William Mcginnis

Title(s)Emeritus Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Regulation of epidermal barrier wound repair
    NIH R01GM077197Jan 1, 2007 - Dec 31, 2010
    Role: Principal Investigator
    FUNCTIONAL SPECIFICITY OF THE DEFORMED PROTEIN
    NIH R01HD030368Apr 1, 1993 - Mar 31, 1998
    Role: Principal Investigator
    Specificity in Homeotic Response Elements
    NIH R37HD028315Aug 9, 1991 - Jun 30, 2016
    Role: Principal Investigator
    Specificity in Homeotic Response Elements
    NIH R01HD028315Aug 1, 1991 - Jul 31, 2006
    Role: Principal Investigator
    BIOCHEMICAL ANALYSIS OF NUCLEAR STRUCTURE
    NIH R37GM033523Apr 1, 1984 - Jun 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A blueprint most wonderful, the homeobox discovery. Development. 2024 Mar 15; 151(6). McGinnis W, Levine M. PMID: 38493800.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. The expression of Drosophila melanogaster Hox gene Ultrabithorax is not overtly regulated by the intronic long noncoding RNA lncRNA:PS4 in a wild-type genetic background. G3 (Bethesda). 2022 01 04; 12(1). Hermann A, Kosman D, McGinnis W, Tour E. PMID: 34791185; PMCID: PMC8727962.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    3. High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoes. G3 (Bethesda). 2022 01 04; 12(1). Terradas G, Hermann A, James AA, McGinnis W, Bier E. PMID: 34791161; PMCID: PMC8728002.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    4. Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by full locus replacement. Sci Adv. 2021 Nov 12; 7(46):eabk1003. Auradkar A, Bulger EA, Devkota S, McGinnis W, Bier E. PMID: 34757777; PMCID: PMC8580299.
      View in: PubMed   Mentions: 1     Fields:    
    5. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 08 08; 35(8):716-718. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. PMID: 28787415; PMCID: PMC5831321.
      View in: PubMed   Mentions: 39     Fields:    
    6. Toll pathway is required for wound-induced expression of barrier repair genes in the Drosophila epidermis. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2682-E2688. Capilla A, Karachentsev D, Patterson RA, Hermann A, Juarez MT, McGinnis W. PMID: 28289197; PMCID: PMC5380074.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    7. Microinjection wound assay and in vivo localization of epidermal wound response reporters in Drosophila embryos. J Vis Exp. 2013 Nov 01; (81):e50750. Juarez MT, Patterson RA, Li W, McGinnis W. PMID: 24300796; PMCID: PMC3969900.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    8. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. PLoS One. 2013; 8(4):e61773. Patterson RA, Juarez MT, Hermann A, Sasik R, Hardiman G, McGinnis W. PMID: 23637905; PMCID: PMC3634835.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    9. The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. PLoS One. 2012; 7(5):e36254. Paré A, Kim M, Juarez MT, Brody S, McGinnis W. PMID: 22590528; PMCID: PMC3348937.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    10. Three Drosophila Hox complex microRNAs do not have major effects on expression of evolutionarily conserved Hox gene targets during embryogenesis. PLoS One. 2012; 7(2):e31365. Lemons D, Paré A, McGinnis W. PMID: 22393361; PMCID: PMC3290615.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila. PLoS Genet. 2011 Dec; 7(12):e1002424. Juarez MT, Patterson RA, Sandoval-Guillen E, McGinnis W. PMID: 22242003; PMCID: PMC3248467.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    12. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. PMID: 21920356; PMCID: PMC3661008.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. Phosphorylation of Grainy head by ERK is essential for wound-dependent regeneration but not for development of an epidermal barrier. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):650-5. Kim M, McGinnis W. PMID: 21187384; PMCID: PMC3021071.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    14. Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution. Dev Biol. 2010 Aug 01; 344(1):358-62. Lemons D, Fritzenwanker JH, Gerhart J, Lowe CJ, McGinnis W. PMID: 20435033; PMCID: PMC2909331.
      View in: PubMed   Mentions: 18     Fields:    
    15. Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk. Evol Dev. 2010 Mar-Apr; 12(2):131-43. Hsia CC, Paré AC, Hannon M, Ronshaugen M, McGinnis W. PMID: 20433454; PMCID: PMC2893884.
      View in: PubMed   Mentions: 8     Fields:    
    16. Minimizing off-target signals in RNA fluorescent in situ hybridization. Nucleic Acids Res. 2010 Jun; 38(10):e115. Arvey A, Hermann A, Hsia CC, Ie E, Freund Y, McGinnis W. PMID: 20164092; PMCID: PMC2879521.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting. Curr Biol. 2009 Dec 15; 19(23):2037-42. Paré A, Lemons D, Kosman D, Beaver W, Freund Y, McGinnis W. PMID: 19931455; PMCID: PMC2805773.
      View in: PubMed   Mentions: 62     Fields:    
    18. Multiple transcription factor codes activate epidermal wound-response genes in Drosophila. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2224-9. Pearson JC, Juarez MT, Kim M, Drivenes Ø, McGinnis W. PMID: 19168633; PMCID: PMC2630199.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    19. Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Dev Genes Evol. 2008 Jun; 218(6):321-32. Taghli-Lamallem O, Hsia C, Ronshaugen M, McGinnis W. PMID: 18504607; PMCID: PMC2443945.
      View in: PubMed   Mentions: 7     Fields:    
    20. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 2008 Feb 14; 451(7180):783-8. King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, Morris A, Nichols S, Richter DJ, Salamov A, Sequencing JG, Bork P, Lim WA, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV, Rokhsar D. PMID: 18273011; PMCID: PMC2562698.
      View in: PubMed   Mentions: 481     Fields:    
    21. Genomic evolution of Hox gene clusters. Science. 2006 Sep 29; 313(5795):1918-22. Lemons D, McGinnis W. PMID: 17008523.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimals
    22. Gap peptides: A new way to control embryonic patterning? Cell. 2006 Aug 11; 126(3):448-9. Tour E, McGinnis W. PMID: 16901778.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. Modulating Hox gene functions during animal body patterning. Nat Rev Genet. 2005 Dec; 6(12):893-904. Pearson JC, Lemons D, McGinnis W. PMID: 16341070.
      View in: PubMed   Mentions: 381     Fields:    Translation:AnimalsCells
    24. Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax. Development. 2005 Dec; 132(23):5271-81. Tour E, Hittinger CT, McGinnis W. PMID: 16284118.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    25. Pattern formation and developmental mechanisms: good mileage from comparative studies in cell biology, gene regulation, development and evolution. Curr Opin Genet Dev. 2005 Aug; 15(4):355-7. McGinnis W, Tickle C. PMID: 15979302.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    26. An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head. Science. 2005 Apr 15; 308(5720):381-5. Mace KA, Pearson JC, McGinnis W. PMID: 15831751.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    27. Bill McGinnis. Curr Biol. 2005 Apr 12; 15(7):R232-3. McGinnis B. PMID: 15864850.
      View in: PubMed   Mentions:    Fields:    
    28. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 06; 305(5685):846. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. PMID: 15297669.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    29. Evolution of transcription factor function. Curr Opin Genet Dev. 2003 Apr; 13(2):199-206. Hsia CC, McGinnis W. PMID: 12672498.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    30. Structure and expression patterns of Drosophila TULP and TUSP, members of the tubby-like gene family. Mech Dev. 2002 Sep; 117(1-2):209-15. Ronshaugen M, McGinnis N, Inglis D, Chou D, Zhao J, McGinnis W. PMID: 12204260.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    31. The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper. Cell. 2002 Aug 23; 110(4):457-66. Lohmann I, McGinnis N, Bodmer M, McGinnis W. PMID: 12202035.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    32. Hox Genes: it's all a matter of context. Curr Biol. 2002 Aug 06; 12(15):R514-6. Lohmann I, McGinnis W. PMID: 12176372.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    33. DEAF-1 function is essential for the early embryonic development of Drosophila. Genesis. 2002 Jun; 33(2):67-76. Veraksa A, Kennison J, McGinnis W. PMID: 12112874.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    34. Hox protein mutation and macroevolution of the insect body plan. Nature. 2002 Feb 21; 415(6874):914-7. Ronshaugen M, McGinnis N, McGinnis W. PMID: 11859370.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    35. Complete mutation analysis panel of the 39 human HOX genes. Teratology. 2002 Feb; 65(2):50-62. Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N. PMID: 11857506.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Prader-Willi and Angelman syndromes: diagnosis with a bisulfite-treated methylation-specific PCR method. Am J Med Genet. 1997 Dec 19; 73(3):308-13. Kosaki K, McGinniss MJ, Veraksa AN, McGinnis WJ, Jones KL. PMID: 9415690.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    37. Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature. 1985 Jan 24-30; 313(6000):284-9. Fjose A, McGinnis WJ, Gehring WJ. PMID: 2481829.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
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