Jejo Koola

Title(s)Associate Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Education and Training
    Vanderbilt University, Nashville, TNMS12/2018Biomedical Informatics
    Department of Veterans Affairs, Nashville, TN09/2016Fellowship in Biomedical Informatics
    Medical College of Virginia, Richmond, VAMedicine06/2011Internal Medicine Residency
    Medical Univ. of South Carolina, Charleston, SCMD05/2008Medicine
    Purdue University, West Lafayette, INBiology, Computer Science

    Collapse Overview 
    Collapse Overview
    Dr. Jejo Koola joined UCSD faculty in 2016. He received his MD degree from the Medical University of South Carolina and subsequently completed his residency in Internal Medicine at the Medical College of Virginia in Richmond, Virginia in 2011. Following residency, Dr. Koola completed a post-doctoral fellowship in Biomedical Informatics through the Department of Veterans Affairs in conjunction with Vanderbilt University in 2016.

    Dr. Koola has a joint appointment in Hospital Medicine and Biomedical Informatics. Clinically, he sees a wide variety of hospitalized patients at UCSD on the hospitalist service. His research interests are in using machine learning to build predictive models using big data. He applies models to improving the care of multi-morbid patients, particularly patients with advanced liver disease. He is currently involved in a multi-center study implementing predictive analytics for cirrhosis care at the Department of Veterans Affairs. Additionally, he leads a study diagnosing hepatic encephalopathy via digital phenotyping.

    Dr. Koola also serves as a medical director within UC San Diego Health Information Systems and the medical director for the UCSD Clinical Informatics Consult Service.

    Collapse Research 
    Collapse Research Activities and Funding
    Incorporating Learning Effects into Medical Device Active Safety Surveillance Methods
    NIH/NHLBI R01 HL149948-01Dec 1, 2019 - Nov 30, 2023
    Role: Co-Investigator
    Description: This proposal seeks to extend the previously validated, open-source, active, prospective device safety surveillance tool, by developing and validating robust learning curve (LC) detection and quantification algorithms, designed to simultaneously account for the effects at the operator and institutional levels.
    Surveillance and prediction of post-acute kidney injury outcomes using digital phenotyping
    UCSD Academy of Clinician Scholars Oct 1, 2019 - Sep 30, 2020
    Role: PI
    Description: Acute Kidney Injury (AKI) occurs in 2 – 5% of hospitalized patients and nearly 70% of critically ill patients. AKI is associated with increased inpatient mortality, hospital length of stay, and post-discharge morbidity. Moreover, its effects may be long-lasting and are associated with cognitive dysfunction, frailty, and reduced quality of life. More real-time information is necessary from patients in the home setting post hospital discharge. This study leverages predictive modeling and digital phenotyping to track post-AKI cognitive and functional changes and their relationship to patient-centered outcomes. Digital phenotyping allows for unobtrusive, continuous monitoring thereby delivering actionable risk predictions conducive to tailored interventions.
    Diagnosing “Chemo Brain” Using Digital Phenotyping
    University of California San Diego Health Sciences Academic Senate GrantDec 1, 2018 - Dec 1, 2019
    Role: PI
    Description: The overall objective of this project is to develop methods of identifying chemotherapy related cognitive impairment. Up to 70% of patients have reported significant reduction in cognitive function, colloquially termed “chemo brain,” from chemotherapy. Studying these changes can be difficult within the clinical setting due to the resource requirements. We will evaluate the feasibility of using “digital phenotyping,” assessing the interaction between a patient’s health and their technology use, to diagnose chemotherapy related cognitive impairment. We will use multiple data streams from passive/wearable sensors to assess their daily cognitive status.
    Assessing Cognitive Status of Patients with Cirrhosis Using Digital Phenotyping
    University of California San Diego Health Sciences Academic Senate GrantMay 1, 2018 - May 1, 2019
    Role: PI
    Description: The overall objective of this project is to develop methods of identifying early hepatic encephalopathy before the patient requires hospitalization. More specifically we will evaluate the feasibility of using “digital phenotyping,” assessing the interaction between a patient’s health and their technology use, to diagnose hepatic encephalopathy. We will use multiple data streams from a FitBit and the patient’s routine interactions with their regular smartphone to assess their daily cognitive status.
    Assessing efficacy of passive and active forms of expressive art therapy in inpatient services
    University of California San Diego Health Sciences Academic Senate GrantJun 1, 2017 - May 31, 2018
    Role: Co-Investigator
    Automated Surveillance and Intervention among Patients with Liver Cirrhosis
    Department of Veterans Affairs HSR&D IIR 13-052Jun 1, 2014 - Jun 1, 2018
    Role: Co-Investigator
    San Diego Biomedical Informatics Education & Research (SABER)
    NIH T15LM011271Jul 1, 2012 - Jun 30, 2022
    Role: Co-Investigator
    Description: Role Description: Director, Summer Internship Program

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases. Kidney International Reports. 2023; 0(0). Yousif, Z. K.; Koola, J. D.; Macedo, E.; Cerda, J.; Goldstein, S. L.; Chakravarthi, R.; Lewington, A.; Selewski, D.; Zappitelli, M.; Cruz, D.; Tolwani, A.; Joy, M. S.; Jha, V.; Ramachandran, R.; Ostermann, M.; Yang, L.; Pandya, B.; Acharya, A.; Brophy, P.; Ponce, D.; Steinke, J.; Bouchard, J.; Irarrazabal, C. E.; Irarrazabal, R.; Boltansky, A.; Askenazi, D.; Kolhe, N.; Granado, R. C.-D.; Benador, N.; Castledine, C.; Davenport, A.; Barratt, J.; Bhandari, S.; Riley, A. A.; Akcan-Arikan, A.; Davis, T. K.; Farmer, C.; Hogarth, M.; Thomas, M.; Murray, P. T.; Robinson-Cohen, C.; Nicoletti, P.; Vaingankar, S.; Mehta, R.; Awdishu, L. View Publication.
    2. Digital health and acute kidney injury: consensus report of the 27th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol. 2023 12; 19(12):807-818. Kashani KB, Awdishu L, Bagshaw SM, Barreto EF, Claure-Del Granado R, Evans BJ, Forni LG, Ghosh E, Goldstein SL, Kane-Gill SL, Koola J, Koyner JL, Liu M, Murugan R, Nadkarni GN, Neyra JA, Ninan J, Ostermann M, Pannu N, Rashidi P, Ronco C, Rosner MH, Selby NM, Shickel B, Singh K, Soranno DE, Sutherland SM, Bihorac A, Mehta RL. PMID: 37580570; PMCID: PMC11285755.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    3. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases. Kidney Int Rep. 2023 Nov; 8(11):2333-2344. Yousif ZK, Koola JD, Macedo E, Cerda J, Goldstein SL, Chakravarthi R, Lewington A, Selewski D, Zappitelli M, Cruz D, Tolwani A, Joy MS, Jha V, Ramachandran R, Ostermann M, Pandya B, Acharya A, Brophy P, Ponce D, Steinke J, Bouchard J, Irarrazabal CE, Irarrazabal R, Boltansky A, Askenazi D, Kolhe N, Claure-Del Granado R, Benador N, Castledine C, Davenport A, Barratt J, Bhandari S, Riley AA, Davis TK, Farmer C, Hogarth M, Thomas M, Murray PT, Robinson-Cohen C, Nicoletti P, Vaingankar S, Mehta R, Awdishu L. PMID: 38025217; PMCID: PMC10658426.
      View in: PubMed   Mentions: 2  
    4. Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions. J Am Med Inform Assoc. 2023 05 19; 30(6):1167-1178. Kuo TT, Pham A, Edelson ME, Kim J, Chan J, Gupta Y, Ohno-Machado L, R2D2 Consortium. PMID: 36916740; PMCID: PMC10198529.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Simulating complex patient populations with hierarchical learning effects to support methods development for post-market surveillance. BMC Med Res Methodol. 2023 04 11; 23(1):89. Davis SE, Ssemaganda H, Koola JD, Mao J, Westerman D, Speroff T, Govindarajulu US, Ramsay CR, Sedrakyan A, Ohno-Machado L, Resnic FS, Matheny ME. PMID: 37041457; PMCID: PMC10088292.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Reducing readmissions in patients with cirrhosis: the time to act is now. Ann Transl Med. 2021 Nov; 9(22):1637. Patel A, Koola JD, Matheny ME. PMID: 34988146; PMCID: PMC8667133.
      View in: PubMed   Mentions: 1  
    7. Privacy-protecting, reliable response data discovery using COVID-19 patient observations. J Am Med Inform Assoc. 2021 07 30; 28(8):1765-1776. Kim J, Neumann L, Paul P, Day ME, Aratow M, Bell DS, Doctor JN, Hinske LC, Jiang X, Kim KK, Matheny ME, Meeker D, Pletcher MJ, Schilling LM, SooHoo S, Xu H, Zheng K, Ohno-Machado L, R2D2 Consortium. PMID: 34051088; PMCID: PMC8194878.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Development of a national Department of Veterans Affairs mortality risk prediction model among patients with cirrhosis. BMJ Open Gastroenterol. 2019; 6(1):e000342. Koola JD, Ho S, Chen G, Perkins AM, Cao A, Davis SE, Matheny ME. PMID: 31875140; PMCID: PMC6904155.
      View in: PubMed   Mentions: 3     Fields:    
    9. Predicting 30-Day Hospital Readmission Risk in a National Cohort of Patients with Cirrhosis. Dig Dis Sci. 2020 04; 65(4):1003-1031. Koola JD, Ho SB, Cao A, Chen G, Perkins AM, Davis SE, Matheny ME. PMID: 31531817; PMCID: PMC7073276.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    10. Rate of Risk Factors for and Interventions to Reduce Hospital Readmission in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 08; 18(9):1939-1948.e7. Nguyen NH, Koola J, Dulai PS, Prokop LJ, Sandborn WJ, Singh S. PMID: 31470176; PMCID: PMC7044053.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    11. A clinical risk prediction model to identify patients with hepatorenal syndrome at hospital admission. Int J Clin Pract. 2019 Nov; 73(11):e13393. Koola JD, Chen G, Malin BA, Fabbri D, Siew ED, Ho SB, Patterson OV, Matheny ME. PMID: 31347754.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Descriptive Usability Study of CirrODS: Clinical Decision and Workflow Support Tool for Management of Patients With Cirrhosis. JMIR Med Inform. 2019 Jul 03; 7(3):e13627. Garvin JH, Ducom J, Matheny M, Miller A, Westerman D, Reale C, Slagle J, Kelly N, Beebe R, Koola J, Groessl EJ, Patterson ES, Weinger M, Perkins AM, Ho SB. PMID: 31271153; PMCID: PMC6636234.
      View in: PubMed   Mentions: 5  
    13. Consumer Health Informatics Adoption among Underserved Populations: Thinking beyond the Digital Divide. Yearb Med Inform. 2018 Aug; 27(1):146-155. Huh J, Koola J, Contreras A, Castillo AK, Ruiz M, Tedone KG, Yakuta M, Schiaffino MK. PMID: 30157518; PMCID: PMC6115231.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    14. Application of contextual design methods to inform targeted clinical decision support interventions in sub-specialty care environments. Int J Med Inform. 2018 09; 117:55-65. Miller A, Koola JD, Matheny ME, Ducom JH, Slagle JM, Groessl EJ, Minter FF, Garvin JH, Weinger MB, Ho SB. PMID: 30032965.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    15. Development of an automated phenotyping algorithm for hepatorenal syndrome. J Biomed Inform. 2018 04; 80:87-95. Koola JD, Davis SE, Al-Nimri O, Parr SK, Fabbri D, Malin BA, Ho SB, Matheny ME. PMID: 29530803; PMCID: PMC5920557.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. Hepatology. Post-Discharge Mortality in a National Cohort of Veterans Affairs Patients with Cirrhosis. 2016; S1(64):862A. Koola J, Cao A, Perkins A, Chen G, Ho SB, Matheny ME.
    17. Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance. Hum Brain Mapp. 2009 Jul; 30(7):2044-55. Herbsman T, Forster L, Molnar C, Dougherty R, Christie D, Koola J, Ramsey D, Morgan PS, Bohning DE, George MS, Nahas Z. PMID: 18973261; PMCID: PMC2893589.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    18. Serial vagus nerve stimulation functional MRI in treatment-resistant depression. Neuropsychopharmacology. 2007 Aug; 32(8):1649-60. Nahas Z, Teneback C, Chae JH, Mu Q, Molnar C, Kozel FA, Walker J, Anderson B, Koola J, Kose S, Lomarev M, Bohning DE, George MS. PMID: 17203016.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCTClinical Trials
    19. Emotion facilitates action: a transcranial magnetic stimulation study of motor cortex excitability during picture viewing. Psychophysiology. 2007 Jan; 44(1):91-7. Hajcak G, Molnar C, George MS, Bolger K, Koola J, Nahas Z. PMID: 17241144.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    20. Estimating resting motor thresholds in transcranial magnetic stimulation research and practice: a computer simulation evaluation of best methods. J ECT. 2006 Sep; 22(3):169-75. Borckardt JJ, Nahas Z, Koola J, George MS. PMID: 16957531.
      View in: PubMed   Mentions: 83     Fields:    
    21. Decreased cortical response to verbal working memory following sleep deprivation. Sleep. 2005 Jan; 28(1):55-67. Mu Q, Nahas Z, Johnson KA, Yamanaka K, Mishory A, Koola J, Hill S, Horner MD, Bohning DE, George MS. PMID: 15700721.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    22. The maximum-likelihood strategy for determining transcranial magnetic stimulation motor threshold, using parameter estimation by sequential testing is faster than conventional methods with similar precision. J ECT. 2004 Sep; 20(3):160-5. Mishory A, Molnar C, Koola J, Li X, Kozel FA, Myrick H, Stroud Z, Nahas Z, George MS. PMID: 15343000.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    23. An Electronic Health Record Phenotyping Algorithm for Identifying Patients with Hepatorenal Syndrome. Koola J, Ho SB, Matheny ME.
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