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William Fenical

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentCenter for Marine Biotechnology and Biomedecine
Address9500 Gilman Drive #0204
La Jolla CA 92093
Phone858-534-2133
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    Collapse Research 
    Collapse Research Activities and Funding
    Identification of novel inhibitors of ocular neovascularization
    NIH/NEI R21EY028701Apr 1, 2018 - Mar 31, 2020
    Role: Co-Principal Investigator
    Mining marine microbial natural products for anthelmintics leads
    NIH/NIAID R21AI101566Feb 1, 2014 - Jan 31, 2016
    Role: Principal Investigator
    An Accurate Mass TOF Mass Spectrometer - HPLC System for Marine Organic Chemistry
    NIH S10OD010640May 15, 2012 - May 14, 2013
    Role: Principal Investigator
    Natural Product Genome Mining
    NIH/NIGMS R01GM085770Aug 1, 2009 - Jul 31, 2021
    Role: Principal Investigator
    The Discovery of New Antibiotics from Deep Sea Actinomycete Bacteria
    NIH/NIGMS R01GM084350Apr 7, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Training Program in Marine Biotechnology
    NIH/NIGMS T32GM067550Jul 1, 2003 - Jun 30, 2020
    Role: Principal Investigator
    NMR Instrumentation for Marine Natural Product Chemistry
    NIH/NCRR S10RR017768May 1, 2003 - Apr 30, 2004
    Role: Principal Investigator
    NEW ANTICANCER DRUGS FOR CULTURED AND COLLECTED MARINE O
    NIH/NCI U19CA067775Sep 8, 1995 - Apr 30, 2007
    Role: Principal Investigator
    Natural Inhibitors of Carcinogenesis
    NIH P01CA048112Sep 15, 1991 - Mar 31, 2012
    Role: Co-Investigator
    Targeted Discovery of Marine-derived Anticancer Leads
    NIH U19CA052955Sep 1, 1990 - Apr 30, 2012
    Role: Co-Investigator
    Antitumor-Antibiotics from Marine Microorganisms
    NIH/NCI R37CA044848Apr 15, 1987 - Feb 28, 2014
    Role: Principal Investigator
    ANTITUMOR ANTIBIOTICS FROM MARINE ORGANISMS
    NIH/NCI R01CA044848Apr 15, 1987 - Feb 29, 2004
    Role: Principal Investigator
    ANTIBIOTICS FROM MARINE ORGANISMS
    NIH/NCI R01CA049084Feb 1, 1977 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv. 2018 Feb; 4(2):eaao4502. PMID: 29507878.
      View in: PubMed
    2. Amos GCA, Awakawa T, Tuttle RN, Letzel AC, Kim MC, Kudo Y, Fenical W, Moore BS, Jensen PR. Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11121-E11130. PMID: 29229817.
      View in: PubMed
    3. Asolkar RN, Singh A, Jensen PR, Aalbersberg W, Carté BK, Feussner KD, Subramani R, DiPasquale A, Rheingold AL, Fenical W. Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4. Tetrahedron. 2017 Apr 20; 73(16):2234-2241. PMID: 28814819.
      View in: PubMed
    4. Kumar A, Borgen M, Aluwihare LI, Fenical W. Ozone-Activated Halogenation of Mono- and Dimethylbipyrrole in Seawater. Environ Sci Technol. 2017 Jan 03; 51(1):589-595. PMID: 27983826.
      View in: PubMed
    5. Zhou X, Fenical W. The unique chemistry and biology of the piericidins. J Antibiot (Tokyo). 2016 Aug; 69(8):582-93. PMID: 27301663.
      View in: PubMed
    6. Hassan HM, Boonlarppradab C, Fenical W. Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975. J Antibiot (Tokyo). 2016 Jul; 69(7):511-4. PMID: 27220408.
      View in: PubMed
    7. Choi EJ, Nam SJ, Paul L, Beatty D, Kauffman CA, Jensen PR, Fenical W. Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production. Chem Biol. 2015 Sep 17; 22(9):1270-9. PMID: 26299672.
      View in: PubMed
    8. Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem. 2015 Sep 21; 16(14):2002-6. PMID: 26267855; PMCID: PMC4835225 [Available on 09/21/16].
    9. Nam SJ, Kauffman CA, Jensen PR, Moore CE, Rheingold AL, Fenical W. Actinobenzoquinoline and Actinophenanthrolines A-C, Unprecedented Alkaloids from a Marine Actinobacterium. Org Lett. 2015 Jul 02; 17(13):3240-3. PMID: 26084575.
      View in: PubMed
    10. Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. Chembiochem. 2015 Jul 06; 16(10):1443-7. PMID: 25930739; PMCID: PMC4545249.
    11. Jensen PR, Moore BS, Fenical W. The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep. 2015 May; 32(5):738-51. PMID: 25730728; PMCID: PMC4414829.
    12. Trzoss L, Fukuda T, Costa-Lotufo LV, Jimenez P, La Clair JJ, Fenical W. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14687-92. PMID: 25271322; PMCID: PMC4205641.
    13. Hassan HM, Degen D, Jang KH, Ebright RH, Fenical W. Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp. J Antibiot (Tokyo). 2015 Mar; 68(3):206-9. PMID: 25227504; PMCID: PMC4363298.
    14. Hensler ME, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan BP, Shaw KJ, Fenical W, Nizet V. Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2014 Aug; 67(8):549-53. PMID: 24736856; PMCID: PMC4146678.
    15. Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W. Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis. J Nat Prod. 2014 Jan 24; 77(1):15-21. PMID: 24328269; PMCID: PMC3913167.
    16. Farnaes L, La Clair JJ, Fenical W. Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94. Org Biomol Chem. 2014 Jan 21; 12(3):418-23. PMID: 24292715; PMCID: PMC3893886.
    17. Nam SJ, Kauffman CA, Paul LA, Jensen PR, Fenical W. Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted Streptomyces sp. Org Lett. 2013 Nov 01; 15(21):5400-3. PMID: 24152065; PMCID: PMC4112586.
    18. Jensen PR, Chavarria KL, Fenical W, Moore BS, Ziemert N. Challenges and triumphs to genomics-based natural product discovery. J Ind Microbiol Biotechnol. 2014 Feb; 41(2):203-9. PMID: 24104399; PMCID: PMC3946964.
    19. Zafrir Ilan E, Torres MR, Prudhomme J, Le Roch K, Jensen PR, Fenical W. Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji. J Nat Prod. 2013 Sep 27; 76(9):1815-8. PMID: 23987585; PMCID: PMC3821698.
    20. Jang KH, Nam SJ, Locke JB, Kauffman CA, Beatty DS, Paul LA, Fenical W. Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete. Angew Chem Int Ed Engl. 2013 Jul 22; 52(30):7822-4. PMID: 23776159; PMCID: PMC3821700.
    21. Cheng YB, Jensen PR, Fenical W. Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived, MAR 4 Streptomyces Strains. European J Org Chem. 2013 Jun 01; 2013(18). PMID: 24376369.
      View in: PubMed
    22. Lane AL, Nam SJ, Fukuda T, Yamanaka K, Kauffman CA, Jensen PR, Fenical W, Moore BS. Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes. J Am Chem Soc. 2013 Mar 20; 135(11):4171-4. PMID: 23458364; PMCID: PMC3611589.
    23. Alvarez-Mico X, Jensen PR, Fenical W, Hughes CC. Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp. Org Lett. 2013 Mar 01; 15(5):988-91. PMID: 23405849; PMCID: PMC3702164.
    24. Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2012 Dec; 65(12):593-8. PMID: 23047246; PMCID: PMC3528839.
    25. Kaysser L, Bernhardt P, Nam SJ, Loesgen S, Ruby JG, Skewes-Cox P, Jensen PR, Fenical W, Moore BS. Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. J Am Chem Soc. 2012 Jul 25; 134(29):11988-91. PMID: 22784372; PMCID: PMC3410959.
    26. Choi EJ, Beatty DS, Paul LA, Fenical W, Jensen PR. Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes. Int J Syst Evol Microbiol. 2013 Apr; 63(Pt 4):1219-28. PMID: 22753528; PMCID: PMC3709535.
    27. Bucarey SA, Penn K, Paul L, Fenical W, Jensen PR. Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock. Appl Environ Microbiol. 2012 Jun; 78(12):4175-82. PMID: 22492446; PMCID: PMC3370544.
    28. Sakoulas G, Nam SJ, Loesgen S, Fenical W, Jensen PR, Nizet V, Hensler M. Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureus. PLoS One. 2012; 7(1):e29439. PMID: 22279537; PMCID: PMC3261149.
    29. Mohimani H, Liu WT, Yang YL, Gaudêncio SP, Fenical W, Dorrestein PC, Pevzner PA. Multiplex de novo sequencing of peptide antibiotics. J Comput Biol. 2011 Nov; 18(11):1371-81. PMID: 22035290; PMCID: PMC3216106.
    30. Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore BS, Dorrestein PC. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Oct 09; 7(11):794-802. PMID: 21983601; PMCID: PMC3258187.
    31. Nam SJ, Kauffman CA, Jensen PR, Fenical W. Isolation and Characterization of Actinoramides A-C, Highly Modified Peptides from a Marine Streptomyces sp. Tetrahedron. 2011 Sep 02; 67(35):6707-6712. PMID: 21857753.
      View in: PubMed
    32. Freel KC, Nam SJ, Fenical W, Jensen PR. Evolution of secondary metabolite genes in three closely related marine actinomycete species. Appl Environ Microbiol. 2011 Oct; 77(20):7261-70. PMID: 21873479; PMCID: PMC3194868.
    33. Fukuda T, Miller ED, Clark BR, Alnauman A, Murphy CD, Jensen PR, Fenical W. Structures and biosynthesis of the pyridinopyrones, polyenepyrones from a marine-derived Streptomyces species. J Nat Prod. 2011 Aug 26; 74(8):1773-8. PMID: 21751787; PMCID: PMC3163021.
    34. Edlund A, Loesgen S, Fenical W, Jensen PR. Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. Appl Environ Microbiol. 2011 Sep; 77(17):5916-25. PMID: 21724881; PMCID: PMC3165397.
    35. Sun P, Maloney KN, Nam SJ, Haste NM, Raju R, Aalbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W. Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg Med Chem. 2011 Nov 15; 19(22):6557-62. PMID: 21745747; PMCID: PMC3205191.
    36. Haste NM, Farnaes L, Perera VR, Fenical W, Nizet V, Hensler ME. Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. Mar Drugs. 2011; 9(4):680-9. PMID: 21731557; PMCID: PMC3124980.
    37. Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jul; 55(7):3305-12. PMID: 21502631; PMCID: PMC3122406.
    38. Wilson MC, Nam SJ, Gulder TA, Kauffman CA, Jensen PR, Fenical W, Moore BS. Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J Am Chem Soc. 2011 Feb 16; 133(6):1971-7. PMID: 21247149; PMCID: PMC3091981.
    39. Eustáquio AS, Nam SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore BS. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem. 2011 Jan 03; 12(1):61-4. PMID: 21154492; PMCID: PMC3088357.
    40. Kwon HC, Espindola AP, Park JS, Prieto-Davó A, Rose M, Jensen PR, Fenical W. Nitropyrrolins A-E, cytotoxic farnesyl-a-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae. J Nat Prod. 2010 Dec 27; 73(12):2047-52. PMID: 21090803; PMCID: PMC3077121.
    41. Hughes CC, Fenical W. Antibacterials from the sea. Chemistry. 2010 Nov 08; 16(42):12512-25. PMID: 20845412; PMCID: PMC3071975.
    42. Gallagher KA, Fenical W, Jensen PR. Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes. Curr Opin Biotechnol. 2010 Dec; 21(6):794-800. PMID: 20951024.
      View in: PubMed
    43. Flachsmann F, Schellhaas K, Moya CE, Jacobs RS, Fenical W. Synthetic pseudopterosin analogues: A novel class of antiinflammatory drug candidates. Bioorg Med Chem. 2010 Dec 01; 18(23):8324-33. PMID: 21041093.
      View in: PubMed
    44. Nam SJ, Gaudêncio SP, Kauffman CA, Jensen PR, Kondratyuk TP, Marler LE, Pezzuto JM, Fenical W. Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis. J Nat Prod. 2010 Jun 25; 73(6):1080-6. PMID: 20481500; PMCID: PMC2901511.
    45. Murphy BT, Narender T, Kauffman CA, Woolery M, Jensen PR, Fenical W. Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-?-Pyrones from the Marine Actinomycete Salinispora arenicola. Aust J Chem. 2010 Jun 01; 63(6). PMID: 24223427.
      View in: PubMed
    46. Oh H, Jensen PR, Murphy BT, Fiorilla C, Sullivan JF, Ramsey T, Fenical W. Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria. J Nat Prod. 2010 May 28; 73(5):998-1001. PMID: 20462271; PMCID: PMC2901504.
    47. Hughes CC, Kauffman CA, Jensen PR, Fenical W. Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. J Org Chem. 2010 May 21; 75(10):3240-50. PMID: 20405892; PMCID: PMC2884375.
    48. Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME. Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2010 May; 63(5):219-24. PMID: 20339399; PMCID: PMC2889693.
    49. Hughes CC, Fenical W. Total synthesis of the ammosamides. J Am Chem Soc. 2010 Mar 03; 132(8):2528-9. PMID: 20131899; PMCID: PMC2828514.
    50. Gontang EA, Gaudêncio SP, Fenical W, Jensen PR. Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria. Appl Environ Microbiol. 2010 Apr; 76(8):2487-99. PMID: 20154113; PMCID: PMC2849207.
    51. Maloney KN, Macmillan JB, Kauffman CA, Jensen PR, Dipasquale AG, Rheingold AL, Fenical W. Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete. Org Lett. 2009 Dec 03; 11(23):5422-4. PMID: 19883103; PMCID: PMC2820114.
    52. Hughes CC, Yang YL, Liu WT, Dorrestein PC, La Clair JJ, Fenical W. Marinopyrrole A target elucidation by acyl dye transfer. J Am Chem Soc. 2009 Sep 02; 131(34):12094-6. PMID: 19673475; PMCID: PMC2769490.
    53. Strangman WK, Kwon HC, Broide D, Jensen PR, Fenical W. Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium. J Med Chem. 2009 Apr 23; 52(8):2317-27. PMID: 19323483; PMCID: PMC2735501.
    54. Asolkar RN, Freel KC, Jensen PR, Fenical W, Kondratyuk TP, Park EJ, Pezzuto JM. Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola. J Nat Prod. 2009 Mar 27; 72(3):396-402. PMID: 19117399; PMCID: PMC2837138.
    55. Kwon HC, Kauffman CA, Jensen PR, Fenical W. Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus Marinispora. J Org Chem. 2009 Jan 16; 74(2):675-84. PMID: 19132943; PMCID: PMC3186066.
    56. Hughes CC, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ. Ammosamides A and B target myosin. Angew Chem Int Ed Engl. 2009; 48(4):728-32. PMID: 19097126; PMCID: PMC2820877.
    57. Hughes CC, MacMillan JB, Gaudêncio SP, Jensen PR, Fenical W. The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angew Chem Int Ed Engl. 2009; 48(4):725-7. PMID: 19090514; PMCID: PMC2819817.
    58. Boonlarppradab C, Kauffman CA, Jensen PR, Fenical W. Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete. Org Lett. 2008 Dec 18; 10(24):5505-8. PMID: 19007176; PMCID: PMC2654761.
    59. Fenical W, Jensen PR, Palladino MA, Lam KS, Lloyd GK, Potts BC. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). Bioorg Med Chem. 2009 Mar 15; 17(6):2175-80. PMID: 19022674; PMCID: PMC2814440.
    60. Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC. An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol. 2008 Nov; 190(5):547-57. PMID: 18629474; PMCID: PMC2574923.
    61. McGlinchey RP, Nett M, Eustáquio AS, Asolkar RN, Fenical W, Moore BS. Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc. 2008 Jun 25; 130(25):7822-3. PMID: 18512922; PMCID: PMC2814216.
    62. Schultz AW, Oh DC, Carney JR, Williamson RT, Udwary DW, Jensen PR, Gould SJ, Fenical W, Moore BS. Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J Am Chem Soc. 2008 Apr 02; 130(13):4507-16. PMID: 18331040.
      View in: PubMed
    63. Oh DC, Gontang EA, Kauffman CA, Jensen PR, Fenical W. Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica. J Nat Prod. 2008 Apr; 71(4):570-5. PMID: 18321059; PMCID: PMC2820078.
    64. Hughes CC, Prieto-Davo A, Jensen PR, Fenical W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org Lett. 2008 Feb 21; 10(4):629-31. PMID: 18205372; PMCID: PMC2820876.
    65. Martin GD, Tan LT, Jensen PR, Dimayuga RE, Fairchild CR, Raventos-Suarez C, Fenical W. Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. J Nat Prod. 2007 Sep; 70(9):1406-9. PMID: 17844998.
      View in: PubMed
    66. Cho JY, Williams PG, Kwon HC, Jensen PR, Fenical W. Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J Nat Prod. 2007 Aug; 70(8):1321-8. PMID: 17630797.
      View in: PubMed
    67. Udwary DW, Zeigler L, Asolkar RN, Singan V, Lapidus A, Fenical W, Jensen PR, Moore BS. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10376-81. PMID: 17563368; PMCID: PMC1965521.
    68. Gontang EA, Fenical W, Jensen PR. Phylogenetic diversity of gram-positive bacteria cultured from marine sediments. Appl Environ Microbiol. 2007 May; 73(10):3272-82. PMID: 17400789; PMCID: PMC1907118.
    69. Abdel-Wahab MA, Asolkar RN, Inderbitzin P, Fenical W. Secondary metabolite chemistry of the marine-derived fungus Massarina sp., strain CNT-016. Phytochemistry. 2007 Apr; 68(8):1212-8. PMID: 17376494; PMCID: PMC2735499.
    70. Oh DC, Strangman WK, Kauffman CA, Jensen PR, Fenical W. Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp. Org Lett. 2007 Apr 12; 9(8):1525-8. PMID: 17373804.
      View in: PubMed
    71. Oh DC, Kauffman CA, Jensen PR, Fenical W. Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture. J Nat Prod. 2007 Apr; 70(4):515-20. PMID: 17323993.
      View in: PubMed
    72. Williams PG, Miller ED, Asolkar RN, Jensen PR, Fenical W. Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola. J Org Chem. 2007 Jul 06; 72(14):5025-34. PMID: 17266372; PMCID: PMC2577615.
    73. Miller ED, Kauffman CA, Jensen PR, Fenical W. Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces. J Org Chem. 2007 Jan 19; 72(2):323-30. PMID: 17221946.
      View in: PubMed
    74. Williams PG, Asolkar RN, Kondratyuk T, Pezzuto JM, Jensen PR, Fenical W. Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. J Nat Prod. 2007 Jan; 70(1):83-8. PMID: 17253854.
      View in: PubMed
    75. Jensen PR, Williams PG, Oh DC, Zeigler L, Fenical W. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl Environ Microbiol. 2007 Feb; 73(4):1146-52. PMID: 17158611; PMCID: PMC1828645.
    76. Fenical W, Jensen PR. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol. 2006 Dec; 2(12):666-73. PMID: 17108984.
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    77. Asolkar RN, Jensen PR, Kauffman CA, Fenical W. Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. J Nat Prod. 2006 Dec; 69(12):1756-9. PMID: 17190455.
      View in: PubMed
    78. Bugni TS, Woolery M, Kauffman CA, Jensen PR, Fenical W. Bohemamines from a marine-derived Streptomyces sp. J Nat Prod. 2006 Nov; 69(11):1626-8. PMID: 17125235.
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    79. Sandler JS, Colin PL, Kelly M, Fenical W. Cytotoxic macrolides from a new species of the deep-water marine sponge Leiodermatium. J Org Chem. 2006 Sep 15; 71(19):7245-51. PMID: 16958517.
      View in: PubMed
    80. Cho JY, Kwon HC, Williams PG, Jensen PR, Fenical W. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). Org Lett. 2006 Jun 08; 8(12):2471-4. PMID: 16737291; PMCID: PMC2596804.
    81. Oh DC, Williams PG, Kauffman CA, Jensen PR, Fenical W. Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica". Org Lett. 2006 Mar 16; 8(6):1021-4. PMID: 16524258.
      View in: PubMed
    82. Cho JY, Kwon HC, Williams PG, Kauffman CA, Jensen PR, Fenical W. Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales). J Nat Prod. 2006 Mar; 69(3):425-8. PMID: 16562851.
      View in: PubMed
    83. Alexander MD, Burkart MD, Leonard MS, Portonovo P, Liang B, Ding X, Joullié MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong BG, Brady TP, Theodorakis EA, La Clair JJ. A central strategy for converting natural products into fluorescent probes. Chembiochem. 2006 Mar; 7(3):409-16. PMID: 16432909.
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    85. Kwon HC, Kauffman CA, Jensen PR, Fenical W. Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora". J Am Chem Soc. 2006 Feb 08; 128(5):1622-32. PMID: 16448135.
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    94. Rowley DC, Kelly S, Jensen P, Fenical W. Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungus. Bioorg Med Chem. 2004 Sep 15; 12(18):4929-36. PMID: 15336272.
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    95. Tan RX, Jensen PR, Williams PG, Fenical W. Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum. J Nat Prod. 2004 Aug; 67(8):1374-82. PMID: 15332857.
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    96. Tan LT, Cheng XC, Jensen PR, Fenical W. Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus Scytalidium. J Org Chem. 2003 Nov 14; 68(23):8767-73. PMID: 14604342.
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    97. Rowley DC, Kelly S, Kauffman CA, Jensen PR, Fenical W. Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus Scytalidium. Bioorg Med Chem. 2003 Sep 15; 11(19):4263-74. PMID: 12951157.
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    98. Liu Z, Jensen PR, Fenical W. A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma. Phytochemistry. 2003 Sep; 64(2):571-4. PMID: 12943777.
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    99. Spyere A, Rowley DC, Jensen PR, Fenical W. New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandis. J Nat Prod. 2003 Jun; 66(6):818-22. PMID: 12828468.
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    100. Garo E, Starks CM, Jensen PR, Fenical W, Lobkovsky E, Clardy J. Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens. J Nat Prod. 2003 Mar; 66(3):423-6. PMID: 12662106.
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    101. Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen PR, Fenical W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angew Chem Int Ed Engl. 2003 Jan 20; 42(3):355-7. PMID: 12548698.
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    102. Rowley DC, Hansen MS, Rhodes D, Sotriffer CA, Ni H, McCammon JA, Bushman FD, Fenical W. Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase. Bioorg Med Chem. 2002 Nov; 10(11):3619-25. PMID: 12213478.
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    103. Mincer TJ, Jensen PR, Kauffman CA, Fenical W. Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments. Appl Environ Microbiol. 2002 Oct; 68(10):5005-11. PMID: 12324350; PMCID: PMC126404.
    104. Engel S, Jensen PR, Fenical W. Chemical ecology of marine microbial defense. J Chem Ecol. 2002 Oct; 28(10):1971-85. PMID: 12474894.
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    105. Cueto M, Jensen PR, Fenical W. Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus. Org Lett. 2002 May 02; 4(9):1583-5. PMID: 11975634.
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    106. Fenical W. New pharmaceuticals from marine organisms. Trends Biotechnol. 1997 Sep; 15(9):339-41. PMID: 9293031.
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    107. Kang H, Fenical W. Ningalins A-D: Novel Aromatic Alkaloids from a Western Australian Ascidian of the Genus Didemnum. J Org Chem. 1997 May 16; 62(10):3254-3262. PMID: 11671712.
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