Jill Wildonger

Title(s)Associate Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-6462-5830 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San Francisco, CAPostdoctoral StudiesNeurogenetics
    Columbia University, New York, NYPhDNeurobiology & Behavior
    Swarthmore College, Swarthmore, PAMABiology

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanistic analysis of microtubule dynamics and stability in neurons
    NIH R01NS116373Dec 15, 2020 - Nov 30, 2025
    Role: Principal Investigator
    Molecular motors and neuronal microtubule polarity
    NIH R01NS102385Jul 15, 2017 - Mar 31, 2023
    Role: Principal Investigator
    Multi-scale analysis and modeling of acetylation effects on neuronal microtubules
    NIH R21NS101553Jul 1, 2017 - Jun 30, 2020
    Role: Principal Investigator
    ROLE OF MICROTUBULE-BASED TRANSPORT IN NEURONAL POLARITY
    NIH R00NS072252Sep 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Role of microtubule-based transport in neuronal polarity
    NIH K99NS072252Sep 1, 2010 - Aug 31, 2012
    Role: Principal Investigator
    How neuronal polarity is established in vivo
    NIH F32HD053199Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Handling Difficult Cryo-ET Samples: A Study with Primary Neurons from Drosophila melanogaster. Microsc Microanal. 2023 Dec 21; 29(6):2127-2148. Kim JY, Yang JE, Mitchell JW, English LA, Yang SZ, Tenpas T, Dent EW, Wildonger J, Wright ER. PMID: 37966978.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons. PLoS Genet. 2023 Nov; 19(11):e1011025. Mitchell JW, Midillioglu I, Schauer E, Wang B, Han C, Wildonger J. PMID: 37943859; PMCID: PMC10662761.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Introduction to CRISPR and Its Use in Drosophila. Cold Spring Harb Protoc. 2023 Oct 03. Gratz S, O'Connor-Giles KM, Wildonger J. PMID: 37788866.
      View in: PubMed   Mentions:    Fields:    
    4. Generating CRISPR Alleles in Drosophila. Cold Spring Harb Protoc. 2023 Oct 03. Gratz S, O'Connor-Giles KM, Wildonger J. PMID: 37788869.
      View in: PubMed   Mentions:    Fields:    
    5. Light-induced trapping of endogenous proteins reveals spatiotemporal roles of microtubule and kinesin-1 in dendrite patterning of Drosophila sensory neurons. bioRxiv. 2023 Oct 02. Xu Y, Wang B, Bush I, Saunders HA, Wildonger J, Han C. PMID: 37873262; PMCID: PMC10592855.
      View in: PubMed   Mentions:
    6. Intracellular transport: Finding the motor that will take you where you need to go. Curr Biol. 2023 09 25; 33(18):R950-R953. Wildonger J, Than H. PMID: 37751706.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Morphological Comparison of Primary Neurons Cryo-Preserved Under Varied Conditions. Microsc Microanal. 2023 Jul 22; 29(Supplement_1):956-957. Kim JY, Yang J, Mitchell JW, English LA, Wildonger J, Dent EW, Wright ER. PMID: 37613647.
      View in: PubMed   Mentions:    Fields:    
    8. Handling difficult cryo-ET samples: A study with primary neurons from Drosophila melanogaster. bioRxiv. 2023 Jul 11. Kim JY, Yang JE, Mitchell JW, English LA, Yang SZ, Tenpas T, Dent EW, Wildonger J, Wright ER. PMID: 37502991; PMCID: PMC10369871.
      View in: PubMed   Mentions:
    9. Live Imaging of Golgi Outposts in Drosophila Dendritic Arbors. Methods Mol Biol. 2023; 2557:635-644. Mitchell JW, Wildonger J. PMID: 36512242.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals. Curr Biol. 2022 02 07; 32(3):614-630.e5. Saunders HAJ, Johnson-Schlitz DM, Jenkins BV, Volkert PJ, Yang SZ, Wildonger J. PMID: 35081332; PMCID: PMC8843987.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    11. Golgi Outposts Locally Regulate Microtubule Orientation in Neurons but Are Not Required for the Overall Polarity of the Dendritic Cytoskeleton. Genetics. 2020 06; 215(2):435-447. Yang SZ, Wildonger J. PMID: 32265236; PMCID: PMC7268992.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    12. Non-enzymatic Activity of the α-Tubulin Acetyltransferase αTAT Limits Synaptic Bouton Growth in Neurons. Curr Biol. 2020 02 24; 30(4):610-623.e5. Coombes CE, Saunders HAJ, Mannava AG, Johnson-Schlitz DM, Reid TA, Parmar S, McClellan M, Yan C, Rogers SL, Parrish JZ, Wagenbach M, Wordeman L, Wildonger J, Gardner MK. PMID: 31928876; PMCID: PMC7047862.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Microtubule control of functional architecture in neurons. Curr Opin Neurobiol. 2019 08; 57:39-45. Kelliher MT, Saunders HA, Wildonger J. PMID: 30738328; PMCID: PMC6629488.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    14. Microtubule Acetylation Is Required for Mechanosensation in Drosophila. Cell Rep. 2018 10 23; 25(4):1051-1065.e6. Yan C, Wang F, Peng Y, Williams CR, Jenkins B, Wildonger J, Kim HJ, Perr JB, Vaughan JC, Kern ME, Falvo MR, O'Brien ET, Superfine R, Tuthill JC, Xiang Y, Rogers SL, Parrish JZ. PMID: 30355484; PMCID: PMC6248335.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    15. Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts. J Cell Biol. 2018 07 02; 217(7):2531-2547. Kelliher MT, Yue Y, Ng A, Kamiyama D, Huang B, Verhey KJ, Wildonger J. PMID: 29728423; PMCID: PMC6028532.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    16. Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 2018 Jan; 208(1):1-18. Bier E, Harrison MM, O'Connor-Giles KM, Wildonger J. PMID: 29301946; PMCID: PMC5753851.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    17. Effects of mutating α-tubulin lysine 40 on sensory dendrite development. J Cell Sci. 2017 Dec 15; 130(24):4120-4131. Jenkins BV, Saunders HAJ, Record HL, Johnson-Schlitz DM, Wildonger J. PMID: 29122984; PMCID: PMC5769580.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    18. Microtubule-microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in Drosophila oocytes. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):E4995-5004. Lu W, Winding M, Lakonishok M, Wildonger J, Gelfand VI. PMID: 27512034; PMCID: PMC5003289.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    19. Role of kinesin-1-based microtubule sliding in Drosophila nervous system development. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):E4985-94. Winding M, Kelliher MT, Lu W, Wildonger J, Gelfand VI. PMID: 27512046; PMCID: PMC5003282.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    20. The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila. Mol Biol Cell. 2016 06 01; 27(11):1740-52. Zheng Y, Mennella V, Marks S, Wildonger J, Elnagdi E, Agard D, Megraw TL. PMID: 27053665; PMCID: PMC4884065.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    21. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. PMID: 26229113; PMCID: PMC4692367.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    22. CRISPR-Cas9 Genome Editing in Drosophila. Curr Protoc Mol Biol. 2015 Jul 01; 111:31.2.1-31.2.20. Gratz SJ, Rubinstein CD, Harrison MM, Wildonger J, O'Connor-Giles KM. PMID: 26131852; PMCID: PMC4506758.
      View in: PubMed   Mentions: 95     Fields:    Translation:Animals
    23. Dendrite arborization requires the dynein cofactor NudE. J Cell Sci. 2015 Jun 01; 128(11):2191-201. Arthur AL, Yang SZ, Abellaneda AM, Wildonger J. PMID: 25908857; PMCID: PMC4450295.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    24. Precise Genome Editing of Drosophila with CRISPR RNA-Guided Cas9. Methods Mol Biol. 2015; 1311:335-48. Gratz SJ, Harrison MM, Wildonger J, O'Connor-Giles KM. PMID: 25981484; PMCID: PMC4467458.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    25. A CRISPR view of development. Genes Dev. 2014 Sep 01; 28(17):1859-72. Harrison MM, Jenkins BV, O'Connor-Giles KM, Wildonger J. PMID: 25184674; PMCID: PMC4197953.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    26. Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes Dev. 2014 Sep 01; 28(17):1940-56. Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN. PMID: 25184680; PMCID: PMC4197945.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. CRISPR/Cas9-mediated genome engineering and the promise of designer flies on demand. Fly (Austin). 2013 Oct-Dec; 7(4):249-55. Gratz SJ, Wildonger J, Harrison MM, O'Connor-Giles KM. PMID: 24088745; PMCID: PMC3896497.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    28. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics. 2013 Aug; 194(4):1029-35. Gratz SJ, Cummings AM, Nguyen JN, Hamm DC, Donohue LK, Harrison MM, Wildonger J, O'Connor-Giles KM. PMID: 23709638; PMCID: PMC3730909.
      View in: PubMed   Mentions: 528     Fields:    Translation:AnimalsCells
    29. The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch. PLoS One. 2012; 7(10):e46724. Zhu S, Wildonger J, Barshow S, Younger S, Huang Y, Lee T. PMID: 23056424; PMCID: PMC3466283.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    30. Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20615-20. Zhu S, Barshow S, Wildonger J, Jan LY, Jan YN. PMID: 22143802; PMCID: PMC3251047.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    31. The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Genes Dev. 2008 Sep 15; 22(18):2447-53. Wildonger J, Jan LY, Jan YN. PMID: 18794342; PMCID: PMC2749676.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    32. Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol. 2008 Oct; 10(10):1172-80. Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN. PMID: 18758451; PMCID: PMC2588425.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    33. Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol. 2005 Oct 15; 286(2):507-20. Wildonger J, Mann RS. PMID: 16168983.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion". Science. 2005 Jul 22; 309(5734):558; author reply 558. Ice RJ, Wildonger J, Mann RS, Hiebert SW. PMID: 16040690.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Lozenge directly activates argos and klumpfuss to regulate programmed cell death. Genes Dev. 2005 May 01; 19(9):1034-9. Wildonger J, Sosinsky A, Honig B, Mann RS. PMID: 15879554; PMCID: PMC1091738.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    36. The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor. Development. 2005 May; 132(10):2263-72. Wildonger J, Mann RS. PMID: 15829516.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
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