Vipin Kumar (Chaturvedi)

Title(s)Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0637
La Jolla CA 92093
Phone858-822-0730
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    Collapse Biography 
    Collapse Education and Training
    Kanpur University, IndiaBS with Honors1978Biology
    Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaMSc1980Biochemistry, Molecular Biology and Immunology
    Indian Institute of Science, Bangalore, IndiaPhD1986Biochemistry
    Harvard University, BostonResearch Fellowship1987Pharmacology
    California Institute of Technology, PasadenaNational Multiple Sclerosis Society Senior Postdoctoral Fellowship1991Biology
    University of California, Los AngelesFellowship1993Microbiology and Molecular Genetics

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    A novel population of PLZF+CD8+ regulatory T cells: phenotype and function
    NIH R56AI146071Sep 17, 2020 - Aug 31, 2021
    Role: Principal Investigator
    Interplay Among NKT Cell Subsets in Alcoholic Liver Disease
    NIH R01AA020864Aug 20, 2012 - Jul 31, 2018
    Role: Principal Investigator
    Sulfatide-reactive type II NKT cells: repertoire and function
    NIH R01CA100660Apr 1, 2003 - May 31, 2016
    Role: Principal Investigator
    Regulatory CD4/CD8 T cells in autoimmune demyelination
    NIH R01AI052227Apr 1, 2003 - Mar 31, 2007
    Role: Principal Investigator
    Targeting TCR in the immunotherapy of T cell tumors
    NIH R21CA098958Jul 1, 2002 - Jun 30, 2004
    Role: Principal Investigator
    T CELL RESPONSE TO MEP-REPERTOIRE AND REGULATION
    NIH R01AI028419Aug 1, 1989 - Jul 31, 2000
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Involvement of Qa-1-restricted CD8+ T cells in anti-micobial and anti-cancer immunity as well as in the immune regulation. Critical reviews in Immunology. 2021; 41:39-53. Huiming Sheng, S. Dasgupta and V. Kumar.
    2. Class Ib MHC-Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine. Immunohorizons. 2021 12 15; 5(12):953-971. Dasgupta S, Maricic I, Tang J, Wandro S, Weldon K, Carpenter CS, Eckmann L, Rivera-Nieves J, Sandborn W, Knight R, Dorrestein P, Swafford AD, Kumar V. PMID: 34911745.
      View in: PubMed   Mentions:
    3. Preface Special Issue: Microbiome-Immune System Interactions. Crit Rev Immunol. 2021; 41(6):v. Passos GA, Chaturvedi VK. PMID: 35695642.
      View in: PubMed   Mentions:
    4. Deficiency of Intestinal a1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice. Alcohol Clin Exp Res. 2020 09; 44(9):1842-1851. Zhou R, Llorente C, Cao J, Gao B, Duan Y, Jiang L, Wang Y, Kumar V, Stärkel P, Bode L, Fan X, Schnabl B. PMID: 32628772; PMCID: PMC7808344.
      View in: PubMed   Mentions:    Fields:    
    5. Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease. Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. Marrero I, Maricic I, Morgan TR, Stolz AA, Schnabl B, Liu ZX, Tsukamoto H, Kumar V. PMID: 32154597; PMCID: PMC7211132.
      View in: PubMed   Mentions: 4     Fields:    
    6. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. A Coordinated Dance of Effector and Regulatory T Cells that are Reactive to Different Determinants in Autoimmune Response Orchestration. Crit Rev Immunol. 2020; 40(3):263-273. Chaturvedi VK. PMID: 33389890.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Distinct PLZF+CD8αα+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity. J Immunol. 2019 10 15; 203(8):2150-2162. Sheng H, Marrero I, Maricic I, Fanchiang SS, Zhang S, Sant'Angelo DB, Kumar V. PMID: 31554695; PMCID: PMC6783388.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Intestinal iNKT cells migrate to liver and contribute to hepatocyte apoptosis during alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2019 05 01; 316(5):G585-G597. Lee KC, Chen P, Maricic I, Inamine T, Hu J, Gong S, Sun JC, Dasgupta S, Lin HC, Lin YT, Loomba R, Stärkel P, Kumar V, Schnabl B. PMID: 30817180; PMCID: PMC6580241.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Advances in the Study of CD8+ Regulatory T Cells. Crit Rev Immunol. 2019; 39(6):409-421. Tang X, Kumar V. PMID: 32421955.
      View in: PubMed   Mentions:
    11. Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. J Immunol. 2018 11 15; 201(10):3017-3035. Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson CD, Dasgupta S, Hernandez CD, Nguyen PS, Swafford AD, Knight R, Feldstein AE, Loomba R, Kumar V. PMID: 30322964; PMCID: PMC6219905.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut. Front Immunol. 2018; 9:2082. Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V. PMID: 30254647; PMCID: PMC6141878.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    13. Complexity and function of natural killer T cells with potential application to hepatic transplant survival. Liver Transpl. 2017 12; 23(12):1589-1592. Ware R, Kumar V. PMID: 28945950; PMCID: PMC6075735.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Crystal structure of Qa-1a with bound Qa-1 determinant modifier peptide. PLoS One. 2017; 12(8):e0182296. Ying G, Wang J, Kumar V, Zajonc DM. PMID: 28767728; PMCID: PMC5540586.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Gut-liver axis at the frontier of host-microbial interactions. Am J Physiol Gastrointest Liver Physiol. 2017 May 01; 312(5):G413-G419. Brandl K, Kumar V, Eckmann L. PMID: 28232456; PMCID: PMC5451561.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    16. Type II NKT Cells and Their Emerging Role in Health and Disease. J Immunol. 2017 02 01; 198(3):1015-1021. Dhodapkar MV, Kumar V. PMID: 28115591; PMCID: PMC5300729.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    17. Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset. Immunogenetics. 2016 Aug; 68(8):665-76. Dasgupta S, Kumar V. PMID: 27405300; PMCID: PMC6334657.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    18. High-throughput sequencing reveals restricted TCR Vβ usage and public TCRβ clonotypes among pancreatic lymph node memory CD4(+) T cells and their involvement in autoimmune diabetes. Mol Immunol. 2016 06; 74:82-95. Marrero I, Aguilera C, Hamm DE, Quinn A, Kumar V. PMID: 27161799; PMCID: PMC6301078.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. NKT cell subsets as key participants in liver physiology and pathology. Cell Mol Immunol. 2016 05; 13(3):337-46. Bandyopadhyay K, Marrero I, Kumar V. PMID: 26972772; PMCID: PMC4856801.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    20. Agent-Based Modeling in Systems Pharmacology. CPT Pharmacometrics Syst Pharmacol. 2015 Nov; 4(11):615-29. Cosgrove J, Butler J, Alden K, Read M, Kumar V, Cucurull-Sanchez L, Timmis J, Coles M. PMID: 26783498; PMCID: PMC4716580.
      View in: PubMed   Mentions:
    21. Type II NKT Cells in Inflammation, Autoimmunity, Microbial Immunity, and Cancer. Front Immunol. 2015; 6:316. Marrero I, Ware R, Kumar V. PMID: 26136748; PMCID: PMC4470258.
      View in: PubMed   Mentions: 33     Fields:    
    22. Correction: Determining disease intervention strategies using spatially resolved simulations. PLoS One. 2015; 10(5):e0128170. Read M, Andrews PS, Timmis J, Williams RA, Greaves RB, Sheng H, Coles M, Kumar V. PMID: 25955716; PMCID: PMC4425704.
      View in: PubMed   Mentions:    Fields:    
    23. Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice. Hepatology. 2015 Apr; 61(4):1357-69. Maricic I, Sheng H, Marrero I, Seki E, Kisseleva T, Chaturvedi S, Molle N, Mathews SA, Gao B, Kumar V. PMID: 25477000; PMCID: PMC4376634.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    24. Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration. Cell Mol Immunol. 2016 Mar; 13(2):206-16. Mathews S, Feng D, Maricic I, Ju C, Kumar V, Gao B. PMID: 25661730; PMCID: PMC4786627.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    25. Modelling biological behaviours with the unified modelling language: an immunological case study and critique. J R Soc Interface. 2014 Oct 06; 11(99). Read M, Andrews PS, Timmis J, Kumar V. PMID: 25142524; PMCID: PMC4233755.
      View in: PubMed   Mentions:
    26. Recognition of lysophosphatidylcholine by type II NKT cells and protection from an inflammatory liver disease. J Immunol. 2014 Nov 01; 193(9):4580-9. Maricic I, Girardi E, Zajonc DM, Kumar V. PMID: 25261475; PMCID: PMC4201983.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    27. Different subsets of natural killer T cells may vary in their roles in health and disease. Immunology. 2014 Jul; 142(3):321-36. Kumar V, Delovitch TL. PMID: 24428389; PMCID: PMC4080948.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    28. Dendritic cells and anergic type I NKT cells play a crucial role in sulfatide-mediated immune regulation in experimental autoimmune encephalomyelitis. J Immunol. 2014 Aug 01; 193(3):1035-46. Maricic I, Halder R, Bischof F, Kumar V. PMID: 24973441; PMCID: PMC4110642.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. NKT-cell subsets: promoters and protectors in inflammatory liver disease. J Hepatol. 2013 Sep; 59(3):618-20. Kumar V. PMID: 23669283; PMCID: PMC4086465.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    30. In silico investigation into dendritic cell regulation of CD8Treg mediated killing of Th1 cells in murine experimental autoimmune encephalomyelitis. BMC Bioinformatics. 2013; 14 Suppl 6:S9. Williams RA, Greaves R, Read M, Timmis J, Andrews PS, Kumar V. PMID: 23734666; PMCID: PMC3633023.
      View in: PubMed   Mentions:
    31. In silico investigation of novel biological pathways: the role of CD200 in regulation of T cell priming in experimental autoimmune encephalomyelitis. Biosystems. 2013 May; 112(2):107-21. Greaves RB, Read M, Timmis J, Andrews PS, Butler JA, Gerckens BO, Kumar V. PMID: 23499816.
      View in: PubMed   Mentions:
    32. Promoters and protectors in inflammatory liver disease. Journal of Hepatology. 2013; 59:618-620. Kumar V.
    33. NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation. Curr Immunol Rev. 2012 Nov 01; 8(4):287-296. Viale R, Ware R, Maricic I, Chaturvedi V, Kumar V. PMID: 25288922; PMCID: PMC4185185.
      View in: PubMed   Mentions: 14  
    34. Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Nat Immunol. 2012 Sep; 13(9):851-6. Girardi E, Maricic I, Wang J, Mac TT, Iyer P, Kumar V, Zajonc DM. PMID: 22820602; PMCID: PMC3442777.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    35. NKT cells stimulated by long fatty acyl chain sulfatides significantly reduce the incidence of type 1 diabetes in nonobese diabetic mice [corrected]. PLoS One. 2012; 7(5):e37771. Subramanian L, Blumenfeld H, Tohn R, Ly D, Aguilera C, Maricic I, Mansson JE, Buschard K, Kumar V, Delovitch TL. PMID: 22649557; PMCID: PMC3359325.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    36. Determining Disease Intervention Strategies using Spatially Resolved Simulations. PLoS One. 2012; 8. Mark Read, Paul S. Andrews, Jon Timmis, Richard Williams, Richard Greaves, Huiming Sheng, Mark Coles, Vipin Kumar.
    37. Extending an established simulation: exploration of the possible effects using a case study in experimental autoimmune encephalomyelitis. 2012. Greaves, R.B., Read, M., Timmis, J., Andrews, P.S., and V. Kumar.
    38. Herbs in the management of hyperglycemia in diabetes: importance of screening methods in the identification of phyto anti-hyperglycemic principles. Diabetes and Metabolism. 2012; 3:7-9. Bassa, B., V.Kumar and U.M. Rao. View Publication.
    39. NKT cell subsets involve distinct regulatory pathways in the control of inflammatory diseases. Current Immunology Reviews. 2012; 8:287-296. Viale, R., R. Ware, I. Maricic, V. Chaturvedi and V. Kumar . .
    40. Global expression profiling of peripheral Qa-1-restricted CD8αα+TCRαβ+ regulatory T cells reveals innate-like features: implications for immune-regulatory repertoire. Hum Immunol. 2012 Mar; 73(3):214-22. Fanchiang SS, Cojocaru R, Othman M, Khanna R, Brooks MJ, Smith T, Tang X, Maricic I, Swaroop A, Kumar V. PMID: 21889557; PMCID: PMC3261310.
      View in: PubMed   Mentions:
    41. Two Domains of Vimentin Are Expressed on the Surface of Lymph Node, Bone and Brain Metastatic Prostate Cancer Lines along with the Putative Stem Cell Marker Proteins CD44 and CD133. Cancers (Basel). 2011 Jul 13; 3(3):2870-85. Steinmetz NF, Maurer J, Sheng H, Bensussan A, Maricic I, Kumar V, Braciak TA. PMID: 24212937; PMCID: PMC3759176.
      View in: PubMed   Mentions: 16  
    42. Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy. J Transl Med. 2011 Mar 31; 9:34. Ma W, Smith T, Bogin V, Zhang Y, Ozkan C, Ozkan M, Hayden M, Schroter S, Carrier E, Messmer D, Kumar V, Minev B. PMID: 21450109; PMCID: PMC3078865.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. Techniques for grounding agent-based simulations in the real domain: a case study in experimental autoimmune encephalomyelitis. Mathematical and Computer Modelling of Dynamical Systems. 2011; 18:67-86. Read, M., Andrews, P., Timmis, J., and Kumar, V.
    44. Sulfatide-mediated activation of type II natural killer T cells prevents hepatic ischemic reperfusion injury in mice. Gastroenterology. 2011 Feb; 140(2):646-55. Arrenberg P, Maricic I, Kumar V. PMID: 20950612; PMCID: PMC3114423.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    45. Involvement of IFN-γ and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010 Dec 15; 229(1-2):91-7. Beeston T, Smith TR, Maricic I, Tang X, Kumar V. PMID: 20708278; PMCID: PMC2991517.
      View in: PubMed   Mentions:
    46. Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5653-7. Dellai A, Maricic I, Kumar V, Arutyunyan S, Bouraoui A, Nefzi A. PMID: 20801649; PMCID: PMC2940269.
      View in: PubMed   Mentions:
    47. CD8alpha+ dendritic cells prime TCR-peptide-reactive regulatory CD4+FOXP3- T cells. Eur J Immunol. 2010 Jul; 40(7):1906-15. Smith TR, Maricic I, Ria F, Schneider S, Kumar V. PMID: 20394075; PMCID: PMC3031495.
      View in: PubMed   Mentions:
    48. Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipid. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10984-9. Arrenberg P, Halder R, Dai Y, Maricic I, Kumar V. PMID: 20534460; PMCID: PMC2890761.
      View in: PubMed   Mentions:
    49. Induction of hepatic Interleukin-12 expression in Cre/LoxP-IL-12 transgenic mice leads to severe liver inflammation and injury. Hepatology. 2010. Garcia-Lazaro, J.F., Klopcic, B., Meyer, E., Halder, R.C., Czochra, P., Frenzel, C., Belderas- Renteria, I., Kumar, V., Lohse, A.W., and Herkel, J.
    50. Sulfatide administration leads to inhibition of HIV-1 replication and enhanced hematopoeisis. J Stem Cells. 2010; 5(1):33-42. Sundell IB, Halder R, Zhang M, Maricic I, Koka PS, Kumar V. PMID: 20861926.
      View in: PubMed   Mentions:
    51. Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties. J Immunol. 2009 Jun 01; 182(11):6959-68. Smith TR, Tang X, Maricic I, Garcia Z, Fanchiang S, Kumar V. PMID: 19454693.
      View in: PubMed   Mentions:
    52. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol. 2009 Mar 01; 182(5):2816-26. Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L, Kaer LV. PMID: 19234176; PMCID: PMC2709814.
      View in: PubMed   Mentions:
    53. Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens. J Cell Physiol. 2009 Feb; 218(2):246-50. Arrenberg P, Halder R, Kumar V. PMID: 18814145; PMCID: PMC2653050.
      View in: PubMed   Mentions:
    54. A domain model of experimental autoimmune encephalomyelitis. COSMOS. 2009; 9-44. Read, M., Timmis, J., Andrews, P., and Kumar, V. View Publication.
    55. Using UML to model EAE and its regulatory network. ICARIS. 2009; 4-6. Read, M., Timmis, J., Andrews, P., and Kumar, V.
    56. Revival of CD8+ Treg-mediated suppression. Trends Immunol. 2008 Jul; 29(7):337-42. Smith TR, Kumar V. PMID: 18514574.
      View in: PubMed   Mentions:
    57. Immunodominance in the TCR repertoire of a [corrected] TCR peptide-specific CD4+ Treg population that controls experimental autoimmune encephalomyelitis. J Immunol. 2008 Apr 01; 180(7):4577-85. Madakamutil LT, Maricic I, Sercarz EE, Kumar V. PMID: 18354180.
      View in: PubMed   Mentions:
    58. Involvement of secretory and endosomal compartments in presentation of an exogenous self-glycolipid to type II NKT cells. J Immunol. 2008 Mar 01; 180(5):2942-50. Roy KC, Maricic I, Khurana A, Smith TR, Halder RC, Kumar V. PMID: 18292516.
      View in: PubMed   Mentions:
    59. A novel population of CD8αα+ Regulatory T cells: Identification, characterization and induction. T cell Vaccination. 2008. Smith, TRF, Kumar, V. Jingwu Zang, Irun Cohen. P.
    60. Immune suppression by a novel population of CD8αα+TCRαβ+ regulatory T cells. Regulatory T Cells and Clinical Application. 2008; 489-500. Smith, TRF, Kumar, V, Dr. Shuiping Jiang. View Publication.
    61. Cross-regulation between type I and type II NKT cells in regulating tumor immunity: a new immunoregulatory axis. J Immunol. 2007 Oct 15; 179(8):5126-36. Ambrosino E, Terabe M, Halder RC, Peng J, Takaku S, Miyake S, Yamamura T, Kumar V, Berzofsky JA. PMID: 17911598.
      View in: PubMed   Mentions:
    62. Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J Clin Invest. 2007 Aug; 117(8):2302-12. Halder RC, Aguilera C, Maricic I, Kumar V. PMID: 17641782; PMCID: PMC1913490.
      View in: PubMed   Mentions:
    63. Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+ TCR alpha beta+ regulatory T cells and prevents experimental autoimmune encephalomyelitis. J Immunol. 2007 May 15; 178(10):6043-50. Tang X, Maricic I, Kumar V. PMID: 17475828.
      View in: PubMed   Mentions:
    64. Priming regulatory T cells and antigen-specific suppression of autoimmune disease. Immune Regulation and Immunotherapy in Autoimmune Disease. 2007; 20-35. Smith, TRF, Tang, X and Kumar, V. View Publication.
    65. Regulation of immunity by a novel population of Qa-1-restricted CD8alphaalpha+TCRalphabeta+ T cells. J Immunol. 2006 Dec 01; 177(11):7645-55. Tang X, Maricic I, Purohit N, Bakamjian B, Reed-Loisel LM, Beeston T, Jensen P, Kumar V. PMID: 17114434.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    66. Mini review: immune response to myelin-derived sulfatide and CNS-demyelination. Neurochem Res. 2007 Feb; 32(2):257-62. Halder RC, Jahng A, Maricic I, Kumar V. PMID: 17006761.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    67. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 05; 202(11):1517-26. Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. PMID: 16314439; PMCID: PMC2213337.
      View in: PubMed   Mentions:
    68. Insulin-dependent diabetes loci Idd5 and Idd9 increase sensitivity to experimental autoimmune encephalomyelitis. Clin Immunol. 2006 Feb-Mar; 118(2-3):219-28. Mayo S, Kohler W, Kumar V, Quinn A. PMID: 16301001.
      View in: PubMed   Mentions:
    69. Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Nov; 168(1-2):40-5. Genoud S, Maricic I, Kumar V, Gage FH. PMID: 16120466.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    70. Feedback regulation of autoimmunity via TCR-centered regulation. Int Rev Immunol. 2005 May-Aug; 24(3-4):199-209. Kumar V, Sercarz E. PMID: 16036374.
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    71. Specific control of immunity by regulatory CD8 T cells. Cell Mol Immunol. 2005 Feb; 2(1):11-9. Tang XL, Smith TR, Kumar V. PMID: 16212906.
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    72. Limited clonality in autoimmunity: drivers and regulators. Autoimmun Rev. 2004 Nov; 3(7-8):524-9. van den Elzen P, Menezes JS, Ametani A, Maverakis E, Madakamutil L, Tang XL, Kumar V, Sercarz EE. PMID: 15546801.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    73. Homeostatic control of immunity by TCR peptide-specific Tregs. J Clin Invest. 2004 Nov; 114(9):1222-6. Kumar V. PMID: 15520851; PMCID: PMC524235.
      View in: PubMed   Mentions:
    74. Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collagen-induced arthritis. Int Immunol. 2004 May; 16(5):737-45. Honda A, Ametani A, Matsumoto T, Iwaya A, Kano H, Hachimura S, Ohkawa K, Kaminogawa S, Suzuki K, Sercarz EE, Kumar V. PMID: 15096482.
      View in: PubMed   Mentions:
    75. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med. 2004 Apr 05; 199(7):947-57. Jahng A, Maricic I, Aguilera C, Cardell S, Halder RC, Kumar V. PMID: 15051763; PMCID: PMC2211873.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    76. Regulatory T cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes. J Immunol. 2003 Mar 15; 170(6):2985-92. Madakamutil LT, Maricic I, Sercarz E, Kumar V. PMID: 12626551.
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    77. Seven surprises in the TCR-centered regulation of immune responsiveness in an autoimmune system. Novartis Found Symposium. 2003; 203-210. 58. Sercarz, E., Maverakis, E., van den Elzen, P., Madakamutil, L., and Kumar, V.
    78. Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10. J Immunol. 2003 Jan 15; 170(2):765-74. Braciak TA, Pedersen B, Chin J, Hsiao C, Ward ES, Maricic I, Jahng A, Graham FL, Gauldie J, Sercarz EE, Kumar V. PMID: 12517939.
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    79. Induction of autoantibody production is limited in nonautoimmune mice. J Immunol. 2002 Jul 01; 169(1):587-94. Singh RR, Ebling FM, Albuquerque DA, Saxena V, Kumar V, Giannini EH, Marion TN, Finkelman FD, Hahn BH. PMID: 12077292.
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    80. Determination of the expressed repertoire: the outcome of competition at the levels of antigen presentation and TCR recognition. In Epitope Recognition since Landsteiner’s discovery. 2002; 65-81. 55. Maverakis, E., Beech, J., Deng, H., Schneider, S., Van den Elzen, P., Madakamutil, L., Ria, F., Moudgil, K., Kumar, V., Campagnoni, A., and Sercarz, E. View Publication.
    81. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J Exp Med. 2001 Dec 17; 194(12):1789-99. Jahng AW, Maricic I, Pedersen B, Burdin N, Naidenko O, Kronenberg M, Koezuka Y, Kumar V. PMID: 11748280; PMCID: PMC2193586.
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    82. T cell vaccination: from basics to the clinic. Trends in Immunology. 2001; 22(10):539-540. 52. Kumar, V., Sercarz, E., Zhang, J, and Cohen, I. View Publication.
    83. Interactions of effectors and regulators are decisive in the manifestation of IDDM in NOD mice. Molecular pathology of Type 1 diabetes mellitus, Current directions in autoimmunity. 2001; 171-192. Quinn, A., Kumar, V., Jensen, K. and Sercarz, E.
    84. An integrative model of regulation centered on recognition of TCR peptide/MHC complexes. Immunol Rev. 2001 Aug; 182:113-21. Kumar V, Sercarz E. PMID: 11722628.
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    85. Induction of a type 1 regulatory CD4 T cell response following Vβ8.2 DNA-vaccination results in immune deviation and protection from experimental autoimmune encephaloymyelitis. International Immunology. 2001; 13(6):835-841. Kumar, V., Maglione, J., Pedersen, B, Sercarz, E., and Sally Ward, E. View Publication.
    86. The beginning of a journey into physiological regulation of autoimmunity. Autoimmunity and emerging diseases. 2001; 118-130. Kumar, V.
    87. Residual public repertoires to self. J Neuroimmunol. 2000 Jul 24; 107(2):233-9. Wilson SS, van den Elzen P, Maverakis E, Beech JT, Braciak TA, Kumar V, Sercarz EE. PMID: 10854662.
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    88. Distinct levels of regulation in organ-specific autoimmune diseases. Life Sci. 1999; 65(15):1523-30. Kumar V, Sercarz E. PMID: 10574217.
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    89. Induction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells. J Immunol. 1998 Dec 15; 161(12):6585-91. Kumar V, Sercarz E. PMID: 9862685.
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    90. TCR peptide-reactive T cells and peripheral tolerance to myelin basic protein. Res Immunol. 1998 Nov-Dec; 149(9):827-34; discussion 852-4, 855-60. Kumar V. PMID: 9923639.
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    91. T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model. J Immunol. 1998 Aug 01; 161(3):1087-93. Borghans JA, De Boer RJ, Sercarz E, Kumar V. PMID: 9686566.
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    92. Determinant spreading during experimental autoimmune encephalomyelitis: is it potentiating, protecting or participating in the disease? Immunol Rev. 1998 Aug; 164:73-80. Kumar V. PMID: 9795765.
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    93. Regulatory mechanisms in organ-specific autoimmunity. Immunologist. 1998; 6:161-166. 43. Kumar, V., Sercarz, E. and L. Adorini.
    94. Recombinant T cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T cells. J Immunol. 1997 Nov 15; 159(10):5150-6. Kumar V, Coulsell E, Ober B, Hubbard G, Sercarz E, Ward ES. PMID: 9366445.
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    95. Regulatory T cells specific for the same framework 3 region of the Vbeta8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis. J Exp Med. 1997 May 19; 185(10):1725-33. Kumar V, Aziz F, Sercarz E, Miller A. PMID: 9151697; PMCID: PMC2196316.
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    96. Structure of the antigenic determinant or the execution of T cell regulatory circuitry can result in immune deviation. Th1/Th2 regulation. 1997; 91-103. Kumar, V. and Sercarz, E.
    97. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J Exp Med. 1996 Nov 01; 184(5):1609-17. Kumar V, Stellrecht K, Sercarz E. PMID: 8920851; PMCID: PMC2192866.
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    98. Dysregulation of potentially pathogenic self reactivity is crucial for the manifestation of clinical autoimmunity. J Neurosci Res. 1996 Aug 15; 45(4):334-9. Kumar V, Sercarz E. PMID: 8872893.
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    99. Genetic vaccination: the advantages of going naked. Nat Med. 1996 Aug; 2(8):857-9. Kumar V, Sercarz E. PMID: 8705850.
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    100. Protected repertoires, the cryptic self, and autoimmunity. New Trends in Immunological diseases. 1996; 49-59. 35. Kumar, V., Moudgil, K.D., Singh, R.R., and Sercarz, E.E.
    101. T cell repertoire directed against dominant and cryptic self-determinants. Transplantation Tolerance induction. 1996; 111-117. Sercarz, E., Deng, H., Grewal, I., Kumar, V., and Moudgil K.
    102. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9510-4. Kumar V, Bhardwaj V, Soares L, Alexander J, Sette A, Sercarz E. PMID: 7568164; PMCID: PMC40831.
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    103. T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J Exp Med. 1995 Jun 01; 181(6):2017-27. Singh RR, Kumar V, Ebling FM, Southwood S, Sette A, Sercarz EE, Hahn BH. PMID: 7539036; PMCID: PMC2192064.
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    104. Determinant flanking regions and the design of appropriate vaccines. Ann N Y Acad Sci. 1995 May 31; 754:48-56. Soares L, Deng H, Grewal IS, Kumar V, Miller A, Moudgil KD, Palmer M, Sercarz EE. PMID: 7625680.
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    105. Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls murine experimental autoimmune encephalomyelitis. J Immunol. 1995 Feb 15; 154(4):1941-50. Kumar V, Tabibiazar R, Geysen HM, Sercarz E. PMID: 7530748.
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    106. Natural priming of functional TCR-peptide-specific T cells indicates that TCR determinants are involved in the regulation of autoimmune disease. T cell vaccination and autoimmune disease. 1995; 21-35. Kumar, V. and Sercarz, E.
    107. Self-determinant selection and selective regulation. Chem Immunol. 1995; 60:1-19. Kumar V, Sercarz E. PMID: 7857523.
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    108. Holes in the T cell repertoire to myelin basic protein owing to the absence of the D beta 2-J beta 2 gene cluster: implications for T cell receptor recognition and autoimmunity. J Exp Med. 1994 May 01; 179(5):1637-43. Kumar V, Sercarz E. PMID: 7513012; PMCID: PMC2191480.
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    109. T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S. J Immunol. 1994 Apr 15; 152(8):3711-9. Bhardwaj V, Kumar V, Grewal IS, Dao T, Lehmann PV, Geysen HM, Sercarz EE. PMID: 7511656.
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    110. Maintenance and re-establishment of self-tolerance: TCR-peptide-specific regulatory T cells. Autoimmunity: Experimental aspects. 1994; 29-38. Kumar, V. and Sercarz, E.
    111. T cell recognition of defined peptides and autoimmune response. Handbook of T and B cells. 1994; 269-287. Kumar, V., Bhardwaj, V. and Sercarz, E, .
    112. Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity. J Immunol. 1993 Nov 01; 151(9):5000-10. Bhardwaj V, Kumar V, Geysen HM, Sercarz EE. PMID: 7691962.
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    113. The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med. 1993 Sep 01; 178(3):909-16. Kumar V, Sercarz EE. PMID: 7688792; PMCID: PMC2191168.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    114. T cell regulatory circuitry: antigen-specific and TCR-idiopeptide-specific T cell interactions in EAE. Int Rev Immunol. 1993; 9(4):287-97. Kumar V, Sercarz E. PMID: 7683710.
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    115. Processing of self-proteins and its impact on shaping the T cell repertoire, autoimmunity and immune regulation. Int Rev Immunol. 1993; 10(4):365-77. Moudgil KD, Ametani A, Grewal IS, Kumar V, Sercarz EE. PMID: 8294849.
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    116. Subjugation of dominant immunogenic determinants within a chimeric peptide. Eur J Immunol. 1992 Aug; 22(8):2009-16. Bhardwaj V, Kumar V, Geysen HM, Sercarz EE. PMID: 1379183.
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    117. Regulation of autoimmunity. Curr Opin Immunol. 1991 Dec; 3(6):888-95. Kumar V, Sercarz EE. PMID: 1793531.
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    118. Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6899. Hood L, Horvath SJ, Kumar V, Urban JL. PMID: 1876607; PMCID: PMC52200.
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    119. Assessment of antigenic determinants for the human T cell response against myelin basic protein using overlapping synthetic peptides. J Neuroimmunol. 1991 Feb; 31(2):105-13. Burns J, Littlefield K, Gomez C, Kumar V. PMID: 1704014.
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    120. Mimicry and dominance in the T cell response to self proteins. Lymphatic Tissues and In Vivo Immune Responses. 1991. Bhardwaj, V., Kumar, V., Lehmann, P.V., and Sercarz, E.
    121. cis-acting negative regulatory element of prolactin gene. J Biol Chem. 1990 Mar 25; 265(9):4785-8. Zhang ZX, Kumar V, Rivera RT, Chisholm J, Biswas DK. PMID: 2318863.
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    122. Suppression of prolactin gene expression in GH cells correlates with site-specific DNA methylation. DNA. 1989 Oct; 8(8):605-13. Zhang ZX, Kumar V, Rivera RT, Pasion SG, Chisholm J, Biswas DK. PMID: 2480873.
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    123. T-cells receptors in experimental allergic encephalomyelitis. Neuroimmune Networks: Physiology and Disease. 1989; 25-30. Urban, J.L., Kumar, V., Kono, D.H., Gomez, C., and Hood, L.
    124. The T-cell receptor repertoire and autoimmune diseases. Annu Rev Immunol. 1989; 7:657-82. Kumar V, Kono DH, Urban JL, Hood L. PMID: 2469443.
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    125. Autoimmune disease and T-cell immunologic recognition. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:859-74. Hood L, Kumar V, Osman G, Beall SS, Gomez C, Funkhouser W, Kono DH, Nickerson D, Zaller DM, Urban JL. PMID: 2484250.
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    126. Dynamic state of site-specific DNA methylation concurrent to altered prolactin and growth hormone gene expression in the pituitary gland of pregnant and lactating rats. J Biol Chem. 1988 Sep 05; 263(25):12645-52. Kumar V, Biswas DK. PMID: 2842337.
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    127. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell. 1988 Aug 12; 54(4):577-92. Urban JL, Kumar V, Kono DH, Gomez C, Horvath SJ, Clayton J, Ando DG, Sercarz EE, Hood L. PMID: 2456857.
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    128. Defective distal regulatory element at the 5' upstream of rat prolactin gene of steroid-nonresponsive GH-subclone. Biochim Biophys Acta. 1987 Dec 08; 910(3):213-23. Kumar V, Wong DT, Pasion SG, Biswas DK. PMID: 2890379.
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    129. DNA sequence responsible for the amplification of adjacent genes. DNA. 1987 Oct; 6(5):419-28. Pasion SG, Hartigan JA, Kumar V, Biswas DK. PMID: 3677995.
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    130. Interaction of lutein with mitochondrial and artificial membranes. Current Trends in Life Sciences. 1987; 145-153. Kumar, V., and Kurup, C.K.R.
    131. Inhibition of mitochondrial electron transport and energy transduction by lutein in vitro. Indian J Biochem Biophys. 1986 Jun; 23(3):156-61. Chaturvedi VK, Kurup CK. PMID: 3793130.
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    132. Interaction of lutein with phosphatidylcholine bilayers. Biochimica et Biophysica Acta. 1986; 860(2):286-292. Kumar, V. and Kurup, C.K.R. View Publication.
    133. Effect of lutein on the transport of Ca2+ across phospholipid bilayer and mitochondrial membrane. Biochem Int. 1986 Feb; 12(2):373-7. Chaturvedi VK, Kurup CK. PMID: 3964291.
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    134. Regulation of mitochondrial oxidative phosphorylation by chloroplasts. Current Science. 1985; 54(12):550-553. Kumar, V, Kurup, CKR. View Publication.