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Diana Hargreaves

Title(s)Assistant Adjunct Professor, Molecular Biology
SchoolAcademic Aff
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    Epigenetic regulation of embryonic stem cells by ATP-dependent BAF chromatin remodeling complexes
    NIH/NIGMS R35GM128943Aug 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Targeting Ovarian Cancer via Cooperative Oncogene Interactions
    NIH/NCI R00CA184043Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Targeting Ovarian Cancer via Cooperative Oncogene Interactions
    NIH/NCI K99CA184043Jun 1, 2014 - May 31, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Mol Cell. 2019 Jul 09. PMID: 31375262.
      View in: PubMed
    2. Hargreaves DC. Tuning the chromatin landscape of embryonic stem cells. Stem Cell Investig. 2019; 6:16. PMID: 31463309.
      View in: PubMed
    3. Gatchalian J, Malik S, Ho J, Lee DS, Kelso TWR, Shokhirev MN, Dixon JR, Hargreaves DC. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 12 03; 9(1):5139. PMID: 30510198.
      View in: PubMed
    4. Gatchalian J, Hargreaves DC. Racheting Up Repair. Immunity. 2018 10 16; 49(4):577-579. PMID: 30332621.
      View in: PubMed
    5. Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20; 25(12):1443-1455.e14. PMID: 30197195.
      View in: PubMed
    6. Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Elife. 2017 10 02; 6. PMID: 28967863.
      View in: PubMed
    7. Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol. 2017 04; 24(4):344-352. PMID: 28250416.
      View in: PubMed
    8. Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. BAF complexes facilitate decatenation of DNA by topoisomerase IIa. Nature. 2013 May 30; 497(7451):624-7. PMID: 23698369; PMCID: PMC3668793.
      View in: PubMed, PubMed Central
    9. Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013 Jun; 45(6):592-601. PMID: 23644491; PMCID: PMC3667980.
      View in: PubMed, PubMed Central
    10. Hargreaves DC, Crabtree GR. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 2011 Mar; 21(3):396-420. PMID: 21358755.
      View in: PubMed
    11. Hargreaves DC, Horng T, Medzhitov R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10; 138(1):129-45. PMID: 19596240; PMCID: PMC2828818.
      View in: PubMed, PubMed Central
    12. Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007 Jun 21; 447(7147):972-8. PMID: 17538624.
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    13. Hargreaves DC, Medzhitov R. Innate sensors of microbial infection. J Clin Immunol. 2005 Nov; 25(6):503-10. PMID: 16380814.
      View in: PubMed
    14. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. PMID: 12077273.
      View in: PubMed
    15. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. PMID: 12405185.
      View in: PubMed
    16. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med. 2001 Jul 02; 194(1):45-56. PMID: 11435471.
      View in: PubMed
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