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Melissa Gymrek

TitleAssistant Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0639
La Jolla CA 92093
Phone858-246-0895
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kaplanis J, Gordon A, Shor T, Weissbrod O, Geiger D, Wahl M, Gershovits M, Markus B, Sheikh M, Gymrek M, Bhatia G, MacArthur DG, Price AL, Erlich Y. Quantitative analysis of population-scale family trees with millions of relatives. Science. 2018 04 13; 360(6385):171-175. PMID: 29496957.
      View in: PubMed
    2. Gymrek M, Willems T, Reich D, Erlich Y. Interpreting short tandem repeat variations in humans using mutational constraint. Nat Genet. 2017 Oct; 49(10):1495-1501. PMID: 28892063.
      View in: PubMed
    3. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 2017 Jun 29; 170(1):199-212.e20. PMID: 28666119.
      View in: PubMed
    4. Willems T, Zielinski D, Yuan J, Gordon A, Gymrek M, Erlich Y. Genome-wide profiling of heritable and de novo STR variations. Nat Methods. 2017 Jun; 14(6):590-592. PMID: 28436466.
      View in: PubMed
    5. Gymrek M. A genomic view of short tandem repeats. Curr Opin Genet Dev. 2017 Jun; 44:9-16. PMID: 28213161.
      View in: PubMed
    6. Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538(7624):201-206. PMID: 27654912.
      View in: PubMed
    7. Gymrek M, Farjoun Y. Recommendations for open data science. Gigascience. 2016; 5:22. PMID: 27195107; PMCID: PMC4870738.
      View in: PubMed, PubMed Central
    8. Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A, Wilson Sayres MA, Ayub Q, McCarthy SA, Narechania A, Kashin S, Chen Y, Banerjee R, Rodriguez-Flores JL, Cerezo M, Shao H, Gymrek M, Malhotra A, Louzada S, Desalle R, Ritchie GR, Cerveira E, Fitzgerald TW, Garrison E, Marcketta A, Mittelman D, Romanovitch M, Zhang C, Zheng-Bradley X, Abecasis GR, McCarroll SA, Flicek P, Underhill PA, Coin L, Zerbino DR, Yang F, Lee C, Clarke L, Auton A, Erlich Y, Handsaker RE. Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nat Genet. 2016 06; 48(6):593-9. PMID: 27111036; PMCID: PMC4884158 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    9. Willems T, Gymrek M, Poznik GD, Tyler-Smith C. Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates. Am J Hum Genet. 2016 05 05; 98(5):919-933. PMID: 27126583.
      View in: PubMed
    10. Quilez J, Guilmatre A, Garg P, Highnam G, Gymrek M, Erlich Y, Joshi RS, Mittelman D, Sharp AJ. Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans. Nucleic Acids Res. 2016 05 05; 44(8):3750-62. PMID: 27060133; PMCID: PMC4857002.
      View in: PubMed, PubMed Central
    11. Gymrek M, Willems T, Guilmatre A, Zeng H, Markus B, Georgiev S, Daly MJ, Price AL, Pritchard JK, Sharp AJ, Erlich Y. Abundant contribution of short tandem repeats to gene expression variation in humans. Nat Genet. 2016 Jan; 48(1):22-9. PMID: 26642241; PMCID: PMC4909355.
      View in: PubMed, PubMed Central
    12. Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell. 2014 Nov 10; 26(5):668-681. PMID: 25453903; PMCID: PMC4492343.
      View in: PubMed, PubMed Central
    13. Gymrek M. PyBamView: a browser-based application for viewing short read alignments. Bioinformatics. 2014 Dec 01; 30(23):3405-7. PMID: 25147359.
      View in: PubMed
    14. Willems T, Gymrek M, Highnam G. The landscape of human STR variation. Genome Res. 2014 Nov; 24(11):1894-904. PMID: 25135957; PMCID: PMC4216929.
      View in: PubMed, PubMed Central
    15. Zielinski D, Markus B, Sheikh M, Gymrek M, Chu C, Zaks M, Srinivasan B, Hoffman JD, Aizenbud D, Erlich Y. OTX2 duplication is implicated in hemifacial microsomia. PLoS One. 2014; 9(5):e96788. PMID: 24816892; PMCID: PMC4016008.
      View in: PubMed, PubMed Central
    16. Breker M, Gymrek M, Moldavski O, Schuldiner M. LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast. Nucleic Acids Res. 2014 Jan; 42(Database issue):D726-30. PMID: 24150937; PMCID: PMC3965041.
      View in: PubMed, PubMed Central
    17. Breker M, Gymrek M, Schuldiner M. A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol. 2013 Mar 18; 200(6):839-50. PMID: 23509072; PMCID: PMC3601363.
      View in: PubMed, PubMed Central
    18. Gymrek M, McGuire AL, Golan D, Halperin E, Erlich Y. Identifying personal genomes by surname inference. Science. 2013 Jan 18; 339(6117):321-4. PMID: 23329047.
      View in: PubMed
    19. Gymrek M, Erlich Y. Profiling short tandem repeats from short reads. Methods Mol Biol. 2013; 1038:113-35. PMID: 23872972.
      View in: PubMed
    20. Zielinski D, Gymrek M, Erlich Y. Back to the family: a renewed approach to rare variant studies. Genome Med. 2012; 4(12):97. PMID: 23253160; PMCID: PMC3580437.
      View in: PubMed, PubMed Central
    21. Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012 Dec 07; 151(6):1185-99. PMID: 23217706; PMCID: PMC3526953.
      View in: PubMed, PubMed Central
    22. Nadler-Holly M, Breker M, Gruber R, Azia A, Gymrek M, Eisenstein M, Willison KR, Schuldiner M, Horovitz A. Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18833-8. PMID: 23112166; PMCID: PMC3503220.
      View in: PubMed, PubMed Central
    23. Gymrek M, Golan D, Rosset S, Erlich Y. lobSTR: A short tandem repeat profiler for personal genomes. Genome Res. 2012 Jun; 22(6):1154-62. PMID: 22522390; PMCID: PMC3371701.
      View in: PubMed, PubMed Central
    24. Ram O, Goren A, Amit I, Shoresh N, Yosef N, Ernst J, Kellis M, Gymrek M, Issner R, Coyne M, Durham T, Zhang X, Donaghey J, Epstein CB, Regev A, Bernstein BE. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell. 2011 Dec 23; 147(7):1628-39. PMID: 22196736; PMCID: PMC3312319.
      View in: PubMed, PubMed Central
    25. Gymrek M, Erlich Y. Using DNA sequencers as stethoscopes. Genome Med. 2011 Nov 21; 3(11):73. PMID: 22103962; PMCID: PMC3308028.
      View in: PubMed, PubMed Central
    26. Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics. 2010 Nov; 9(11):2558-70. PMID: 20631208; PMCID: PMC2984232.
      View in: PubMed, PubMed Central
    27. Ozsolak F, Goren A, Gymrek M, Guttman M, Regev A, Bernstein BE, Milos PM. Digital transcriptome profiling from attomole-level RNA samples. Genome Res. 2010 Apr; 20(4):519-25. PMID: 20133332; PMCID: PMC2847755.
      View in: PubMed, PubMed Central
    28. Goren A, Ozsolak F, Shoresh N, Ku M, Adli M, Hart C, Gymrek M, Zuk O, Regev A, Milos PM, Bernstein BE. Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nat Methods. 2010 Jan; 7(1):47-9. PMID: 19946276; PMCID: PMC2862482.
      View in: PubMed, PubMed Central
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