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Robert Fahey

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0314
La Jolla CA 92093
Phone858-534-2163
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    Collapse Research 
    Collapse Research Activities and Funding
    Whole cell and essential enzyme screening assays for mycothiol biosynthesis
    NIH/NIAID R01AI072133Apr 1, 2007 - Mar 31, 2011
    Role: Principal Investigator
    MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    NIH/NIAID R01AI049174Aug 1, 2000 - May 31, 2008
    Role: Principal Investigator
    MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    NIH/NIAID R21AI049174Aug 1, 2000 - May 31, 2004
    Role: Principal Investigator
    MOLECULAR GENETICS OF MYCOTHIOL BIOSYNTHESIS
    NIH/FIC R03TW000976Sep 1, 1998 - Aug 31, 2002
    Role: Principal Investigator
    MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    NIH/NIAAA R01AA011393Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator
    ACTINOTHIONE IN THE DIAGNOSIS OF MYCOBACTERIAL INFECTION
    NIH/NIAID R01AI036971Sep 30, 1994 - Jul 31, 1998
    Role: Principal Investigator
    MECHANISM OF RADIOPROTECTION BY AMINOTHIOLS
    NIH/NCI R01CA039582Apr 1, 1985 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fahey RC. Glutathione analogs in prokaryotes. Biochim Biophys Acta. 2013 May; 1830(5):3182-98. PMID: 23075826.
      View in: PubMed
    2. Upton H, Newton GL, Gushiken M, Lo K, Holden D, Fahey RC, Rawat M. Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett. 2012 Apr 05; 586(7):1004-8. PMID: 22569254; PMCID: PMC3668096.
    3. Newton GL, Fahey RC, Rawat M. Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology. 2012 Apr; 158(Pt 4):1117-26. PMID: 22262099; PMCID: PMC3949421.
    4. Newton GL, Leung SS, Wakabayashi JI, Rawat M, Fahey RC. The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases. Biochemistry. 2011 Dec 13; 50(49):10751-60. PMID: 22059487; PMCID: PMC3232311.
    5. Hatzios SK, Schelle MW, Newton GL, Sogi KM, Holsclaw CM, Fahey RC, Bertozzi CR. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4956-9. PMID: 21795043; PMCID: PMC3184767.
    6. Newton GL, Buchmeier N, La Clair JJ, Fahey RC. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011 Jul 01; 19(13):3956-64. PMID: 21665483; PMCID: PMC3123436.
    7. Ta P, Buchmeier N, Newton GL, Rawat M, Fahey RC. Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. J Bacteriol. 2011 Apr; 193(8):1981-90. PMID: 21335456; PMCID: PMC3133051.
    8. Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD. Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6482-6. PMID: 20308541; PMCID: PMC2851989.
    9. Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009 Sep; 5(9):625-7. PMID: 19578333; PMCID: PMC3510479.
    10. Newton GL, Buchmeier N, Fahey RC. Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev. 2008 Sep; 72(3):471-94. PMID: 18772286; PMCID: PMC2546866.
    11. Johnson T, Newton GL, Fahey RC, Rawat M. Unusual production of glutathione in Actinobacteria. Arch Microbiol. 2009 Jan; 191(1):89-93. PMID: 18719892; PMCID: PMC2605195.
    12. Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC. An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol. 2008 Nov; 190(5):547-57. PMID: 18629474; PMCID: PMC2574923.
    13. Newton GL, Fahey RC. Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA. Mol Microbiol. 2008 May; 68(4):805-9. PMID: 18430078.
      View in: PubMed
    14. Bzymek KP, Newton GL, Ta P, Fahey RC. Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production. J Bacteriol. 2007 Oct; 189(19):6796-805. PMID: 17644601; PMCID: PMC2045207.
    15. Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry. 2007 Mar 20; 46(11):3234-45. PMID: 17323930; PMCID: PMC2613803.
    16. Buchmeier N, Fahey RC. The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman. FEMS Microbiol Lett. 2006 Nov; 264(1):74-9. PMID: 17020551.
      View in: PubMed
    17. Buchmeier NA, Newton GL, Fahey RC. A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress. J Bacteriol. 2006 Sep; 188(17):6245-52. PMID: 16923891; PMCID: PMC1595396.
    18. Newton GL, Ta P, Bzymek KP, Fahey RC. Biochemistry of the initial steps of mycothiol biosynthesis. J Biol Chem. 2006 Nov 10; 281(45):33910-20. PMID: 16940050.
      View in: PubMed
    19. Gutierrez-Lugo MT, Newton GL, Fahey RC, Bewley CA. Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr Purif. 2006 Nov; 50(1):128-36. PMID: 16908186.
      View in: PubMed
    20. Newton GL, Ta P, Sareen D, Fahey RC. A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. Anal Biochem. 2006 Jun 15; 353(2):167-73. PMID: 16674910.
      View in: PubMed
    21. Newton GL, Ko M, Ta P, Av-Gay Y, Fahey RC. Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Protein Expr Purif. 2006 Jun; 47(2):542-50. PMID: 16630724.
      View in: PubMed
    22. Newton GL, Ta P, Fahey RC. A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status. J Bacteriol. 2005 Nov; 187(21):7309-16. PMID: 16237013; PMCID: PMC1272995.
    23. Seligman J, Newton GL, Fahey RC, Shalgi R, Kosower NS. Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation. J Androl. 2005 Sep-Oct; 26(5):629-37; discussion 638-40. PMID: 16088041.
      View in: PubMed
    24. Rawat M, Uppal M, Newton G, Steffek M, Fahey RC, Av-Gay Y. Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol. 2004 Sep; 186(18):6050-8. PMID: 15342574; PMCID: PMC515152.
    25. Sareen D, Newton GL, Fahey RC, Buchmeier NA. Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. J Bacteriol. 2003 Nov; 185(22):6736-40. PMID: 14594852; PMCID: PMC262099.
    26. Steffek M, Newton GL, Av-Gay Y, Fahey RC. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry. 2003 Oct 21; 42(41):12067-76. PMID: 14556638.
      View in: PubMed
    27. Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem. 2003 Nov 21; 278(47):47166-70. PMID: 12958317.
      View in: PubMed
    28. Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J Bacteriol. 2003 Jun; 185(11):3476-9. PMID: 12754249; PMCID: PMC155378.
    29. Buchmeier NA, Newton GL, Koledin T, Fahey RC. Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. Mol Microbiol. 2003 Mar; 47(6):1723-32. PMID: 12622824.
      View in: PubMed
    30. Nicholas GM, Eckman LL, Newton GL, Fahey RC, Ray S, Bewley CA. Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem. 2003 Feb 20; 11(4):601-8. PMID: 12538025.
      View in: PubMed
    31. Rawat M, Newton GL, Ko M, Martinez GJ, Fahey RC, Av-Gay Y. Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics. Antimicrob Agents Chemother. 2002 Nov; 46(11):3348-55. PMID: 12384335; PMCID: PMC128700.
    32. Newton GL, Fahey RC. Mycothiol biochemistry. Arch Microbiol. 2002 Dec; 178(6):388-94. PMID: 12420157.
      View in: PubMed
    33. Koledin T, Newton GL, Fahey RC. Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch Microbiol. 2002 Nov; 178(5):331-7. PMID: 12375100.
      View in: PubMed
    34. Sareen D, Steffek M, Newton GL, Fahey RC. ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry. 2002 Jun 04; 41(22):6885-90. PMID: 12033919.
      View in: PubMed
    35. Fahey RC. Novel thiols of prokaryotes. Annu Rev Microbiol. 2001; 55:333-56. PMID: 11544359.
      View in: PubMed
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