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    Patricia Jennings

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0375
    CA La Jolla 92093
    Phone858-534-6417
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      Collapse Research 
      Collapse Research Activities and Funding
      The New Family of NEET Proteins: 2Fe-2S Protein Mediated Health and Disease
      NIH/NIGMS R01GM101467Sep 21, 2012 - Aug 31, 2016
      Role: Principal Investigator
      HTS for Modulators of MitoNEET Proteins'Function
      NIH/NIDA R03DA034597May 1, 2012 - Apr 30, 2014
      Role: Principal Investigator
      Acquisition of a 500 MHz NMR Console
      NIH/NCRR S10RR020874Apr 1, 2006 - Mar 31, 2007
      Role: Principal Investigator
      PKA & PKC Targeting Mechanisms (Program Project)
      NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
      Role: Co-Investigator
      Investigation of the Functional/Folding Landscapes of the Il-1 Family
      NIH/NIGMS R01GM054038Aug 1, 1996 - Feb 28, 2012
      Role: Principal Investigator
      FOLDING MECHANISM OF A BETA PROTEIN
      NIH/NIGMS R29GM054038May 1, 1996 - Apr 30, 2002
      Role: Principal Investigator
      AN NMR INVESTIGATION OF PROTEIN FOLDING MECHANISMS
      NIH/NIGMS F32GM014541Dec 31, 1991
      Role: Principal Investigator
      A Synchroton Radiation Structural Biology Resource
      NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Karmi O, Holt SH, Song L, Tamir S, Luo Y, Bai F, Adenwalla A, Darash-Yahana M, Sohn YS, Jennings P, Azad RK, Onuchic JN, Morcos F, Nechushtai R, Mittler R. Interactions between mitoNEET and NAF-1 in cells. PLoS One. 2017; 12(4):e0175796. PMID: 28426722.
        View in: PubMed
      2. Burban DJ, Jennings P. Backbone assignments for the SPOUT methyltransferase MTT Tm , a knotted protein from Thermotoga maritima. Biomol NMR Assign. 2017 Mar 10. PMID: 28284017.
        View in: PubMed
      3. Inupakutika MA, Sengupta S, Nechushtai R, Jennings P, Onuchic JN, Azad RK, Padilla P, Mittler R. Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates. Sci Rep. 2017 Feb 16; 7:42571. PMID: 28205535.
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      4. Haglund E, Pilko A, Wollman R, Jennings P, Onuchic JN. The Pierced Lasso Topology Controls Function in Leptin. J Phys Chem B. 2016 Dec 30. PMID: 28035835.
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      5. Darash-Yahana M, Pozniak Y, Lu M, Sohn YS, Karmi O, Tamir S, Bai F, Song L, Jennings P, Pikarsky E, Geiger T, Onuchic JN, Mittler R, Nechushtai R. Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters. Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39):10890-5. PMID: 27621439.
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      6. Yim KH, Prince TL, Qu S, Bai F, Jennings P, Onuchic JN, Theodorakis EA, Neckers L. Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90ß. Proc Natl Acad Sci U S A. 2016 Aug 16; 113(33):E4801-9. PMID: 27466407.
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      7. Capraro DT, Jennings P. Untangling the Influence of a Protein Knot on Folding. Biophys J. 2016 Mar 8; 110(5):1044-51. PMID: 26958882.
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      8. Fisher KM, Haglund E, Noel JK, Hailey KL, Onuchic JN, Jennings P. Geometrical Frustration in Interleukin-33 Decouples the Dynamics of the Functional Element from the Folding Transition State Ensemble. PLoS One. 2015; 10(12):e0144067. PMID: 26630011.
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      9. Lipper CH, Paddock ML, Onuchic JN, Mittler R, Nechushtai R, Jennings P. Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis. PLoS One. 2015; 10(10):e0139699. PMID: 26448442.
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      10. Keshwani MM, Hailey KL, Aubol BE, Fattet L, McGlone ML, Jennings P, Adams JA. Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. Biochem J. 2015 Dec 15; 472(3):329-38. PMID: 26443864.
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      11. Barkho S, Pierce LC, Li S, Adams JA, Jennings P. Correction: Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation. PLoS One. 2015; 10(7):e0133801. PMID: 26191813.
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      12. Daniel KB, Sullivan ED, Chen Y, Chan JC, Jennings P, Fierke CA, Cohen SM. Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. J Med Chem. 2015 Jun 11; 58(11):4812-21. PMID: 25974739.
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      13. Barkho S, Pierce LC, Li S, Adams JA, Jennings P. Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation. PLoS One. 2015; 10(6):e0127724. PMID: 26030592.
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      14. Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis EA, Jennings P, Onuchic JN, Mittler R, Nechushtai R. The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3698-703. PMID: 25762074.
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      15. Keshwani MM, Aubol BE, Fattet L, Ma CT, Qiu J, Jennings P, Fu XD, Adams JA. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 1; 466(2):311-22. PMID: 25529026.
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      16. Tamir S, Paddock ML, Darash-Yahana-Baram M, Holt SH, Sohn YS, Agranat L, Michaeli D, Stofleth JT, Lipper CH, Morcos F, Cabantchik IZ, Onuchic JN, Jennings P, Mittler R, Nechushtai R. Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. Biochim Biophys Acta. 2015 Jun; 1853(6):1294-315. PMID: 25448035.
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      17. Haglund E, Sulkowska JI, Noel JK, Lammert H, Onuchic JN, Jennings P. Pierced Lasso Bundles Are a New Class of Knot-like Motifs. PLoS Comput Biol. 2014 Jun; 10(6):e1003613. PMID: 24945798.
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      18. Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings P, Livnah O, Nechushtai R. A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr D Biol Crystallogr. 2014 Jun; 70(Pt 6):1572-8. PMID: 24914968.
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      19. Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings P, Friedler A, Nechushtai R. Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proc Natl Acad Sci U S A. 2014 Apr 8; 111(14):5177-82. PMID: 24706857.
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      20. Xiang Z, Lacey VK, Ren H, Xu J, Burban DJ, Jennings P, Wang L. Proximity-Enabled Protein Crosslinking through Genetically Encoding Haloalkane Unnatural Amino Acids. Angew Chem Int Ed Engl. 2014 Feb 17; 53(8):2190-3. PMID: 24449339.
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      21. Barkho S, Pierce LC, McGlone ML, Li S, Woods VL, Walker RC, Adams JA, Jennings P. Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol. 2013; 9(9):e1003188. PMID: 24039559.
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      22. Capraro DT, Lammert H, Heidary DK, Roy M, Gross LA, Onuchic JN, Jennings P. Altered backbone and side-chain interactions result in route heterogeneity during the folding of interleukin-1ß (IL-1ß). Biophys J. 2013 Aug 20; 105(4):975-83. PMID: 23972849.
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      23. Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings P, Nechushtai R, Mittler R. NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth. Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36):14676-81. PMID: 23959881.
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      24. Tamir S, Zuris JA, Agranat L, Lipper CH, Conlan AR, Michaeli D, Harir Y, Paddock ML, Mittler R, Cabantchik ZI, Jennings P, Nechushtai R. Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs. PLoS One. 2013; 8(5):e61202. PMID: 23717386.
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      25. Hailey KL, Capraro DT, Barkho S, Jennings P. Allosteric switching of agonist/antagonist activity by a single point mutation in the interluekin-1 receptor antagonist, IL-1Ra. J Mol Biol. 2013 Jul 10; 425(13):2382-92. PMID: 23499887.
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      26. Onuchic JN, Jennings P, Ben-Jacob E. Learning from cancer how to defeat bacteria. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3212-3. PMID: 23407166.
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      27. Baxter EL, Zuris JA, Wang C, Vo PL, Axelrod HL, Cohen AE, Paddock ML, Nechushtai R, Onuchic JN, Jennings P. Allosteric control in a metalloprotein dramatically alters function. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):948-53. PMID: 23271805.
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      28. Andrews BT, Capraro DT, Sulkowska JI, Onuchic JN, Jennings P. Hysteresis as a Marker for Complex, Overlapping Landscapes in Proteins. J Phys Chem Lett. 2013 Jan 3; 4(1):180-188. PMID: 23525263.
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      29. Haglund E, Sulkowska JI, He Z, Feng GS, Jennings P, Onuchic JN. The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One. 2012; 7(9):e45654. PMID: 23029163.
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      30. Jamros MA, Oliveira LC, Whitford PC, Onuchic JN, Adams JA, Jennings P. Substrate-specific reorganization of the conformational ensemble of CSK implicates novel modes of kinase function. PLoS Comput Biol. 2012; 8(9):e1002695. PMID: 23028292.
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      31. Capraro DT, Gosavi S, Roy M, Onuchic JN, Jennings P. Folding circular permutants of IL-1ß: route selection driven by functional frustration. PLoS One. 2012; 7(6):e38512. PMID: 22693643.
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      32. Nechushtai R, Conlan AR, Harir Y, Song L, Yogev O, Eisenberg-Domovich Y, Livnah O, Michaeli D, Rosen R, Ma V, Luo Y, Zuris JA, Paddock ML, Cabantchik ZI, Jennings P, Mittler R. Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism. Plant Cell. 2012 May; 24(5):2139-54. PMID: 22562611.
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      33. Zuris JA, Ali SS, Yeh H, Nguyen TA, Nechushtai R, Paddock ML, Jennings P. NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein. J Biol Chem. 2012 Apr 6; 287(15):11649-55. PMID: 22351774.
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      34. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings P, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721.
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      35. Baxter EL, Jennings P, Onuchic JN. Strand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEET. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):1955-60. PMID: 22308404.
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      36. Capraro DT, Roy M, Onuchic JN, Gosavi S, Jennings P. ß-Bulge triggers route-switching on the functional landscape of interleukin-1ß. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1490-3. PMID: 22307602.
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      37. Zuris JA, Harir Y, Conlan AR, Shvartsman M, Michaeli D, Tamir S, Paddock ML, Onuchic JN, Mittler R, Cabantchik ZI, Jennings P, Nechushtai R. Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein. Proc Natl Acad Sci U S A. 2011 Aug 9; 108(32):13047-52. PMID: 21788481.
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      38. Conlan AR, Paddock ML, Homer C, Axelrod HL, Cohen AE, Abresch EC, Zuris JA, Nechushtai R, Jennings P. Mutation of the His ligand in mitoNEET stabilizes the 2Fe-2S cluster despite conformational heterogeneity in the ligand environment. Acta Crystallogr D Biol Crystallogr. 2011 Jun; 67(Pt 6):516-23. PMID: 21636891.
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      39. Plocinik RM, Li S, Liu T, Hailey KL, Whitesides J, Whitehouse J, Ma CT, Fu XD, Gosh G, Woods VL, Jennings P, Adams JA. Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol. 2011 Jul 1; 410(1):131-45. PMID: 21600902.
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      40. Baxter EL, Jennings P, Onuchic JN. Interdomain communication revealed in the diabetes drug target mitoNEET. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5266-71. PMID: 21402934.
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      41. Nechushtai R, Lammert H, Michaeli D, Eisenberg-Domovich Y, Zuris JA, Luca MA, Capraro DT, Fish A, Shimshon O, Roy M, Schug A, Whitford PC, Livnah O, Onuchic JN, Jennings P. Allostery in the ferredoxin protein motif does not involve a conformational switch. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2240-5. PMID: 21266547.
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      42. Zuris JA, Halim DA, Conlan AR, Abresch EC, Nechushtai R, Paddock ML, Jennings P. Engineering the redox potential over a wide range within a new class of FeS proteins. J Am Chem Soc. 2010 Sep 29; 132(38):13120-2. PMID: 20812736.
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      43. Jamros MA, Oliveira LC, Whitford PC, Onuchic JN, Adams JA, Blumenthal DK, Jennings P. Proteins at work: a combined small angle X-RAY scattering and theoretical determination of the multiple structures involved on the protein kinase functional landscape. J Biol Chem. 2010 Nov 12; 285(46):36121-8. PMID: 20801888.
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      44. Plesniak LA, Salzameda B, Hinderberger H, Regan E, Kahn J, Mills SA, Teriete P, Yao Y, Jennings P, Marassi F, Adams JA. Structure and activity of CPNGRC: a modified CD13/APN peptidic homing motif. Chem Biol Drug Des. 2010 Jun; 75(6):551-62. PMID: 20374250.
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      45. Dicus MM, Conlan A, Nechushtai R, Jennings P, Paddock ML, Britt RD, Stoll S. Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET. J Am Chem Soc. 2010 Feb 17; 132(6):2037-49. PMID: 20099820.
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      46. Bak DW, Zuris JA, Paddock ML, Jennings P, Elliott SJ. Redox characterization of the FeS protein MitoNEET and impact of thiazolidinedione drug binding. Biochemistry. 2009 Nov 3; 48(43):10193-5. PMID: 19791753.
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      47. Hailey KL, Li S, Andersen MD, Roy M, Woods VL, Jennings P. Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study. J Biol Chem. 2009 Sep 18; 284(38):26137-48. PMID: 19592498.
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      48. Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings P, Paddock ML. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. J Mol Biol. 2009 Sep 11; 392(1):143-53. PMID: 19580816.
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      49. Andrews BT, Roy M, Jennings P. Chromophore packing leads to hysteresis in GFP. J Mol Biol. 2009 Sep 11; 392(1):218-27. PMID: 19577576.
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      50. Conlan AR, Paddock ML, Axelrod HL, Cohen AE, Abresch EC, Wiley S, Roy M, Nechushtai R, Jennings P. The novel 2Fe-2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1; 65(Pt 7):654-9. PMID: 19574633.
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      51. Tirrell TF, Paddock ML, Conlan AR, Smoll EJ, Nechushtai R, Jennings P, Kim JE. Resonance Raman studies of the (His)(Cys)3 2Fe-2S cluster of MitoNEET: comparison to the (Cys)4 mutant and implications of the effects of pH on the labile metal center. Biochemistry. 2009 Jun 9; 48(22):4747-52. PMID: 19388667.
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      52. Hyeon C, Jennings P, Adams JA, Onuchic JN. Ligand-induced global transitions in the catalytic domain of protein kinase A. Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9):3023-8. PMID: 19204278.
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      53. Capraro DT, Roy M, Onuchic JN, Jennings P. Backtracking on the folding landscape of the beta-trefoil protein interleukin-1beta? Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):14844-8. PMID: 18806223.
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      54. Andrews BT, Gosavi S, Finke JM, Onuchic JN, Jennings P. The dual-basin landscape in GFP folding. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12283-8. PMID: 18713871.
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      55. Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings P, Fu XD, Adams JA. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2008 Oct 17; 382(4):894-909. PMID: 18687337.
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      56. Gosavi S, Whitford PC, Jennings P, Onuchic JN. Extracting function from a beta-trefoil folding motif. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10384-9. PMID: 18650393.
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      57. Plesniak LA, Botsch K, Leibrand M, Kelly M, Sem D, Adams JA, Jennings P. Transferred NOE and saturation transfer difference NMR studies of novobiocin binding to EnvZ suggest binding mode similar to DNA gyrase. Chem Biol Drug Des. 2008 Jan; 71(1):28-35. PMID: 18093089.
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      58. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings P. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 4; 104(36):14342-7. PMID: 17766440.
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      59. Andrews BT, Schoenfish AR, Roy M, Waldo G, Jennings P. The rough energy landscape of superfolder GFP is linked to the chromophore. J Mol Biol. 2007 Oct 19; 373(2):476-90. PMID: 17822714.
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      60. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings P, Dixon JE. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem. 2007 Aug 17; 282(33):23745-9. PMID: 17584744.
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      61. Finke JM, Jennings P, Lee JC, Onuchic JN, Winkler JR. Equilibrium unfolding of the poly(glutamic acid)20 helix. Biopolymers. 2007 Jun 15; 86(3):193-211. PMID: 17370320.
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      62. Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings P, Taylor SS. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell. 2006 Nov 3; 24(3):397-408. PMID: 17081990.
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      63. Mills JE, Whitford PC, Shaffer J, Onuchic JN, Adams JA, Jennings P. A novel disulfide bond in the SH2 Domain of the C-terminal Src kinase controls catalytic activity. J Mol Biol. 2007 Feb 2; 365(5):1460-8. PMID: 17137590.
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      64. Onuchic JN, Kobayashi C, Miyashita O, Jennings P, Baldridge KK. Exploring biomolecular machines: energy landscape control of biological reactions. Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29; 361(1472):1439-43. PMID: 16873130.
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      65. Chavez LL, Gosavi S, Jennings P, Onuchic JN. Multiple routes lead to the native state in the energy landscape of the beta-trefoil family. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10254-8. PMID: 16801558.
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      66. Sandoval CM, Geierstanger BH, Fujimura S, Balatbat C, Williams T, de Unamuno J, Whiles-Lillig JA, Ellerby LM, Ellerby HM, Jennings P, Plesniak LA. Structural evaluation of a novel pro-apoptotic peptide coupled to CNGRC tumor homing sequence by NMR. Chem Biol Drug Des. 2006 Jun; 67(6):417-24. PMID: 16882316.
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      67. Gosavi S, Chavez LL, Jennings P, Onuchic JN. Topological frustration and the folding of interleukin-1 beta. J Mol Biol. 2006 Mar 31; 357(3):986-96. PMID: 16469330.
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      68. Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings P, Taylor SS, Woods VL. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci. 2005 Dec; 14(12):2982-92. PMID: 16260760.
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      69. Heidary DK, Roy M, Daumy GO, Cong Y, Jennings P. Long-range coupling between separate docking sites in interleukin-1beta. J Mol Biol. 2005 Nov 11; 353(5):1187-98. PMID: 16216268.
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      70. Lieser SA, Aubol BE, Wong L, Jennings P, Adams JA. Coupling phosphoryl transfer and substrate interactions in protein kinases. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):191-9. PMID: 16213199.
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      71. Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods VL, Jennings P. Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol. 2005 Aug 5; 351(1):131-43. PMID: 16002086.
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      72. Covalt JC, Cao TB, Magdaroag JR, Gross LA, Jennings P. Temperature, media, and point of induction affect the N-terminal processing of interleukin-1beta. Protein Expr Purif. 2005 May; 41(1):45-52. PMID: 15802220.
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      73. Roy M, Chavez LL, Finke JM, Heidary DK, Onuchic JN, Jennings P. The native energy landscape for interleukin-1beta. Modulation of the population ensemble through native-state topology. J Mol Biol. 2005 Apr 29; 348(2):335-47. PMID: 15811372.
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      74. Wriggers W, Chakravarty S, Jennings P. Control of protein functional dynamics by peptide linkers. Biopolymers. 2005; 80(6):736-46. PMID: 15880774.
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      75. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings P, Tsien RY. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17867-72. PMID: 15601762.
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      76. Rodríguez JC, Jennings P, Melacini G. Using chemical exchange to assign non-covalent protein complexes in slow exchange with the free state: enhanced resolution and efficient signal editing. J Biomol NMR. 2004 Oct; 30(2):155-61. PMID: 15557802.
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      77. Plesniak LA, Parducho JI, Ziebart A, Geierstanger BH, Whiles JA, Melacini G, Jennings P. Orientation and helical conformation of a tissue-specific hunter-killer peptide in micelles. Protein Sci. 2004 Aug; 13(8):1988-96. PMID: 15273301.
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      78. Wong L, Lieser S, Chie-Leon B, Miyashita O, Aubol B, Shaffer J, Onuchic JN, Jennings P, Woods VL, Adams JA. Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J Mol Biol. 2004 Jul 30; 341(1):93-106. PMID: 15312765.
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      79. Wong L, Jennings P, Adams JA. Communication pathways between the nucleotide pocket and distal regulatory sites in protein kinases. Acc Chem Res. 2004 May; 37(5):304-11. PMID: 15147171.
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      80. Morikis D, Elcock AH, Jennings P, McCammon JA. The pH dependence of stability of the activation helix and the catalytic site of GART. Biophys Chem. 2003 Sep; 105(2-3):279-91. PMID: 14499900.
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      81. Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor SS, Jennings P. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J Mol Biol. 2003 Jul 25; 330(5):1117-29. PMID: 12860132.
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      82. Roy M, Jennings P. Real-time NMR kinetic studies provide global and residue-specific information on the non-cooperative unfolding of the beta-trefoil protein, interleukin-1beta. J Mol Biol. 2003 May 2; 328(3):693-703. PMID: 12706726.
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      83. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings P, Scott JD. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4445-50. PMID: 12672969.
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      84. Rodríguez JC, Wong L, Jennings P. The solvent in CNBr cleavage reactions determines the fragmentation efficiency of ketosteroid isomerase fusion proteins used in the production of recombinant peptides. Protein Expr Purif. 2003 Apr; 28(2):224-31. PMID: 12699685.
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      85. Fayos R, Melacini G, Newlon MG, Burns L, Scott JD, Jennings P. Induction of flexibility through protein-protein interactions. J Biol Chem. 2003 May 16; 278(20):18581-7. PMID: 12604595.
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      86. Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings P, Wilson IA. Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta. Acta Crystallogr D Biol Crystallogr. 2003 Feb; 59(Pt 2):290-8. PMID: 12554939.
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      87. Finke JM, Jennings P. Interleukin-1 beta folding between pH 5 and 7: experimental evidence for three-state folding behavior and robust transition state positions late in folding. Biochemistry. 2002 Dec 17; 41(50):15056-67. PMID: 12475255.
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      88. Plesniak L, Horiuchi Y, Sem D, Meinenger D, Stiles L, Shaffer J, Jennings P, Adams JA. Probing the nucleotide binding domain of the osmoregulator EnvZ using fluorescent nucleotide derivatives. Biochemistry. 2002 Nov 26; 41(47):13876-82. PMID: 12437344.
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      89. Hamuro Y, Wong L, Shaffer J, Kim JS, Stranz DD, Jennings P, Woods VL, Adams JA. Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS). J Mol Biol. 2002 Nov 8; 323(5):871-81. PMID: 12417200.
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      90. Rodríguez JC, Jennings P, Melacini G. Effect of chemical exchange on radiation damping in aqueous solutions of the osmolyte glycine. J Am Chem Soc. 2002 Jun 5; 124(22):6240-1. PMID: 12033843.
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      91. Morikis D, Roy M, Newlon MG, Scott JD, Jennings P. Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIalpha. Eur J Biochem. 2002 Apr; 269(8):2040-51. PMID: 11985580.
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      92. Heidary DK, Jennings P. Three topologically equivalent core residues affect the transition state ensemble in a protein folding reaction. J Mol Biol. 2002 Feb 22; 316(3):789-98. PMID: 11866531.
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      93. Morikis D, Roy M, Sahu A, Troganis A, Jennings P, Tsokos GC, Lambris JD. The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR. J Biol Chem. 2002 Apr 26; 277(17):14942-53. PMID: 11847226.
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      94. Morikis D, Elcock AH, Jennings P, McCammon JA. Native-state conformational dynamics of GART: a regulatory pH-dependent coil-helix transition examined by electrostatic calculations. Protein Sci. 2001 Nov; 10(11):2363-78. PMID: 11604542.
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      95. Morikis D, Elcock AH, Jennings P, McCammon JA. Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations. Protein Sci. 2001 Nov; 10(11):2379-92. PMID: 11604543.
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      96. Dalrymple BP, Kongsuwan K, Wijffels G, Dixon NE, Jennings P. A universal protein-protein interaction motif in the eubacterial DNA replication and repair systems. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11627-32. PMID: 11573000.
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      97. Clementi C, Jennings P, Onuchic JN. Prediction of folding mechanism for circular-permuted proteins. J Mol Biol. 2001 Aug 24; 311(4):879-90. PMID: 11518537.
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      98. Finke JM, Jennings P. Early aggregated States in the folding of interleukin-1ß. J Biol Phys. 2001 Jun; 27(2-3):119-31. PMID: 23345738.
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      99. Newlon MG, Roy M, Morikis D, Carr DW, Westphal R, Scott JD, Jennings P. A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J. 2001 Apr 2; 20(7):1651-62. PMID: 11285229.
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      100. Covalt JC, Roy M, Jennings P. Core and surface mutations affect folding kinetics, stability and cooperativity in IL-1 beta: does alteration in buried water play a role? J Mol Biol. 2001 Mar 23; 307(2):657-69. PMID: 11254388.
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      101. Andersen MD, Shaffer J, Jennings P, Adams JA. Structural characterization of protein kinase A as a function of nucleotide binding. Hydrogen-deuterium exchange studies using matrix-assisted laser desorption ionization-time of flight mass spectrometry detection. J Biol Chem. 2001 Apr 27; 276(17):14204-11. PMID: 11278927.
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      102. Finke JM, Gross LA, Ho HM, Sept D, Zimm BH, Jennings P. Commitment to folded and aggregated states occurs late in interleukin-1 beta folding. Biochemistry. 2000 Dec 19; 39(50):15633-42. PMID: 11112552.
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      103. Banky P, Newlon MG, Roy M, Garrod S, Taylor SS, Jennings P. Isoform-specific differences between the type Ialpha and IIalpha cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR. J Biol Chem. 2000 Nov 10; 275(45):35146-52. PMID: 10899163.
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      104. Heidary DK, O'Neill JC, Roy M, Jennings P. An essential intermediate in the folding of dihydrofolate reductase. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5866-70. PMID: 10811909.
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      105. Clementi C, Jennings P, Onuchic JN. How native-state topology affects the folding of dihydrofolate reductase and interleukin-1beta. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5871-6. PMID: 10811910.
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      106. Finke JM, Roy M, Zimm BH, Jennings P. Aggregation events occur prior to stable intermediate formation during refolding of interleukin 1beta. Biochemistry. 2000 Jan 25; 39(3):575-83. PMID: 10642182.
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      107. Newlon MG, Roy M, Morikis D, Hausken ZE, Coghlan V, Scott JD, Jennings P. The molecular basis for protein kinase A anchoring revealed by solution NMR. Nat Struct Biol. 1999 Mar; 6(3):222-7. PMID: 10074940.
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      108. Wright DS, Graham LD, Jennings P. Cloning of a Lysobacter enzymogenes gene that encodes an arginyl endopeptidase (endoproteinase Arg-C). Biochim Biophys Acta. 1998 Dec 22; 1443(3):369-74. PMID: 9878833.
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      109. Jennings P. Speeding along the protein folding highway, are we reading the signs correctly? Nat Struct Biol. 1998 Oct; 5(10):846-8. PMID: 9783738.
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      110. Su Y, Yamashita MM, Greasley SE, Mullen CA, Shim JH, Jennings P, Benkovic SJ, Wilson IA. A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. J Mol Biol. 1998 Aug 21; 281(3):485-99. PMID: 9698564.
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      111. Mullen CA, Jennings P. A single mutation disrupts the pH-dependent dimerization of glycinamide ribonucleotide transformylase. J Mol Biol. 1998 Mar 6; 276(4):819-27. PMID: 9500916.
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      112. Jennings P, Roy M, Heidary D, Gross L. Folding pathway of interleukin-1 beta. Nat Struct Biol. 1998 Jan; 5(1):11. PMID: 9437419.
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      113. Eliezer D, Jennings P, Dyson HJ, Wright PE. Populating the equilibrium molten globule state of apomyoglobin under conditions suitable for structural characterization by NMR. FEBS Lett. 1997 Nov 3; 417(1):92-6. PMID: 9395082.
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      114. Newlon MG, Roy M, Hausken ZE, Scott JD, Jennings P. The A-kinase anchoring domain of type IIalpha cAMP-dependent protein kinase is highly helical. J Biol Chem. 1997 Sep 19; 272(38):23637-44. PMID: 9295304.
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      115. Heidary DK, Gross LA, Roy M, Jennings P. Evidence for an obligatory intermediate in the folding of interleukin-1 beta. Nat Struct Biol. 1997 Sep; 4(9):725-31. PMID: 9303000.
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      116. Sánchez M, Jennings P, Murre C. Conformational changes induced in Hoxb-8/Pbx-1 heterodimers in solution and upon interaction with specific DNA. Mol Cell Biol. 1997 Sep; 17(9):5369-76. PMID: 9271414.
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      117. Mullen CA, Jennings P. Glycinamide ribonucleotide transformylase undergoes pH-dependent dimerization. J Mol Biol. 1996 Oct 11; 262(5):746-55. PMID: 8876651.
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      118. Massari ME, Jennings P, Murre C. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol Cell Biol. 1996 Jan; 16(1):121-9. PMID: 8524288.
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      119. Jennings P, Stone MJ, Wright PE. Overexpression of myoglobin and assignment of its amide, C alpha and C beta resonances. J Biomol NMR. 1995 Nov; 6(3):271-6. PMID: 8520219.
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      120. Eliezer D, Jennings P, Wright PE, Doniach S, Hodgson KO, Tsuruta H. The radius of gyration of an apomyoglobin folding intermediate. Science. 1995 Oct 20; 270(5235):487-8. PMID: 7570004.
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      121. Hendry P, McCall MJ, Santiago FS, Jennings P. In vitro activity of minimised hammerhead ribozymes. Nucleic Acids Res. 1995 Oct 11; 23(19):3922-7. PMID: 7479037.
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      122. Graham LD, Haggett KD, Hayes PJ, Schober PA, Jennings P, Whittaker RG. Random mutagenesis of the substrate-binding site of a serine protease. A new library of alpha-lytic protease S1 mutants. Ann N Y Acad Sci. 1995 Mar 31; 750:10-4. PMID: 7785837.
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      123. Gerendasy DD, Herron SR, Jennings P, Sutcliffe JG. Calmodulin stabilizes an amphiphilic alpha-helix within RC3/neurogranin and GAP-43/neuromodulin only when Ca2+ is absent. J Biol Chem. 1995 Mar 24; 270(12):6741-50. PMID: 7896819.
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      124. Jones BE, Jennings P, Pierre RA, Matthews CR. Development of nonpolar surfaces in the folding of Escherichia coli dihydrofolate reductase detected by 1-anilinonaphthalene-8-sulfonate binding. Biochemistry. 1994 Dec 27; 33(51):15250-8. PMID: 7803387.
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      125. Hendry P, Moghaddam MJ, McCall MJ, Jennings P, Ebel S, Brown T. Using linkers to investigate the spatial separation of the conserved nucleotides A9 and G12 in the hammerhead ribozyme. Biochim Biophys Acta. 1994 Oct 18; 1219(2):405-12. PMID: 7522573.
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      126. Jennings P, Wright PE. Formation of a molten globule intermediate early in the kinetic folding pathway of apomyoglobin. Science. 1993 Nov 5; 262(5135):892-6. PMID: 8235610.
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      127. Hannan GN, Lehnert SA, MacAvoy ES, Jennings P, Molloy PL. An engineered PGK promoter and lac operator-repressor system for the regulation of gene expression in mammalian cells. Gene. 1993 Aug 25; 130(2):233-9. PMID: 8359690.
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      128. Graham LD, Haggett KD, Jennings P, Le Brocque DS, Whittaker RG, Schober PA. Random mutagenesis of the substrate-binding site of a serine protease can generate enzymes with increased activities and altered primary specificities. Biochemistry. 1993 Jun 22; 32(24):6250-8. PMID: 8512935.
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      129. Jennings P, Finn BE, Jones BE, Matthews CR. A reexamination of the folding mechanism of dihydrofolate reductase from Escherichia coli: verification and refinement of a four-channel model. Biochemistry. 1993 Apr 13; 32(14):3783-9. PMID: 8466916.
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      130. Jennings P, Saalau-Bethell SM, Finn BE, Chen XW, Matthews CR. Mutational analysis of protein folding mechanisms. Methods Enzymol. 1991; 202:113-26. PMID: 1784172.
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      131. Dunn IS, Jennings P. Protein modification from mutational analysis of an autologous peptide fragment. Protein Eng. 1990 Dec; 4(2):205-13. PMID: 2127459.
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      132. Dunn IS, Cowan R, Jennings P. Improved peptide function from random mutagenesis over short 'windows'. Protein Eng. 1988 Oct; 2(4):283-91. PMID: 3150542.
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      133. Jennings P, Molloy PL. Inhibition of SV40 replicon function by engineered antisense RNA transcribed by RNA polymerase III. EMBO J. 1987 Oct; 6(10):3043-7. PMID: 2446865.
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      134. Hoffmann D, Jennings P, Spradbrow PB. Transplantation of bovine squamous cell carcinoma into congenitally athymic nude mice. Vet Rec. 1977 Nov 5; 101(19):384-5. PMID: 595272.
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