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Nadejda Beliakova-Bethell

Title(s)Assistant Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0679
La Jolla CA 92093
ORCID ORCID Icon0000-0001-9765-7786 Additional info
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    Collapse Biography 
    Collapse Education and Training
    St. Petersburg State University, St. Petersburg, RussiaB.S.12/1998Cell Biology and Histology
    University of California, Irvine, Irvine, CA, USAPh.D.03/2009Virology, Molecular Biology
    University of California, San Diego, La Jolla, CA, USAPostdoctoral06/2013HIV/AIDS, Bioinformatics

    Collapse Overview 
    Collapse Overview
    Despite success of the antiretroviral therapy to control HIV infection, the latent reservoir formed by this virus remains the main barrier to a complete cure. Our laboratory studies the molecular mechanisms of HIV latency establishment and maintenance in human primary CD4+ T cells. We aim to determine how gene expression profiles in phenotypically different cells influence the proviral state and its ability to reactivate from latency. We use the in vitro primary T cell models of HIV latency and CD4+ T cells obtained from people with HIV. Our most recent study has focused on delineating the heterogeneity of the latent reservoir cells using single cell RNA-Seq technology coupled with immunophenotyping. Within these heterogeneous cell populations, we aim to identify molecular signatures (“a biomarker”) of latency that can define latently infected cells. This knowledge will likely lead to development of approaches to capture the latently infected cells and, ultimately, to target them for elimination.

    Collapse Research 
    Collapse Research Activities and Funding
    Opioid Impacts on T Cell Pathways and Epigenetics to Modulate HIV Integration, Latency and Reservoirs.
    NIH/NIDA R61DA047039Sep 30, 2018 - Jun 30, 2021
    Role: Co-Investigator
    HIV reactivation from latency - role of CD4 T cell maturation phenotype
    Office of Research and Development, Veterans Health Administration IK2 BX002731Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Use of GapmeRs for gene expression knockdowns in human primary resting CD4+ T cells. J Immunol Methods. 2020 01; 476:112674. Abewe H, Deshmukh S, Mukim A, Beliakova-Bethell N. PMID: 31629740.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation. J Biol Chem. 2019 04 05; 294(14):5576-5589. Beliakova-Bethell N, Mukim A, White CH, Deshmukh S, Abewe H, Richman DD, Spina CA. PMID: 30745362.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. PMID: 28527342.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026. White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina CA, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. PMID: 27898737.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Nov; 29(17):2235-44. Reardon B, Beliakova-Bethell N, Spina CA, Singhania A, Margolis DM, Richman DR, Woelk CH. PMID: 26258524.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85. White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina CA, Garbis SD, Woelk CH, Beliakova-Bethell N. PMID: 26343910.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    7. Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression. Antiviral Res. 2014 Jul; 107:42-9. Beliakova-Bethell N, Jain S, Woelk CH, Witt MD, Sun X, Lada SM, Spina CA, Goicoechea M, Rought SE, Haubrich R, Dubé MP. PMID: 24769244.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. The effect of cell subset isolation method on gene expression in leukocytes. Cytometry A. 2014 Jan; 85(1):94-104. Beliakova-Bethell N, Massanella M, White C, Lada S, Du P, Vaida F, Blanco J, Spina CA, Woelk CH. PMID: 24115734.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    9. Differential gene expression in HIV-infected individuals following ART. Antiviral Res. 2013 Nov; 100(2):420-8. Massanella M, Singhania A, Beliakova-Bethell N, Pier R, Lada SM, White CH, Pérez-Santiago J, Blanco J, Richman DD, Little SJ, Woelk CH. PMID: 23933117.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    10. Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 02; 27(1):29-37. Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina CA, Woelk CH. PMID: 23221426.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery. AIDS. 2010 Jan 16; 24(2):217-22. Woelk CH, Beliakova-Bethell N, Goicoechea M, Zhao Y, Du P, Rought SE, Lozach J, Pérez-Santiago J, Richman DD, Smith DM, Little SJ. PMID: 19952713.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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