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    William Mcginnis

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0349
    CA La Jolla 92093
    Phone858-822-0458
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      Collapse Research 
      Collapse Research Activities and Funding
      Regulation of epidermal barrier wound repair
      NIH/NIGMS R01GM077197Jan 1, 2007 - Dec 31, 2010
      Role: Principal Investigator
      FUNCTIONAL SPECIFICITY OF THE DEFORMED PROTEIN
      NIH/NICHD R01HD030368Apr 1, 1993 - Mar 31, 1998
      Role: Principal Investigator
      Specificity in Homeotic Response Elements
      NIH/NICHD R37HD028315Aug 9, 1991 - Jun 30, 2016
      Role: Principal Investigator
      Specificity in Homeotic Response Elements
      NIH/NICHD R01HD028315Aug 1, 1991 - Jul 31, 2006
      Role: Principal Investigator
      BIOCHEMICAL ANALYSIS OF NUCLEAR STRUCTURE
      NIH/NIGMS R37GM033523Apr 1, 1984 - Jun 30, 2006
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 Aug 08; 35(8):716-718. PMID: 28787415.
        View in: PubMed
      2. Capilla A, Karachentsev D, Patterson RA, Hermann A, Juarez MT, McGinnis W. Toll pathway is required for wound-induced expression of barrier repair genes in the Drosophila epidermis. Proc Natl Acad Sci U S A. 2017 Mar 28; 114(13):E2682-E2688. PMID: 28289197.
        View in: PubMed
      3. Juarez MT, Patterson RA, Li W, McGinnis W. Microinjection wound assay and in vivo localization of epidermal wound response reporters in Drosophila embryos. J Vis Exp. 2013 Nov 01; (81):e50750. PMID: 24300796; PMCID: PMC3969900.
        View in: PubMed, PubMed Central
      4. Patterson RA, Juarez MT, Hermann A, Sasik R, Hardiman G, McGinnis W. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. PLoS One. 2013; 8(4):e61773. PMID: 23637905; PMCID: PMC3634835.
        View in: PubMed, PubMed Central
      5. Paré A, Kim M, Juarez MT, Brody S, McGinnis W. The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. PLoS One. 2012; 7(5):e36254. PMID: 22590528; PMCID: PMC3348937.
        View in: PubMed, PubMed Central
      6. Lemons D, Paré A, McGinnis W. Three Drosophila Hox complex microRNAs do not have major effects on expression of evolutionarily conserved Hox gene targets during embryogenesis. PLoS One. 2012; 7(2):e31365. PMID: 22393361; PMCID: PMC3290615.
        View in: PubMed, PubMed Central
      7. Juarez MT, Patterson RA, Sandoval-Guillen E, McGinnis W. Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila. PLoS Genet. 2011 Dec; 7(12):e1002424. PMID: 22242003; PMCID: PMC3248467.
        View in: PubMed, PubMed Central
      8. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. PMID: 21920356; PMCID: PMC3661008.
        View in: PubMed, PubMed Central
      9. Kim M, McGinnis W. Phosphorylation of Grainy head by ERK is essential for wound-dependent regeneration but not for development of an epidermal barrier. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):650-5. PMID: 21187384; PMCID: PMC3021071.
        View in: PubMed, PubMed Central
      10. Lemons D, Fritzenwanker JH, Gerhart J, Lowe CJ, McGinnis W. Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution. Dev Biol. 2010 Aug 01; 344(1):358-62. PMID: 20435033; PMCID: PMC2909331.
        View in: PubMed, PubMed Central
      11. Hsia CC, Paré AC, Hannon M, Ronshaugen M, McGinnis W. Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk. Evol Dev. 2010 Mar-Apr; 12(2):131-43. PMID: 20433454; PMCID: PMC2893884.
        View in: PubMed, PubMed Central
      12. Arvey A, Hermann A, Hsia CC, Ie E, Freund Y, McGinnis W. Minimizing off-target signals in RNA fluorescent in situ hybridization. Nucleic Acids Res. 2010 Jun; 38(10):e115. PMID: 20164092; PMCID: PMC2879521.
        View in: PubMed, PubMed Central
      13. Paré A, Lemons D, Kosman D, Beaver W, Freund Y, McGinnis W. Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting. Curr Biol. 2009 Dec 15; 19(23):2037-42. PMID: 19931455; PMCID: PMC2805773.
        View in: PubMed, PubMed Central
      14. Pearson JC, Juarez MT, Kim M, Drivenes Ø, McGinnis W. Multiple transcription factor codes activate epidermal wound-response genes in Drosophila. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2224-9. PMID: 19168633; PMCID: PMC2630199.
        View in: PubMed, PubMed Central
      15. Taghli-Lamallem O, Hsia C, Ronshaugen M, McGinnis W. Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Dev Genes Evol. 2008 Jun; 218(6):321-32. PMID: 18504607; PMCID: PMC2443945.
        View in: PubMed, PubMed Central
      16. King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, Morris A, Nichols S, Richter DJ, Salamov A, Sequencing JG, Bork P, Lim WA, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV, Rokhsar D. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 2008 Feb 14; 451(7180):783-8. PMID: 18273011; PMCID: PMC2562698.
        View in: PubMed, PubMed Central
      17. Lemons D, McGinnis W. Genomic evolution of Hox gene clusters. Science. 2006 Sep 29; 313(5795):1918-22. PMID: 17008523.
        View in: PubMed
      18. Tour E, McGinnis W. Gap peptides: A new way to control embryonic patterning? Cell. 2006 Aug 11; 126(3):448-9. PMID: 16901778.
        View in: PubMed
      19. Tour E, Hittinger CT, McGinnis W. Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax. Development. 2005 Dec; 132(23):5271-81. PMID: 16284118.
        View in: PubMed
      20. Pearson JC, Lemons D, McGinnis W. Modulating Hox gene functions during animal body patterning. Nat Rev Genet. 2005 Dec; 6(12):893-904. PMID: 16341070.
        View in: PubMed
      21. McGinnis W, Tickle C. Pattern formation and developmental mechanisms: good mileage from comparative studies in cell biology, gene regulation, development and evolution. Curr Opin Genet Dev. 2005 Aug; 15(4):355-7. PMID: 15979302.
        View in: PubMed
      22. Mace KA, Pearson JC, McGinnis W. An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head. Science. 2005 Apr 15; 308(5720):381-5. PMID: 15831751.
        View in: PubMed
      23. McGinnis B. Bill McGinnis. Curr Biol. 2005 Apr 12; 15(7):R232-3. PMID: 15864850.
        View in: PubMed
      24. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 06; 305(5685):846. PMID: 15297669.
        View in: PubMed
      25. Hsia CC, McGinnis W. Evolution of transcription factor function. Curr Opin Genet Dev. 2003 Apr; 13(2):199-206. PMID: 12672498.
        View in: PubMed
      26. Ronshaugen M, McGinnis N, Inglis D, Chou D, Zhao J, McGinnis W. Structure and expression patterns of Drosophila TULP and TUSP, members of the tubby-like gene family. Mech Dev. 2002 Sep; 117(1-2):209-15. PMID: 12204260.
        View in: PubMed
      27. Lohmann I, McGinnis N, Bodmer M, McGinnis W. The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper. Cell. 2002 Aug 23; 110(4):457-66. PMID: 12202035.
        View in: PubMed
      28. Lohmann I, McGinnis W. Hox Genes: it's all a matter of context. Curr Biol. 2002 Aug 06; 12(15):R514-6. PMID: 12176372.
        View in: PubMed
      29. Veraksa A, Kennison J, McGinnis W. DEAF-1 function is essential for the early embryonic development of Drosophila. Genesis. 2002 Jun; 33(2):67-76. PMID: 12112874.
        View in: PubMed
      30. Ronshaugen M, McGinnis N, McGinnis W. Hox protein mutation and macroevolution of the insect body plan. Nature. 2002 Feb 21; 415(6874):914-7. PMID: 11859370.
        View in: PubMed
      31. Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N. Complete mutation analysis panel of the 39 human HOX genes. Teratology. 2002 Feb; 65(2):50-62. PMID: 11857506.
        View in: PubMed
      32. Kosaki K, McGinniss MJ, Veraksa AN, McGinnis WJ, Jones KL. Prader-Willi and Angelman syndromes: diagnosis with a bisulfite-treated methylation-specific PCR method. Am J Med Genet. 1997 Dec 19; 73(3):308-13. PMID: 9415690.
        View in: PubMed
      33. Fjose A, McGinnis WJ, Gehring WJ. Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature. 1985 Jan 24-30; 313(6000):284-9. PMID: 2481829.
        View in: PubMed
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