Diana Hargreaves

Title(s)	Associate Adjunct Professor, Molecular Biology
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

research activities and funding

The role of BAF related complexes in regulatory T cell development and function
NIH R01AI151123Jun 1, 2020 - May 31, 2025
Role: Co-Principal Investigator

Mitochondria-to-Nucleus Signaling in Colorectal Cancer
NIH R01CA228211Dec 1, 2019 - Nov 30, 2024
Role: Co-Principal Investigator

Epigenetic regulation of embryonic stem cells by ATP-dependent BAF chromatin remodeling complexes
NIH R35GM128943Aug 1, 2018 - Jul 31, 2023
Role: Principal Investigator

Targeting Ovarian Cancer via Cooperative Oncogene Interactions
NIH R00CA184043Aug 1, 2015 - Jul 31, 2018
Role: Principal Investigator

Targeting Ovarian Cancer via Cooperative Oncogene Interactions
NIH K99CA184043Jun 1, 2014 - May 31, 2016
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming. bioRxiv. 2025 Jan 04. Chung HK, Liu C, Jambor AN, Riesenberg BP, Sun M, Casillas E, Chick B, Wang A, Wang J, Ma S, Mcdonald B, He P, Yang Q, Chen T, Varanasi SK, LaPorte M, Mann TH, Chen D, Hoffmann F, Tripple V, Ho J, Modliszewski J, Williams A, Cho UH, Liu L, Wang Y, Hargreaves DC, Thaxton JE, Kaech SM, Wang W. PMID: 36711632; PMCID: PMC9881845.

View in: PubMed Mentions:
Transcription factor dependencies identify BAF-dependent cancers. Cancer Cell. 2024 Aug 12; 42(8):1326-1328. McRae HM, Hargreaves DC. PMID: 39029465.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Humans
Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes. Immunity. 2024 08 13; 57(8):1780-1795.e6. Liao J, Ho J, Burns M, Dykhuizen EC, Hargreaves DC. PMID: 38843835; PMCID: PMC11324393.

View in: PubMed Mentions: 5 Fields:
All Allergy and Immunology
Translation:Animals Cells
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity. Cell. 2024 Jun 20; 187(13):3390-3408.e19. Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, Burns MJ, McRae HM, Stevenson BT, Coakley KE, Ho J, Gastelum KB, Bell JC, Jones AC, Eskander RN, Dykhuizen EC, Shadel GS, Kaech SM, Hargreaves DC. PMID: 38754421; PMCID: PMC11193641.

View in: PubMed Mentions: 18 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Control of Inflammatory Response by Tissue Microenvironment. bioRxiv. 2024 May 14. Wu Z, Pope SD, Ahmed NS, Leung DL, Hajjar S, Yue Q, Anand DM, Kopp EB, Okin D, Ma W, Kagan JC, Hargreaves DC, Medzhitov R, Zhou X. PMID: 38798655; PMCID: PMC11118380.

View in: PubMed Mentions:
Coordination of transcription factors and SWI-SNF complexes regulates chromatin priming in developing T cells. Nat Immunol. 2024 May; 25(5):725-727. Liao J, Hargreaves DC. PMID: 38641719.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling. Nat Genet. 2024 Jan; 56(1):19-20. Chick BY, Hargreaves DC. PMID: 38129539.

View in: PubMed Mentions: Fields:
Gen Genetics
Translation:Cells
Early Chromatin Remodeling Events in Acutely Stimulated CD8+ T Cells. Yale J Biol Med. 2023 12; 96(4):467-473. McDonald B, Chick BY, Hargreaves DC, Kaech SM. PMID: 38161581; PMCID: PMC10751865.

View in: PubMed Mentions: Fields:
Bio Biology Med Medicine (General)
Translation:Humans Cells
Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science. 2023 09 22; 381(6664):1316-1323. Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. PMID: 37733872; PMCID: PMC11034774.

View in: PubMed Mentions: 29 Fields:
Sci Science
Translation:Humans Cells
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates. Immunity. 2023 06 13; 56(6):1303-1319.e5. McDonald B, Chick BY, Ahmed NS, Burns M, Ma S, Casillas E, Chen D, Mann TH, O'Connor C, Hah N, Hargreaves DC, Kaech SM. PMID: 37315534; PMCID: PMC10281564.

View in: PubMed Mentions: 9 Fields:
All Allergy and Immunology
Translation:Cells
Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nat Commun. 2023 01 18; 14(1):292. Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T. PMID: 36653361; PMCID: PMC9849267.

View in: PubMed Mentions: 10 Fields:
Bio Biology Sci Science
Translation:Humans Animals
Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer. Nat Struct Mol Biol. 2022 11; 29(11):1040-1042. Chick BY, Hargreaves DC. PMID: 36344845.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Rep. 2022 04 26; 39(4):110730. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC. PMID: 35476977; PMCID: PMC9807246.

View in: PubMed Mentions: 33 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Old macrophages lose their (circadian) rhythm. Trends Immunol. 2022 04; 43(4):265-267. McRae HM, Hargreaves DC. PMID: 35283014; PMCID: PMC9678643.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology
Translation:Animals Cells
BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ahmed NS, Gatchalian J, Ho J, Burns MJ, Hah N, Wei Z, Downes M, Evans RM, Hargreaves DC. PMID: 34983841; PMCID: PMC8740701.

View in: PubMed Mentions: 24 Fields:
Sci Science
Translation:Humans Cells
Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma. Cancer Discov. 2021 10; 11(10):2375-2377. Maxwell MB, Hargreaves DC. PMID: 34598951.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Animals
Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). Wang L, Oh TG, Magida J, Estepa G, Obayomi SMB, Chong LW, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. PMID: 34446564; PMCID: PMC8536317.

View in: PubMed Mentions: 17 Fields:
Sci Science
Translation:Animals Cells
Chromatin openness requires continuous SWI/SNF activity. Nat Genet. 2021 03; 53(3):263-264. Hargreaves DC. PMID: 33558759; PMCID: PMC8455072.

View in: PubMed Mentions: 11 Fields:
Gen Genetics
Translation:Animals Cells
The alternative macrophage relay: STAT6 passes the baton to EGR2. Genes Dev. 2020 11 01; 34(21-22):1407-1409. Liao J, Hargreaves DC. PMID: 33872194; PMCID: PMC7608745.

View in: PubMed Mentions: 4 Fields:
Mol Molecular Biology
Translation:Animals Cells
A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Immunity. 2020 Jul 14; 53(1):143-157.e8. Loo CS, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, Venkatraghavan B, Hargreaves DC, Zheng Y. PMID: 32640256; PMCID: PMC7341821.

View in: PubMed Mentions: 54 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. 2020 06; 582(7812):416-420. Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, Prator GY, Zhang B, Lee Y, Sun Z, Ifergan I, Van Gool F, Hargreaves DC, Bluestone JA, Marson A, Fang D. PMID: 32499641; PMCID: PMC7305989.

View in: PubMed Mentions: 125 Fields:
Sci Science
Translation:Humans Animals Cells
Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes. Trends Immunol. 2020 02; 41(2):126-140. Gatchalian J, Liao J, Maxwell MB, Hargreaves DC. PMID: 31928914; PMCID: PMC6995420.

View in: PubMed Mentions: 19 Fields:
All Allergy and Immunology
Translation:Humans Cells
Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Mol Cell. 2019 09 05; 75(5):891-904.e7. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. PMID: 31375262; PMCID: PMC7291823.

View in: PubMed Mentions: 25 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Tuning the chromatin landscape of embryonic stem cells. Stem Cell Investig. 2019; 6:16. Hargreaves DC. PMID: 31463309; PMCID: PMC6691084.

View in: PubMed Mentions:
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 12 03; 9(1):5139. Gatchalian J, Malik S, Ho J, Lee DS, Kelso TWR, Shokhirev MN, Dixon JR, Hargreaves DC. PMID: 30510198; PMCID: PMC6277444.

View in: PubMed Mentions: 118 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Racheting Up Repair. Immunity. 2018 10 16; 49(4):577-579. Gatchalian J, Hargreaves DC. PMID: 30332621.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Cells
Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 12 20; 25(12):1443-1455.e14. Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. PMID: 30197195; PMCID: PMC6404985.

View in: PubMed Mentions: 36 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Animals Cells
Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Elife. 2017 10 02; 6. Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC. PMID: 28967863; PMCID: PMC5643100.

View in: PubMed Mentions: 94 Fields:
Bio Biology
Translation:Humans Cells
TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol. 2017 04; 24(4):344-352. Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR. PMID: 28250416; PMCID: PMC5395302.

View in: PubMed Mentions: 44 Fields:
Mol Molecular Biology
Translation:Animals Cells
BAF complexes facilitate decatenation of DNA by topoisomerase IIα. Nature. 2013 May 30; 497(7451):624-7. Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. PMID: 23698369; PMCID: PMC3668793.

View in: PubMed Mentions: 133 Fields:
Sci Science
Translation:Humans Animals Cells
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013 Jun; 45(6):592-601. Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR. PMID: 23644491; PMCID: PMC3667980.

View in: PubMed Mentions: 689 Fields:
Gen Genetics
Translation:Humans Animals Cells
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 2011 Mar; 21(3):396-420. Hargreaves DC, Crabtree GR. PMID: 21358755; PMCID: PMC3110148.

View in: PubMed Mentions: 418 Fields:
Cel Cell Biology
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10; 138(1):129-45. Hargreaves DC, Horng T, Medzhitov R. PMID: 19596240; PMCID: PMC2828818.

View in: PubMed Mentions: 338 Fields:
Cel Cell Biology
Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007 Jun 21; 447(7147):972-8. Foster SL, Hargreaves DC, Medzhitov R. PMID: 17538624.

View in: PubMed Mentions: 575 Fields:
Sci Science
Translation:Animals Cells
Innate sensors of microbial infection. J Clin Immunol. 2005 Nov; 25(6):503-10. Hargreaves DC, Medzhitov R. PMID: 16380814.

View in: PubMed Mentions: 30 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. PMID: 12077273.

View in: PubMed Mentions: 203 Fields:
All Allergy and Immunology
Translation:Animals Cells
Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. PMID: 12405185.

View in: PubMed Mentions: 6 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals Cells
A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med. 2001 Jul 02; 194(1):45-56. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. PMID: 11435471; PMCID: PMC2193440.

View in: PubMed Mentions: 181 Fields:
All Allergy and Immunology Med Medicine (General)
A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale. Br J Psychiatry. 1995 Jul; 167(1):99-103. Snaith RP, Hamilton M, Morley S, Humayan A, Hargreaves D, Trigwell P. PMID: 7551619.

View in: PubMed Mentions: 581 Fields:
Psy Psychiatry
Translation:Humans