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    Christopher Wills

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentEcology, Behavior, and Evolution
    Address9500 Gilman Drive #0116
    CA La Jolla 92093
    Phone858-534-4113
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      Collapse Research 
      Collapse Research Activities and Funding
      USING MICROSATELLITES TO ANALYZE CYTOMEGALOVIRUS STRAINS
      NIH/NIAID R03AI041370Jun 1, 1997 - May 31, 2000
      Role: Principal Investigator
      MITOCHONDRIAL FUNCTION AND YEAST METABOLISM REGULATION
      NIH/NIGMS R01GM031962Jul 1, 1983 - Mar 31, 1987
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wills C, Harms KE, Wiegand T, Punchi-Manage R, Gilbert GS, Erickson D, Kress WJ, Hubbell SP, Gunatilleke CV, Gunatilleke IA. Correction: Persistence of Neighborhood Demographic Influences over Long Phylogenetic Distances May Help Drive Post-Speciation Adaptation in Tropical Forests. PLoS One. 2016; 11(12):e0168976. PMID: 27997606.
        View in: PubMed
      2. Trivedi S, Wills C, Metzgar D. Analysis of simple sequence repeats in mammalian cell cycle genes. Recent Adv DNA Gene Seq. 2014; 8(1):20-9. PMID: 25564025.
        View in: PubMed
      3. Wills C. Genetic and phenotypic consequences of introgression between humans and Neanderthals. Adv Genet. 2011; 76:27-54. PMID: 22099691.
        View in: PubMed
      4. Wills C. Rapid recent human evolution and the accumulation of balanced genetic polymorphisms. High Alt Med Biol. 2011; 12(2):149-55. PMID: 21718163.
        View in: PubMed
      5. Veretnik S, Wills C, Youkharibache P, Valas RE, Bourne PE. Sm/Lsm genes provide a glimpse into the early evolution of the spliceosome. PLoS Comput Biol. 2009 Mar; 5(3):e1000315. PMID: 19282982; PMCID: PMC2650416.
      6. Muller-Landau HC, Condit RS, Chave J, Thomas SC, Bohlman SA, Bunyavejchewin S, Davies S, Foster R, Gunatilleke S, Gunatilleke N, Harms KE, Hart T, Hubbell SP, Itoh A, Kassim AR, LaFrankie JV, Lee HS, Losos E, Makana JR, Ohkubo T, Sukumar R, Sun IF, Nur Supardi MN, Tan S, Thompson J, Valencia R, Muñoz GV, Wills C, Yamakura T, Chuyong G, Dattaraja HS, Esufali S, Hall P, Hernandez C, Kenfack D, Kiratiprayoon S, Suresh HS, Thomas D, Vallejo MI, Ashton P. Testing metabolic ecology theory for allometric scaling of tree size, growth and mortality in tropical forests. Ecol Lett. 2006 May; 9(5):575-88. PMID: 16643303.
        View in: PubMed
      7. Wills C, Harms KE, Condit R, King D, Thompson J, He F, Muller-Landau HC, Ashton P, Losos E, Comita L, Hubbell S, Lafrankie J, Bunyavejchewin S, Dattaraja HS, Davies S, Esufali S, Foster R, Gunatilleke N, Gunatilleke S, Hall P, Itoh A, John R, Kiratiprayoon S, de Lao SL, Massa M, Nath C, Noor MN, Kassim AR, Sukumar R, Suresh HS, Sun IF, Tan S, Yamakura T, Zimmerman J. Nonrandom processes maintain diversity in tropical forests. Science. 2006 Jan 27; 311(5760):527-31. PMID: 16439661.
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      8. Blasiole DA, Metzgar D, Daum LT, Ryan MA, Wu J, Wills C, Le CT, Freed NE, Hansen CJ, Gray GC, Russell KL. Molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults. J Clin Microbiol. 2004 Apr; 42(4):1686-93. PMID: 15071026; PMCID: PMC387592.
      9. Smith D, Metzgar D, Wills C, Fierer J. Fatal Saccharomyces cerevisiae aortic graft infection. J Clin Microbiol. 2002 Jul; 40(7):2691-2. PMID: 12089311; PMCID: PMC120603.
      10. Metzgar D, Liu L, Hansen C, Dybvig K, Wills C. Domain-level differences in microsatellite distribution and content result from different relative rates of insertion and deletion mutations. Genome Res. 2002 Mar; 12(3):408-13. PMID: 11875028; PMCID: PMC155286.
      11. Chang DK, Metzgar D, Wills C, Boland CR. Microsatellites in the eukaryotic DNA mismatch repair genes as modulators of evolutionary mutation rate. Genome Res. 2001 Jul; 11(7):1145-6. PMID: 11435395.
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      12. Metzgar D, Thomas E, Davis C, Field D, Wills C. The microsatellites of Escherichia coli: rapidly evolving repetitive DNAs in a non-pathogenic prokaryote. Mol Microbiol. 2001 Jan; 39(1):183-90. PMID: 11123700.
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      13. Metzgar D, Wills C. Evolutionary changes in mutation rates and spectra and their influence on the adaptation of pathogens. Microbes Infect. 2000 Oct; 2(12):1513-22. PMID: 11099938.
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      14. Metzgar D, Wills C. Evidence for the adaptive evolution of mutation rates. Cell. 2000 Jun 09; 101(6):581-4. PMID: 10892644.
        View in: PubMed
      15. Metzgar D, Bytof J, Wills C. Selection against frameshift mutations limits microsatellite expansion in coding DNA. Genome Res. 2000 Jan; 10(1):72-80. PMID: 10645952; PMCID: PMC310501.
      16. Davis CL, Field D, Metzgar D, Saiz R, Morin PA, Smith IL, Spector SA, Wills C. Numerous length polymorphisms at short tandem repeats in human cytomegalovirus. J Virol. 1999 Aug; 73(8):6265-70. PMID: 10400717; PMCID: PMC112704.
      17. Wills C, Condit R. Similar non-random processes maintain diversity in two tropical rainforests. Proc Biol Sci. 1999 Jul 22; 266(1427):1445-52. PMID: 10457617; PMCID: PMC1690088.
      18. Field D, Magnasco MO, Moxon ER, Metzgar D, Tanaka MM, Wills C, Thaler DS. Contingency loci, mutator alleles, and their interactions. Synergistic strategies for microbial evolution and adaptation in pathogenesis. Ann N Y Acad Sci. 1999 May 18; 870:378-82. PMID: 10415502.
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      19. Gagneux P, Wills C, Gerloff U, Tautz D, Morin PA, Boesch C, Fruth B, Hohmann G, Ryder OA, Woodruff DS. Mitochondrial sequences show diverse evolutionary histories of African hominoids. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5077-82. PMID: 10220421; PMCID: PMC21819.
      20. Metzgar D, van Belkum A, Field D, Haubrich R, Wills C. Random amplification of polymorphic DNA and microsatellite genotyping of pre- and posttreatment isolates of Candida spp. from human immunodeficiency virus-infected patients on different fluconazole regimens. J Clin Microbiol. 1998 Aug; 36(8):2308-13. PMID: 9666011; PMCID: PMC105037.
      21. Field D, Wills C. Abundant microsatellite polymorphism in Saccharomyces cerevisiae, and the different distributions of microsatellites in eight prokaryotes and S. cerevisiae, result from strong mutation pressures and a variety of selective forces. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1647-52. PMID: 9465070; PMCID: PMC19132.
      22. Metzgar D, Field D, Haubrich R, Wills C. Sequence analysis of a compound coding-region microsatellite in Candida albicans resolves homoplasies and provides a high-resolution tool for genotyping. FEMS Immunol Med Microbiol. 1998 Feb; 20(2):103-9. PMID: 9544777.
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      23. Selk E, Wills C. Mismatch repair and the accumulation of deleterious mutations influence the competitive advantage of MAT (mating type) heterozygosity in the yeast Saccharomyces cerevisiae. Genet Res. 1998 Feb; 71(1):1-10. PMID: 9674378.
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      24. Wills C, Condit R, Foster RB, Hubbell SP. Strong density- and diversity-related effects help to maintain tree species diversity in a neotropical forest. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1252-7. PMID: 11038601; PMCID: PMC19777.
      25. Wills C. Another nail in the coffin of the multiple-origins theory? Bioessays. 1996 Dec; 18(12):1017-20. PMID: 8976159.
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      26. Wills C, Farmer A, Myers G. Rapid sequon evolution in human immunodeficiency virus type 1 relative to human immunodeficiency virus type 2. AIDS Res Hum Retroviruses. 1996 Sep 20; 12(14):1383-4. PMID: 8891118.
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      27. Field D, Eggert L, Metzgar D, Rose R, Wills C. Use of polymorphic short and clustered coding-region microsatellites to distinguish strains of Candida albicans. FEMS Immunol Med Microbiol. 1996 Sep; 15(2-3):73-9. PMID: 8880131.
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      28. Wills C. Some puzzles about carbon catabolite repression in yeast. Res Microbiol. 1996 Jul-Sep; 147(6-7):566-72. PMID: 9084771.
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      29. Wills C. TOPIARY PRUNING AND WEIGHTING REINFORCE AN AFRICAN ORIGIN FOR THE HUMAN MITOCHONDRIAL DNA TREE. Evolution. 1996 Jun; 50(3):977-989. PMID: 28565262.
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      30. Wills C. Improving the analysis of phylogenetic data. Comput Chem. 1996 Mar; 20(1):61-6. PMID: 8867842.
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      31. Field D, Wills C. Long, polymorphic microsatellites in simple organisms. Proc Biol Sci. 1996 Feb 22; 263(1367):209-15. PMID: 8728984.
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      32. Birdsell J, Wills C. Significant competitive advantage conferred by meiosis and syngamy in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):908-12. PMID: 8570658; PMCID: PMC40157.
      33. Wills C. Topiary pruning of the HIV and SIV phylogenetic tree. AIDS Res Hum Retroviruses. 1995 Nov; 11(11):1417-9. PMID: 8573401.
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      34. Wills C. WHEN DID EVE LIVE? AN EVOLUTIONARY DETECTIVE STORY. Evolution. 1995 Aug; 49(4):593-607. PMID: 28565132.
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      35. Wills C, Green DR. A genetic herd-immunity model for the maintenance of MHC polymorphism. Immunol Rev. 1995 Feb; 143:263-92. PMID: 7558080.
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      36. Mickey G, Sim J, Durand J, Wills C. Use of denaturing gradient electrophoresis to determine the distributions of polymorphisms in entire genes in natural populations. Biochim Biophys Acta. 1995 Jan 25; 1260(2):123-31. PMID: 7841188.
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      37. Hultner M, Smith DW, Wills C. Similarity landscapes: a way to detect many structural and sequence motifs in both introns and exons. J Mol Evol. 1994 Feb; 38(2):188-203. PMID: 8169961.
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      38. Durand J, Birdsell J, Wills C. Pleiotropic effects of heterozygosity at the mating-type locus of the yeast Saccharomyces cerevisiae on repair, recombination and transformation. Mutat Res. 1993 Dec; 290(2):239-47. PMID: 7694115.
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      39. Wills C. Maintenance of multiallelic polymorphism at the MHC region. Immunol Rev. 1991 Dec; 124:165-220. PMID: 1804778.
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      40. Wills C. The role of molecular biology in human evolutionary studies: current status and future prospects. Mol Genet Med. 1991; 1:169-232. PMID: 1842572.
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      41. Wills C. Regulation of sugar and ethanol metabolism in Saccharomyces cerevisiae. Crit Rev Biochem Mol Biol. 1990; 25(4):245-80. PMID: 2171877.
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      42. Ashley MV, Wills C. MITOCHONDRIAL-DNA AND ALLOZYME DIVERGENCE PATTERNS ARE CORRELATED AMONG ISLAND DEER MICE. Evolution. 1989 May; 43(3):646-650. PMID: 28568394.
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      43. Wills C, Hom D. An efficient selection producing structural gene mutants of yeast alcohol dehydrogenase resistant to pyrazole. Genetics. 1988 Aug; 119(4):791-5. PMID: 3044924; PMCID: PMC1203465.
      44. Hall JG, Wills C. Conditional overdominance at an alcohol dehydrogenase locus in yeast. Genetics. 1987 Nov; 117(3):421-7. PMID: 3319769; PMCID: PMC1203218.
      45. Ashley M, Wills C. ANALYSIS OF MITOCHONDRIAL DNA POLYMORPHISMS AMONG CHANNEL ISLAND DEER MICE. Evolution. 1987 Jul; 41(4):854-863. PMID: 28564361.
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      46. Wills C. Rank-order selection is capable of maintaining all genetic polymorphisms. Genetics. 1978 Jun; 89(2):403-17. PMID: 17248841.
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