Diana Hargreaves

Title(s)	Assistant Adjunct Professor, Molecular Biology
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

The role of BAF related complexes in regulatory T cell development and function
NIH R01AI151123Jun 1, 2020 - May 31, 2025
Role: Co-Principal Investigator

Mitochondria-to-Nucleus Signaling in Colorectal Cancer
NIH R01CA228211Dec 1, 2019 - Nov 30, 2024
Role: Co-Principal Investigator

Epigenetic regulation of embryonic stem cells by ATP-dependent BAF chromatin remodeling complexes
NIH R35GM128943Aug 1, 2018 - Jul 31, 2023
Role: Principal Investigator

Targeting Ovarian Cancer via Cooperative Oncogene Interactions
NIH R00CA184043Aug 1, 2015 - Jul 31, 2018
Role: Principal Investigator

Targeting Ovarian Cancer via Cooperative Oncogene Interactions
NIH K99CA184043Jun 1, 2014 - May 31, 2016
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Rep. 2022 04 26; 39(4):110730. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC. PMID: 35476977.

View in: PubMed Mentions:
Old macrophages lose their (circadian) rhythm. Trends Immunol. 2022 04; 43(4):265-267. McRae HM, Hargreaves DC. PMID: 35283014.

View in: PubMed Mentions:
BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ahmed NS, Gatchalian J, Ho J, Burns MJ, Hah N, Wei Z, Downes M, Evans RM, Hargreaves DC. PMID: 34983841; PMCID: PMC8740701.

View in: PubMed Mentions:
Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma. Cancer Discov. 2021 10; 11(10):2375-2377. Maxwell MB, Hargreaves DC. PMID: 34598951.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). Wang L, Oh TG, Magida J, Estepa G, Obayomi SMB, Chong LW, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. PMID: 34446564; PMCID: PMC8536317.

View in: PubMed Mentions: Fields:
Sci Science
Chromatin openness requires continuous SWI/SNF activity. Nat Genet. 2021 03; 53(3):263-264. Hargreaves DC. PMID: 33558759; PMCID: PMC8455072.

View in: PubMed Mentions: 1 Fields:
Gen Genetics
Translation:Animals Cells
The alternative macrophage relay: STAT6 passes the baton to EGR2. Genes Dev. 2020 11 01; 34(21-22):1407-1409. Liao J, Hargreaves DC. PMID: 33872194; PMCID: PMC7608745.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Translation:Animals Cells
A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Immunity. 2020 07 14; 53(1):143-157.e8. Loo CS, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, Venkatraghavan B, Hargreaves DC, Zheng Y. PMID: 32640256; PMCID: PMC7341821.

View in: PubMed Mentions: 12 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. 2020 06; 582(7812):416-420. Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, Prator GY, Zhang B, Lee Y, Sun Z, Ifergan I, Van Gool F, Hargreaves DC, Bluestone JA, Marson A, Fang D. PMID: 32499641; PMCID: PMC7305989.

View in: PubMed Mentions: 28 Fields:
Sci Science
Translation:Humans Animals Cells
Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes. Trends Immunol. 2020 02; 41(2):126-140. Gatchalian J, Liao J, Maxwell MB, Hargreaves DC. PMID: 31928914; PMCID: PMC6995420.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology
Translation:Humans Cells
Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Mol Cell. 2019 09 05; 75(5):891-904.e7. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. PMID: 31375262; PMCID: PMC7291823.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Tuning the chromatin landscape of embryonic stem cells. Stem Cell Investig. 2019; 6:16. Hargreaves DC. PMID: 31463309; PMCID: PMC6691084.

View in: PubMed Mentions:
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 12 03; 9(1):5139. Gatchalian J, Malik S, Ho J, Lee DS, Kelso TWR, Shokhirev MN, Dixon JR, Hargreaves DC. PMID: 30510198; PMCID: PMC6277444.

View in: PubMed Mentions: 49 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Racheting Up Repair. Immunity. 2018 10 16; 49(4):577-579. Gatchalian J, Hargreaves DC. PMID: 30332621.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Cells
Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 12 20; 25(12):1443-1455.e14. Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. PMID: 30197195; PMCID: PMC6404985.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Animals Cells
Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Elife. 2017 10 02; 6. Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC. PMID: 28967863; PMCID: PMC5643100.

View in: PubMed Mentions: 41 Fields:
Bio Biology
Translation:Humans Cells
TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol. 2017 04; 24(4):344-352. Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR. PMID: 28250416; PMCID: PMC5395302.

View in: PubMed Mentions: 28 Fields:
Mol Molecular Biology
Translation:Animals Cells
BAF complexes facilitate decatenation of DNA by topoisomerase IIα. Nature. 2013 May 30; 497(7451):624-7. Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. PMID: 23698369; PMCID: PMC3668793.

View in: PubMed Mentions: 106 Fields:
Sci Science
Translation:Humans Animals Cells
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013 Jun; 45(6):592-601. Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR. PMID: 23644491; PMCID: PMC3667980.

View in: PubMed Mentions: 449 Fields:
Gen Genetics
Translation:Humans Animals Cells
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 2011 Mar; 21(3):396-420. Hargreaves DC, Crabtree GR. PMID: 21358755; PMCID: PMC3110148.

View in: PubMed Mentions: 350 Fields:
Cel Cell Biology
Translation:Humans Animals
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10; 138(1):129-45. Hargreaves DC, Horng T, Medzhitov R. PMID: 19596240; PMCID: PMC2828818.

View in: PubMed Mentions: 344 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007 Jun 21; 447(7147):972-8. Foster SL, Hargreaves DC, Medzhitov R. PMID: 17538624.

View in: PubMed Mentions: 486 Fields:
Sci Science
Translation:Animals Cells
Innate sensors of microbial infection. J Clin Immunol. 2005 Nov; 25(6):503-10. Hargreaves DC, Medzhitov R. PMID: 16380814.

View in: PubMed Mentions: 31 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. PMID: 12077273.

View in: PubMed Mentions: 167 Fields:
All Allergy and Immunology
Translation:Animals Cells
Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. PMID: 12405185.

View in: PubMed Mentions: 6 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals Cells
A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med. 2001 Jul 02; 194(1):45-56. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. PMID: 11435471; PMCID: PMC2193440.

View in: PubMed Mentions: 195 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Animals