Nadejda Beliakova-bethell
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Title(s) | Associate Adjunct Professor, Medicine |
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School | Vc-health Sciences-schools |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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ORCID
| 0000-0001-9765-7786 |
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vCard | Download vCard |
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Biography
St. Petersburg State University, St. Petersburg, Russia | B.S. | 12/1998 | Cell Biology and Histology |
University of California, Irvine, Irvine, CA, USA | Ph.D. | 03/2009 | Virology, Molecular Biology |
University of California, San Diego, La Jolla, CA, USA | Postdoctoral | 06/2013 | HIV/AIDS, Bioinformatics |
Overview
Despite the success of antiretroviral therapy to control HIV infection, the latent reservoir formed by this virus remains the main barrier to a complete cure. Our laboratory studies the molecular mechanisms of HIV latency establishment and maintenance in human primary CD4+ T cells. We aim to determine how gene expression profiles in phenotypically different cells influence the proviral state and its ability to reactivate from latency. Currently, we focus on investigating the roles of long non-coding RNAs in the regulation of HIV gene expression and latency. We use the in vitro primary T cell models of HIV latency and CD4+ T cells obtained from people with HIV. Our most recent study has focused on delineating the heterogeneity of the latent reservoir cells using single-cell RNA-Seq technology coupled with immunophenotyping. Within these heterogeneous cell populations, we aim to identify molecular signatures (“a biomarker”) of latency that can define latently infected cells. This knowledge will likely lead to the development of approaches to capture the latently infected cells and, ultimately, to target them for elimination.
Research
Bibliographic
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Targeting noncoding RNAs to reactivate or eliminate latent HIV reservoirs. Curr Opin HIV AIDS. 2024 03 01; 19(2):47-55.
Beliakova-Bethell N. PMID: 38169367; PMCID: PMC10872953.
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HumansCells
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Single-cell RNA sequencing reveals common and unique gene expression profiles in primary CD4+ T cells latently infected with HIV under different conditions. Front Cell Infect Microbiol. 2023; 13:1286168.
Zhang X, Qazi AA, Deshmukh S, Lobato Ventura R, Mukim A, Beliakova-Bethell N. PMID: 38156317; PMCID: PMC10754520.
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HumansCells
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Humans
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HIV Infection Elicits Differential Transcriptomic Remodeling in CD4+ T Cells with Variable Proliferative Responses to the T Cell Receptor Stimulus. Pathogens. 2023 Mar 24; 12(4).
Zhang X, Deshmukh S, Mukim A, Zhang J, Beliakova-Bethell N. PMID: 37111397; PMCID: PMC10145558.
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2
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An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review. HIV AIDS (Auckl). 2023; 15:115-134.
Ramirez PW, Pantoja C, Beliakova-Bethell N. PMID: 36942082; PMCID: PMC10024501.
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5
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A Camptothetin Analog, Topotecan, Promotes HIV Latency via Interference with HIV Transcription and RNA Splicing. J Virol. 2023 Feb 28; 97(2):e0163022.
Mukim A, Smith DM, Deshmukh S, Qazi AA, Beliakova-Bethell N. PMID: 36719238; PMCID: PMC9973035.
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1 Fields:
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HumansCells
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HIV-1 latency is established preferentially in minimally activated and non-dividing cells during productive infection of primary CD4 T cells. PLoS One. 2022; 17(7):e0271674.
Soto PC, Terry VH, Lewinski MK, Deshmukh S, Beliakova-Bethell N, Spina CA. PMID: 35895672; PMCID: PMC9328514.
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7 Fields:
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HumansCells
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Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals. Front Immunol. 2022; 13:894543.
Beliakova-Bethell N, Maruthai K, Xu R, Salvador LCM, Garg A. PMID: 35812392; PMCID: PMC9263272.
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8 Fields:
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HumansCells
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Integrated proteomics and transcriptomics analyses identify novel cell surface markers of HIV latency. Virology. 2022 08; 573:50-58.
Beliakova-Bethell N, Manousopoulou A, Deshmukh S, Mukim A, Richman DD, Garbis SD, Spina CA. PMID: 35714458; PMCID: PMC10427345.
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2 Fields:
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HumansCells
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Micro RNA Targets in HIV Latency: Insights into Novel Layers of Latency Control. AIDS Res Hum Retroviruses. 2021 02; 37(2):109-121.
Heinson AI, Woo J, Mukim A, White CH, Moesker B, Bosque A, Spina CA, Woelk CH, Macarthur BD, Beliakova-Bethell N. PMID: 33045840; PMCID: PMC7876363.
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11 Fields:
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HumansCells
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Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation. iScience. 2020 Oct 23; 23(10):101582.
Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB. PMID: 33205009; PMCID: PMC7648132.
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19
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Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal. PLoS One. 2019; 14(11):e0224879.
Trypsteen W, White CH, Mukim A, Spina CA, De Spiegelaere W, Lefever S, Planelles V, Bosque A, Woelk CH, Vandekerckhove L, Beliakova-Bethell N. PMID: 31710657; PMCID: PMC6844474.
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15 Fields:
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HumansCells
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Use of GapmeRs for gene expression knockdowns in human primary resting CD4+ T cells. J Immunol Methods. 2020 01; 476:112674.
Abewe H, Deshmukh S, Mukim A, Beliakova-Bethell N. PMID: 31629740; PMCID: PMC6939142.
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2 Fields:
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HumansCells
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Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation. J Biol Chem. 2019 04 05; 294(14):5576-5589.
Beliakova-Bethell N, Mukim A, White CH, Deshmukh S, Abewe H, Richman DD, Spina CA. PMID: 30745362; PMCID: PMC6462528.
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14 Fields:
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HumansCells
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Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment. Front Immunol. 2018; 9:603.
White CH, Beliakova-Bethell N, Lada SM, Breen MS, Hurst TP, Spina CA, Richman DD, Frater J, Magiorkinis G, Woelk CH. PMID: 29706951; PMCID: PMC5906534.
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14 Fields:
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HumansCells
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Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133.
Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. PMID: 28527342; PMCID: PMC5654527.
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14 Fields:
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HumansCells
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Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026.
White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina CA, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. PMID: 27898737; PMCID: PMC5127598.
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20 Fields:
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HumansCells
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Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Nov; 29(17):2235-44.
Reardon B, Beliakova-Bethell N, Spina CA, Singhania A, Margolis DM, Richman DR, Woelk CH. PMID: 26258524; PMCID: PMC4917679.
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11 Fields:
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HumansCells
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Acute psychological stress induces short-term variable immune response. Brain Behav Immun. 2016 Mar; 53:172-182.
Breen MS, Beliakova-Bethell N, Mujica-Parodi LR, Carlson JM, Ensign WY, Woelk CH, Rana BK. PMID: 26476140.
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21 Fields:
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Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85.
White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina CA, Garbis SD, Woelk CH, Beliakova-Bethell N. PMID: 26343910; PMCID: PMC5606336.
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26 Fields:
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HumansCells
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Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression. Antiviral Res. 2014 Jul; 107:42-9.
Beliakova-Bethell N, Jain S, Woelk CH, Witt MD, Sun X, Lada SM, Spina CA, Goicoechea M, Rought SE, Haubrich R, Dubé MP. PMID: 24769244; PMCID: PMC4116489.
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8 Fields:
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HumansCells
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The effect of cell subset isolation method on gene expression in leukocytes. Cytometry A. 2014 Jan; 85(1):94-104.
Beliakova-Bethell N, Massanella M, White C, Lada S, Du P, Vaida F, Blanco J, Spina CA, Woelk CH. PMID: 24115734; PMCID: PMC3975050.
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40 Fields:
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HumansCells
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Differential gene expression in HIV-infected individuals following ART. Antiviral Res. 2013 Nov; 100(2):420-8.
Massanella M, Singhania A, Beliakova-Bethell N, Pier R, Lada SM, White CH, Pérez-Santiago J, Blanco J, Richman DD, Little SJ, Woelk CH. PMID: 23933117; PMCID: PMC3899918.
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19 Fields:
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Humans
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Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 02; 27(1):29-37.
Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina CA, Woelk CH. PMID: 23221426; PMCID: PMC3752851.
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18 Fields:
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HumansCells
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HIV downregulates interferon-stimulated genes in primary macrophages. J Interferon Cytokine Res. 2013 Feb; 33(2):90-5.
Wie SH, Du P, Luong TQ, Rought SE, Beliakova-Bethell N, Lozach J, Corbeil J, Kornbluth RS, Richman DD, Woelk CH. PMID: 23276142; PMCID: PMC3573720.
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21 Fields:
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HumansCells
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Sequence requirements for localization and packaging of Ty3 retroelement RNA. Virus Res. 2013 Feb; 171(2):319-31.
Clemens K, Bilanchone V, Beliakova-Bethell N, Larsen LS, Nguyen K, Sandmeyer S. PMID: 23073180; PMCID: PMC3578171.
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7 Fields:
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AnimalsCells
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Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery. AIDS. 2010 Jan 16; 24(2):217-22.
Woelk CH, Beliakova-Bethell N, Goicoechea M, Zhao Y, Du P, Rought SE, Lozach J, Pérez-Santiago J, Richman DD, Smith DM, Little SJ. PMID: 19952713; PMCID: PMC2915828.
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13 Fields:
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HumansCells
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Ty3 nuclear entry is initiated by viruslike particle docking on GLFG nucleoporins. J Virol. 2009 Nov; 83(22):11914-25.
Beliakova-Bethell N, Terry LJ, Bilanchone V, DaSilva R, Nagashima K, Wente SR, Sandmeyer S. PMID: 19759143; PMCID: PMC2772691.
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12 Fields:
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AnimalsCells
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Ty3 nucleocapsid controls localization of particle assembly. J Virol. 2008 Mar; 82(5):2501-14.
Larsen LS, Beliakova-Bethell N, Bilanchone V, Zhang M, Lamsa A, Dasilva R, Hatfield GW, Nagashima K, Sandmeyer S. PMID: 18094177; PMCID: PMC2258933.
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25 Fields:
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AnimalsCells
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Ty3 capsid mutations reveal early and late functions of the amino-terminal domain. J Virol. 2007 Jul; 81(13):6957-72.
Larsen LS, Zhang M, Beliakova-Bethell N, Bilanchone V, Lamsa A, Nagashima K, Najdi R, Kosaka K, Kovacevic V, Cheng J, Baldi P, Hatfield GW, Sandmeyer S. PMID: 17442718; PMCID: PMC1933270.
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23 Fields:
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AnimalsCells
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Virus-like particles of the Ty3 retrotransposon assemble in association with P-body components. RNA. 2006 Jan; 12(1):94-101.
Beliakova-Bethell N, Beckham C, Giddings TH, Winey M, Parker R, Sandmeyer S. PMID: 16373495; PMCID: PMC1370889.
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63 Fields:
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AnimalsCells
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Retroviruses and yeast retrotransposons use overlapping sets of host genes. Genome Res. 2005 May; 15(5):641-54.
Irwin B, Aye M, Baldi P, Beliakova-Bethell N, Cheng H, Dou Y, Liou W, Sandmeyer S. PMID: 15837808; PMCID: PMC1088292.
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59 Fields:
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Host factors that affect Ty3 retrotransposition in Saccharomyces cerevisiae. Genetics. 2004 Nov; 168(3):1159-76.
Aye M, Irwin B, Beliakova-Bethell N, Chen E, Garrus J, Sandmeyer S. PMID: 15579677; PMCID: PMC1448793.
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32 Fields:
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AnimalsCells
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Ty3 integrase is required for initiation of reverse transcription. J Virol. 2002 Mar; 76(6):2804-16.
Nymark-McMahon MH, Beliakova-Bethell NS, Darlix JL, Le Grice SF, Sandmeyer SB. PMID: 11861848; PMCID: PMC135951.
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24 Fields:
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AnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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Year | Publications |
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2002 | 1 |
2004 | 1 |
2005 | 1 |
2006 | 1 |
2007 | 2 |
2009 | 1 |
2010 | 1 |
2012 | 2 |
2013 | 3 |
2014 | 1 |
2015 | 3 |
2016 | 1 |
2017 | 1 |
2018 | 1 |
2019 | 3 |
2020 | 2 |
2022 | 3 |
2023 | 6 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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