Xiaoxu Yang

Title(s)Postdoctoral Scholar, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailxiy010@ucsd.edu
ORCID ORCID Icon0000-0003-0219-0023 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Peking University, ChinaPhD07/2018Bioinformatics
    Beijing Normal University, ChinaBS07/2013Bioscience
    Collapse Awards and Honors
    Peking University2018  - 2018Outstanding Graduate
    Peking University2013  - 2017The President's Scholarship
    Beijing Normal University2013  - 2013Outstanding Graduate
    Ministry of Education, China2011  - 2011National Scholarship
    Beijing Normal University2010  - 2012First Prize Scholarship

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development. Nat Genet. 2023 Jan 12. Chung C, Yang X, Bae T, Vong KI, Mittal S, Donkels C, Westley Phillips H, Li Z, Marsh APL, Breuss MW, Ball LL, Garcia CAB, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry AS, Khoury S, Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH, Kang HC, Schulze-Bonhage A, Haas CA, Urbach H, Prinz M, Limbrick DD, Gurnett CA, Smyth MD, Sattar S, Nespeca M, Gonda DD, Imai K, Takahashi Y, Chen HH, Tsai JW, Conti V, Guerrini R, Devinsky O, Silva WA, Machado HR, Mathern GW, Abyzov A, Baldassari S, Baulac S, Focal Cortical Dysplasia Neurogenetics Consortium, Brain Somatic Mosaicism Network, Gleeson JG. PMID: 36635388.
      View in: PubMed   Mentions:
    2. Control-independent mosaic single nucleotide variant detection with DeepMosaic. Nat Biotechnol. 2023 Jan 02. Yang X, Xu X, Breuss MW, Antaki D, Ball LL, Chung C, Shen J, Li C, George RD, Wang Y, Bae T, Cheng Y, Abyzov A, Wei L, Alexandrov LB, Sebat JL, NIMH Brain Somatic Mosaicism Network, Gleeson JG. PMID: 36593400.
      View in: PubMed   Mentions:
    3. Detecting genomic mosaicism in "de novo" genetic epilepsy by amplicon-based deep sequencing. J Hum Genet. 2022 Dec 08. Chen J, Chen Y, Yang Y, Niu X, Zhang J, Zeng Q, Liu A, Xu X, Yang X, Li S, Yang X, Wang Y, Zhang Y. PMID: 36482122.
      View in: PubMed   Mentions:
    4. RJAfinder: An automated tool for quantification of responding to joint attention behaviors in autism spectrum disorder using eye tracking data. Front Neurosci. 2022; 16:915464. Zhang J, Li Z, Wu Y, Ye AY, Chen L, Yang X, Wu Q, Wei L. PMID: 36466175; PMCID: PMC9714660.
      View in: PubMed   Mentions:
    5. PCDH19-related epilepsy in mosaic males: The phenotypic implication of genotype and variant allele frequency. Front Neurol. 2022; 13:1041509. Chen Y, Yang X, Chen J, Yang X, Yang Y, Liu A, Zhang X, Wu W, Sun D, Yang Z, Jiang Y, Zhang Y. PMID: 36408521; PMCID: PMC9669318.
      View in: PubMed   Mentions:
    6. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science. 2022 07 29; 377(6605):511-517. Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Brain Somatic Mosaicism Network§, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. PMID: 35901164; PMCID: PMC9420557.
      View in: PubMed   Mentions:    Fields:    
    7. Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission. Elife. 2022 07 05; 11. Breuss MW, Yang X, Stanley V, McEvoy-Venneri J, Xu X, Morales AJ, Gleeson JG. PMID: 35787314; PMCID: PMC9255958.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Biallelic FRA10AC1 variants cause a neurodevelopmental disorder with growth retardation. Brain. 2022 05 24; 145(4):1551-1563. von Elsner L, Chai G, Schneeberger PE, Harms FL, Casar C, Qi M, Alawi M, Abdel-Salam GMH, Zaki MS, Arndt F, Yang X, Stanley V, Hempel M, Gleeson JG, Kutsche K. PMID: 34694367; PMCID: PMC9128818.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Somatic mosaicism reveals clonal distributions of neocortical development. Nature. 2022 04; 604(7907):689-696. Breuss MW, Yang X, Schlachetzki JCM, Antaki D, Lana AJ, Xu X, Chung C, Chai G, Stanley V, Song Q, Newmeyer TF, Nguyen A, O'Brien S, Hoeksema MA, Cao B, Nott A, McEvoy-Venneri J, Pasillas MP, Barton ST, Copeland BR, Nahas S, Van Der Kraan L, Ding Y, NIMH Brain Somatic Mosaicism Network, Glass CK, Gleeson JG. PMID: 35444276; PMCID: PMC9436791.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. N Engl J Med. 2021 09 30; 385(14):1292-1301. Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, Marshall T, Jiang N, Yang X, McEvoy-Venneri J, Stanley V, Anzenberg P, Lang N, Wazny V, Yu J, Virshup DM, Nygaard R, Mancia F, Merdzanic R, Toralles MBP, Pitanga PML, Puri RD, Hernan R, Chung WK, Bertoli-Avella AM, Al-Sannaa N, Zaki MS, Willert K, Reversade B, Gleeson JG. PMID: 34587386; PMCID: PMC9017221.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Developmental and temporal characteristics of clonal sperm mosaicism. Cell. 2021 09 02; 184(18):4772-4783.e15. Yang X, Breuss MW, Xu X, Antaki D, James KN, Stanley V, Ball LL, George RD, Wirth SA, Cao B, Nguyen A, McEvoy-Venneri J, Chai G, Nahas S, Van Der Kraan L, Ding Y, Sebat J, Gleeson JG. PMID: 34388390; PMCID: PMC8496133.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Sperm mosaicism: implications for genomic diversity and disease. Trends Genet. 2021 10; 37(10):890-902. Breuss MW, Yang X, Gleeson JG. PMID: 34158173; PMCID: PMC9484299.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Comprehensive identification of somatic nucleotide variants in human brain tissue. Genome Biol. 2021 03 29; 22(1):92. Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Brain Somatic Mosaicism Network, Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A. PMID: 33781308; PMCID: PMC8006362.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Landmarks of human embryonic development inscribed in somatic mutations. Science. 2021 03 19; 371(6535):1249-1253. Bizzotto S, Dou Y, Ganz J, Doan RN, Kwon M, Bohrson CL, Kim SN, Bae T, Abyzov A, NIMH Brain Somatic Mosaicism Network, Park PJ, Walsh CA. PMID: 33737485; PMCID: PMC8170505.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    15. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 01 20; 109(2):241-256.e9. Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG. PMID: 33220177; PMCID: PMC8800389.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. A relatively common homozygous TRAPPC4 splicing variant is associated with an early-infantile neurodegenerative syndrome. Eur J Hum Genet. 2021 02; 29(2):271-279. Ghosh SG, Scala M, Beetz C, Helman G, Stanley V, Yang X, Breuss MW, Mazaheri N, Selim L, Hadipour F, Pais L, Stutterd CA, Karageorgou V, Begtrup A, Crunk A, Juusola J, Willaert R, Flore LA, Kennelly K, Spencer C, Brown M, Trapane P, Hurst ACE, Lane Rutledge S, Goodloe DH, McDonald MT, Shashi V, Schoch K, Undiagnosed Diseases Network, Tomoum H, Zaitoun R, Hadipour Z, Galehdari H, Pagnamenta AT, Mojarrad M, Sedaghat A, Dias P, Quintas S, Eslahi A, Shariati G, Bauer P, Simons C, Houlden H, Issa MY, Zaki MS, Maroofian R, Gleeson JG. PMID: 32901138; PMCID: PMC7868361.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and Healthy Human Individuals. Genomics Proteomics Bioinformatics. 2020 04; 18(2):140-149. Yang X, Yang C, Zheng X, Xiong L, Tao Y, Wang M, Ye AY, Wu Q, Dou Y, Luo J, Wei L, Huang AY. PMID: 32911083; PMCID: PMC7646124.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. mTOR pathway somatic variants and the molecular pathogenesis of hemimegalencephaly. Epilepsia Open. 2020 Mar; 5(1):97-106. Garcia CAB, Carvalho SCS, Yang X, Ball LL, George RD, James KN, Stanley V, Breuss MW, Thomé U, Santos MV, Saggioro FP, Neder Serafini L, Silva WA, Gleeson JG, Machado HR. PMID: 32140648; PMCID: PMC7049797.
      View in: PubMed   Mentions: 4     Fields:    
    19. Autism risk in offspring can be assessed through quantification of male sperm mosaicism. Nat Med. 2020 01; 26(1):143-150. Breuss MW, Antaki D, George RD, Kleiber M, James KN, Ball LL, Hong O, Mitra I, Yang X, Wirth SA, Gu J, Garcia CAB, Gujral M, Brandler WM, Musaev D, Nguyen A, McEvoy-Venneri J, Knox R, Sticca E, Botello MCC, Uribe Fenner J, Pérez MC, Arranz M, Moffitt AB, Wang Z, Hervás A, Devinsky O, Gymrek M, Sebat J, Gleeson JG. PMID: 31873310; PMCID: PMC7032648.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    20. Somatic double-hit in MTOR and RPS6 in hemimegalencephaly with intractable epilepsy. Hum Mol Genet. 2019 11 15; 28(22):3755-3765. Pelorosso C, Watrin F, Conti V, Buhler E, Gelot A, Yang X, Mei D, McEvoy-Venneri J, Manent JB, Cetica V, Ball LL, Buccoliero AM, Vinck A, Barba C, Gleeson JG, Guerrini R, Represa A. PMID: 31411685; PMCID: PMC6935386.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Recurrent homozygous damaging mutation in TMX2, encoding a protein disulfide isomerase, in four families with microlissencephaly. J Med Genet. 2020 04; 57(4):274-282. Ghosh SG, Wang L, Breuss MW, Green JD, Stanley V, Yang X, Ross D, Traynor BJ, Alhashem AM, Azam M, Selim L, Bastaki L, Elbastawisy HI, Temtamy S, Zaki M, Gleeson JG. PMID: 31586943; PMCID: PMC7405652.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. An expanded landscape of human long noncoding RNA. Nucleic Acids Res. 2019 09 05; 47(15):7842-7856. Jiang S, Cheng SJ, Ren LC, Wang Q, Kang YJ, Ding Y, Hou M, Yang XX, Lin Y, Liang N, Gao G. PMID: 31350901; PMCID: PMC6735957.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    23. Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals. PLoS Genet. 2019 04; 15(4):e1008043. Zhao B, Wu Q, Ye AY, Guo J, Zheng X, Yang X, Yan L, Liu QR, Hyde TM, Wei L, Huang AY. PMID: 30973874; PMCID: PMC6478352.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. ATP1A3 mosaicism in families with alternating hemiplegia of childhood. Clin Genet. 2019 07; 96(1):43-52. Yang X, Yang X, Chen J, Li S, Zeng Q, Huang AY, Ye AY, Yu Z, Wang S, Jiang Y, Wu X, Wu Q, Wei L, Zhang Y. PMID: 30891744; PMCID: PMC6850116.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Genomic mosaicism in the pathogenesis and inheritance of a Rett syndrome cohort. Genet Med. 2019 06; 21(6):1330-1338. Zhang Q, Yang X, Wang J, Li J, Wu Q, Wen Y, Zhao Y, Zhang X, Yao H, Wu X, Yu S, Wei L, Bao X. PMID: 30405208; PMCID: PMC6752670.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    26. Mosaicism and incomplete penetrance of PCDH19 mutations. J Med Genet. 2019 02; 56(2):81-88. Liu A, Yang X, Yang X, Wu Q, Zhang J, Sun D, Yang Z, Jiang Y, Wu X, Wei L, Zhang Y. PMID: 30287595; PMCID: PMC6581080.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    27. A model for postzygotic mosaicisms quantifies the allele fraction drift, mutation rate, and contribution to de novo mutations. Genome Res. 2018 07; 28(7):943-951. Ye AY, Dou Y, Yang X, Wang S, Huang AY, Wei L. PMID: 29875290; PMCID: PMC6028137.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs. PLoS Genet. 2018 05; 14(5):e1007395. Huang AY, Yang X, Wang S, Zheng X, Wu Q, Ye AY, Wei L. PMID: 29763432; PMCID: PMC5969758.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    29. AutismKB 2.0: a knowledgebase for the genetic evidence of autism spectrum disorder. Database (Oxford). 2018 01 01; 2018. Yang C, Li J, Wu Q, Yang X, Huang AY, Zhang J, Ye AY, Dou Y, Yan L, Zhou WZ, Kong L, Wang M, Ai C, Yang D, Wei L. PMID: 30339214; PMCID: PMC6193446.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Genomic mosaicism in paternal sperm and multiple parental tissues in a Dravet syndrome cohort. Sci Rep. 2017 Nov 15; 7(1):15677. Yang X, Liu A, Xu X, Yang X, Zeng Q, Ye AY, Yu Z, Wang S, Huang AY, Wu X, Wu Q, Wei L, Zhang Y. PMID: 29142202; PMCID: PMC5688122.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    31. [Study on mosaicism of SCN1A gene mutation in parents of children with Dravet syndrome]. Zhonghua Er Ke Za Zhi. 2017 Nov 02; 55(11):818-823. Liu AJ, Yang XX, Xu XJ, Wu QX, Tian XJ, Yang XL, Wu XR, Wei LP, Zhang YH. PMID: 29141311.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. MosaicHunter: accurate detection of postzygotic single-nucleotide mosaicism through next-generation sequencing of unpaired, trio, and paired samples. Nucleic Acids Res. 2017 Jun 02; 45(10):e76. Huang AY, Zhang Z, Ye AY, Dou Y, Yan L, Yang X, Zhang Y, Wei L. PMID: 28132024; PMCID: PMC5449543.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    33. Postzygotic single-nucleotide mosaicisms contribute to the etiology of autism spectrum disorder and autistic traits and the origin of mutations. Hum Mutat. 2017 08; 38(8):1002-1013. Dou Y, Yang X, Li Z, Wang S, Zhang Z, Ye AY, Yan L, Yang C, Wu Q, Li J, Zhao B, Huang AY, Wei L. PMID: 28503910; PMCID: PMC5518181.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    34. Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq. Nat Commun. 2017 05 22; 8:15335. Wang K, Lai S, Yang X, Zhu T, Lu X, Wu CI, Ruan J. PMID: 28530222; PMCID: PMC5458117.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. Amplicon Resequencing Identified Parental Mosaicism for Approximately 10% of "de novo" SCN1A Mutations in Children with Dravet Syndrome. Hum Mutat. 2015 Sep; 36(9):861-72. Xu X, Yang X, Wu Q, Liu A, Yang X, Ye AY, Huang AY, Li J, Wang M, Yu Z, Wang S, Zhang Z, Wu X, Wei L, Zhang Y. PMID: 26096185; PMCID: PMC5034833.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    36. "Bioinformatics: introduction and methods," a bilingual Massive Open Online Course (MOOC) as a new example for global bioinformatics education. PLoS Comput Biol. 2014 Dec; 10(12):e1003955. Ding Y, Wang M, He Y, Ye AY, Yang X, Liu F, Meng Y, Gao G, Wei L. PMID: 25503717; PMCID: PMC4263353.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals. Cell Res. 2014 Nov; 24(11):1311-27. Huang AY, Xu X, Ye AY, Wu Q, Yan L, Zhao B, Yang X, He Y, Wang S, Zhang Z, Gu B, Zhao HQ, Wang M, Gao H, Gao G, Zhang Z, Yang X, Wu X, Zhang Y, Wei L. PMID: 25312340; PMCID: PMC4220156.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
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