheras JC. PMID: 31196863; PMCID: PMC7048533.

View in: PubMed Mentions: 8 Fields:
Neu Neurology Rad Radiology
Translation:Humans
Three-Dimensional Monolayer Stress Microscopy. Biophys J. 2019 07 09; 117(1):111-128. Serrano R, Aung A, Yeh YT, Varghese S, Lasheras JC, Del Álamo JC. PMID: 31103228; PMCID: PMC6626853.

View in: PubMed Mentions: 13 Fields:
Bio Biophysics
Translation:Humans Cells
Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment. J R Soc Interface. 2019 01 31; 16(150):20180675. Zhang S, Skinner D, Joshi P, Criado-Hidalgo E, Yeh YT, Lasheras JC, Caffrey CR, Del Alamo JC. PMID: 30958153; PMCID: PMC6364656.

View in: PubMed Mentions: 4 Fields:
Bio Biology Bio Biomedical Engineering Bio Biophysics
Translation:Animals
Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):133-138. Yeh YT, Serrano R, François J, Chiu JJ, Li YJ, Del Álamo JC, Chien S, Lasheras JC. PMID: 29255056; PMCID: PMC5776826.

View in: PubMed Mentions: 23 Fields:
Sci Science
Translation:Humans Cells
Self-organized mechano-chemical dynamics in amoeboid locomotion of Physarum fragments. J Phys D Appl Phys. 2017 May 24; 50(20). Zhang S, Guy RD, Lasheras JC, Del Álamo JC. PMID: 30906070; PMCID: PMC6430145.

View in: PubMed Mentions: 7
Two-Layer Elastographic 3-D Traction Force Microscopy. Sci Rep. 2017 01 11; 7:39315. Álvarez-González B, Zhang S, Gómez-González M, Meili R, Firtel RA, Lasheras JC, Del Álamo JC. PMID: 28074837; PMCID: PMC5225457.

View in: PubMed Mentions: 13 Fields:
Sci Science
Translation:Animals
Cooperative cell motility during tandem locomotion of amoeboid cells. Mol Biol Cell. 2016 Apr 15; 27(8):1262-71. Bastounis E, Álvarez-González B, del Álamo JC, Lasheras JC, Firtel RA. PMID: 26912787; PMCID: PMC4831880.

View in: PubMed Mentions: 6 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals
Three-dimensional balance of cortical tension and axial contractility enables fast amoeboid migration. Biophys J. 2015 Feb 17; 108(4):821-832. Álvarez-González B, Meili R, Bastounis E, Firtel RA, Lasheras JC, Del Álamo JC. PMID: 25692587; PMCID: PMC4336364.

View in: PubMed Mentions: 25 Fields:
Bio Biophysics
Translation:Animals Cells
FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep. 2014 Aug 12; 4:6024. Hu YL, Lu S, Szeto KW, Sun J, Wang Y, Lasheras JC, Chien S. PMID: 25113375; PMCID: PMC4129417.

View in: PubMed Mentions: 95 Fields:
Sci Science
Translation:Animals Cells
Cytoskeletal Mechanics Regulating Amoeboid Cell Locomotion. Appl Mech Rev. 2014 Jun 05; 66(5). Alvarez-González B, Meili R, Firtel R, Bastounis E, Del Álamo JC, Lasheras JC. PMID: 25328163; PMCID: PMC4201387.

View in: PubMed Mentions: 7
Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol. 2014 Mar 17; 204(6):1045-61. Bastounis E, Meili R, Álvarez-González B, Francois J, del Álamo JC, Firtel RA, Lasheras JC. PMID: 24637328; PMCID: PMC3998796.

View in: PubMed Mentions: 33 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves. World J Pediatr Congenit Heart Surg. 2013 Oct; 4(4):362-6. Szeto K, Pastuszko P, del Álamo JC, Lasheras J, Nigam V. PMID: 24327628; PMCID: PMC6261454.

View in: PubMed Mentions: 9 Fields:
Car Cardiology Gen General Surgery Ped Pediatrics
Translation:Animals
Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy. PLoS One. 2013; 8(9):e69850. del Álamo JC, Meili R, Álvarez-González B, Alonso-Latorre B, Bastounis E, Firtel R, Lasheras JC. PMID: 24023712; PMCID: PMC3762859.

View in: PubMed Mentions: 52 Fields:
Med Medicine (General)Sci Science
Translation:Animals
Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2840-5. Lee HH, Lee HC, Chou CC, Hur SS, Osterday K, del Álamo JC, Lasheras JC, Chien S. PMID: 23359696; PMCID: PMC3581906.

View in: PubMed Mentions: 18 Fields:
Sci Science
Translation:Animals Cells
Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11110-5. Hur SS, del Álamo JC, Park JS, Li YS, Nguyen HA, Teng D, Wang KC, Flores L, Alonso-Latorre B, Lasheras JC, Chien S. PMID: 22665785; PMCID: PMC3396533.

View in: PubMed Mentions: 55 Fields:
Sci Science
Translation:Humans Animals Cells
The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility. Mol Biol Cell. 2011 Nov; 22(21):3995-4003. Bastounis E, Meili R, Alonso-Latorre B, del Álamo JC, Lasheras JC, Firtel RA. PMID: 21900496; PMCID: PMC3204062.

View in: PubMed Mentions: 18 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells. Cell Mol Bioeng. 2011 Dec; 4(4):603-615. Alonso-Latorre B, Del Álamo JC, Meili R, Firtel RA, Lasheras JC. PMID: 22207880; PMCID: PMC3234362.

View in: PubMed Mentions: 7
The mechanics of the adhesive locomotion of terrestrial gastropods. J Exp Biol. 2010 Nov 15; 213(Pt 22):3920-33. Lai JH, del Alamo JC, Rodríguez-Rodríguez J, Lasheras JC. PMID: 21037072; PMCID: PMC6514465.

View in: PubMed Mentions: 13 Fields:
Bio Biology
Translation:Animals
Myosin II is essential for the spatiotemporal organization of traction forces during cell motility. Mol Biol Cell. 2010 Feb 01; 21(3):405-17. Meili R, Alonso-Latorre B, del Alamo JC, Firtel RA, Lasheras JC. PMID: 19955212; PMCID: PMC2814786.

View in: PubMed Mentions: 49 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Recent advances in the application of computational mechanics to the diagnosis and treatment of cardiovascular disease. Rev Esp Cardiol. 2009 Jul; 62(7):781-805. Del Alamo JC, Marsden AL, Lasheras JC. PMID: 19709514; PMCID: PMC6089365.

View in: PubMed Mentions: 4 Fields:
Car Cardiology
Translation:Humans
Distribution of traction forces associated with shape changes during amoeboid cell migration. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:3346-9. Alonso-Latorre B, Meili R, Bastounis E, Del Alamo JC, Firtel R, Lasheras JC. PMID: 19964075; PMCID: PMC6157266.

View in: PubMed Mentions: 4 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Anisotropic rheology and directional mechanotransduction in vascular endothelial cells. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15411-6. del Alamo JC, Norwich GN, Li YS, Lasheras JC, Chien S. PMID: 18840694; PMCID: PMC2563098.

View in: PubMed Mentions: 38 Fields:
Sci Science
Translation:Animals Cells
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13343-8. Del Alamo JC, Meili R, Alonso-Latorre B, Rodríguez-Rodríguez J, Aliseda A, Firtel RA, Lasheras JC. PMID: 17684097; PMCID: PMC1940228.

View in: PubMed Mentions: 103 Fields:
Sci Science
Translation:Animals
Intraoperative brain ultrasound: a new approach to study flow dynamics in intracranial aneurysms. Ultrasound Med Biol. 2006 Sep; 32(9):1307-13. Hölscher T, Rodriguez-Rodriguez J, Wilkening WG, Lasheras JC, U HS. PMID: 16965970.

View in: PubMed Mentions: 4 Fields:
Dia Diagnostic Imaging
Translation:Humans
Flow changes caused by the sequential placement of stents across the neck of sidewall cerebral aneurysms. J Neurosurg. 2005 Nov; 103(5):891-902. Cantón G, Levy DI, Lasheras JC, Nelson PK. PMID: 16304994.

View in: PubMed Mentions: 52 Fields:
Neu Neurosurgery
Translation:Humans
Hemodynamic changes due to stent placement in bifurcating intracranial aneurysms. J Neurosurg. 2005 Jul; 103(1):146-55. Cantón G, Levy DI, Lasheras JC. PMID: 16121985.

View in: PubMed Mentions: 34 Fields:
Neu Neurosurgery
Translation:Humans
Changes in the intraaneurysmal pressure due to HydroCoil embolization. AJNR Am J Neuroradiol. 2005 Apr; 26(4):904-7. Cantón G, Levy DI, Lasheras JC. PMID: 15814942; PMCID: PMC7977101.

View in: PubMed Mentions: 11 Fields:
Neu Neurology Rad Radiology
Hemodynamic changes occurring during the progressive enlargement of abdominal aortic aneurysms. Ann Vasc Surg. 2004 Jan; 18(1):14-21. Salsac AV, Sparks SR, Lasheras JC. PMID: 14712379.

View in: PubMed Mentions: 21 Fields:
Gen General Surgery Vas Vascular Diseases
Translation:Humans