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Diana Hargreaves

Title(s)Assistant Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #0932
La Jolla CA 92093
Phone000-000-NULL
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of BAF related complexes in regulatory T cell development and function
    NIH/NIAID R01AI151123Jun 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Mitochondria-to-Nucleus Signaling in Colorectal Cancer
    NIH/NCI R01CA228211Dec 1, 2019 - Nov 30, 2024
    Role: Co-Principal Investigator
    Epigenetic regulation of embryonic stem cells by ATP-dependent BAF chromatin remodeling complexes
    NIH/NIGMS R35GM128943Aug 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Targeting Ovarian Cancer via Cooperative Oncogene Interactions
    NIH/NCI R00CA184043Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Targeting Ovarian Cancer via Cooperative Oncogene Interactions
    NIH/NCI K99CA184043Jun 1, 2014 - May 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Immunity. 2020 Jul 14; 53(1):143-157.e8. Loo CS, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, Venkatraghavan B, Hargreaves DC, Zheng Y. PMID: 32640256.
      View in: PubMed   Mentions:    Fields:    
    2. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. 2020 06; 582(7812):416-420. Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, Prator GY, Zhang B, Lee Y, Sun Z, Ifergan I, Van Gool F, Hargreaves DC, Bluestone JA, Marson A, Fang D. PMID: 32499641.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes. Trends Immunol. 2020 Feb; 41(2):126-140. Gatchalian J, Liao J, Maxwell MB, Hargreaves DC. PMID: 31928914.
      View in: PubMed   Mentions: 1     Fields:    
    4. Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Mol Cell. 2019 09 05; 75(5):891-904.e7. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. PMID: 31375262.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Tuning the chromatin landscape of embryonic stem cells. Stem Cell Investig. 2019; 6:16. Hargreaves DC. PMID: 31463309.
      View in: PubMed   Mentions:
    6. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 12 03; 9(1):5139. Gatchalian J, Malik S, Ho J, Lee DS, Kelso TWR, Shokhirev MN, Dixon JR, Hargreaves DC. PMID: 30510198.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Racheting Up Repair. Immunity. 2018 10 16; 49(4):577-579. Gatchalian J, Hargreaves DC. PMID: 30332621.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 12 20; 25(12):1443-1455.e14. Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. PMID: 30197195.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Elife. 2017 10 02; 6. Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC. PMID: 28967863.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    10. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol. 2017 04; 24(4):344-352. Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR. PMID: 28250416.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    11. BAF complexes facilitate decatenation of DNA by topoisomerase IIa. Nature. 2013 May 30; 497(7451):624-7. Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. PMID: 23698369.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    12. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013 Jun; 45(6):592-601. Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR. PMID: 23644491.
      View in: PubMed   Mentions: 309     Fields:    Translation:HumansAnimalsCells
    13. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 2011 Mar; 21(3):396-420. Hargreaves DC, Crabtree GR. PMID: 21358755.
      View in: PubMed   Mentions: 291     Fields:    Translation:HumansAnimals
    14. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10; 138(1):129-45. Hargreaves DC, Horng T, Medzhitov R. PMID: 19596240.
      View in: PubMed   Mentions: 314     Fields:    Translation:HumansAnimalsCells
    15. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007 Jun 21; 447(7147):972-8. Foster SL, Hargreaves DC, Medzhitov R. PMID: 17538624.
      View in: PubMed   Mentions: 415     Fields:    Translation:AnimalsCells
    16. Innate sensors of microbial infection. J Clin Immunol. 2005 Nov; 25(6):503-10. Hargreaves DC, Medzhitov R. PMID: 16380814.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    17. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. PMID: 12077273.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    18. Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. PMID: 12405185.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med. 2001 Jul 02; 194(1):45-56. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. PMID: 11435471.
      View in: PubMed   Mentions: 172     Fields:    Translation:Animals