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William Fenical

Title(s)Recall Faculty, Center for Marine Biotechnology and Biomedecine
SchoolVc-marine Sciences
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Discovery of PD-1/PDL-1 inhibitors from marine microbial natural products
    NIH R01CA245739Jul 14, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Identification of novel inhibitors of ocular neovascularization
    NIH R21EY028701Apr 1, 2018 - Mar 31, 2020
    Role: Co-Principal Investigator
    Mining marine microbial natural products for anthelmintics leads
    NIH R21AI101566Feb 1, 2014 - Jan 31, 2017
    Role: Principal Investigator
    An Accurate Mass TOF Mass Spectrometer - HPLC System for Marine Organic Chemistry
    NIH S10OD010640May 15, 2012 - May 14, 2013
    Role: Principal Investigator
    Natural Product Genome Mining
    NIH R01GM085770Aug 1, 2009 - Jul 31, 2025
    Role: Principal Investigator
    The Discovery of New Antibiotics from Deep Sea Actinomycete Bacteria
    NIH R01GM084350Apr 7, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Training Program in Marine Biotechnology
    NIH T32GM067550Jul 1, 2003 - Jun 30, 2021
    Role: Principal Investigator
    NMR Instrumentation for Marine Natural Product Chemistry
    NIH S10RR017768May 1, 2003 - Apr 30, 2004
    Role: Principal Investigator
    NEW ANTICANCER DRUGS FOR CULTURED AND COLLECTED MARINE O
    NIH U19CA067775Sep 8, 1995 - Apr 30, 2007
    Role: Principal Investigator
    Natural Inhibitors of Carcinogenesis
    NIH P01CA048112Sep 15, 1991 - Mar 31, 2012
    Role: Co-Investigator
    Targeted Discovery of Marine-derived Anticancer Leads
    NIH U19CA052955Sep 1, 1990 - Apr 30, 2012
    Role: Co-Investigator
    Antitumor-Antibiotics from Marine Microorganisms
    NIH R37CA044848Apr 15, 1987 - Aug 28, 2014
    Role: Principal Investigator
    ANTITUMOR ANTIBIOTICS FROM MARINE ORGANISMS
    NIH R01CA044848Apr 15, 1987 - Feb 29, 2004
    Role: Principal Investigator
    ANTIBIOTICS FROM MARINE ORGANISMS
    NIH R01CA049084Feb 1, 1977 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp. J Antibiot (Tokyo). 2022 Nov; 75(11):619-625. Kim S, Hillman PF, Lee JY, Lee J, Lee J, Cha SS, Oh DC, Nam SJ, Fenical W. PMID: 36109669.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    2. Correction to: Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp. J Antibiot (Tokyo). 2022 Jul; 75(7):415. Hassan HM, Degen D, Jang KH, Ebright RH, Fenical W. PMID: 35546183.
      View in: PubMed   Mentions:    Fields:    
    3. Marine microbial natural products: the evolution of a new field of science. J Antibiot (Tokyo). 2020 08; 73(8):481-487. Fenical WB. PMID: 32713942.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    4. Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp. Mar Drugs. 2019 Feb 02; 17(2). Le TC, Lee EJ, Lee J, Hong A, Yim CY, Yang I, Choi H, Chin J, Cho SJ, Ko J, Hwang H, Nam SJ, Fenical W. PMID: 30717397; PMCID: PMC6410326.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis. J Antibiot (Tokyo). 2018 06; 71(6):609-612. Leutou AS, Yang I, Le TC, Hahn D, Lim KM, Nam SJ, Fenical W. PMID: 29467379.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    6. Saccharomonopyrones A-C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490. Mar Drugs. 2017 Aug 03; 15(8). Yim CY, Le TC, Lee TG, Yang I, Choi H, Lee J, Kang KY, Lee JS, Lim KM, Yee ST, Kang H, Nam SJ, Fenical W. PMID: 28771166; PMCID: PMC5577594.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    7. Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp. Bioorg Med Chem Lett. 2017 07 15; 27(14):3123-3126. Le TC, Yim CY, Park S, Katila N, Yang I, Song MC, Yoon YJ, Choi DY, Choi H, Nam SJ, Fenical W. PMID: 28539221.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    8. Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production. Chem Biol. 2015 Sep 17; 22(9):1270-9. Choi EJ, Nam SJ, Paul L, Beatty D, Kauffman CA, Jensen PR, Fenical W. PMID: 26299672.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    9. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem. 2015 Sep 21; 16(14):2002-6. Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. PMID: 26267855; PMCID: PMC4835225.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14687-92. Trzoss L, Fukuda T, Costa-Lotufo LV, Jimenez P, La Clair JJ, Fenical W. PMID: 25271322; PMCID: PMC4205641.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    11. Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94. Org Biomol Chem. 2014 Jan 21; 12(3):418-23. Farnaes L, La Clair JJ, Fenical W. PMID: 24292715; PMCID: PMC3893886.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol. 2006 Dec; 2(12):666-73. Fenical W, Jensen PR. PMID: 17108984.
      View in: PubMed   Mentions: 258     Fields:    Translation:Cells
    13. New pharmaceuticals from marine organisms. Trends Biotechnol. 1997 Sep; 15(9):339-41. Fenical W. PMID: 9293031.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
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