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Gordon Gill

Title(s)Emeritus Professor, Medicine
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Experimental Endocrinology and Metabolism
    NIH/NIDDK T32DK007044Sep 15, 1978 - Mar 31, 2021
    Role: Co-Principal Investigator
    EXPERIMENTAL ENDOCRINOLOGY AND METABOLISM
    NIH/NIADDK T32AM007044Sep 15, 1978 - Aug 31, 1988
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Principal Investigator
    HORMONAL REGULATION OF CONTROL MECHANISMS
    NIH/NIDDK R01DK013149Jan 1, 1977 - Dec 31, 2005
    Role: Principal Investigator
    HORMONAL REGULATION OF CONTROL MECHANISMS
    NIH/NIDDK R37DK013149Jan 1, 1977 - Dec 31, 1994
    Role: Principal Investigator
    HORMONAL REGULATION OF CONTROL MECHANISMS
    NIH/NIADDK R01AM013149Jan 1, 1977 - Dec 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang M, Yogesha SD, Mayfield JE, Gill GN, Zhang Y. Viewing serine/threonine protein phosphatases through the eyes of drug designers. FEBS J. 2013 Oct; 280(19):4739-60. PMID: 23937612.
      View in: PubMed
    2. Zhang M, Gill GN, Zhang Y. Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II. Nano Rev. 2010; 1. PMID: 22110856.
      View in: PubMed
    3. Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel JP, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 May; 19(5):974-86. PMID: 20222012.
      View in: PubMed
    4. Song MR, Sun Y, Bryson A, Gill GN, Evans SM, Pfaff SL. Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development. 2009 Sep; 136(17):2923-32. PMID: 19666821.
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    5. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 08; 24(5):759-770. PMID: 17157258.
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    6. Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN, Roop DR, Wertz P, Andersen B. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol. 2006 Nov 01; 299(1):122-36. PMID: 16949565.
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    7. Lee SK, Jurata LW, Nowak R, Lettieri K, Kenny DA, Pfaff SL, Gill GN. The LIM domain-only protein LMO4 is required for neural tube closure. Mol Cell Neurosci. 2005 Feb; 28(2):205-14. PMID: 15691703.
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    8. Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN. Small CTD phosphatases function in silencing neuronal gene expression. Science. 2005 Jan 28; 307(5709):596-600. PMID: 15681389.
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    9. Zhong Q, Watson MJ, Lazar CS, Hounslow AM, Waltho JP, Gill GN. Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell. 2005 Apr; 16(4):2049-57. PMID: 15673616.
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    10. Lazar CS, Cresson CM, Lauffenburger DA, Gill GN. The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol Biol Cell. 2004 Dec; 15(12):5470-80. PMID: 15469991.
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    11. Yeo M, Lin PS, Dahmus ME, Gill GN. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem. 2003 Jul 11; 278(28):26078-85. PMID: 12721286.
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    12. Gill GN. Decoding the LIM development code. Trans Am Clin Climatol Assoc. 2003; 114:179-89. PMID: 12813919.
      View in: PubMed
    13. Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell. 2002 Jul 26; 110(2):237-49. PMID: 12150931.
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    14. Zhong Q, Lazar CS, Tronchère H, Sato T, Meerloo T, Yeo M, Songyang Z, Emr SD, Gill GN. Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6767-72. PMID: 11997453.
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    15. Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM. Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem. 2002 Jul 05; 277(27):24252-7. PMID: 11983694.
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    16. Gill GN. A pit stop at the ER. Science. 2002 Mar 01; 295(5560):1654-5. PMID: 11872824.
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    17. Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science. 2001 Nov 30; 294(5548):1939-42. PMID: 11729322.
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    18. Edwards DC, Sanders LC, Bokoch GM, Gill GN. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol. 1999 Sep; 1(5):253-9. PMID: 10559936.
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    19. Guy PM, Kenny DA, Gill GN. The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. Mol Biol Cell. 1999 Jun; 10(6):1973-84. PMID: 10359609.
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    20. Nesterov A, Carter RE, Sorkina T, Gill GN, Sorkin A. Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. EMBO J. 1999 May 04; 18(9):2489-99. PMID: 10228163.
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    21. Edwards DC, Gill GN. Structural features of LIM kinase that control effects on the actin cytoskeleton. J Biol Chem. 1999 Apr 16; 274(16):11352-61. PMID: 10196227.
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    22. Klingbeil CK, Gill GN. A basic residue, Lys 782, composes part of the ATP-binding site on the epidermal growth factor receptor tyrosine kinase. Arch Biochem Biophys. 1999 Mar 01; 363(1):27-32. PMID: 10049496.
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    23. Kenny DA, Jurata LW, Saga Y, Gill GN. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11257-62. PMID: 9736723.
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    24. Durick K, Gill GN, Taylor SS. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol Cell Biol. 1998 Apr; 18(4):2298-308. PMID: 9528800.
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    25. Jurata LW, Pfaff SL, Gill GN. The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. J Biol Chem. 1998 Feb 06; 273(6):3152-7. PMID: 9452425.
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    26. Jurata LW, Gill GN. Structure and function of LIM domains. Curr Top Microbiol Immunol. 1998; 228:75-113. PMID: 9401203.
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    27. Jurata LW, Gill GN. Functional analysis of the nuclear LIM domain interactor NLI. Mol Cell Biol. 1997 Oct; 17(10):5688-98. PMID: 9315627.
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    28. Cadena DL, Kurten RC, Gill GN. The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis. Biochemistry. 1997 Jun 10; 36(23):6960-7. PMID: 9188692.
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    29. Chen Y, Fischer WH, Gill GN. Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem. 1997 May 30; 272(22):14110-4. PMID: 9162037.
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    30. Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem. 1997 Jan 31; 272(5):2927-35. PMID: 9006938.
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    31. Jurata LW, Kenny DA, Gill GN. Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11693-8. PMID: 8876198.
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    32. Chan Cl, Gill GN. Mutational analysis of the nucleotide binding site of the epidermal growth factor receptor and v-Src protein-tyrosine kinases. J Biol Chem. 1996 Sep 13; 271(37):22619-23. PMID: 8798432.
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    33. Xu J, Luznik L, Wong-Staal F, Gill GN. Hormone Receptor Regulation of the Human Immunodeficiency Virus Type 1 and Type 2 Long Terminal Repeats. J Biomed Sci. 1996 Sep-Oct; 3(5):323-331. PMID: 11725114.
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    34. Wu R, Durick K, Songyang Z, Cantley LC, Taylor SS, Gill GN. Specificity of LIM domain interactions with receptor tyrosine kinases. J Biol Chem. 1996 Jul 05; 271(27):15934-41. PMID: 8663233.
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    35. Durick K, Wu RY, Gill GN, Taylor SS. Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain. J Biol Chem. 1996 May 31; 271(22):12691-4. PMID: 8662982.
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    36. Kurten RC, Cadena DL, Gill GN. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science. 1996 May 17; 272(5264):1008-10. PMID: 8638121.
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    37. Chen Y, Gill GN. A heterodimeric nuclear protein complex binds two palindromic sequences in the proximal enhancer of the human erbB-2 gene. J Biol Chem. 1996 Mar 01; 271(9):5183-8. PMID: 8617800.
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    38. Gill GN. The enigma of LIM domains. Structure. 1995 Dec 15; 3(12):1285-9. PMID: 8747454.
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    39. Nesterov A, Wiley HS, Gill GN. Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8719-23. PMID: 7568004.
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    40. Nesterov A, Kurten RC, Gill GN. Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism. J Biol Chem. 1995 Mar 17; 270(11):6320-7. PMID: 7534311.
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    41. Klingbeil CK, Gill GN, Cadena DL. Analysis of substrate recognition determinants in a synthetic peptide containing the Tyr 1173 autophosphorylation site of the epidermal growth factor receptor. Arch Biochem Biophys. 1995 Feb 01; 316(2):745-50. PMID: 7864629.
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    42. Wu RY, Gill GN. LIM domain recognition of a tyrosine-containing tight turn. J Biol Chem. 1994 Oct 07; 269(40):25085-90. PMID: 7929196.
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    43. Chen Y, Gill GN. Positive and negative regulatory elements in the human erbB-2 gene promoter. Oncogene. 1994 Aug; 9(8):2269-76. PMID: 7913545.
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    44. Welsh JB, Worthylake R, Wiley HS, Gill GN. Specific factors are required for kinase-dependent endocytosis of insulin receptors. Mol Biol Cell. 1994 May; 5(5):539-47. PMID: 7919536.
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    45. Cadena DL, Chan CL, Gill GN. The intracellular tyrosine kinase domain of the epidermal growth factor receptor undergoes a conformational change upon autophosphorylation. J Biol Chem. 1994 Jan 07; 269(1):260-5. PMID: 8276804.
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    46. Ertl AP, Gill GN. Structural features of the 5' region of the human erbB-2 gene. Gene. 1993 Dec 22; 136(1-2):361-4. PMID: 7904974.
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    47. Xu J, Thompson KL, Shephard LB, Hudson LG, Gill GN. T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites. J Biol Chem. 1993 Jul 25; 268(21):16065-73. PMID: 8393457.
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    48. Cadena DL, Gill GN. Expression and purification of the epidermal growth factor receptor extracellular domain utilizing a polycistronic expression system. Protein Expr Purif. 1993 Jun; 4(3):177-86. PMID: 8518559.
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    49. Knighton DR, Cadena DL, Zheng J, Ten Eyck LF, Taylor SS, Sowadski JM, Gill GN. Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5001-5. PMID: 8389462.
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    50. Bouvet M, Feldman JI, Gill GN, Dillmann WH, Nahum AM, Russack V, Robbins KT. Surgical management of the thyroid nodule: patient selection based on the results of fine-needle aspiration cytology. Laryngoscope. 1992 Dec; 102(12 Pt 1):1353-6. PMID: 1453841.
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    51. Thompson KL, Santon JB, Shephard LB, Walton GM, Gill GN. A nuclear protein is required for thyroid hormone receptor binding to an inhibitory half-site in the epidermal growth factor receptor promoter. Mol Endocrinol. 1992 Apr; 6(4):627-35. PMID: 1584225.
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    52. Cadena DL, Gill GN. Receptor tyrosine kinases. FASEB J. 1992 Mar; 6(6):2332-7. PMID: 1312047.
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    53. Vega QC, Cochet C, Filhol O, Chang CP, Rhee SG, Gill GN. A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C. Mol Cell Biol. 1992 Jan; 12(1):128-35. PMID: 1729595.
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    54. Wedegaertner PB, Gill GN. Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor. Arch Biochem Biophys. 1992 Jan; 292(1):273-80. PMID: 1309297.
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    55. Chang CP, Kao JP, Lazar CS, Walsh BJ, Wells A, Wiley HS, Gill GN, Rosenfeld MG. Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor. J Biol Chem. 1991 Dec 05; 266(34):23467-70. PMID: 1744139.
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    56. Welsh JB, Gill GN, Rosenfeld MG, Wells A. A negative feedback loop attenuates EGF-induced morphological changes. J Cell Biol. 1991 Aug; 114(3):533-43. PMID: 1860884.
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    57. Carpenter CD, Ingraham HA, Cochet C, Walton GM, Lazar CS, Sowadski JM, Rosenfeld MG, Gill GN. Structural analysis of the transmembrane domain of the epidermal growth factor receptor. J Biol Chem. 1991 Mar 25; 266(9):5750-5. PMID: 2005111.
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    58. Hudson LG, Gill GN. Regulation of gene expression by epidermal growth factor. Genet Eng (N Y). 1991; 13:137-51. PMID: 1367411.
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    59. Hudson LG, Thompson KL, Xu J, Gill GN. Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7536-40. PMID: 2170982.
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    60. Hudson LG, Santon JB, Glass CK, Gill GN. Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression. Cell. 1990 Sep 21; 62(6):1165-75. PMID: 2169350.
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    61. Gill GN. Regulation of EGF receptor expression and function. Mol Reprod Dev. 1990 Sep; 27(1):46-53. PMID: 2271186.
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    62. Heisermann GJ, Wiley HS, Walsh BJ, Ingraham HA, Fiol CJ, Gill GN. Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor. J Biol Chem. 1990 Aug 05; 265(22):12820-7. PMID: 2115882.
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    63. Hudson LG, Ertl AP, Gill GN. Structure and inducible regulation of the human c-erb B2/neu promoter. J Biol Chem. 1990 Mar 15; 265(8):4389-93. PMID: 1968458.
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    64. Wells A, Welsh JB, Lazar CS, Wiley HS, Gill GN, Rosenfeld MG. Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science. 1990 Feb 23; 247(4945):962-4. PMID: 2305263.
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    65. Walton GM, Chen WS, Rosenfeld MG, Gill GN. Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates. J Biol Chem. 1990 Jan 25; 265(3):1750-4. PMID: 1688559.
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    66. Chen WS, Lazar CS, Lund KA, Welsh JB, Chang CP, Walton GM, Der CJ, Wiley HS, Gill GN, Rosenfeld MG. Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell. 1989 Oct 06; 59(1):33-43. PMID: 2790960.
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    67. Wedegaertner PB, Gill GN. Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. J Biol Chem. 1989 Jul 05; 264(19):11346-53. PMID: 2661557.
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    68. Hudson LG, Santon JB, Gill GN. Regulation of epidermal growth factor receptor gene expression. Mol Endocrinol. 1989 Feb; 3(2):400-8. PMID: 2540431.
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    69. Heisermann GJ, Gill GN. Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo. J Biol Chem. 1988 Sep 15; 263(26):13152-8. PMID: 3138233.
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    70. Gill GN, Chen WS, Lazar CS, Glenney JR, Wiley HS, Ingraham HA, Rosenfeld MG. Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:467-76. PMID: 3254778.
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    71. Gill GN, Rosenfeld MG, Chen WS, Bertics PJ, Lazar CS. Analysis of functional domains in the epidermal growth factor receptor using site-directed mutagenesis. Adv Exp Med Biol. 1988; 234:91-103. PMID: 3063092.
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    72. Gill GN. Growth factors, receptors and oncogenes. Mead Johnson Symp Perinat Dev Med. 1988; (32):5-11. PMID: 2485438.
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    73. Gill GN, Santon JB, Bertics PJ. Regulatory features of the epidermal growth factor receptor. J Cell Physiol Suppl. 1987; Suppl 5:35-41. PMID: 3316253.
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    74. Thompson DM, Gill GN. The EGF receptor: structure, regulation and potential role in malignancy. Cancer Surv. 1985; 4(4):767-88. PMID: 2824044.
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