|St. Petersburg State University, St. Petersburg, Russia||B.S.||12/1998||Cell Biology and Histology|
|University of California, Irvine, Irvine, CA, USA||Ph.D.||03/2009||Virology, Molecular Biology|
|University of California, San Diego, La Jolla, CA, USA||Postdoctoral||06/2013||HIV/AIDS, Bioinformatics|
Despite success of the antiretroviral therapy to control HIV infection, the latent reservoir formed by this virus remains the main barrier to a complete cure. Our laboratory studies the molecular mechanisms of HIV latency establishment and maintenance in human primary CD4+ T cells. We aim to determine how gene expression profiles in phenotypically different cells influence the proviral state and its ability to reactivate from latency. We use the in vitro primary T cell models of HIV latency and CD4+ T cells obtained from people with HIV. Our most recent study has focused on delineating the heterogeneity of the latent reservoir cells using single cell RNA-Seq technology coupled with immunophenotyping. Within these heterogeneous cell populations, we aim to identify molecular signatures (“a biomarker”) of latency that can define latently infected cells. This knowledge will likely lead to development of approaches to capture the latently infected cells and, ultimately, to target them for elimination.