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    Melissa Gymrek

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0639
    CA La Jolla 92093
    Phone858-246-0895
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gymrek M, Willems T, Reich D, Erlich Y. Interpreting short tandem repeat variations in humans using mutational constraint. Nat Genet. 2017 Sep 11. PMID: 28892063.
        View in: PubMed
      2. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 2017 Jun 29; 170(1):199-212.e20. PMID: 28666119.
        View in: PubMed
      3. Willems T, Zielinski D, Yuan J, Gordon A, Gymrek M, Erlich Y. Genome-wide profiling of heritable and de novo STR variations. Nat Methods. 2017 Jun; 14(6):590-592. PMID: 28436466.
        View in: PubMed
      4. Gymrek M. A genomic view of short tandem repeats. Curr Opin Genet Dev. 2017 Jun; 44:9-16. PMID: 28213161.
        View in: PubMed
      5. Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538(7624):201-206. PMID: 27654912.
        View in: PubMed
      6. Gymrek M, Farjoun Y. Recommendations for open data science. Gigascience. 2016; 5:22. PMID: 27195107; PMCID: PMC4870738.
        View in: PubMed, PubMed Central
      7. Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A, Wilson Sayres MA, Ayub Q, McCarthy SA, Narechania A, Kashin S, Chen Y, Banerjee R, Rodriguez-Flores JL, Cerezo M, Shao H, Gymrek M, Malhotra A, Louzada S, Desalle R, Ritchie GR, Cerveira E, Fitzgerald TW, Garrison E, Marcketta A, Mittelman D, Romanovitch M, Zhang C, Zheng-Bradley X, Abecasis GR, McCarroll SA, Flicek P, Underhill PA, Coin L, Zerbino DR, Yang F, Lee C, Clarke L, Auton A, Erlich Y, Handsaker RE, Bustamante CD, Tyler-Smith C. Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nat Genet. 2016 Jun; 48(6):593-9. PMID: 27111036; PMCID: PMC4884158 [Available on 12/01/16].
        View in: PubMed, PubMed Central
      8. Willems T, Gymrek M, Poznik GD, Tyler-Smith C, Erlich Y. Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates. Am J Hum Genet. 2016 May 05; 98(5):919-933. PMID: 27126583; PMCID: PMC4863667 [Available on 11/05/16].
        View in: PubMed, PubMed Central
      9. Quilez J, Guilmatre A, Garg P, Highnam G, Gymrek M, Erlich Y, Joshi RS, Mittelman D, Sharp AJ. Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans. Nucleic Acids Res. 2016 May 05; 44(8):3750-62. PMID: 27060133; PMCID: PMC4857002.
        View in: PubMed, PubMed Central
      10. Gymrek M, Willems T, Guilmatre A, Zeng H, Markus B, Georgiev S, Daly MJ, Price AL, Pritchard JK, Sharp AJ, Erlich Y. Abundant contribution of short tandem repeats to gene expression variation in humans. Nat Genet. 2016 Jan; 48(1):22-9. PMID: 26642241; PMCID: PMC4909355.
        View in: PubMed, PubMed Central
      11. Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell. 2014 Nov 10; 26(5):668-81. PMID: 25453903; NIHMSID: NIHMS639914.
        View in: PubMed
      12. Gymrek M. PyBamView: a browser-based application for viewing short read alignments. Bioinformatics. 2014 Dec 01; 30(23):3405-7. PMID: 25147359.
        View in: PubMed
      13. Willems T, Gymrek M, Highnam G, Mittelman D, Erlich Y. The landscape of human STR variation. Genome Res. 2014 Nov; 24(11):1894-904. PMID: 25135957; PMCID: PMC4216929.
        View in: PubMed, PubMed Central
      14. Zielinski D, Markus B, Sheikh M, Gymrek M, Chu C, Zaks M, Srinivasan B, Hoffman JD, Aizenbud D, Erlich Y. OTX2 duplication is implicated in hemifacial microsomia. PLoS One. 2014; 9(5):e96788. PMID: 24816892; PMCID: PMC4016008.
        View in: PubMed, PubMed Central
      15. Breker M, Gymrek M, Moldavski O, Schuldiner M. LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast. Nucleic Acids Res. 2014 Jan; 42(Database issue):D726-30. PMID: 24150937; PMCID: PMC3965041.
        View in: PubMed, PubMed Central
      16. Breker M, Gymrek M, Schuldiner M. A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol. 2013 Mar 18; 200(6):839-50. PMID: 23509072; PMCID: PMC3601363.
        View in: PubMed, PubMed Central
      17. Gymrek M, McGuire AL, Golan D, Halperin E, Erlich Y. Identifying personal genomes by surname inference. Science. 2013 Jan 18; 339(6117):321-4. PMID: 23329047.
        View in: PubMed
      18. Gymrek M, Erlich Y. Profiling short tandem repeats from short reads. Methods Mol Biol. 2013; 1038:113-35. PMID: 23872972.
        View in: PubMed
      19. Zielinski D, Gymrek M, Erlich Y. Back to the family: a renewed approach to rare variant studies. Genome Med. 2012; 4(12):97. PMID: 23253160; PMCID: PMC3580437.
        View in: PubMed, PubMed Central
      20. Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012 Dec 07; 151(6):1185-99. PMID: 23217706; PMCID: PMC3526953.
        View in: PubMed, PubMed Central
      21. Nadler-Holly M, Breker M, Gruber R, Azia A, Gymrek M, Eisenstein M, Willison KR, Schuldiner M, Horovitz A. Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18833-8. PMID: 23112166; PMCID: PMC3503220.
        View in: PubMed, PubMed Central
      22. Gymrek M, Golan D, Rosset S, Erlich Y. lobSTR: A short tandem repeat profiler for personal genomes. Genome Res. 2012 Jun; 22(6):1154-62. PMID: 22522390; PMCID: PMC3371701.
        View in: PubMed, PubMed Central
      23. Ram O, Goren A, Amit I, Shoresh N, Yosef N, Ernst J, Kellis M, Gymrek M, Issner R, Coyne M, Durham T, Zhang X, Donaghey J, Epstein CB, Regev A, Bernstein BE. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell. 2011 Dec 23; 147(7):1628-39. PMID: 22196736; PMCID: PMC3312319.
        View in: PubMed, PubMed Central
      24. Gymrek M, Erlich Y. Using DNA sequencers as stethoscopes. Genome Med. 2011 Nov 21; 3(11):73. PMID: 22103962; PMCID: PMC3308028.
        View in: PubMed, PubMed Central
      25. Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics. 2010 Nov; 9(11):2558-70. PMID: 20631208; PMCID: PMC2984232.
        View in: PubMed, PubMed Central
      26. Ozsolak F, Goren A, Gymrek M, Guttman M, Regev A, Bernstein BE, Milos PM. Digital transcriptome profiling from attomole-level RNA samples. Genome Res. 2010 Apr; 20(4):519-25. PMID: 20133332; PMCID: PMC2847755.
        View in: PubMed, PubMed Central
      27. Goren A, Ozsolak F, Shoresh N, Ku M, Adli M, Hart C, Gymrek M, Zuk O, Regev A, Milos PM, Bernstein BE. Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nat Methods. 2010 Jan; 7(1):47-9. PMID: 19946276; PMCID: PMC2862482.
        View in: PubMed, PubMed Central
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