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Daniel Donoghue

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0367
La Jolla CA 92093
Phone858-534-7146
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    Collapse Research 
    Collapse Research Activities and Funding
    Abberant Activation of FGFR3 Signaling in Human Cancer
    NIH/NCI R01CA090900May 1, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Regulation of Receptor Tyrosine Kinases
    NIH/NIGMS R01GM065490Jul 1, 2002 - Jun 30, 2006
    Role: Principal Investigator
    Transmembrane Domains of Receptor Tyrosine Kinases
    NIH/NIGMS R01GM061163Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Biochemistry of Growth Regulation and Oncogenesis
    NIH/NCI T32CA009523Jul 1, 1985 - Jun 30, 2019
    Role: Principal Investigator
    MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    NIH/NIDCR R01DE012581Jul 1, 1985 - Jul 31, 2002
    Role: Principal Investigator
    MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    NIH/NCI R01CA040573Jul 1, 1985 - Jun 30, 1997
    Role: Principal Investigator
    EXPRESSION OF RETROVIRAL ENVELOPE GENE FUSION PROTEINS
    NIH/NCI R01CA034456Apr 1, 1983 - Apr 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Meyer AN, Gallo LH, Ko J, Cardenas G, Nelson KN, Siari A, Campos AR, Whisenant TC, Donoghue DJ. Oncogenic mutations in IKKß function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation. PLoS One. 2018; 13(10):e0206014. PMID: 30335863.
      View in: PubMed
    2. Nelson KN, Meyer AN, Wang CG, Donoghue DJ. Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling. Oncotarget. 2018 Sep 28; 9(76):34306-34319. PMID: 30344944.
      View in: PubMed
    3. Casar B, Badrock AP, Jiménez I, Arozarena I, Colón-Bolea P, Lorenzo-Martín LF, Barinaga-Rementería I, Barriuso J, Cappitelli V, Donoghue DJ, Bustelo XR, Hurlstone A, Crespo P. RAS at the Golgi antagonizes malignant transformation through PTPR?-mediated inhibition of ERK activation. Nat Commun. 2018 Sep 05; 9(1):3595. PMID: 30185827.
      View in: PubMed
    4. Yin HB, Chen CH, Darre MJ, Donoghue AM, Donoghue DJ, Venkitanarayanan K. Phytochemicals reduce aflatoxin-induced toxicity in chicken embryos. Poult Sci. 2017 Oct 01; 96(10):3725-3732. PMID: 28938783.
      View in: PubMed
    5. Kollanoor Johny A, Frye JG, Donoghue A, Donoghue DJ, Porwollik S, McClelland M, Venkitanarayanan K. Gene Expression Response of Salmonella enterica Serotype Enteritidis Phage Type 8 to Subinhibitory Concentrations of the Plant-Derived Compounds Trans-Cinnamaldehyde and Eugenol. Front Microbiol. 2017; 8:1828. PMID: 29018419.
      View in: PubMed
    6. Upadhyay A, Arsi K, Wagle BR, Upadhyaya I, Shrestha S, Donoghue AM, Donoghue DJ. Trans-Cinnamaldehyde, Carvacrol, and Eugenol Reduce Campylobacter jejuni Colonization Factors and Expression of Virulence Genes in Vitro. Front Microbiol. 2017; 8:713. PMID: 28487683.
      View in: PubMed
    7. Wagle BR, Upadhyay A, Arsi K, Shrestha S, Venkitanarayanan K, Donoghue AM, Donoghue DJ. Application of ß-Resorcylic Acid as Potential Antimicrobial Feed Additive to Reduce Campylobacter Colonization in Broiler Chickens. Front Microbiol. 2017; 8:599. PMID: 28428779.
      View in: PubMed
    8. Nelson KN, Peiris MN, Meyer AN, Siari A, Donoghue DJ. Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders. Trends Mol Med. 2017 01; 23(1):59-79. PMID: 27988109.
      View in: PubMed
    9. Jiang MY, Lee TL, Hao SS, Mahooti S, Baird SM, Donoghue DJ, Haas M. Visualization of early prostatic adenocarcinoma as a stem cell disease. Oncotarget. 2016 Nov 15; 7(46):76159-76168. PMID: 27764770.
      View in: PubMed
    10. Nelson KN, Meyer AN, Siari A, Campos AR, Motamedchaboki K, Donoghue DJ. Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation. Mol Cancer Res. 2016 05; 14(5):458-69. PMID: 26869289.
      View in: PubMed
    11. Gallo LH, Nelson KN, Meyer AN, Donoghue DJ. Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations. Cytokine Growth Factor Rev. 2015 Aug; 26(4):425-49. PMID: 26003532.
      View in: PubMed
    12. Salazar L, Kashiwada T, Krejci P, Meyer AN, Casale M, Hallowell M, Wilcox WR, Donoghue DJ, Thompson LM. Fibroblast growth factor receptor 3 interacts with and activates TGFß-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. PLoS One. 2014; 9(1):e86470. PMID: 24466111; PMCID: PMC3900522.
    13. Gallo LH, Meyer AN, Motamedchaboki K, Nelson KN, Haas M, Donoghue DJ. Novel Lys63-linked ubiquitination of IKKß induces STAT3 signaling. Cell Cycle. 2014; 13(24):3964-76. PMID: 25486864; PMCID: PMC4615003.
    14. Meyer AN, Drafahl KA, McAndrew CW, Gilda JE, Gallo LH, Haas M, Brill LM, Donoghue DJ. Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKß. PLoS One. 2013; 8(12):e84497. PMID: 24386391; PMCID: PMC3873999.
    15. Manickam K, Donoghue DJ, Meyer AN, Snyder PJ, Prior TW. Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation. Am J Med Genet A. 2014 Jan; 164A(1):243-50. PMID: 24352917.
      View in: PubMed
    16. Fiñones RR, Yeargin J, Lee M, Kaur AP, Cheng C, Sun P, Wu C, Nguyen C, Wang-Rodriguez J, Meyer AN, Baird SM, Donoghue DJ, Haas M. Early human prostate adenocarcinomas harbor androgen-independent cancer cells. PLoS One. 2013; 8(9):e74438. PMID: 24086346; PMCID: PMC3783414.
    17. Aguiar VF, Donoghue AM, Arsi K, Reyes-Herrera I, Metcalf JH, de los Santos FS, Blore PJ, Donoghue DJ. Targeting motility properties of bacteria in the development of probiotic cultures against Campylobacter jejuni in broiler chickens. Foodborne Pathog Dis. 2013 May; 10(5):435-41. PMID: 23531121.
      View in: PubMed
    18. Locascio LE, Donoghue DJ. KIDs rule: regulatory phosphorylation of RTKs. Trends Biochem Sci. 2013 Feb; 38(2):75-84. PMID: 23312584.
      View in: PubMed
    19. Fidalgo da Silva E, Ansari SB, Maimaiti J, Barnes EA, Kong-Beltran M, Donoghue DJ, Porter LA. The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1. Cell Cycle. 2011 Sep 15; 10(18):3129-39. PMID: 21900748.
      View in: PubMed
    20. Park SH, Hanning I, Jarquin R, Moore P, Donoghue DJ, Donoghue AM, Ricke SC. Multiplex PCR assay for the detection and quantification of Campylobacter spp., Escherichia coli O157:H7, and Salmonella serotypes in water samples. FEMS Microbiol Lett. 2011 Mar; 316(1):7-15. PMID: 21204924.
      View in: PubMed
    21. Drafahl KA, McAndrew CW, Meyer AN, Haas M, Donoghue DJ. The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling. PLoS One. 2010 Dec 22; 5(12):e14412. PMID: 21203561; PMCID: PMC3008709.
    22. Solís de los Santos F, Hume M, Venkitanarayanan K, Donoghue AM, Hanning I, Slavik MF, Aguiar VF, Metcalf JH, Reyes-Herrera I, Blore PJ, Donoghue DJ. Caprylic Acid reduces enteric campylobacter colonization in market-aged broiler chickens but does not appear to alter cecal microbial populations. J Food Prot. 2010 Feb; 73(2):251-7. PMID: 20132669.
      View in: PubMed
    23. Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue DJ, Gauthier M, Pin JP, Dissous C. A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One. 2009 May 21; 4(5):e5651. PMID: 19461966; PMCID: PMC2680970.
    24. Johny AK, Baskaran SA, Charles AS, Amalaradjou MA, Darre MJ, Khan MI, Hoagland TA, Schreiber DT, Donoghue AM, Donoghue DJ, Venkitanarayanan K. Prophylactic supplementation of caprylic acid in feed reduces Salmonella enteritidis colonization in commercial broiler chicks. J Food Prot. 2009 Apr; 72(4):722-7. PMID: 19435218.
      View in: PubMed
    25. McAndrew CW, Gastwirt RF, Donoghue DJ. The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis. Cell Cycle. 2009 Jan 01; 8(1):66-75. PMID: 19106603; PMCID: PMC2782695.
    26. Meyer AN, McAndrew CW, Donoghue DJ. Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells. Cancer Res. 2008 Sep 15; 68(18):7362-70. PMID: 18794123; PMCID: PMC2745924.
    27. Golipour A, Myers D, Seagroves T, Murphy D, Evan GI, Donoghue DJ, Moorehead RA, Porter LA. The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Res. 2008 May 15; 68(10):3591-600. PMID: 18483240.
      View in: PubMed
    28. Reyes-Herrera I, Donoghue DJ. Antibiotic residues distribute uniformly in broiler chicken breast muscle tissue. J Food Prot. 2008 Jan; 71(1):223-5. PMID: 18236689.
      View in: PubMed
    29. Schneider MJ, Reyes-Herrera I, Donoghue DJ. Evaluation of serum as a potential matrix for multiresidue determination of fluoroquinolone antibiotics in chicken using liquid chromatography-fluorescence-mass spectrometry(n). J AOAC Int. 2007 Nov-Dec; 90(6):1716-23. PMID: 18193751.
      View in: PubMed
    30. McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ. Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27. Cell Cycle. 2007 Aug 01; 6(15):1937-45. PMID: 17671428.
      View in: PubMed
    31. Gastwirt RF, McAndrew CW, Donoghue DJ. Speedy/RINGO regulation of CDKs in cell cycle, checkpoint activation and apoptosis. Cell Cycle. 2007 May 15; 6(10):1188-93. PMID: 17507798.
      View in: PubMed
    32. Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ. Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation. J Biol Chem. 2006 Nov 17; 281(46):35425-35. PMID: 16951407.
      View in: PubMed
    33. Schneider MJ, Braden SE, Reyes-Herrera I, Donoghue DJ. Simultaneous determination of fluoroquinolones and tetracyclines in chicken muscle using HPLC with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 01; 846(1-2):8-13. PMID: 16931182.
      View in: PubMed
    34. Reyes-Herrera I, Schneider MJ, Cole K, Farnell MB, Blore PJ, Donoghue DJ. Concentrations of antibiotic residues vary between different edible muscle tissues in poultry. J Food Prot. 2005 Oct; 68(10):2217-9. PMID: 16245733.
      View in: PubMed
    35. Chen J, Williams IR, Lee BH, Duclos N, Huntly BJ, Donoghue DJ, Gilliland DG. Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation. Blood. 2005 Jul 01; 106(1):328-37. PMID: 15784730; PMCID: PMC1895117.
    36. Barnes EA, Heidtman KJ, Donoghue DJ. Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC. Oncogene. 2005 Jan 27; 24(5):902-15. PMID: 15592520.
      View in: PubMed
    37. Meyer AN, Gastwirt RF, Schlaepfer DD, Donoghue DJ. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J Biol Chem. 2004 Jul 02; 279(27):28450-7. PMID: 15105428.
      View in: PubMed
    38. Porter LA, Kong-Beltran M, Donoghue DJ. Spy1 interacts with p27Kip1 to allow G1/S progression. Mol Biol Cell. 2003 Sep; 14(9):3664-74. PMID: 12972555; PMCID: PMC196558.
    39. Donoghue DJ, Schneider MJ. Comparison between a bioassay and liquid chromatography-fluorescence-mass spectrometry(n) for the determination of incurred enrofloxacin in whole eggs. J AOAC Int. 2003 Jul-Aug; 86(4):669-74. PMID: 14509422.
      View in: PubMed
    40. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ. Human Spy1 promotes survival of mammalian cells following DNA damage. Cancer Res. 2003 Jul 01; 63(13):3701-7. PMID: 12839962.
      View in: PubMed
    41. Donoghue DJ. Antibiotic residues in poultry tissues and eggs: human health concerns? Poult Sci. 2003 Apr; 82(4):618-21. PMID: 12710482.
      View in: PubMed
    42. Porter LA, Donoghue DJ. Cyclin B1 and CDK1: nuclear localization and upstream regulators. Prog Cell Cycle Res. 2003; 5:335-47. PMID: 14593728.
      View in: PubMed
    43. Schneider MJ, Donoghue DJ. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15; 780(1):83-92. PMID: 12383483.
      View in: PubMed
    44. Peter M, Le Peuch C, Labbé JC, Meyer AN, Donoghue DJ, Dorée M. Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1. EMBO Rep. 2002 Jun; 3(6):551-6. PMID: 12034754; PMCID: PMC1084145.
    45. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. J Cell Biol. 2002 Apr 29; 157(3):357-66. PMID: 11980914; PMCID: PMC2173287.
    46. Kong M, Wang CS, Donoghue DJ. Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. J Biol Chem. 2002 May 03; 277(18):15962-70. PMID: 11827956.
      View in: PubMed