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Angels Almenar

Photo of Angels Almenar
Title(s)Assistant Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Angels Almenar is a stem cell neurobiologist interested in understanding the cellular and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders, and in leveraging this knowledge to develop novel therapeutic strategies. She is an Assistant Professor at the University of California, San Diego, where her research focuses on human stem cell–based models of brain disease.
    Her scientific interests include glial biology, neuroimmune interactions, and gene regulation in the developing and aging brain. Her work uses human induced pluripotent stem cell (hiPSC)–derived neurons, neural organoids, astrocytes, and microglia, combined with genome editing and multi-omics approaches, to dissect disease mechanisms and to test proof-of-principle therapeutic strategies. Current projects in her lab investigate how genetic risk factors impact neuronal and glial function in neurodevelopmental disorders and Alzheimer’s disease, and whether targeted genetic or molecular interventions can restore neuronal dysfunction.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics. Nat Commun. 2025 Aug 20; 16(1):7499. Molokanova E, Zhou T, Vasupal P, Cherkas VP, Narute P, Ferraz MSA, Reiss M, Almenar-Queralt A, Chaldaiopoulou G, de Souza JS, Hemati H, Downey F, Olajide OO, Thörn Perez C, Puppo F, Mesci P, Pfaff SL, Kireev D, Muotri AR, Savchenko A. PMID: 40835596; PMCID: PMC12368249.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir. PLoS Biol. 2022 11; 20(11):e3001845. Mesci P, de Souza JS, Martin-Sancho L, Macia A, Saleh A, Yin X, Snethlage C, Adams JW, Avansini SH, Herai RH, Almenar-Queralt A, Pu Y, Szeto RA, Goldberg G, Bruck PT, Papes F, Chanda SK, Muotri AR. PMID: 36327326; PMCID: PMC9632769.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    3. Heads Up! Interlinked Amyloidogenic and Axonal Transport Pathways in Concussion-Induced Neurodegeneration. Neurosci Insights. 2022; 17:26331055221129641. Almenar-Queralt A, Dos Santos Chaves R, Kwon EJ, Shah SB. PMID: 36274925; PMCID: PMC9580075.
      View in: PubMed   Mentions: 2  
    4. Analysis of Clonal Composition in Human iPSC and ESC and Derived 2D and 3D Differentiated Cultures. Methods Mol Biol. 2022; 2454:31-47. Del Olmo B, Merkurjev D, Yao L, Pinsach-Abuin ML, Garcia-Bassets I, Almenar-Queralt A. PMID: 34505265.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons. J Neurosci. 2021 12 08; 41(49):10034-10053. Chaves RS, Tran M, Holder AR, Balcer AM, Dickey AM, Roberts EA, Bober BG, Gutierrez E, Head BP, Groisman A, Goldstein LSB, Almenar-Queralt A, Shah SB. PMID: 34663629; PMCID: PMC8660048.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    6. Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells. Cell Rep. 2020 04 21; 31(3):107532. Ma Q, Yang F, Mackintosh C, Jayani RS, Oh S, Jin C, Nair SJ, Merkurjev D, Ma W, Allen S, Wang D, Almenar-Queralt A, Garcia-Bassets I. PMID: 32320655.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    7. Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells. Nat Genet. 2019 12; 51(12):1691-1701. Almenar-Queralt A, Merkurjev D, Kim HS, Navarro M, Ma Q, Chaves RS, Allegue C, Driscoll SP, Chen AG, Kohlnhofer B, Fong LK, Woodruff G, Mackintosh C, Bohaciakova D, Hruska-Plochan M, Tadokoro T, Young JE, El Hajj N, Dittrich M, Marsala M, Goldstein LSB, Garcia-Bassets I. PMID: 31740836; PMCID: PMC7061033.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    8. Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. Front Cell Neurosci. 2019; 13:324. Wang S, Zhang Z, Almenar-Queralt A, Leem J, DerMardirossian C, Roth DM, Patel PM, Patel HH, Head BP. PMID: 31379509; PMCID: PMC6650578.
      View in: PubMed   Mentions: 8  
    9. Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes. J Cell Sci. 2018 06 11; 131(11). Otero MG, Fernandez Bessone I, Hallberg AE, Cromberg LE, De Rossi MC, Saez TM, Levi V, Almenar-Queralt A, Falzone TL. PMID: 29724915.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. J Neurophysiol. 2017 01 01; 117(1):436-444. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP. PMID: 27832597; PMCID: PMC5253400.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    11. Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics. Cell Mol Neurobiol. 2017 May; 37(4):571-585. Pearn ML, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, Shah SB, Duckworth JL, Head BP. PMID: 27383839; PMCID: PMC11482200.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimals
    12. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. 2014 Feb 26; 34(9):3320-39. Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS. PMID: 24573290; PMCID: PMC3935090.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci. 2014 Apr 01; 127(Pt 7):1537-49. Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL. PMID: 24522182.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    14. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 06; 288(49):35222-36. Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. PMID: 24145027; PMCID: PMC3853272.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. 2012; 7(1):e29755. Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS. PMID: 22272245; PMCID: PMC3260181.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem. 2009 Dec 11; 284(50):34628-39. Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V. PMID: 19801628; PMCID: PMC2787325.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    17. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet. 2008 Nov 15; 17(22):3474-86. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. PMID: 18694898; PMCID: PMC2722897.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    18. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 06; 414(6864):643-8. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. PMID: 11740561.
      View in: PubMed   Mentions: 214     Fields:    Translation:AnimalsCells
    19. Linkers, packages and pathways: new concepts in axonal transport. Curr Opin Neurobiol. 2001 Oct; 11(5):550-7. Almenar-Queralt A, Goldstein LS. PMID: 11595487.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Actin dynamics at pointed ends regulates thin filament length in striated muscle. Nat Cell Biol. 2001 Jun; 3(6):544-51. Littlefield R, Almenar-Queralt A, Fowler VM. PMID: 11389438.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    21. Leiomodins: larger members of the tropomodulin (Tmod) gene family. Genomics. 2001 Apr 15; 73(2):127-39. Conley CA, Fritz-Six KL, Almenar-Queralt A, Fowler VM. PMID: 11318603.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    22. Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. J Biol Chem. 1999 Oct 01; 274(40):28466-75. Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM. PMID: 10497209.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    23. Tropomodulin assembles early in myofibrillogenesis in chick skeletal muscle: evidence that thin filaments rearrange to form striated myofibrils. J Cell Sci. 1999 Apr; 112 ( Pt 8):1111-23. Almenar-Queralt A, Gregorio CC, Fowler VM. PMID: 10085247.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    24. Apical topography and modulation of ICAM-1 expression on activated endothelium. Am J Pathol. 1995 Nov; 147(5):1278-88. Almenar-Queralt A, Duperray A, Miles LA, Felez J, Altieri DC. PMID: 7485391; PMCID: PMC1869507.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
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