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Daniel Donoghue

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0367
La Jolla CA 92093
Phone858-534-7146
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    Collapse Research 
    Collapse Research Activities and Funding
    Abberant Activation of FGFR3 Signaling in Human Cancer
    NIH/NCI R01CA090900May 1, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Regulation of Receptor Tyrosine Kinases
    NIH/NIGMS R01GM065490Jul 1, 2002 - Jun 30, 2006
    Role: Principal Investigator
    Transmembrane Domains of Receptor Tyrosine Kinases
    NIH/NIGMS R01GM061163Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Biochemistry of Growth Regulation and Oncogenesis
    NIH/NCI T32CA009523Jul 1, 1985 - Jun 30, 2019
    Role: Principal Investigator
    MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    NIH/NIDCR R01DE012581Jul 1, 1985 - Jul 31, 2002
    Role: Principal Investigator
    MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    NIH/NCI R01CA040573Jul 1, 1985 - Jun 30, 1997
    Role: Principal Investigator
    EXPRESSION OF RETROVIRAL ENVELOPE GENE FUSION PROTEINS
    NIH/NCI R01CA034456Apr 1, 1983 - Apr 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yin HB, Chen CH, Darre MJ, Donoghue AM, Donoghue D, Venkitanarayanan K. Phytochemicals reduce aflatoxin-induced toxicity in chicken embryos. Poult Sci. 2017 Oct 01; 96(10):3725-3732. PMID: 28938783.
      View in: PubMed
    2. Kollanoor Johny A, Frye JG, Donoghue A, Donoghue D, Porwollik S, McClelland M, Venkitanarayanan K. Gene Expression Response of Salmonella enterica Serotype Enteritidis Phage Type 8 to Subinhibitory Concentrations of the Plant-Derived Compounds Trans-Cinnamaldehyde and Eugenol. Front Microbiol. 2017; 8:1828. PMID: 29018419.
      View in: PubMed
    3. Upadhyay A, Arsi K, Wagle BR, Upadhyaya I, Shrestha S, Donoghue AM, Donoghue D. Trans-Cinnamaldehyde, Carvacrol, and Eugenol Reduce Campylobacter jejuni Colonization Factors and Expression of Virulence Genes in Vitro. Front Microbiol. 2017; 8:713. PMID: 28487683.
      View in: PubMed
    4. Wagle BR, Upadhyay A, Arsi K, Shrestha S, Venkitanarayanan K, Donoghue AM, Donoghue D. Application of ß-Resorcylic Acid as Potential Antimicrobial Feed Additive to Reduce Campylobacter Colonization in Broiler Chickens. Front Microbiol. 2017; 8:599. PMID: 28428779.
      View in: PubMed
    5. Nelson KN, Peiris MN, Meyer AN, Siari A, Donoghue D. Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders. Trends Mol Med. 2017 01; 23(1):59-79. PMID: 27988109.
      View in: PubMed
    6. Jiang MY, Lee TL, Hao SS, Mahooti S, Baird SM, Donoghue D, Haas M. Visualization of early prostatic adenocarcinoma as a stem cell disease. Oncotarget. 2016 Nov 15; 7(46):76159-76168. PMID: 27764770.
      View in: PubMed
    7. Nelson KN, Meyer AN, Siari A, Campos AR, Motamedchaboki K, Donoghue D. Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation. Mol Cancer Res. 2016 05; 14(5):458-69. PMID: 26869289.
      View in: PubMed
    8. Gallo LH, Nelson KN, Meyer AN, Donoghue D. Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations. Cytokine Growth Factor Rev. 2015 Aug; 26(4):425-49. PMID: 26003532.
      View in: PubMed
    9. Salazar L, Kashiwada T, Krejci P, Meyer AN, Casale M, Hallowell M, Wilcox WR, Donoghue D, Thompson LM. Fibroblast growth factor receptor 3 interacts with and activates TGFß-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. PLoS One. 2014; 9(1):e86470. PMID: 24466111; PMCID: PMC3900522.
      View in: PubMed, PubMed Central
    10. Gallo LH, Meyer AN, Motamedchaboki K, Nelson KN, Haas M, Donoghue D. Novel Lys63-linked ubiquitination of IKKß induces STAT3 signaling. Cell Cycle. 2014; 13(24):3964-76. PMID: 25486864; PMCID: PMC4615003.
      View in: PubMed, PubMed Central
    11. Meyer AN, Drafahl KA, McAndrew CW, Gilda JE, Gallo LH, Haas M, Brill LM, Donoghue D. Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKß. PLoS One. 2013; 8(12):e84497. PMID: 24386391; PMCID: PMC3873999.
      View in: PubMed, PubMed Central
    12. Manickam K, Donoghue D, Meyer AN, Snyder PJ, Prior TW. Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation. Am J Med Genet A. 2014 Jan; 164A(1):243-50. PMID: 24352917.
      View in: PubMed
    13. Fiñones RR, Yeargin J, Lee M, Kaur AP, Cheng C, Sun P, Wu C, Nguyen C, Wang-Rodriguez J, Meyer AN, Baird SM, Donoghue D, Haas M. Early human prostate adenocarcinomas harbor androgen-independent cancer cells. PLoS One. 2013; 8(9):e74438. PMID: 24086346; PMCID: PMC3783414.
      View in: PubMed, PubMed Central
    14. Aguiar VF, Donoghue AM, Arsi K, Reyes-Herrera I, Metcalf JH, de los Santos FS, Blore PJ, Donoghue D. Targeting motility properties of bacteria in the development of probiotic cultures against Campylobacter jejuni in broiler chickens. Foodborne Pathog Dis. 2013 May; 10(5):435-41. PMID: 23531121.
      View in: PubMed
    15. Locascio LE, Donoghue D. KIDs rule: regulatory phosphorylation of RTKs. Trends Biochem Sci. 2013 Feb; 38(2):75-84. PMID: 23312584.
      View in: PubMed
    16. Fidalgo da Silva E, Ansari SB, Maimaiti J, Barnes EA, Kong-Beltran M, Donoghue D, Porter LA. The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1. Cell Cycle. 2011 Sep 15; 10(18):3129-39. PMID: 21900748.
      View in: PubMed
    17. Park SH, Hanning I, Jarquin R, Moore P, Donoghue D, Donoghue AM, Ricke SC. Multiplex PCR assay for the detection and quantification of Campylobacter spp., Escherichia coli O157:H7, and Salmonella serotypes in water samples. FEMS Microbiol Lett. 2011 Mar; 316(1):7-15. PMID: 21204924.
      View in: PubMed
    18. Drafahl KA, McAndrew CW, Meyer AN, Haas M, Donoghue D. The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling. PLoS One. 2010 Dec 22; 5(12):e14412. PMID: 21203561; PMCID: PMC3008709.
      View in: PubMed, PubMed Central
    19. Solís de los Santos F, Hume M, Venkitanarayanan K, Donoghue AM, Hanning I, Slavik MF, Aguiar VF, Metcalf JH, Reyes-Herrera I, Blore PJ, Donoghue D. Caprylic Acid reduces enteric campylobacter colonization in market-aged broiler chickens but does not appear to alter cecal microbial populations. J Food Prot. 2010 Feb; 73(2):251-7. PMID: 20132669.
      View in: PubMed
    20. Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue D, Gauthier M, Pin JP, Dissous C. A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One. 2009 May 21; 4(5):e5651. PMID: 19461966; PMCID: PMC2680970.
      View in: PubMed, PubMed Central
    21. Johny AK, Baskaran SA, Charles AS, Amalaradjou MA, Darre MJ, Khan MI, Hoagland TA, Schreiber DT, Donoghue AM, Donoghue D, Venkitanarayanan K. Prophylactic supplementation of caprylic acid in feed reduces Salmonella enteritidis colonization in commercial broiler chicks. J Food Prot. 2009 Apr; 72(4):722-7. PMID: 19435218.
      View in: PubMed
    22. McAndrew CW, Gastwirt RF, Donoghue D. The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis. Cell Cycle. 2009 Jan 01; 8(1):66-75. PMID: 19106603; PMCID: PMC2782695.
      View in: PubMed, PubMed Central
    23. Meyer AN, McAndrew CW, Donoghue D. Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells. Cancer Res. 2008 Sep 15; 68(18):7362-70. PMID: 18794123; PMCID: PMC2745924.
      View in: PubMed, PubMed Central
    24. Golipour A, Myers D, Seagroves T, Murphy D, Evan GI, Donoghue D, Moorehead RA, Porter LA. The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Res. 2008 May 15; 68(10):3591-600. PMID: 18483240.
      View in: PubMed
    25. Reyes-Herrera I, Donoghue D. Antibiotic residues distribute uniformly in broiler chicken breast muscle tissue. J Food Prot. 2008 Jan; 71(1):223-5. PMID: 18236689.
      View in: PubMed
    26. Schneider MJ, Reyes-Herrera I, Donoghue D. Evaluation of serum as a potential matrix for multiresidue determination of fluoroquinolone antibiotics in chicken using liquid chromatography-fluorescence-mass spectrometry(n). J AOAC Int. 2007 Nov-Dec; 90(6):1716-23. PMID: 18193751.
      View in: PubMed
    27. McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue D. Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27. Cell Cycle. 2007 Aug 01; 6(15):1937-45. PMID: 17671428.
      View in: PubMed
    28. Gastwirt RF, McAndrew CW, Donoghue D. Speedy/RINGO regulation of CDKs in cell cycle, checkpoint activation and apoptosis. Cell Cycle. 2007 May 15; 6(10):1188-93. PMID: 17507798.
      View in: PubMed
    29. Gastwirt RF, Slavin DA, McAndrew CW, Donoghue D. Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation. J Biol Chem. 2006 Nov 17; 281(46):35425-35. PMID: 16951407.
      View in: PubMed
    30. Schneider MJ, Braden SE, Reyes-Herrera I, Donoghue D. Simultaneous determination of fluoroquinolones and tetracyclines in chicken muscle using HPLC with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 01; 846(1-2):8-13. PMID: 16931182.
      View in: PubMed
    31. Reyes-Herrera I, Schneider MJ, Cole K, Farnell MB, Blore PJ, Donoghue D. Concentrations of antibiotic residues vary between different edible muscle tissues in poultry. J Food Prot. 2005 Oct; 68(10):2217-9. PMID: 16245733.
      View in: PubMed
    32. Chen J, Williams IR, Lee BH, Duclos N, Huntly BJ, Donoghue D, Gilliland DG. Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation. Blood. 2005 Jul 01; 106(1):328-37. PMID: 15784730; PMCID: PMC1895117.
      View in: PubMed, PubMed Central
    33. Barnes EA, Heidtman KJ, Donoghue D. Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC. Oncogene. 2005 Jan 27; 24(5):902-15. PMID: 15592520.
      View in: PubMed
    34. Meyer AN, Gastwirt RF, Schlaepfer DD, Donoghue D. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J Biol Chem. 2004 Jul 02; 279(27):28450-7. PMID: 15105428.
      View in: PubMed
    35. Porter LA, Kong-Beltran M, Donoghue D. Spy1 interacts with p27Kip1 to allow G1/S progression. Mol Biol Cell. 2003 Sep; 14(9):3664-74. PMID: 12972555; PMCID: PMC196558.
      View in: PubMed, PubMed Central
    36. Donoghue D, Schneider MJ. Comparison between a bioassay and liquid chromatography-fluorescence-mass spectrometry(n) for the determination of incurred enrofloxacin in whole eggs. J AOAC Int. 2003 Jul-Aug; 86(4):669-74. PMID: 14509422.
      View in: PubMed
    37. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue D. Human Spy1 promotes survival of mammalian cells following DNA damage. Cancer Res. 2003 Jul 01; 63(13):3701-7. PMID: 12839962.
      View in: PubMed
    38. Donoghue D. Antibiotic residues in poultry tissues and eggs: human health concerns? Poult Sci. 2003 Apr; 82(4):618-21. PMID: 12710482.
      View in: PubMed
    39. Porter LA, Donoghue D. Cyclin B1 and CDK1: nuclear localization and upstream regulators. Prog Cell Cycle Res. 2003; 5:335-47. PMID: 14593728.
      View in: PubMed
    40. Schneider MJ, Donoghue D. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15; 780(1):83-92. PMID: 12383483.
      View in: PubMed
    41. Peter M, Le Peuch C, Labbé JC, Meyer AN, Donoghue D, Dorée M. Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1. EMBO Rep. 2002 Jun; 3(6):551-6. PMID: 12034754; PMCID: PMC1084145.
      View in: PubMed, PubMed Central
    42. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue D. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. J Cell Biol. 2002 Apr 29; 157(3):357-66. PMID: 11980914; PMCID: PMC2173287.
      View in: PubMed, PubMed Central
    43. Kong M, Wang CS, Donoghue D. Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. J Biol Chem. 2002 May 03; 277(18):15962-70. PMID: 11827956.
      View in: PubMed
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