Mark Paddock

Title(s)Lecturer, Physics
SchoolAcademic Aff
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Boyd JS, Cheng RR, Paddock ML, Sancar C, Morcos F, Golden SS. A Combined Computational and Genetic Approach Uncovers Network Interactions of the Cyanobacterial Circadian Clock. J Bacteriol. 2016 09 15; 198(18):2439-47. PMID: 27381914.
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    2. Holt SH, Darash-Yahana M, Sohn YS, Song L, Karmi O, Tamir S, Michaeli D, Luo Y, Paddock ML, Jennings PA, Onuchic JN, Azad RK, Pikarsky E, Cabantchik IZ, Nechushtai R, Mittler R. Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells. J Cell Sci. 2016 Jan 01; 129(1):155-65. PMID: 26621032; PMCID: PMC4732299.
    3. Lipper CH, Paddock ML, Onuchic JN, Mittler R, Nechushtai R, Jennings PA. Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis. PLoS One. 2015; 10(10):e0139699. PMID: 26448442; PMCID: PMC4598119.
    4. Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis EA, Jennings PA, Onuchic JN, Mittler R, Nechushtai R. The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3698-703. PMID: 25762074; PMCID: PMC4378444.
    5. Shultzaberger RK, Paddock ML, Katsuki T, Greenspan RJ, Golden SS. High-throughput and quantitative approaches for measuring circadian rhythms in cyanobacteria using bioluminescence. Methods Enzymol. 2015; 551:53-72. PMID: 25662451; PMCID: PMC4771492.
    6. Tamir S, Paddock ML, Darash-Yahana-Baram M, Holt SH, Sohn YS, Agranat L, Michaeli D, Stofleth JT, Lipper CH, Morcos F, Cabantchik IZ, Onuchic JN, Jennings PA, Mittler R, Nechushtai R. Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. Biochim Biophys Acta. 2015 Jun; 1853(6):1294-315. PMID: 25448035.
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    7. Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings PA, Livnah O, Nechushtai R. A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr D Biol Crystallogr. 2014 Jun; 70(Pt 6):1572-8. PMID: 24914968.
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    8. Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R. Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5177-82. PMID: 24706857; PMCID: PMC3986192.
    9. Paddock ML, Boyd JS, Adin DM, Golden SS. Active output state of the Synechococcus Kai circadian oscillator. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):E3849-57. PMID: 24043774; PMCID: PMC3791705.
    10. Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R. NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14676-81. PMID: 23959881; PMCID: PMC3767537.
    11. Tamir S, Zuris JA, Agranat L, Lipper CH, Conlan AR, Michaeli D, Harir Y, Paddock ML, Mittler R, Cabantchik ZI, Jennings PA, Nechushtai R. Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs. PLoS One. 2013; 8(5):e61202. PMID: 23717386; PMCID: PMC3661554.
    12. Baxter EL, Zuris JA, Wang C, Vo PL, Axelrod HL, Cohen AE, Paddock ML, Nechushtai R, Onuchic JN, Jennings PA. Allosteric control in a metalloprotein dramatically alters function. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):948-53. PMID: 23271805; PMCID: PMC3549116.
    13. Nechushtai R, Conlan AR, Harir Y, Song L, Yogev O, Eisenberg-Domovich Y, Livnah O, Michaeli D, Rosen R, Ma V, Luo Y, Zuris JA, Paddock ML, Cabantchik ZI, Jennings PA, Mittler R. Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism. Plant Cell. 2012 May; 24(5):2139-54. PMID: 22562611.
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    14. Zuris JA, Ali SS, Yeh H, Nguyen TA, Nechushtai R, Paddock ML, Jennings PA. NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein. J Biol Chem. 2012 Apr 06; 287(15):11649-55. PMID: 22351774; PMCID: PMC3320914.
    15. Zuris JA, Harir Y, Conlan AR, Shvartsman M, Michaeli D, Tamir S, Paddock ML, Onuchic JN, Mittler R, Cabantchik ZI, Jennings PA, Nechushtai R. Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13047-52. PMID: 21788481; PMCID: PMC3156153.
    16. Conlan AR, Paddock ML, Homer C, Axelrod HL, Cohen AE, Abresch EC, Zuris JA, Nechushtai R, Jennings PA. Mutation of the His ligand in mitoNEET stabilizes the 2Fe-2S cluster despite conformational heterogeneity in the ligand environment. Acta Crystallogr D Biol Crystallogr. 2011 Jun; 67(Pt 6):516-23. PMID: 21636891; PMCID: PMC3107049.
    17. Flores M, Savitsky A, Paddock ML, Abresch EC, Dubinskii AA, Okamura MY, Lubitz W, Möbius K. Electron-nuclear and electron-electron double resonance spectroscopies show that the primary quinone acceptor QA in reaction centers from photosynthetic bacteria Rhodobacter sphaeroides remains in the same orientation upon light-induced reduction. J Phys Chem B. 2010 Dec 23; 114(50):16894-901. PMID: 21090818.
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    18. Zuris JA, Halim DA, Conlan AR, Abresch EC, Nechushtai R, Paddock ML, Jennings PA. Engineering the redox potential over a wide range within a new class of FeS proteins. J Am Chem Soc. 2010 Sep 29; 132(38):13120-2. PMID: 20812736; PMCID: PMC2944382.
    19. Dicus MM, Conlan A, Nechushtai R, Jennings PA, Paddock ML, Britt RD, Stoll S. Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET. J Am Chem Soc. 2010 Feb 17; 132(6):2037-49. PMID: 20099820; PMCID: PMC2820139.
    20. Abresch EC, Gong XM, Paddock ML, Okamura MY. Electron transfer from cytochrome c(2) to the reaction center: a transition state model for ionic strength effects due to neutral mutations. Biochemistry. 2009 Dec 08; 48(48):11390-8. PMID: 19877711; PMCID: PMC2789999.
    21. Bak DW, Zuris JA, Paddock ML, Jennings PA, Elliott SJ. Redox characterization of the FeS protein MitoNEET and impact of thiazolidinedione drug binding. Biochemistry. 2009 Nov 03; 48(43):10193-5. PMID: 19791753; PMCID: PMC3322619.
    22. Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA, Paddock ML. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. J Mol Biol. 2009 Sep 11; 392(1):143-53. PMID: 19580816; PMCID: PMC2739586.
    23. Conlan AR, Paddock ML, Axelrod HL, Cohen AE, Abresch EC, Wiley S, Roy M, Nechushtai R, Jennings PA. The novel 2Fe-2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 01; 65(Pt 7):654-9. PMID: 19574633; PMCID: PMC2705628.
    24. Tirrell TF, Paddock ML, Conlan AR, Smoll EJ, Nechushtai R, Jennings PA, Kim JE. Resonance Raman studies of the (His)(Cys)3 2Fe-2S cluster of MitoNEET: comparison to the (Cys)4 mutant and implications of the effects of pH on the labile metal center. Biochemistry. 2009 Jun 09; 48(22):4747-52. PMID: 19388667; PMCID: PMC2861891.
    25. Lin S, Jaschke PR, Wang H, Paddock M, Tufts A, Allen JP, Rosell FI, Mauk AG, Woodbury NW, Beatty JT. Electron transfer in the Rhodobacter sphaeroides reaction center assembled with zinc bacteriochlorophyll. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8537-42. PMID: 19439660; PMCID: PMC2689001.
    26. Iwata T, Paddock ML, Okamura MY, Kandori H. Identification of FTIR bands due to internal water molecules around the quinone binding sites in the reaction center from Rhodobacter sphaeroides. Biochemistry. 2009 Feb 17; 48(6):1220-9. PMID: 19161296; PMCID: PMC2701474.
    27. Abresch EC, Paddock ML, Villalobos M, Chang C, Okamura MY. Interaction between cytochrome c2 and the photosynthetic reaction center from Rhodobacter sphaeroides: role of interprotein hydrogen bonds in binding and electron transfer. Biochemistry. 2008 Dec 16; 47(50):13318-25. PMID: 19053264; PMCID: PMC2615004.
    28. Marchanka A, Paddock M, Lubitz W, van Gastel M. Low-temperature pulsed EPR study at 34 GHz of the triplet states of the primary electron Donor P865 and the carotenoid in native and mutant bacterial reaction centers of Rhodobacter sphaeroides. Biochemistry. 2007 Dec 25; 46(51):14782-94. PMID: 18052205; PMCID: PMC2562510.
    29. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14342-7. PMID: 17766440; PMCID: PMC1963346.
    30. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem. 2007 Aug 17; 282(33):23745-9. PMID: 17584744.
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    31. Nabedryk E, Paddock ML, Okamura MY, Breton J. Monitoring the pH dependence of IR carboxylic acid signals upon Q(B)- formation in the Glu-L212 --> Asp/Asp-L213 --> Glu swap mutant reaction center from Rhodobacter sphaeroides. Biochemistry. 2007 Feb 06; 46(5):1176-82. PMID: 17260947.
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    32. Nabedryk E, Paddock ML, Okamura MY, Breton J. An isotope-edited FTIR investigation of the role of Ser-L223 in binding quinone (QB) and semiquinone (QB-) in the reaction center from Rhodobacter sphaeroides. Biochemistry. 2005 Nov 08; 44(44):14519-27. PMID: 16262252.
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    33. Nabedryk E, Breton J, Okamura MY, Paddock ML. Identification of a novel protonation pattern for carboxylic acids upon Q(B) photoreduction in Rhodobacter sphaeroides reaction center mutants at Asp-L213 and Glu-L212 sites. Biochemistry. 2004 Jun 15; 43(23):7236-43. PMID: 15182169.
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    34. Xu Q, Axelrod HL, Abresch EC, Paddock ML, Okamura MY, Feher G. X-Ray structure determination of three mutants of the bacterial photosynthetic reaction centers from Rb. sphaeroides; altered proton transfer pathways. Structure. 2004 Apr; 12(4):703-15. PMID: 15062092.
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    35. Gong XM, Paddock ML, Okamura MY. Interactions between cytochrome c2 and photosynthetic reaction center from Rhodobacter sphaeroides: changes in binding affinity and electron transfer rate due to mutation of interfacial hydrophobic residues are strongly correlated. Biochemistry. 2003 Dec 16; 42(49):14492-500. PMID: 14661961.
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    36. Mezzetti A, Nabedryk E, Breton J, Okamura MY, Paddock ML, Giacometti G, Leibl W. Rapid-scan Fourier transform infrared spectroscopy shows coupling of GLu-L212 protonation and electron transfer to Q(B) in Rhodobacter sphaeroides reaction centers. Biochim Biophys Acta. 2002 Feb 15; 1553(3):320-30. PMID: 11997141.
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