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Viewing serine/threonine protein phosphatases through the eyes of drug designers. FEBS J. 2013 Oct; 280(19):4739-60.
Zhang M, Yogesha SD, Mayfield JE, Gill GN, Zhang Y. PMID: 23937612; PMCID: PMC4349438.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II. Nano Rev. 2010; 1.
Zhang M, Gill GN, Zhang Y. PMID: 22110856; PMCID: PMC3215212.
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PubMed Mentions:
4
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Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 May; 19(5):974-86.
Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel JP, Zhang Y. PMID: 20222012; PMCID: PMC2868240.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development. 2009 Sep; 136(17):2923-32.
Song MR, Sun Y, Bryson A, Gill GN, Evans SM, Pfaff SL. PMID: 19666821; PMCID: PMC2723064.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 08; 24(5):759-770.
Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. PMID: 17157258; PMCID: PMC2859291.
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PubMed Mentions:
59 Fields:
Translation:
HumansCells
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The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol. 2006 Nov 01; 299(1):122-36.
Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN, Roop DR, Wertz P, Andersen B. PMID: 16949565.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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The LIM domain-only protein LMO4 is required for neural tube closure. Mol Cell Neurosci. 2005 Feb; 28(2):205-14.
Lee SK, Jurata LW, Nowak R, Lettieri K, Kenny DA, Pfaff SL, Gill GN. PMID: 15691703.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Small CTD phosphatases function in silencing neuronal gene expression. Science. 2005 Jan 28; 307(5709):596-600.
Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN. PMID: 15681389.
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PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell. 2005 Apr; 16(4):2049-57.
Zhong Q, Watson MJ, Lazar CS, Hounslow AM, Waltho JP, Gill GN. PMID: 15673616; PMCID: PMC1073682.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol Biol Cell. 2004 Dec; 15(12):5470-80.
Lazar CS, Cresson CM, Lauffenburger DA, Gill GN. PMID: 15469991; PMCID: PMC532026.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem. 2003 Jul 11; 278(28):26078-85.
Yeo M, Lin PS, Dahmus ME, Gill GN. PMID: 12721286.
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PubMed Mentions:
85 Fields:
Translation:
HumansCells
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Decoding the LIM development code. Trans Am Clin Climatol Assoc. 2003; 114:179-89.
Gill GN. PMID: 12813919; PMCID: PMC2194522.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell. 2002 Jul 26; 110(2):237-49.
Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL. PMID: 12150931.
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PubMed Mentions:
171 Fields:
Translation:
AnimalsCells
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Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6767-72.
Zhong Q, Lazar CS, Tronchère H, Sato T, Meerloo T, Yeo M, Songyang Z, Emr SD, Gill GN. PMID: 11997453; PMCID: PMC124477.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem. 2002 Jul 05; 277(27):24252-7.
Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM. PMID: 11983694.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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A pit stop at the ER. Science. 2002 Mar 01; 295(5560):1654-5.
Gill GN. PMID: 11872824.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science. 2001 Nov 30; 294(5548):1939-42.
Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. PMID: 11729322.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol. 1999 Sep; 1(5):253-9.
Edwards DC, Sanders LC, Bokoch GM, Gill GN. PMID: 10559936.
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PubMed Mentions:
411 Fields:
Translation:
HumansAnimalsCells
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The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. Mol Biol Cell. 1999 Jun; 10(6):1973-84.
Guy PM, Kenny DA, Gill GN. PMID: 10359609; PMCID: PMC25398.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. EMBO J. 1999 May 04; 18(9):2489-99.
Nesterov A, Carter RE, Sorkina T, Gill GN, Sorkin A. PMID: 10228163; PMCID: PMC1171331.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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Structural features of LIM kinase that control effects on the actin cytoskeleton. J Biol Chem. 1999 Apr 16; 274(16):11352-61.
Edwards DC, Gill GN. PMID: 10196227.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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A basic residue, Lys 782, composes part of the ATP-binding site on the epidermal growth factor receptor tyrosine kinase. Arch Biochem Biophys. 1999 Mar 01; 363(1):27-32.
Klingbeil CK, Gill GN. PMID: 10049496.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11257-62.
Kenny DA, Jurata LW, Saga Y, Gill GN. PMID: 9736723; PMCID: PMC21629.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol Cell Biol. 1998 Apr; 18(4):2298-308.
Durick K, Gill GN, Taylor SS. PMID: 9528800; PMCID: PMC121481.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. J Biol Chem. 1998 Feb 06; 273(6):3152-7.
Jurata LW, Pfaff SL, Gill GN. PMID: 9452425.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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Structure and function of LIM domains. Curr Top Microbiol Immunol. 1998; 228:75-113.
Jurata LW, Gill GN. PMID: 9401203.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Functional analysis of the nuclear LIM domain interactor NLI. Mol Cell Biol. 1997 Oct; 17(10):5688-98.
Jurata LW, Gill GN. PMID: 9315627; PMCID: PMC232417.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis. Biochemistry. 1997 Jun 10; 36(23):6960-7.
Cadena DL, Kurten RC, Gill GN. PMID: 9188692.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem. 1997 May 30; 272(22):14110-4.
Chen Y, Fischer WH, Gill GN. PMID: 9162037.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem. 1997 Jan 31; 272(5):2927-35.
Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK. PMID: 9006938.
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PubMed Mentions:
232 Fields:
Translation:
HumansAnimalsCells
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Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11693-8.
Jurata LW, Kenny DA, Gill GN. PMID: 8876198; PMCID: PMC38120.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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Mutational analysis of the nucleotide binding site of the epidermal growth factor receptor and v-Src protein-tyrosine kinases. J Biol Chem. 1996 Sep 13; 271(37):22619-23.
Chan Cl, Gill GN. PMID: 8798432.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Hormone Receptor Regulation of the Human Immunodeficiency Virus Type 1 and Type 2 Long Terminal Repeats. J Biomed Sci. 1996 Sep-Oct; 3(5):323-331.
Xu J, Luznik L, Wong-Staal F, Gill GN. PMID: 11725114.
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PubMed Mentions:
2 Fields:
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Specificity of LIM domain interactions with receptor tyrosine kinases. J Biol Chem. 1996 Jul 05; 271(27):15934-41.
Wu R, Durick K, Songyang Z, Cantley LC, Taylor SS, Gill GN. PMID: 8663233.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain. J Biol Chem. 1996 May 31; 271(22):12691-4.
Durick K, Wu RY, Gill GN, Taylor SS. PMID: 8662982.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science. 1996 May 17; 272(5264):1008-10.
Kurten RC, Cadena DL, Gill GN. PMID: 8638121.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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A heterodimeric nuclear protein complex binds two palindromic sequences in the proximal enhancer of the human erbB-2 gene. J Biol Chem. 1996 Mar 01; 271(9):5183-8.
Chen Y, Gill GN. PMID: 8617800.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The enigma of LIM domains. Structure. 1995 Dec 15; 3(12):1285-9.
Gill GN. PMID: 8747454.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8719-23.
Nesterov A, Wiley HS, Gill GN. PMID: 7568004; PMCID: PMC41038.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism. J Biol Chem. 1995 Mar 17; 270(11):6320-7.
Nesterov A, Kurten RC, Gill GN. PMID: 7534311.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Analysis of substrate recognition determinants in a synthetic peptide containing the Tyr 1173 autophosphorylation site of the epidermal growth factor receptor. Arch Biochem Biophys. 1995 Feb 01; 316(2):745-50.
Klingbeil CK, Gill GN, Cadena DL. PMID: 7864629.
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PubMed Mentions: Fields:
Translation:
Cells
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LIM domain recognition of a tyrosine-containing tight turn. J Biol Chem. 1994 Oct 07; 269(40):25085-90.
Wu RY, Gill GN. PMID: 7929196.
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PubMed Mentions:
35 Fields:
Translation:
Cells
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Positive and negative regulatory elements in the human erbB-2 gene promoter. Oncogene. 1994 Aug; 9(8):2269-76.
Chen Y, Gill GN. PMID: 7913545.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Specific factors are required for kinase-dependent endocytosis of insulin receptors. Mol Biol Cell. 1994 May; 5(5):539-47.
Welsh JB, Worthylake R, Wiley HS, Gill GN. PMID: 7919536; PMCID: PMC301066.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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The intracellular tyrosine kinase domain of the epidermal growth factor receptor undergoes a conformational change upon autophosphorylation. J Biol Chem. 1994 Jan 07; 269(1):260-5.
Cadena DL, Chan CL, Gill GN. PMID: 8276804.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Structural features of the 5' region of the human erbB-2 gene. Gene. 1993 Dec 22; 136(1-2):361-4.
Ertl AP, Gill GN. PMID: 7904974.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites. J Biol Chem. 1993 Jul 25; 268(21):16065-73.
Xu J, Thompson KL, Shephard LB, Hudson LG, Gill GN. PMID: 8393457.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5001-5.
Knighton DR, Cadena DL, Zheng J, Ten Eyck LF, Taylor SS, Sowadski JM, Gill GN. PMID: 8389462; PMCID: PMC46641.
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PubMed Mentions:
32 Fields:
Translation:
Cells
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Expression and purification of the epidermal growth factor receptor extracellular domain utilizing a polycistronic expression system. Protein Expr Purif. 1993 Jun; 4(3):177-86.
Cadena DL, Gill GN. PMID: 8518559.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Surgical management of the thyroid nodule: patient selection based on the results of fine-needle aspiration cytology. Laryngoscope. 1992 Dec; 102(12 Pt 1):1353-6.
Bouvet M, Feldman JI, Gill GN, Dillmann WH, Nahum AM, Russack V, Robbins KT. PMID: 1453841.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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A nuclear protein is required for thyroid hormone receptor binding to an inhibitory half-site in the epidermal growth factor receptor promoter. Mol Endocrinol. 1992 Apr; 6(4):627-35.
Thompson KL, Santon JB, Shephard LB, Walton GM, Gill GN. PMID: 1584225.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Receptor tyrosine kinases. FASEB J. 1992 Mar; 6(6):2332-7.
Cadena DL, Gill GN. PMID: 1312047.
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PubMed Mentions:
39 Fields:
Translation:
Cells
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Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor. Arch Biochem Biophys. 1992 Jan; 292(1):273-80.
Wedegaertner PB, Gill GN. PMID: 1309297.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C. Mol Cell Biol. 1992 Jan; 12(1):128-35.
Vega QC, Cochet C, Filhol O, Chang CP, Rhee SG, Gill GN. PMID: 1729595; PMCID: PMC364076.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor. J Biol Chem. 1991 Dec 05; 266(34):23467-70.
Chang CP, Kao JP, Lazar CS, Walsh BJ, Wells A, Wiley HS, Gill GN, Rosenfeld MG. PMID: 1744139.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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A negative feedback loop attenuates EGF-induced morphological changes. J Cell Biol. 1991 Aug; 114(3):533-43.
Welsh JB, Gill GN, Rosenfeld MG, Wells A. PMID: 1860884; PMCID: PMC2289101.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Structural analysis of the transmembrane domain of the epidermal growth factor receptor. J Biol Chem. 1991 Mar 25; 266(9):5750-5.
Carpenter CD, Ingraham HA, Cochet C, Walton GM, Lazar CS, Sowadski JM, Rosenfeld MG, Gill GN. PMID: 2005111.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Regulation of gene expression by epidermal growth factor. Genet Eng (N Y). 1991; 13:137-51.
Hudson LG, Gill GN. PMID: 1367411.
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PubMed Mentions: Fields:
Translation:
Cells
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Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7536-40.
Hudson LG, Thompson KL, Xu J, Gill GN. PMID: 2170982; PMCID: PMC54782.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression. Cell. 1990 Sep 21; 62(6):1165-75.
Hudson LG, Santon JB, Glass CK, Gill GN. PMID: 2169350.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Regulation of EGF receptor expression and function. Mol Reprod Dev. 1990 Sep; 27(1):46-53.
Gill GN. PMID: 2271186.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor. J Biol Chem. 1990 Aug 05; 265(22):12820-7.
Heisermann GJ, Wiley HS, Walsh BJ, Ingraham HA, Fiol CJ, Gill GN. PMID: 2115882.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Structure and inducible regulation of the human c-erb B2/neu promoter. J Biol Chem. 1990 Mar 15; 265(8):4389-93.
Hudson LG, Ertl AP, Gill GN. PMID: 1968458.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science. 1990 Feb 23; 247(4945):962-4.
Wells A, Welsh JB, Lazar CS, Wiley HS, Gill GN, Rosenfeld MG. PMID: 2305263.
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PubMed Mentions:
107 Fields:
Translation:
Cells
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Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates. J Biol Chem. 1990 Jan 25; 265(3):1750-4.
Walton GM, Chen WS, Rosenfeld MG, Gill GN. PMID: 1688559.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell. 1989 Oct 06; 59(1):33-43.
Chen WS, Lazar CS, Lund KA, Welsh JB, Chang CP, Walton GM, Der CJ, Wiley HS, Gill GN, Rosenfeld MG. PMID: 2790960.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. J Biol Chem. 1989 Jul 05; 264(19):11346-53.
Wedegaertner PB, Gill GN. PMID: 2661557.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Regulation of epidermal growth factor receptor gene expression. Mol Endocrinol. 1989 Feb; 3(2):400-8.
Hudson LG, Santon JB, Gill GN. PMID: 2540431.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo. J Biol Chem. 1988 Sep 15; 263(26):13152-8.
Heisermann GJ, Gill GN. PMID: 3138233.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Growth factors, receptors and oncogenes. Mead Johnson Symp Perinat Dev Med. 1988; (32):5-11.
Gill GN. PMID: 2485438.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:467-76.
Gill GN, Chen WS, Lazar CS, Glenney JR, Wiley HS, Ingraham HA, Rosenfeld MG. PMID: 3254778.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Analysis of functional domains in the epidermal growth factor receptor using site-directed mutagenesis. Adv Exp Med Biol. 1988; 234:91-103.
Gill GN, Rosenfeld MG, Chen WS, Bertics PJ, Lazar CS. PMID: 3063092.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Regulatory features of the epidermal growth factor receptor. J Cell Physiol Suppl. 1987; Suppl 5:35-41.
Gill GN, Santon JB, Bertics PJ. PMID: 3316253.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The EGF receptor: structure, regulation and potential role in malignancy. Cancer Surv. 1985; 4(4):767-88.
Thompson DM, Gill GN. PMID: 2824044.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells