Nadejda Beliakova-bethell
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| Title(s) | Associate Adjunct Professor, Medicine |
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| School | Vc-health Sciences-schools |
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| Address | 9500 Gilman Drive #
La Jolla CA 92093
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ORCID
.gif) | 0000-0001-9765-7786  |
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| vCard | Download vCard |
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Biography
| St. Petersburg State University, St. Petersburg, Russia | B.S. | 12/1998 | Cell Biology and Histology |
| University of California, Irvine, Irvine, CA, USA | Ph.D. | 03/2009 | Virology, Molecular Biology |
| University of California, San Diego, La Jolla, CA, USA | Postdoctoral | 06/2013 | HIV/AIDS, Bioinformatics |
Overview
Despite success of the antiretroviral therapy to control HIV infection, the latent reservoir formed by this virus remains the main barrier to a complete cure. Our laboratory studies the molecular mechanisms of HIV latency establishment and maintenance in human primary CD4+ T cells. We aim to determine how gene expression profiles in phenotypically different cells influence the proviral state and its ability to reactivate from latency. We use the in vitro primary T cell models of HIV latency and CD4+ T cells obtained from people with HIV. Our most recent study has focused on delineating the heterogeneity of the latent reservoir cells using single cell RNA-Seq technology coupled with immunophenotyping. Within these heterogeneous cell populations, we aim to identify molecular signatures (“a biomarker”) of latency that can define latently infected cells. This knowledge will likely lead to development of approaches to capture the latently infected cells and, ultimately, to target them for elimination.
Research
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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HIV Infection Elicits Differential Transcriptomic Remodeling in CD4+ T Cells with Variable Proliferative Responses to the T Cell Receptor Stimulus. Pathogens. 2023 Mar 24; 12(4).
Zhang X, Deshmukh S, Mukim A, Zhang J, Beliakova-Bethell N. PMID: 37111397; PMCID: PMC10145558.
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PubMed Mentions:
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Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals. Front Immunol. 2022; 13:894543.
Beliakova-Bethell N, Maruthai K, Xu R, Salvador LCM, Garg A. PMID: 35812392; PMCID: PMC9263272.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Integrated proteomics and transcriptomics analyses identify novel cell surface markers of HIV latency. Virology. 2022 08; 573:50-58.
Beliakova-Bethell N, Manousopoulou A, Deshmukh S, Mukim A, Richman DD, Garbis SD, Spina CA. PMID: 35714458; PMCID: PMC10427345.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Micro RNA Targets in HIV Latency: Insights into Novel Layers of Latency Control. AIDS Res Hum Retroviruses. 2021 02; 37(2):109-121.
Heinson AI, Woo J, Mukim A, White CH, Moesker B, Bosque A, Spina CA, Woelk CH, Macarthur BD, Beliakova-Bethell N. PMID: 33045840; PMCID: PMC7876363.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal. PLoS One. 2019; 14(11):e0224879.
Trypsteen W, White CH, Mukim A, Spina CA, De Spiegelaere W, Lefever S, Planelles V, Bosque A, Woelk CH, Vandekerckhove L, Beliakova-Bethell N. PMID: 31710657; PMCID: PMC6844474.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Use of GapmeRs for gene expression knockdowns in human primary resting CD4+ T cells. J Immunol Methods. 2020 01; 476:112674.
Abewe H, Deshmukh S, Mukim A, Beliakova-Bethell N. PMID: 31629740; PMCID: PMC6939142.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation. J Biol Chem. 2019 04 05; 294(14):5576-5589.
Beliakova-Bethell N, Mukim A, White CH, Deshmukh S, Abewe H, Richman DD, Spina CA. PMID: 30745362; PMCID: PMC6462528.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133.
Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. PMID: 28527342; PMCID: PMC5654527.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026.
White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina CA, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. PMID: 27898737; PMCID: PMC5127598.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Nov; 29(17):2235-44.
Reardon B, Beliakova-Bethell N, Spina CA, Singhania A, Margolis DM, Richman DR, Woelk CH. PMID: 26258524; PMCID: PMC4917679.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85.
White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina CA, Garbis SD, Woelk CH, Beliakova-Bethell N. PMID: 26343910; PMCID: PMC5606336.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression. Antiviral Res. 2014 Jul; 107:42-9.
Beliakova-Bethell N, Jain S, Woelk CH, Witt MD, Sun X, Lada SM, Spina CA, Goicoechea M, Rought SE, Haubrich R, Dubé MP. PMID: 24769244; PMCID: PMC4116489.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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The effect of cell subset isolation method on gene expression in leukocytes. Cytometry A. 2014 Jan; 85(1):94-104.
Beliakova-Bethell N, Massanella M, White C, Lada S, Du P, Vaida F, Blanco J, Spina CA, Woelk CH. PMID: 24115734; PMCID: PMC3975050.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Differential gene expression in HIV-infected individuals following ART. Antiviral Res. 2013 Nov; 100(2):420-8.
Massanella M, Singhania A, Beliakova-Bethell N, Pier R, Lada SM, White CH, Pérez-Santiago J, Blanco J, Richman DD, Little SJ, Woelk CH. PMID: 23933117; PMCID: PMC3899918.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 02; 27(1):29-37.
Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina CA, Woelk CH. PMID: 23221426; PMCID: PMC3752851.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery. AIDS. 2010 Jan 16; 24(2):217-22.
Woelk CH, Beliakova-Bethell N, Goicoechea M, Zhao Y, Du P, Rought SE, Lozach J, Pérez-Santiago J, Richman DD, Smith DM, Little SJ. PMID: 19952713; PMCID: PMC2915828.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
This graph shows the total number of publications by year. To see the data as text,
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| Year | Publications |
|---|
| 2010 | 1 |
| 2013 | 3 |
| 2014 | 1 |
| 2015 | 2 |
| 2016 | 1 |
| 2017 | 1 |
| 2019 | 3 |
| 2020 | 1 |
| 2022 | 2 |
| 2023 | 1 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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