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    Kirk Knowlton

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9300 Campus Point Drive #7411
    CA La Jolla 92037
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      Collapse Research 
      Collapse Research Activities and Funding
      Role of mTOR, a Component of the Akt Pathway, in Regulating Cardiac Function
      NIH/NHLBI R01HL078797Dec 1, 2004 - Nov 30, 2014
      Role: Principal Investigator
      Dystrophin-glycoprotein complex in viral cardiomyopathy
      NIH/NHLBI R01HL066424Jul 1, 2001 - Jun 30, 2006
      Role: Principal Investigator
      Cardiac SOCS Proteins: A Role in Enterovirus Infection
      NIH/NHLBI R01HL057365Dec 5, 1998 - Apr 30, 2009
      Role: Principal Investigator
      MOLECULAR PHYSIOLOGY OF HEART FAILURE
      NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
      Role: Co-Investigator
      Molecular Pathways for Hypertrophy and Cardiomyopathy
      NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
      Role: Principal Investigator
      REGULATION OF ANF GENE DURING VENTRICULAR HYPERTROPHY
      NIH/NHLBI K08HL002618Aug 1, 1991 - Jul 31, 1997
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      Training In Cardiovascular Physiology & Pharmacology
      NIH/NHLBI T32HL007444Jul 1, 1979 - Jun 30, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Peter AK, Bradford WH, Dalton ND, Gu Y, Chao CJ, Peterson KL, Knowlton K. Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis. PLoS One. 2016; 11(8):e0159971. PMID: 27486657.
        View in: PubMed
      2. Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton K, Ross RS, Zhou X, Chen J. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 Aug; 9(8). PMID: 27502369.
        View in: PubMed
      3. Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton K, Peterson KL, Lieber RL, Chen J. Lmo7 is dispensable for skeletal muscle and cardiac function. Am J Physiol Cell Physiol. 2015 Oct 1; 309(7):C470-9. PMID: 26157009.
        View in: PubMed
      4. Lee NS, Blanchard DG, Knowlton K, McDivit AM, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Poch DS, Auger WR, Daniels LB. Prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension. Pulm Circ. 2015 Jun; 5(2):313-21. PMID: 26064456.
        View in: PubMed
      5. Lim BK, Peter AK, Xiong D, Narezkina A, Yung A, Dalton ND, Hwang KK, Yajima T, Chen J, Knowlton K. Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J Clin Invest. 2013 Dec 2; 123(12):5146-51. PMID: 24200690.
        View in: PubMed
      6. Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton K, Imaizumi T. Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2012 Feb 28; 59(9):838-52. PMID: 22361405.
        View in: PubMed
      7. Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton K, Patapoutian A, Beutler B. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19413-8. PMID: 22087007.
        View in: PubMed
      8. Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton K. Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation. 2011 Dec 13; 124(24):2690-701. PMID: 22082679.
        View in: PubMed
      9. Peter AK, Cheng H, Ross RS, Knowlton K, Chen J. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. PMID: 24039381.
        View in: PubMed
      10. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton K, Sheikh F, Chen J. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 1; 20(9):1751-62. PMID: 21303826.
        View in: PubMed
      11. Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton K, Peterson KL, Chen J. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 6; 107(3):348-56. PMID: 20538684.
        View in: PubMed
      12. Yajima T, Knowlton K. Viral myocarditis: from the perspective of the virus. Circulation. 2009 May 19; 119(19):2615-24. PMID: 19451363.
        View in: PubMed
      13. Knowlton K, Lim BK. Viral myocarditis: is infection of the heart required? J Am Coll Cardiol. 2009 Apr 7; 53(14):1227-8. PMID: 19341865.
        View in: PubMed
      14. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton K. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. PMID: 18636119.
        View in: PubMed
      15. Knowlton K. CVB infection and mechanisms of viral cardiomyopathy. Curr Top Microbiol Immunol. 2008; 323:315-35. PMID: 18357777.
        View in: PubMed
      16. Wang YX, da Cunha V, Vincelette J, White K, Velichko S, Xu Y, Gross C, Fitch RM, Halks-Miller M, Larsen BR, Yajima T, Knowlton K, Vergona R, Sullivan ME, Croze E. Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H69-76. PMID: 17434974.
        View in: PubMed
      17. Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton K. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 2007 Jan 2; 115(1):94-102. PMID: 17190866.
        View in: PubMed
      18. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton K. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. PMID: 17101849.
        View in: PubMed
      19. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton K, Peterson KL, Perriard JC, Chen J. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 5; 114(10):1046-55. PMID: 16923756.
        View in: PubMed
      20. Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton K, Chesebro B, Oldstone MB. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science. 2006 Jul 7; 313(5783):94-7. PMID: 16825571.
        View in: PubMed
      21. Bang ML, Li X, Littlefield R, Bremner S, Thor A, Knowlton K, Lieber RL, Chen J. Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 2006 Jun 19; 173(6):905-16. PMID: 16769824.
        View in: PubMed
      22. Knowlton K. Unsolved medical issues and new targets for further research in viral myocarditis and dilated cardiomyopathy. Ernst Schering Res Found Workshop. 2006; (55):19-35. PMID: 16329655.
        View in: PubMed
      23. Lim BK, Shin JO, Lee SC, Kim DK, Choi DJ, Choe SC, Knowlton K, Jeon ES. Long-term cardiac gene expression using a coxsackieviral vector. J Mol Cell Cardiol. 2005 May; 38(5):745-51. PMID: 15850568.
        View in: PubMed
      24. Auger WR, Kerr KM, Kim NH, Ben-Yehuda O, Knowlton K, Fedullo PF. Chronic thromboembolic pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):453-66, vii. PMID: 15302364.
        View in: PubMed
      25. Dörner A, Xiong D, Couch K, Yajima T, Knowlton K. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004 Apr 30; 279(18):18497-503. PMID: 14978041.
        View in: PubMed
      26. Kim NH, Fesler P, Channick RN, Knowlton K, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation. 2004 Jan 6; 109(1):18-22. PMID: 14699009.
        View in: PubMed
      27. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton K, Lew WY, Tsimikas S. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. PMID: 15560019.
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      28. Badorff C, Knowlton K. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. Med Microbiol Immunol. 2004 May; 193(2-3):121-6. PMID: 12920582.
        View in: PubMed
      29. Nelson JA, Knowlton K, Harrigan R, Pollack ML, Chan TC. Electrocardiographic manifestations: wide complex tachycardia due to accessory pathway. J Emerg Med. 2003 Apr; 24(3):295-301. PMID: 12676301.
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      30. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton K. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. PMID: 12588885.
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      31. Zhao X, Lamphear BJ, Xiong D, Knowlton K, Rhoads RE. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease. J Biol Chem. 2003 Feb 14; 278(7):4449-57. PMID: 12475969.
        View in: PubMed
      32. Xiong D, Lee GH, Badorff C, Dorner A, Lee S, Wolf P, Knowlton K. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med. 2002 Aug; 8(8):872-7. PMID: 12118246.
        View in: PubMed
      33. Ryoke T, Gu Y, Ikeda Y, Martone ME, Oh SS, Jeon ES, Knowlton K, Ross J. Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster. Basic Res Cardiol. 2002 Jan; 97(1):65-75. PMID: 12004790.
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      34. Wu PS, Moriscot AS, Knowlton K, Hilal-Dandan R, He H, Dillmann WH. a1-Adrenergic Stimulation Inhibits 3,5,3'-Triiodothyronine-Induced Expression of the Rat Heart Sarcoplasmic Reticulum Ca2+ Adenosine Triphosphatase Gene1. Endocrinology. 1997 Jan 01; 138(1):114-120. PMID: 28204244.
        View in: PubMed
      35. Knowlton K, Jeon ES, Berkley N, Wessely R, Huber S. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J Virol. 1996 Nov; 70(11):7811-8. PMID: 8892902.
        View in: PubMed
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