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Gail Laughlin

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentFamily Medicine and Public Health
Address9500 Gilman Drive #0725
La Jolla CA 92093
Phone858-822-2416
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    Collapse Biography 
    Collapse Education and Training
    University of California, San DiegoPhDPublic Health, Epidemiology
    University of MissouriBSChemistry
    AHA Ten Day SeminarFellowEpidemiology and Prevention of Cardiovascular Disease

    Collapse Overview 
    Collapse Overview
    Gail A Laughlin, PhD is an Associate Professor in the Department of Family Medicine and Public Health, Division of Epidemiology. She is Co-Director of the Epidemiology track of the UCSD/SDSU Joint Doctoral Program in Public Health. Dr. Laughlin’s research interest is focused on the role of endogenous hormones in the development of diseases of aging, including cardiovascular disease, cancer, cognitive decline, diabetes and osteoporosis. She has an extensive background in endocrinology with investigations encompassing hypothalamic, pituitary, adrenal and gonadal hormones, as well as a number of metabolic hormones (the GH-IGF axis, adiponectin, leptin, insulin, glucose) and inflammatory markers. Dr. Laughlin is a primary investigator of the Rancho Bernardo Study (RBS), and Director of the RBS Data Coordinating Center. She is a participant in the Endogenous Hormones and Breast Cancer Collaborative Group at Oxford, an investigator in the DAWN (DHEA and Wellness) trial, and co-author of publications based on endocrine data from the MrOS study (The Osteoporotic Fractures in Men Study).

    Dr. Laughlin is particularly interested in the role of endogenous sex hormones in determining sex differences in diseases of aging, and in defining the biological factors linking diseases of the heart with those of the bone, brain, and breast.


    Collapse Research 
    Collapse Research Activities and Funding
    Archiving the Rancho Bernardo Study of Healthy Aging
    NIH/NIA RF1AG054067Sep 1, 2016 - Jun 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mills PJ, McEvoy LK, Laughlin G. Glyphosate Levels in Older Adults-Reply. JAMA. 2018 04 03; 319(13):1385. PMID: 29614176.
      View in: PubMed
    2. Eriksson AL, Perry JRB, Coviello AD, Delgado GE, Ferrucci L, Hoffman AR, Huhtaniemi IT, Ikram MA, Karlsson MK, Kleber ME, Laughlin G, Liu Y, Lorentzon M, Lunetta KL, Mellström D, Murabito JM, Murray A, Nethander M, Nielson CM, Prokopenko I, Pye SR, Raffel LJ, Rivadeneira F, Srikanth P, Stolk L, Teumer A, Travison TG, Uitterlinden AG, Vaidya D, Vanderschueren D, Zmuda JM, März W, Orwoll ES, Ouyang P, Vandenput L, Wu FCW, de Jong FH, Bhasin S, Kiel DP, Ohlsson C. Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men. J Clin Endocrinol Metab. 2018 Mar 01; 103(3):991-1004. PMID: 29325096.
      View in: PubMed
    3. Mills PJ, Kania-Korwel I, Fagan J, McEvoy LK, Laughlin G, Barrett-Connor E. Excretion of the Herbicide Glyphosate in Older Adults Between 1993 and 2016. JAMA. 2017 10 24; 318(16):1610-1611. PMID: 29067413.
      View in: PubMed
    4. Larsen BA, Laughlin G, Cummins K, Barrett-Connor E, Wassel CL. Adipokines and severity and progression of coronary artery calcium: Findings from the Rancho Bernardo Study. Atherosclerosis. 2017 Oct; 265:1-6. PMID: 28825974.
      View in: PubMed
    5. Reas ET, Laughlin G, Bergstrom J, Kritz-Silverstein D, Barrett-Connor E, McEvoy LK. Effects of Sex and Education on Cognitive Change Over a 27-Year Period in Older Adults: The Rancho Bernardo Study. Am J Geriatr Psychiatry. 2017 Aug; 25(8):889-899. PMID: 28433548.
      View in: PubMed
    6. Nelson SH, Brasky TM, Patterson RE, Laughlin G, Kritz-Silverstein D, Edwards BJ, Lane D, Rohan TE, Ho GYF, Manson JE, LaCroix AZ. The Association of the C-Reactive Protein Inflammatory Biomarker with Breast Cancer Incidence and Mortality in the Women's Health Initiative. Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):1100-1106. PMID: 28292922.
      View in: PubMed
    7. Vandenput L, Mellström D, Laughlin G, Cawthon PM, Cauley JA, Hoffman AR, Karlsson MK, Rosengren BE, Ljunggren Ö, Nethander M, Eriksson AL, Lorentzon M, Leung J, Kwok T, Orwoll ES, Ohlsson C. Low Testosterone, but Not Estradiol, Is Associated With Incident Falls in Older Men: The International MrOS Study. J Bone Miner Res. 2017 Jun; 32(6):1174-1181. PMID: 28135013.
      View in: PubMed
    8. Richard EL, Kritz-Silverstein D, Laughlin G, Fung TT, Barrett-Connor E, McEvoy LK. Alcohol Intake and Cognitively Healthy Longevity in Community-Dwelling Adults: The Rancho Bernardo Study. J Alzheimers Dis. 2017; 59(3):803-814. PMID: 28671111.
      View in: PubMed
    9. Laughlin G, Kritz-Silverstein D, Bergstrom J, Reas ET, Jassal SK, Barrett-Connor E, McEvoy LK. Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study. J Alzheimers Dis. 2017; 58(3):871-883. PMID: 28505973.
      View in: PubMed
    10. Orwoll ES, Lapidus J, Wang PY, Vandenput L, Hoffman A, Fink HA, Laughlin G, Nethander M, Ljunggren Ö, Kindmark A, Lorentzon M, Karlsson MK, Mellström D, Kwok A, Khosla S, Kwok T, Ohlsson C. The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men. J Bone Miner Res. 2017 Mar; 32(3):633-640. PMID: 27753150.
      View in: PubMed
    11. Woods GN, Huang MH, Cawthon PM, Laughlin G, Schousboe JT, McDaniels-Davidson C, Cauley JA, Orwoll E, Barrett-Connor E, Kado DM. SHBG, Sex Steroids, and Kyphosis in Older Men: The MrOS Study. J Bone Miner Res. 2016 Dec; 31(12):2123-2128. PMID: 27355438.
      View in: PubMed
    12. Hill LL, Laughlin G, Bettencourt R, Barrett-Connor E. Associations Between Health and Driving in an Older Adult Cohort in Rancho Bernardo. J Aging Health. 2016 Aug 01; 898264316661828. PMID: 27492614.
      View in: PubMed
    13. McDaniels-Davidson CR, Kritz-Silverstein D, Huang MH, Laughlin G, Johnson S, Haapalahti J, Schneider DL, Barrett-Connor E, Kado DM. The association between bone turnover markers and kyphosis in community-dwelling older adults. Bone Rep. 2016 Dec; 5:57-61. PMID: 27868084.
      View in: PubMed
    14. Cawthon PM, Schousboe JT, Harrison SL, Ensrud KE, Black D, Cauley JA, Cummings SR, LeBlanc ES, Laughlin G, Nielson CM, Broughton A, Kado DM, Hoffman AR, Jamal SA, Barrett-Connor E, Orwoll ES. Sex hormones, sex hormone binding globulin, and vertebral fractures in older men. Bone. 2016 Mar; 84:271-278. PMID: 26778261.
      View in: PubMed
    15. Bellettiere J, Kritz-Silverstein D, Laughlin G, LaCroix AZ, McEvoy LK, Barrett-Connor E. Relation of Depressive Symptoms With Coronary Artery Calcium Determined by Electron-Beam Computed Tomography (from the Rancho Bernardo Study). Am J Cardiol. 2016 Feb 01; 117(3):325-32. PMID: 26747734; PMCID: PMC4718863 [Available on 02/01/17].
    16. Wassel CL, Laughlin G, Saad SD, Araneta MR, Wooten W, Barrett-Connor E, Allison MA. Associations of Abdominal Muscle Area with 4-Year Change in Coronary Artery Calcium Differ by Ethnicity Among Post-Menopausal Women. Ethn Dis. 2015 Nov 05; 25(4):435-42. PMID: 26673520; PMCID: PMC4671440.
    17. Kalyani RR, Kim C, Ferrucci L, Laughlin G, Kritz-Silverstein D, Kong S, Nan B, Barrett-Connor E. Sex differences in the association of fasting and postchallenge glucose levels with grip strength among older adults: the Rancho Bernardo Study. BMJ Open Diabetes Res Care. 2015; 3(1):e000086. PMID: 25969742; PMCID: PMC4419462.
    18. Patterson RE, Laughlin G, LaCroix AZ, Hartman SJ, Natarajan L, Senger CM, Martínez ME, Villaseñor A, Sears DD, Marinac CR, Gallo LC. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. 2015 Aug; 115(8):1203-12. PMID: 25857868; PMCID: PMC4516560.
    19. Larsen BA, Laughlin G, Saad SD, Barrett-Connor E, Allison MA, Wassel CL. Pericardial fat is associated with all-cause mortality but not incident CVD: the Rancho Bernardo Study. Atherosclerosis. 2015 Apr; 239(2):470-5. PMID: 25702617.
      View in: PubMed
    20. Larsen BA, Allison MA, Laughlin G, Araneta MR, Barrett-Connor E, Wooten WJ, Saad SD, Wassel CL. The association between abdominal muscle and type II diabetes across weight categories in diverse post-menopausal women. J Clin Endocrinol Metab. 2015 Jan; 100(1):E105-9. PMID: 25250636; PMCID: PMC4283010.
    21. Armenta RF, Kritz-Silverstein D, Wingard D, Laughlin G, Wooten W, Barrett-Connor E, Araneta MR. Association of breastfeeding with postmenopausal visceral adiposity among three racial/ethnic groups. Obesity (Silver Spring). 2015 Feb; 23(2):475-80. PMID: 25522135; PMCID: PMC4310786.
    22. Shadyab AH, Kritz-Silverstein D, Laughlin G, Wooten WJ, Barrett-Connor E, Araneta MR. Ethnic-specific associations of sleep duration and daytime napping with prevalent type 2 diabetes in postmenopausal women. Sleep Med. 2015 Feb; 16(2):243-9. PMID: 25637103.
      View in: PubMed
    23. Jassal SK, Wassel CL, Laughlin G, Barrett-Connor E, Rifkin DE, Ix JH. Urine creatinine-based estimates of fat-free mass in community-dwelling older persons: the Rancho Bernardo study. J Ren Nutr. 2015 Mar; 25(2):97-102. PMID: 25218878.
      View in: PubMed
    24. Larsen BA, Allison MA, Kang E, Saad S, Laughlin G, Araneta MR, Barrett-Connor E, Wassel CL. Associations of physical activity and sedentary behavior with regional fat deposition. Med Sci Sports Exerc. 2014 Mar; 46(3):520-8. PMID: 23924920; PMCID: PMC3916942.
    25. Daniels LB, Clopton P, Laughlin G, Maisel AS, Barrett-Connor E. Galectin-3 is independently associated with cardiovascular mortality in community-dwelling older adults without known cardiovascular disease: The Rancho Bernardo Study. Am Heart J. 2014 May; 167(5):674-82.e1. PMID: 24766977; PMCID: PMC4012893.
    26. Calvo RY, Araneta MR, Kritz-Silverstein D, Laughlin G, Barrett-Connor E. Relation of serum uric acid to severity and progression of coronary artery calcium in postmenopausal White and Filipino women (from the Rancho Bernardo study). Am J Cardiol. 2014 Apr 01; 113(7):1153-8. PMID: 24513465.
      View in: PubMed
    27. Laughlin G, McEvoy LK, Barrett-Connor E, Daniels LB, Ix JH. Fetuin-A, a new vascular biomarker of cognitive decline in older adults. Clin Endocrinol (Oxf). 2014 Jul; 81(1):134-40. PMID: 24325554; PMCID: PMC4053483.
    28. Bansal N, Katz R, de Boer IH, Kestenbaum B, Siscovick DS, Hoofnagle AN, Tracy R, Laughlin G, Criqui MH, Budoff MJ, Li D, Ix JH. Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA study. J Clin Endocrinol Metab. 2013 Dec; 98(12):4890-8. PMID: 24092825; PMCID: PMC3849680.
    29. McEvoy LK, Kritz-Silverstein D, Barrett-Connor E, Bergstrom J, Laughlin G. Changes in alcohol intake and their relationship with health status over a 24-year follow-up period in community-dwelling older adults. J Am Geriatr Soc. 2013 Aug; 61(8):1303-8. PMID: 23865905; PMCID: PMC3819601.
    30. Jovanovich A, Bùzková P, Chonchol M, Robbins J, Fink HA, de Boer IH, Kestenbaum B, Katz R, Carbone L, Lee J, Laughlin G, Mukamal KJ, Fried LF, Shlipak MG, Ix JH. Fibroblast growth factor 23, bone mineral density, and risk of hip fracture among older adults: the cardiovascular health study. J Clin Endocrinol Metab. 2013 Aug; 98(8):3323-31. PMID: 23771921; PMCID: PMC3733860.
    31. Wassel CL, Laughlin G, Araneta MR, Kang E, Morgan CM, Barrett-Connor E, Allison MA. Associations of pericardial and intrathoracic fat with coronary calcium presence and progression in a multiethnic study. Obesity (Silver Spring). 2013 Aug; 21(8):1704-12. PMID: 23666866; PMCID: PMC3748173.
    32. Kim C, Kong S, Laughlin G, Golden SH, Mather KJ, Nan B, Randolph JF, Edelstein SL, Labrie F, Buschur E, Barrett-Connor E. Reductions in glucose among postmenopausal women who use and do not use estrogen therapy. Menopause. 2013 Apr; 20(4):393-400. PMID: 23168523; PMCID: PMC3582709.
    33. Laughlin G, Barrett-Connor E, Cummins KM, Daniels LB, Wassel CL, Ix JH. Sex-specific association of fetuin-A with type 2 diabetes in older community-dwelling adults: the Rancho Bernardo study. Diabetes Care. 2013 Jul; 36(7):1994-2000. PMID: 23315604; PMCID: PMC3687317.
    34. Dominguez JR, Kestenbaum B, Chonchol M, Block G, Laughlin G, Lewis CE, Katz R, Barrett-Connor E, Cummings S, Orwoll ES, Ix JH. Relationships between serum and urine phosphorus with all-cause and cardiovascular mortality: the Osteoporotic Fractures in Men (MrOS) Study. Am J Kidney Dis. 2013 Apr; 61(4):555-63. PMID: 23261120; PMCID: PMC3815620.
    35. Barrett-Connor E, Laughlin G, Li H, Nielson CM, Wang PY, Dam TT, Cauley JA, Ensrud KE, Stefanick ML, Lau E, Hoffman AR, Orwoll ES. The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: the osteoporotic fractures in men (MrOS) study. J Bone Miner Res. 2012 Nov; 27(11):2306-13. PMID: 22777902; PMCID: PMC3474871.
    36. Laughlin G, Ix JH, Cummins K, Allison MA, Daniels LB. Extremes of an aromatase index predict increased 25-year risk of cardiovascular mortality in older women. Clin Endocrinol (Oxf). 2012 Sep; 77(3):391-8. PMID: 22066939; PMCID: PMC3298636.
    37. Kim C, Golden SH, Mather KJ, Laughlin G, Kong S, Nan B, Barrett-Connor E, Randolph JF. Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program. J Clin Endocrinol Metab. 2012 Nov; 97(11):4051-60. PMID: 22879633; PMCID: PMC3485611.
    38. Jassal SK, Chonchol M, Laughlin G, Cummins KM, Smits G, Kramer CK, Ix JH, Barrett-Connor E. Kidney function and progression of coronary artery calcium in community-dwelling older adults (from the Rancho Bernardo Study). Am J Cardiol. 2012 Nov 15; 110(10):1425-33. PMID: 22883164; PMCID: PMC3483450.
    39. Kim C, Kong S, Laughlin G, Golden SH, Mather KJ, Nan B, Edelstein SL, Randolph JF, Labrie F, Buschur E, Barrett-Connor E. Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program. J Clin Endocrinol Metab. 2012 Aug; 97(8):2853-61. PMID: 22689695; PMCID: PMC3410266.
    40. Laughlin G, Cummins KM, Wassel CL, Daniels LB, Ix JH. The association of fetuin-A with cardiovascular disease mortality in older community-dwelling adults: the Rancho Bernardo study. J Am Coll Cardiol. 2012 May 08; 59(19):1688-96. PMID: 22554599; PMCID: PMC3345127.
    41. Daniels LB, Barrett-Connor E, Clopton P, Laughlin G, Ix JH, Maisel AS. Plasma neutrophil gelatinase-associated lipocalin is independently associated with cardiovascular disease and mortality in community-dwelling older adults: The Rancho Bernardo Study. J Am Coll Cardiol. 2012 Mar 20; 59(12):1101-9. PMID: 22421304; PMCID: PMC3312791.
    42. McEvoy LK, Laughlin G, Barrett-Connor E, Bergstrom J, Kritz-Silverstein D, Der-Martirosian C, von Mühlen D. Metabolic syndrome and 16-year cognitive decline in community-dwelling older adults. Ann Epidemiol. 2012 May; 22(5):310-7. PMID: 22285865; PMCID: PMC3338905.
    43. Ix JH, Barrett-Connor E, Wassel CL, Cummins K, Bergstrom J, Daniels LB, Laughlin G. The associations of fetuin-A with subclinical cardiovascular disease in community-dwelling persons: the Rancho Bernardo Study. J Am Coll Cardiol. 2011 Nov 29; 58(23):2372-9. PMID: 22115642; PMCID: PMC3224791.
    44. LeBlanc ES, Wang PY, Lee CG, Barrett-Connor E, Cauley JA, Hoffman AR, Laughlin G, Marshall LM, Orwoll ES. Higher testosterone levels are associated with less loss of lean body mass in older men. J Clin Endocrinol Metab. 2011 Dec; 96(12):3855-63. PMID: 21976718; PMCID: PMC3232620.
    45. Laughlin G, McEvoy LK, von Mühlen D, Daniels LB, Kritz-Silverstein D, Bergstrom J, Cummins K, Der-Martirosian C, Jassal SK, Barrett-Connor E. Sex differences in the association of Framingham Cardiac Risk Score with cognitive decline in community-dwelling elders without clinical heart disease. Psychosom Med. 2011 Oct; 73(8):683-9. PMID: 21949428; PMCID: PMC3188670.
    46. Ix JH, Chonchol M, Laughlin G, Shlipak MG, Whooley MA. Relation of sex and estrogen therapy to serum fibroblast growth factor 23, serum phosphorus, and urine phosphorus: the Heart and Soul Study. Am J Kidney Dis. 2011 Nov; 58(5):737-45. PMID: 21855188; PMCID: PMC3199317.
    47. Daniels LB, Laughlin G, Kritz-Silverstein D, Clopton P, Chen WC, Maisel AS, Barrett-Connor E. Elevated natriuretic peptide levels and cognitive function in community-dwelling older adults. Am J Med. 2011 Jul; 124(7):670.e1-8. PMID: 21683832; PMCID: PMC3173742.
    48. Daniels LB, Clopton P, Laughlin G, Maisel AS, Barrett-Connor E. Growth-differentiation factor-15 is a robust, independent predictor of 11-year mortality risk in community-dwelling older adults: the Rancho Bernardo Study. Circulation. 2011 May 17; 123(19):2101-10. PMID: 21536998; PMCID: PMC3107013.
    49. Lasley BL, Crawford SL, Laughlin G, Santoro N, McConnell DS, Crandall C, Greendale GA, Polotsky AJ, Vuga M. Circulating dehydroepiandrosterone sulfate levels in women who underwent bilateral salpingo-oophorectomy during the menopausal transition. Menopause. 2011 May; 18(5):494-8. PMID: 21178790; PMCID: PMC3123411.
    50. Emond JA, Patterson RE, Natarajan L, Laughlin G, Gold EB, Pierce JP. Sex hormone concentrations and the risk of breast cancer recurrence in postmenopausal women without hot flashes. Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):939-45. PMID: 21415358; PMCID: PMC3089679.
    51. Al-Delaimy WK, Flatt SW, Natarajan L, Laughlin G, Rock CL, Gold EB, Caan BJ, Parker BA, Pierce JP. IGF1 and risk of additional breast cancer in the WHEL study. Endocr Relat Cancer. 2011 Apr; 18(2):235-44. PMID: 21263044.
      View in: PubMed
    52. Laughlin G, Allison MA, Jensky NE, Aboyans V, Wong ND, Detrano R, Criqui MH. Abdominal aortic diameter and vascular atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. Eur J Vasc Endovasc Surg. 2011 Apr; 41(4):481-7. PMID: 21236707.
      View in: PubMed
    53. Erickson K, Patterson RE, Flatt SW, Natarajan L, Parker BA, Heath DD, Laughlin G, Saquib N, Rock CL, Pierce JP. Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol. 2011 Jan 01; 29(1):54-60. PMID: 21115861; PMCID: PMC3055860.
    54. Wassel CL, Barrett-Connor E, Laughlin G. Association of circulating C-reactive protein and interleukin-6 with longevity into the 80s and 90s: The Rancho Bernardo Study. J Clin Endocrinol Metab. 2010 Oct; 95(10):4748-55. PMID: 20660034; PMCID: PMC3050106.
    55. Cawthon PM, Parimi N, Barrett-Connor E, Laughlin G, Ensrud KE, Hoffman AR, Shikany JM, Cauley JA, Lane NE, Bauer DC, Orwoll ES, Cummings SR. Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men. J Clin Endocrinol Metab. 2010 Oct; 95(10):4625-34. PMID: 20631024; PMCID: PMC3050100.
    56. Meng J, Ohlsson C, Laughlin G, Chonchol M, Wassel CL, Ljunggren O, Karlsson MK, Mellstrom D, Orwoll ES, Barrett-Connor E, Ix JH. Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study. Kidney Int. 2010 Aug; 78(4):415-22. PMID: 20531458; PMCID: PMC3787687.
    57. Muth ND, Laughlin G, von Mühlen D, Smith SC, Barrett-Connor E. High-density lipoprotein subclasses are a potential intermediary between alcohol intake and reduced risk of cardiovascular disease: the Rancho Bernardo Study. Br J Nutr. 2010 Oct; 104(7):1034-42. PMID: 20426890.
      View in: PubMed
    58. Major JM, Laughlin G, Kritz-Silverstein D, Wingard DL, Barrett-Connor E. Insulin-like growth factor-I and cancer mortality in older men. J Clin Endocrinol Metab. 2010 Mar; 95(3):1054-9. PMID: 20080855; PMCID: PMC2841529.
    59. Patterson RE, Flatt SW, Saquib N, Rock CL, Caan BJ, Parker BA, Laughlin G, Erickson K, Thomson CA, Bardwell WA, Hajek RA, Pierce JP. Medical comorbidities predict mortality in women with a history of early stage breast cancer. Breast Cancer Res Treat. 2010 Aug; 122(3):859-65. PMID: 20077000; PMCID: PMC2895945.
    60. Laughlin G, Goodell V, Barrett-Connor E. Extremes of endogenous testosterone are associated with increased risk of incident coronary events in older women. J Clin Endocrinol Metab. 2010 Feb; 95(2):740-7. PMID: 19934360; PMCID: PMC2840853.
    61. Cawthon PM, Ensrud KE, Laughlin G, Cauley JA, Dam TT, Barrett-Connor E, Fink HA, Hoffman AR, Lau E, Lane NE, Stefanick ML, Cummings SR, Orwoll ES. Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study. J Clin Endocrinol Metab. 2009 Oct; 94(10):3806-15. PMID: 19737923; PMCID: PMC2758722.
    62. LeBlanc ES, Nielson CM, Marshall LM, Lapidus JA, Barrett-Connor E, Ensrud KE, Hoffman AR, Laughlin G, Ohlsson C, Orwoll ES. The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab. 2009 Sep; 94(9):3337-46. PMID: 19584177; PMCID: PMC2741717.
    63. Crawford S, Santoro N, Laughlin G, Sowers MF, McConnell D, Sutton-Tyrrell K, Weiss G, Vuga M, Randolph J, Lasley B. Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab. 2009 Aug; 94(8):2945-51. PMID: 19470626; PMCID: PMC2730879.
    64. Barrett-Connor E, Laughlin G. Endogenous and exogenous estrogen, cognitive function, and dementia in postmenopausal women: evidence from epidemiologic studies and clinical trials. Semin Reprod Med. 2009 May; 27(3):275-82. PMID: 19401958; PMCID: PMC2701737.
    65. Laughlin G, Kritz-Silverstein D, Barrett-Connor E. Endogenous oestrogens predict 4-year decline in verbal fluency in postmenopausal women: the Rancho Bernardo Study. Clin Endocrinol (Oxf). 2010 Jan; 72(1):99-106. PMID: 19508596; PMCID: PMC2805055.
    66. Svartberg J, Braekkan SK, Laughlin G, Hansen JB. Endogenous sex hormone levels in men are not associated with risk of venous thromboembolism: the Tromso study. Eur J Endocrinol. 2009 May; 160(5):833-8. PMID: 19208774.
      View in: PubMed
    67. Gold EB, Pierce JP, Natarajan L, Stefanick ML, Laughlin G, Caan BJ, Flatt SW, Emond JA, Saquib N, Madlensky L, Kealey S, Wasserman L, Thomson CA, Rock CL, Parker BA, Karanja N, Jones V, Hajek RA, Pu M, Mortimer JE. Dietary pattern influences breast cancer prognosis in women without hot flashes: the women's healthy eating and living trial. J Clin Oncol. 2009 Jan 20; 27(3):352-9. PMID: 19075284; PMCID: PMC2645853.
    68. Kramer CK, von Mühlen D, Gross JL, Laughlin G, Barrett-Connor E. Blood pressure and fasting plasma glucose rather than metabolic syndrome predict coronary artery calcium progression: the Rancho Bernardo Study. Diabetes Care. 2009 Jan; 32(1):141-6. PMID: 18852333; PMCID: PMC2606850.
    69. Daniels LB, Laughlin G, Clopton P, Maisel AS, Barrett-Connor E. Minimally elevated cardiac troponin T and elevated N-terminal pro-B-type natriuretic peptide predict mortality in older adults: results from the Rancho Bernardo Study. J Am Coll Cardiol. 2008 Aug 05; 52(6):450-9. PMID: 18672166; PMCID: PMC2613773.
    70. Crandall CJ, Guan M, Laughlin G, Ursin GA, Stanczyk FZ, Ingles SA, Barrett-Connor E, Greendale GA. Increases in serum estrone sulfate level are associated with increased mammographic density during menopausal hormone therapy. Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7):1674-81. PMID: 18628419; PMCID: PMC2745228.
    71. Kritz-Silverstein D, von Mühlen D, Laughlin G, Bettencourt R. Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial. J Am Geriatr Soc. 2008 Jul; 56(7):1292-8. PMID: 18482290; PMCID: PMC2574781.
    72. Rock CL, Flatt SW, Laughlin G, Gold EB, Thomson CA, Natarajan L, Jones LA, Caan BJ, Stefanick ML, Hajek RA, Al-Delaimy WK, Stanczyk FZ, Pierce JP. Reproductive steroid hormones and recurrence-free survival in women with a history of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008 Mar; 17(3):614-20. PMID: 18323413; PMCID: PMC2575111.
    73. Bakhireva LN, Laughlin G, Bettencourt R, Barrett-Connor E. Does osteoprotegerin or receptor activator of nuclear factor-kappaB ligand mediate the association between bone and coronary artery calcification? J Clin Endocrinol Metab. 2008 May; 93(5):2009-12. PMID: 18319315; PMCID: PMC2386279.
    74. Daniels LB, Laughlin G, Sarno MJ, Bettencourt R, Wolfert RL, Barrett-Connor E. Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo Study. J Am Coll Cardiol. 2008 Mar 04; 51(9):913-9. PMID: 18308160; PMCID: PMC3096479.
    75. Kim DJ, Bergstrom J, Barrett-Connor E, Laughlin G. Visceral adiposity and subclinical coronary artery disease in elderly adults: Rancho Bernardo Study. Obesity (Silver Spring). 2008 Apr; 16(4):853-8. PMID: 18356852; PMCID: PMC2673099.
    76. Laughlin G, Barrett-Connor E, Bergstrom J. Low serum testosterone and mortality in older men. J Clin Endocrinol Metab. 2008 Jan; 93(1):68-75. PMID: 17911176; PMCID: PMC2190742.
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