Juan Lasheras

InstitutionUniversity of California San Diego
DepartmentMechanical and Aerospace Engineering
Address9500 Gilman Drive #0411
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Bio-Mechanics of Directional Migration of Leukocytes
    NIH/NIGMS R01GM084227Sep 30, 2010 - Jun 30, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yeh YT, Serrano R, François J, Chiu JJ, Li YJ, Del Álamo JC, Chien S, Lasheras J. Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis. Proc Natl Acad Sci U S A. 2018 Jan 02; 115(1):133-138. PMID: 29255056.
      View in: PubMed
    2. Álvarez-González B, Zhang S, Gómez-González M, Meili R, Firtel RA, Lasheras J, Del Álamo JC. Two-Layer Elastographic 3-D Traction Force Microscopy. Sci Rep. 2017 Jan 11; 7:39315. PMID: 28074837.
      View in: PubMed
    3. Bastounis E, Álvarez-González B, del Álamo JC, Lasheras J, Firtel RA. Cooperative cell motility during tandem locomotion of amoeboid cells. Mol Biol Cell. 2016 Apr 15; 27(8):1262-71. PMID: 26912787; PMCID: PMC4831880.
    4. Álvarez-González B, Meili R, Bastounis E, Firtel RA, Lasheras J, Del Álamo JC. Three-dimensional balance of cortical tension and axial contractility enables fast amoeboid migration. Biophys J. 2015 Feb 17; 108(4):821-832. PMID: 25692587.
      View in: PubMed
    5. Hu YL, Lu S, Szeto KW, Sun J, Wang Y, Lasheras J, Chien S. FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep. 2014 Aug 12; 4:6024. PMID: 25113375; PMCID: PMC4129417.
    6. Alvarez-González B, Meili R, Firtel R, Bastounis E, Del Álamo JC, Lasheras J. Cytoskeletal Mechanics Regulating Amoeboid Cell Locomotion. Appl Mech Rev. 2014 Jun 05; 66(5). PMID: 25328163.
      View in: PubMed
    7. Bastounis E, Meili R, Álvarez-González B, Francois J, del Álamo JC, Firtel RA, Lasheras J. Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol. 2014 Mar 17; 204(6):1045-61. PMID: 24637328; PMCID: PMC3998796.
    8. Szeto K, Pastuszko P, del Álamo JC, Lasheras J, Nigam V. Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves. World J Pediatr Congenit Heart Surg. 2013 Oct; 4(4):362-6. PMID: 24327628.
      View in: PubMed
    9. del Álamo JC, Meili R, Álvarez-González B, Alonso-Latorre B, Bastounis E, Firtel R, Lasheras J. Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy. PLoS One. 2013; 8(9):e69850. PMID: 24023712; PMCID: PMC3762859.
    10. Lee HH, Lee HC, Chou CC, Hur SS, Osterday K, del Álamo JC, Lasheras J, Chien S. Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2840-5. PMID: 23359696; PMCID: PMC3581906.
    11. Hur SS, del Álamo JC, Park JS, Li YS, Nguyen HA, Teng D, Wang KC, Flores L, Alonso-Latorre B, Lasheras J, Chien S. Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11110-5. PMID: 22665785; PMCID: PMC3396533.
    12. Bastounis E, Meili R, Alonso-Latorre B, del Álamo JC, Lasheras J, Firtel RA. The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility. Mol Biol Cell. 2011 Nov; 22(21):3995-4003. PMID: 21900496; PMCID: PMC3204062.
    13. Alonso-Latorre B, Del Álamo JC, Meili R, Firtel RA, Lasheras J. An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells. Cell Mol Bioeng. 2011 Dec; 4(4):603-615. PMID: 22207880.
      View in: PubMed
    14. Lai JH, del Alamo JC, Rodríguez-Rodríguez J, Lasheras J. The mechanics of the adhesive locomotion of terrestrial gastropods. J Exp Biol. 2010 Nov 15; 213(Pt 22):3920-33. PMID: 21037072.
      View in: PubMed
    15. Meili R, Alonso-Latorre B, del Alamo JC, Firtel RA, Lasheras J. Myosin II is essential for the spatiotemporal organization of traction forces during cell motility. Mol Biol Cell. 2010 Feb 01; 21(3):405-17. PMID: 19955212; PMCID: PMC2814786.
    16. Del Alamo JC, Marsden AL, Lasheras J. Recent advances in the application of computational mechanics to the diagnosis and treatment of cardiovascular disease. Rev Esp Cardiol. 2009 Jul; 62(7):781-805. PMID: 19709514.
      View in: PubMed
    17. del Alamo JC, Norwich GN, Li YS, Lasheras J, Chien S. Anisotropic rheology and directional mechanotransduction in vascular endothelial cells. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15411-6. PMID: 18840694; PMCID: PMC2563098.
    18. Del Alamo JC, Meili R, Alonso-Latorre B, Rodríguez-Rodríguez J, Aliseda A, Firtel RA, Lasheras J. Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13343-8. PMID: 17684097; PMCID: PMC1940228.
    19. Hölscher T, Rodriguez-Rodriguez J, Wilkening WG, Lasheras J, U HS. Intraoperative brain ultrasound: a new approach to study flow dynamics in intracranial aneurysms. Ultrasound Med Biol. 2006 Sep; 32(9):1307-13. PMID: 16965970.
      View in: PubMed
    20. Cantón G, Levy DI, Lasheras J, Nelson PK. Flow changes caused by the sequential placement of stents across the neck of sidewall cerebral aneurysms. J Neurosurg. 2005 Nov; 103(5):891-902. PMID: 16304994.
      View in: PubMed
    21. Cantón G, Levy DI, Lasheras J. Hemodynamic changes due to stent placement in bifurcating intracranial aneurysms. J Neurosurg. 2005 Jul; 103(1):146-55. PMID: 16121985.
      View in: PubMed
    22. Cantón G, Levy DI, Lasheras J. Changes in the intraaneurysmal pressure due to HydroCoil embolization. AJNR Am J Neuroradiol. 2005 Apr; 26(4):904-7. PMID: 15814942.
      View in: PubMed
    23. Salsac AV, Sparks SR, Lasheras J. Hemodynamic changes occurring during the progressive enlargement of abdominal aortic aneurysms. Ann Vasc Surg. 2004 Jan; 18(1):14-21. PMID: 14712379.
      View in: PubMed