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    Robert Fahey

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0314
    CA La Jolla 92093
    Phone858-534-2163
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      Collapse Research 
      Collapse Research Activities and Funding
      Whole cell and essential enzyme screening assays for mycothiol biosynthesis
      NIH/NIAID R01AI072133Apr 1, 2007 - Mar 31, 2011
      Role: Principal Investigator
      MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
      NIH/NIAID R01AI049174Aug 1, 2000 - May 31, 2008
      Role: Principal Investigator
      MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
      NIH/NIAID R21AI049174Aug 1, 2000 - May 31, 2004
      Role: Principal Investigator
      MOLECULAR GENETICS OF MYCOTHIOL BIOSYNTHESIS
      NIH/FIC R03TW000976Sep 1, 1998 - Aug 31, 2002
      Role: Principal Investigator
      MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
      NIH/NIAAA R01AA011393Jul 1, 1996 - Jun 30, 2000
      Role: Principal Investigator
      ACTINOTHIONE IN THE DIAGNOSIS OF MYCOBACTERIAL INFECTION
      NIH/NIAID R01AI036971Sep 30, 1994 - Jul 31, 1998
      Role: Principal Investigator
      MECHANISM OF RADIOPROTECTION BY AMINOTHIOLS
      NIH/NCI R01CA039582Apr 1, 1985 - Jun 30, 1997
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Panchen ZA, Primack RB, Nordt B, Ellwood ER, Stevens AD, Renner SS, Willis CG, Fahey R, Whittemore A, Du Y, Davis CC. Leaf out times of temperate woody plants are related to phylogeny, deciduousness, growth habit and wood anatomy. New Phytol. 2014 Sep; 203(4):1208-19. PMID: 24942252.
        View in: PubMed
      2. Fahey R. Glutathione analogs in prokaryotes. Biochim Biophys Acta. 2013 May; 1830(5):3182-98. PMID: 23075826.
        View in: PubMed
      3. Upton H, Newton GL, Gushiken M, Lo K, Holden D, Fahey R, Rawat M. Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett. 2012 Apr 05; 586(7):1004-8. PMID: 22569254; PMCID: PMC3668096.
      4. Newton GL, Fahey R, Rawat M. Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology. 2012 Apr; 158(Pt 4):1117-26. PMID: 22262099; PMCID: PMC3949421.
      5. Newton GL, Leung SS, Wakabayashi JI, Rawat M, Fahey R. The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases. Biochemistry. 2011 Dec 13; 50(49):10751-60. PMID: 22059487; PMCID: PMC3232311.
      6. Hatzios SK, Schelle MW, Newton GL, Sogi KM, Holsclaw CM, Fahey R, Bertozzi CR. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4956-9. PMID: 21795043; PMCID: PMC3184767.
      7. Newton GL, Buchmeier N, La Clair JJ, Fahey R. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011 Jul 01; 19(13):3956-64. PMID: 21665483; PMCID: PMC3123436.
      8. Ta P, Buchmeier N, Newton GL, Rawat M, Fahey R. Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. J Bacteriol. 2011 Apr; 193(8):1981-90. PMID: 21335456; PMCID: PMC3133051.
      9. Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey R, Helmann JD. Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6482-6. PMID: 20308541; PMCID: PMC2851989.
      10. Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey R. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009 Sep; 5(9):625-7. PMID: 19578333; PMCID: PMC3510479.
      11. Newton GL, Buchmeier N, Fahey R. Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev. 2008 Sep; 72(3):471-94. PMID: 18772286; PMCID: PMC2546866.
      12. Johnson T, Newton GL, Fahey R, Rawat M. Unusual production of glutathione in Actinobacteria. Arch Microbiol. 2009 Jan; 191(1):89-93. PMID: 18719892; PMCID: PMC2605195.
      13. Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey R. An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol. 2008 Nov; 190(5):547-57. PMID: 18629474; PMCID: PMC2574923.
      14. Newton GL, Fahey R. Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA. Mol Microbiol. 2008 May; 68(4):805-9. PMID: 18430078.
        View in: PubMed
      15. Bzymek KP, Newton GL, Ta P, Fahey R. Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production. J Bacteriol. 2007 Oct; 189(19):6796-805. PMID: 17644601; PMCID: PMC2045207.
      16. Nicely NI, Parsonage D, Paige C, Newton GL, Fahey R, Leonardi R, Jackowski S, Mallett TC, Claiborne A. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry. 2007 Mar 20; 46(11):3234-45. PMID: 17323930; PMCID: PMC2613803.
      17. Buchmeier N, Fahey R. The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman. FEMS Microbiol Lett. 2006 Nov; 264(1):74-9. PMID: 17020551.
        View in: PubMed
      18. Buchmeier NA, Newton GL, Fahey R. A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress. J Bacteriol. 2006 Sep; 188(17):6245-52. PMID: 16923891; PMCID: PMC1595396.
      19. Newton GL, Ta P, Bzymek KP, Fahey R. Biochemistry of the initial steps of mycothiol biosynthesis. J Biol Chem. 2006 Nov 10; 281(45):33910-20. PMID: 16940050.
        View in: PubMed
      20. Gutierrez-Lugo MT, Newton GL, Fahey R, Bewley CA. Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr Purif. 2006 Nov; 50(1):128-36. PMID: 16908186.
        View in: PubMed
      21. Newton GL, Ta P, Sareen D, Fahey R. A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. Anal Biochem. 2006 Jun 15; 353(2):167-73. PMID: 16674910.
        View in: PubMed
      22. Newton GL, Ko M, Ta P, Av-Gay Y, Fahey R. Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Protein Expr Purif. 2006 Jun; 47(2):542-50. PMID: 16630724.
        View in: PubMed
      23. Newton GL, Ta P, Fahey R. A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status. J Bacteriol. 2005 Nov; 187(21):7309-16. PMID: 16237013; PMCID: PMC1272995.
      24. Seligman J, Newton GL, Fahey R, Shalgi R, Kosower NS. Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation. J Androl. 2005 Sep-Oct; 26(5):629-37; discussion 638-40. PMID: 16088041.
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      25. Rawat M, Uppal M, Newton G, Steffek M, Fahey R, Av-Gay Y. Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol. 2004 Sep; 186(18):6050-8. PMID: 15342574; PMCID: PMC515152.
      26. Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464. PMID: 27770180.
        View in: PubMed
      27. Sareen D, Newton GL, Fahey R, Buchmeier NA. Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. J Bacteriol. 2003 Nov; 185(22):6736-40. PMID: 14594852; PMCID: PMC262099.
      28. Steffek M, Newton GL, Av-Gay Y, Fahey R. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry. 2003 Oct 21; 42(41):12067-76. PMID: 14556638.
        View in: PubMed
      29. Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey R, James MN. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem. 2003 Nov 21; 278(47):47166-70. PMID: 12958317.
        View in: PubMed
      30. Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey R, Av-Gay Y. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J Bacteriol. 2003 Jun; 185(11):3476-9. PMID: 12754249; PMCID: PMC155378.
      31. Buchmeier NA, Newton GL, Koledin T, Fahey R. Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. Mol Microbiol. 2003 Mar; 47(6):1723-32. PMID: 12622824.
        View in: PubMed
      32. Nicholas GM, Eckman LL, Newton GL, Fahey R, Ray S, Bewley CA. Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem. 2003 Feb 20; 11(4):601-8. PMID: 12538025.
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      33. Rawat M, Newton GL, Ko M, Martinez GJ, Fahey R, Av-Gay Y. Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics. Antimicrob Agents Chemother. 2002 Nov; 46(11):3348-55. PMID: 12384335; PMCID: PMC128700.
      34. Newton GL, Fahey R. Mycothiol biochemistry. Arch Microbiol. 2002 Dec; 178(6):388-94. PMID: 12420157.
        View in: PubMed
      35. Koledin T, Newton GL, Fahey R. Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch Microbiol. 2002 Nov; 178(5):331-7. PMID: 12375100.
        View in: PubMed
      36. Sareen D, Steffek M, Newton GL, Fahey R. ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry. 2002 Jun 04; 41(22):6885-90. PMID: 12033919.
        View in: PubMed
      37. Souid AK, Fahey R, Aktas MK, Sayin OA, Karjoo S, Newton GL, Sadowitz PD, Dubowy RL, Bernstein ML. Blood thiols following amifostine and mesna infusions, a pediatric oncology group study. Drug Metab Dispos. 2001 Nov; 29(11):1460-6. PMID: 11602522.
        View in: PubMed
      38. Nicholas GM, Newton GL, Fahey R, Bewley CA. Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase. Org Lett. 2001 May 17; 3(10):1543-5. PMID: 11388862.
        View in: PubMed
      39. Fahey R. Novel thiols of prokaryotes. Annu Rev Microbiol. 2001; 55:333-56. PMID: 11544359.
        View in: PubMed
      40. Newton GL, Av-Gay Y, Fahey R. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J Bacteriol. 2000 Dec; 182(24):6958-63. PMID: 11092856; PMCID: PMC94821.
      41. Newton GL, Av-Gay Y, Fahey R. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry. 2000 Sep 05; 39(35):10739-46. PMID: 10978158.
        View in: PubMed
      42. Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, Pørksen N, Sturis J, Hollingdal M, Pincus S, Veldhuis J, Dejgaard A, Schmitz O, Kristensen JS, Frandsen KB, Bayer T, Müller P, Dunning BE, Paladini S, Gutierrez C, Deacon R, Valentin M, Grunberger G, Weston WM, Patwardhan R, Rappaport EB, Sargeant LA, Wareham NJ, Khaw KT, Zethelius B, Lithell H, Hales CN, Berne C, Lakka HM, Oksanen L, Tuomainen TP, Kontula K, Salonen JT, Dekker JM, de Boks P, de Vegt F, Stehouwer CD, Nijpels G, Bouter LM, Heine RJ, Bruno G, Cavallo-Perin P, Bargero G, D'Errico N, Borra M, Macchia G, Pagano G, Newton RW, Ruta DA, New JP, Wallace C, Roxburgh MA, Young RJ, Vaughan NJ, Elliott P, Brennan G, Devers M, MacAlpine R, Steinke D, Lawson DH, Decallonne B, Casteels K, Gysemans C, Bouillon R, Mathieu C, Linn T, Strate C, Schneider K, Funda DP, Jirsa M, Kozáková H, Kaas A, Kofronová O, Tlaskalová-Hogenová H, Buschard K, Wanka H, Hartmann A, Kuttler B, Rasmussen SB, Sørensen TS, Markholst H, Petersen JS, Karounos D, Dyrberg T, Mabley JG, Haskó G, Szabó C, Seissler J, Nguyen TB, Steinbrenner H, Scherbaum WA, Cipriani R, Gabriele A, Sensi M, Guidobaldi L, Pantellini F, Cerrito MG, Scarpa S, Di Mario U, Morano S, Ceolotto G, Iori E, Baritono E, Del Prato S, Semplicini A, Trevisan R, Zerbini G, Meregalli G, Asnaghi V, Tentori F, Maestroni A, Mangili R, Marescotti C, Vedovato M, Tiengo A, Tadjieva J, Mankovsky BN, Van Aken S, Raes A, Vande Walle J, Matthys D, Craen M, Hansen HP, Lund SS, Rossing P, Jensen T, Parving HH, Andersen S, Tarnow L, Hansen BV, Trautner C, Haastert B, Ennenbach N, Willich S, Tabák ÁG, Orchard TJ, Spranger J, Preissner KT, Schatz H, Pfeiffer A, Cantón A, Burgos R, Hernández C, Lecube A, Mesa J, Segura RM, Mateo C, Simó R, Fathallah L, Greene DA, Obrosova I, Gilbert RE, Kelly DJ, Cox AJ, Berka-Wilkinson JL, Taylor HR, Panagiotopoulos S, Lee V, Jerums G, Cooper ME, Hitman GA, Aganna E, Ogunkolade WB, Rema M, Deepa R, Shanthi-Rani CS, Barakat K, Kumarajeewa TR, Cassell PG, McDermott MF, Mohan V, Ways K, Bursell S, Devries T, Woodworth J, Alatorre C, King G, Aiello LP, Karisen AE, Pavlovic D, Nielsen K, Jensen J, Andersen HU, Pociot F, Mandrup-Poulsen T, Eizirik DL, Nerup J, Lortz S, Tiedge M, Lenzen S, Lally FJ, Bone AJ, Darville MI, Ho YS, Sternesjö J, Sandler S, Chen MC, Schuit F, Pipeleers DG, Merezak S, Hardikar A, Hoet JJ, Remacle C, Reusens B, Bréant B, Garofano A, Czernichow P, Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Nakano R, Komeda K, Eto K, Tobe K, Kimura S, Kadowaki T, Ide T, Murakami K, Tsunoda M, Mochizuki T, Ozanne SE, Nave BT, Wang CL, Dorling MW, Petry CJ, Koopmans SJ, van der Bent C, Que I, Radder JK, Sebokova E, Sana AK, Klimes I, Ruderman N, Morviducci L, Pastore L, Morelli S, Sagratella E, Zorretta D, Buongiomo A, Tamburrano G, Giaccari A, Martinenghi S, De Angelis GC, Ravasi F, Bifari F, Bordignon C, Falqui L, Kessler A, Dransfeld O, Sasson S, Tomas E, Zorzano A, Eckel J, Thorsby P, Rosenfalck AM, Kjems L, Hanssen KF, Madsbad S, Birkeland KI, Hamilton-Wessler M, Markussen J, Bergman RN, Melki V, Hanaire-Broutin H, Bessières-Lacombe S, Tauber JP, Home PD, Lindholm A, Riis A, Rosenstock J, Schwartz S, Clark C, Edwards M, Donley D, Swift P, Mortensen HB, Lynggaard H, Hougaard P, Cull CA, Neil HA, Frighi V, Manley SE, Holman RR, Turner RC, Steiner G, Davis WA, Weeraratna T, Bruce DG, Davis TM, Vergès B, Duvillard L, Pont F, Florentin E, Gambert P, Benko B, Ljubic S, Turk Z, Granic M, März W, Wollschläger H, Klein G, Neiss A, Wehling M, Huxtable SJ, Saker PJ, Walker M, Frayling TM, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI, Orecchio A, Giacchini A, Dominici R, Canettieri G, Trinti B, Zani M, Andreoli M, Sciacchitano S, de Silva AM, Whitecross K, Pasco J, Kotowicz M, Nicholson G, Zimmet P, Boyko EJ, Collier GR, Frittitta L, Pizzuti A, Argiolas A, Graci S, Goldfine ID, Bozzali M, Ercolino T, et al. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 1999 Aug; 42(Suppl 1):A1-A330. PMID: 27770183.
        View in: PubMed
      43. Unson MD, Newton GL, Arnold KF, Davis CE, Fahey R. Improved methods for immunoassay of mycothiol. J Clin Microbiol. 1999 Jul; 37(7):2153-7. PMID: 10364578; PMCID: PMC85106.
      44. Warters RL, Newton GL, Olive PL, Fahey R. Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine. Radiat Res. 1999 Mar; 151(3):354-62. PMID: 10073674.
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      45. Newton GL, Unson MD, Anderberg SJ, Aguilera JA, Oh NN, delCardayre SB, Av-Gay Y, Fahey R. Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis. Biochem Biophys Res Commun. 1999 Feb 16; 255(2):239-44. PMID: 10049692.
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      46. Souid AK, Fahey R, Dubowy RL, Newton GL, Bernstein ML. WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study. Cancer Chemother Pharmacol. 1999; 44(6):498-504. PMID: 10550571.
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      47. Anderberg SJ, Newton GL, Fahey R. Mycothiol biosynthesis and metabolism. Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol in mycobacterium smegmatis. J Biol Chem. 1998 Nov 13; 273(46):30391-7. PMID: 9804803.
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      48. Calabro-Jones PM, Aguilera JA, Ward JF, Fahey R. The limits to radioprotection of Chinese hamster V79 cells by WR-1065 under aerobic conditions. Radiat Res. 1998 Jun; 149(6):550-9. PMID: 9611093.
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      49. Unson MD, Newton GL, Davis C, Fahey R. An immunoassay for the detection and quantitative determination of mycothiol. J Immunol Methods. 1998 May 01; 214(1-2):29-39. PMID: 9692856.
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      50. delCardayre SB, Stock KP, Newton GL, Fahey R, Davies JE. Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme. J Biol Chem. 1998 Mar 06; 273(10):5744-51. PMID: 9488707.
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      51. Sherrill C, Fahey R. Import and metabolism of glutathione by Streptococcus mutans. J Bacteriol. 1998 Mar; 180(6):1454-9. PMID: 9515913; PMCID: PMC107044.
      52. Souid AK, Newton GL, Dubowy RL, Fahey R, Bernstein ML. Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography. Cancer Chemother Pharmacol. 1998; 42(5):400-6. PMID: 9771955.
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      53. Newton GL, Aguilera JA, Ward JF, Fahey R. Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage. Radiat Res. 1997 Sep; 148(3):272-84. PMID: 9291359.
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      54. Newton GL, Aguilera JA, Ward JF, Fahey R. Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei. Radiat Res. 1996 Sep; 146(3):298-305. PMID: 8752308.
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      55. Newton GL, Aguilera JA, Kim T, Ward JF, Fahey R. Transport of aminothiol radioprotectors into mammalian cells: passive diffusion versus mediated uptake. Radiat Res. 1996 Aug; 146(2):206-15. PMID: 8693070.
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      56. Bartsch RG, Newton GL, Sherrill C, Fahey R. Glutathione amide and its perthiol in anaerobic sulfur bacteria. J Bacteriol. 1996 Aug; 178(15):4742-6. PMID: 8755912; PMCID: PMC178251.
      57. Newton GL, Aguilera JA, Ward JF, Fahey R. Polyamine-induced compaction and aggregation of DNA--a major factor in radioprotection of chromatin under physiological conditions. Radiat Res. 1996 Jun; 145(6):776-80. PMID: 8643839.
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      58. Newton GL, Arnold K, Price MS, Sherrill C, Delcardayre SB, Aharonowitz Y, Cohen G, Davies J, Fahey R, Davis C. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J Bacteriol. 1996 Apr; 178(7):1990-5. PMID: 8606174; PMCID: PMC177895.
      59. Milligan JR, Ng JY, Wu CC, Aguilera JA, Fahey R, Ward JF. DNA repair by thiols in air shows two radicals make a double-strand break. Radiat Res. 1995 Sep; 143(3):273-80. PMID: 7652164.
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      60. Newton GL, Bewley CA, Dwyer TJ, Horn R, Aharonowitz Y, Cohen G, Davies J, Faulkner DJ, Fahey R. The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol. Eur J Biochem. 1995 Jun 01; 230(2):821-5. PMID: 7607257.
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      61. Prise KM, Gillies NE, Whelan A, Newton GL, Fahey R, Michael BD. Role of charge in the radioprotection of E. coli by thiols. Int J Radiat Biol. 1995 Apr; 67(4):393-401. PMID: 7738402.
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      62. Grdina DJ, Shigematsu N, Dale P, Newton GL, Aguilera JA, Fahey R. Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis. 1995 Apr; 16(4):767-74. PMID: 7728953.
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      63. Newton GL, Fahey R. Determination of biothiols by bromobimane labeling and high-performance liquid chromatography. Methods Enzymol. 1995; 251:148-66. PMID: 7651194.
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      64. Newton GL, Fahey R, Cohen G, Aharonowitz Y. Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants. J Bacteriol. 1993 May; 175(9):2734-42. PMID: 8478335; PMCID: PMC204577.
      65. Newton GL, Dwyer TJ, Kim T, Ward JF, Fahey R. Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy. Radiat Res. 1992 Aug; 131(2):143-51. PMID: 1641468.
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      66. Zheng S, Newton GL, Ward JF, Fahey R. Aerobic radioprotection of pBR322 by thiols: effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat Res. 1992 May; 130(2):183-93. PMID: 1574574.
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      67. Aguilera JA, Newton GL, Fahey R, Ward JF. Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol. Radiat Res. 1992 May; 130(2):194-204. PMID: 1574575.
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      68. Newton GL, Aguilera JA, Fahey R, Ward JF, Radkowsky AE, Kosower EM. para-sulfobenzoyloxybromobimane: a new membrane-impermeable reagent useful for the analysis of thiols and their export from cells. Anal Biochem. 1992 Feb 14; 201(1):30-42. PMID: 1621960.
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      69. Gillies NE, Prise KM, Michael BD, Fahey R. The role of charge in intracellular radioprotection by thiols. BJR Suppl. 1992; 24:32-4. PMID: 1290708.
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      70. Fahey R, Vojnovic B, Michael BD. The effects of counter-ion condensation and co-ion depletion upon the rates of chemical repair of poly(U) radicals by thiols. Int J Radiat Biol. 1991 Apr; 59(4):885-99. PMID: 1674274.
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      71. Fahey R, Prise KM, Stratford MR, Watfa RR, Michael BD. Rates for repair of pBR 322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength. Int J Radiat Biol. 1991 Apr; 59(4):901-17. PMID: 1674275.
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      72. Fahey R, Sundquist AR. Evolution of glutathione metabolism. Adv Enzymol Relat Areas Mol Biol. 1991; 64:1-53. PMID: 1675828.
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      73. Loh SN, Dethlefsen LA, Newton GL, Aguilera JA, Fahey R. Nuclear thiols: technical limitations on the determination of endogenous nuclear glutathione and the potential importance of sulfhydryl proteins. Radiat Res. 1990 Jan; 121(1):98-106. PMID: 2300674.
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      74. Sundquist AR, Fahey R. Evolution of antioxidant mechanisms: thiol-dependent peroxidases and thioltransferase among procaryotes. J Mol Evol. 1989 Nov; 29(5):429-35. PMID: 2515292.
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      75. Sundquist AR, Fahey R. The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium. J Biol Chem. 1989 Jan 15; 264(2):719-25. PMID: 2910862.
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      76. Sundquist AR, Fahey R. The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes. J Bacteriol. 1988 Aug; 170(8):3459-67. PMID: 3136140; PMCID: PMC211315.
      77. Smoluk GD, Fahey R, Calabro-Jones PM, Aguilera JA, Ward JF. Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection. Cancer Res. 1988 Jul 01; 48(13):3641-7. PMID: 2837320.
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      78. Calabro-Jones PM, Aguilera JA, Ward JF, Smoluk GD, Fahey R. Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer Res. 1988 Jul 01; 48(13):3634-40. PMID: 2837319.
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      79. Zheng S, Newton GL, Gonick G, Fahey R, Ward JF. Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA. Radiat Res. 1988 Apr; 114(1):11-27. PMID: 3127858.
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      80. Smoluk GD, Fahey R, Ward JF. Interaction of glutathione and other low-molecular-weight thiols with DNA: evidence for counterion condensation and coion depletion near DNA. Radiat Res. 1988 Apr; 114(1):3-10. PMID: 3127859.
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      81. Fahey R. Protection of DNA by thiols. Pharmacol Ther. 1988; 39(1-3):101-8. PMID: 3059361.
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      82. Fahey R, Newton GL. Determination of low-molecular-weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography. Methods Enzymol. 1987; 143:85-96. PMID: 3657565.
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      83. Fahey R, Buschbacher RM, Newton GL. The evolution of glutathione metabolism in phototrophic microorganisms. J Mol Evol. 1987; 25:81-8. PMID: 11542078.
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      84. Newton GL, Fahey R. Purification of thiols from biological samples. Methods Enzymol. 1987; 143:96-101. PMID: 3657566.
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      85. Chinn PC, Pigiet V, Fahey R. Determination of thiol proteins using monobromobimane labeling and high-performance liquid chromatographic analysis: application to Escherichia coli thioredoxin. Anal Biochem. 1986 Nov 15; 159(1):143-9. PMID: 3544950.
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      86. Smoluk GD, Fahey R, Ward JF. Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiat Res. 1986 Aug; 107(2):194-204. PMID: 3018831.
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      87. Fenton SS, Fahey R. Analysis of biological thiols: determination of thiol components of disulfides and thioesters. Anal Biochem. 1986 Apr; 154(1):34-42. PMID: 2939769.
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      88. Fahey R, Newton GL. Measurement of WR-2721, WR-1065, and WR-33278 in plasma. Int J Radiat Oncol Biol Phys. 1985 Jun; 11(6):1193-7. PMID: 2987166.
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      89. Calabro-Jones PM, Fahey R, Smoluk GD, Ward JF. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jan; 47(1):23-7. PMID: 2982751.
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      90. Utley JF, Seaver N, Newton GL, Fahey R. Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. Int J Radiat Oncol Biol Phys. 1984 Sep; 10(9):1525-8. PMID: 6090355.
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      91. Fahey R, Newton GL, Arrick B, Overdank-Bogart T, Aley SB. Entamoeba histolytica: a eukaryote without glutathione metabolism. Science. 1984 Apr 06; 224(4644):70-2. PMID: 6322306.
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      92. Brody S, Mikolajczyk SD, Fahey R. Levels of sulfhydryls and disulfides in proteins from Neurospora crassa conidia and mycelia. J Bacteriol. 1983 Nov; 156(2):703-9. PMID: 6226648; PMCID: PMC217886.
      93. Newton GL, Dorian R, Fahey R. Analysis of biological thiols: derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography. Anal Biochem. 1981 Jul 01; 114(2):383-7. PMID: 7304929.
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      94. Fahey R, Newton GL, Dorian R, Kosower EM. Analysis of biological thiols: quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography. Anal Biochem. 1981 Mar 01; 111(2):357-65. PMID: 7247030.
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      95. Fahey R, Newton GL, Dorian R, Kosower EM. Analysis of biological thiols: derivatization with monobromotrimethylammoniobimane and characterization by electrophoresis and chromatography. Anal Biochem. 1980 Sep 01; 107(1):1-10. PMID: 6449160.
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      96. Fahey R, Di Stefano DL, Meier GP, Bryan RN. Role of hydration state and thiol-disulfide status in the control of thermal stability and protein synthesis in wheat embryo. Plant Physiol. 1980 Jun; 65(6):1062-6. PMID: 16661331.
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      97. Fahey R, Mikolajczyk SD, Brody S. Correlation of enzymatic activity and thermal resistance with hydration state in ungerminated Neurospora conidia. J Bacteriol. 1978 Sep; 135(3):868-75. PMID: 151096; PMCID: PMC222458.
      98. Fahey R, Brown WC, Adams WB, Worsham MB. Occurrence of glutathione in bacteria. J Bacteriol. 1978 Mar; 133(3):1126-9. PMID: 417060; PMCID: PMC222142.
      99. Fahey R, Hunt JS, Windham GC. On the cysteine and cystine content of proteins. Differences between intracellular and extracellular proteins. J Mol Evol. 1977 Nov 25; 10(2):155-60. PMID: 592421.
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      100. Fahey R. Biologically important thiol-disulfide reactions and the role of cyst(e)ine in proteins: an evolutionary perspective. Adv Exp Med Biol. 1977; 86A:1-30. PMID: 335836.
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      101. Fahey R, Mikolajczyk SD, Meier GP, Epel D, Carroll EJ. The glutathione thiol-disulfide status in the sea urchin egg during fertilization and the first cell division cycle. Biochim Biophys Acta. 1976 Jul 21; 437(2):445-53. PMID: 952928.
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      102. Fahey R, Brody S, Mikolajczyk SD. Changes in the glutathione thiol-disulfide status of Neurospora crassa conidia during germination and aging. J Bacteriol. 1975 Jan; 121(1):144-51. PMID: 123243; PMCID: PMC285624.
      103. Fahey R, Fischer EF. A nonenzyme-coupled assay for triosephosphate isomerase based upon circular dichroism of glyceraldehyde-3-phosphate. Anal Biochem. 1974 Feb; 57(2):547-54. PMID: 4819742.
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