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Rakesh Malhotra

Title(s)Associate Professor Of Clinical, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Associations of Biomarkers of Kidney Tubule Health with Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis (MESA). Kidney360. 2025 Sep 05. Ahmadi A, Gorji H, Shashikant S, Katz R, Houben AJHM, Weinreb RN, Allison M, Meuer SM, Klein BE, Cotch MF, Gutierrez OM, Sarnak MJ, Shlipak M, Ix JH, Malhotra R. PMID: 40911362.
      View in: PubMed   Mentions:    Fields:    
    2. The Utility of Urine Microscopy Score for Early Detection and Prediction of Acute Kidney Injury in At-Risk Patients. Kidney360. 2025 Aug 13. Claure-Del Granado R, Torrico-Moreira D, Zhang J, Breunig J, Shamel B, Gupta V, Chopra T, Dasgupta S, Malhotra R. PMID: 40802455.
      View in: PubMed   Mentions:    Fields:    
    3. Bicarbonate-Based Solution for the Management of Established Acute Kidney Injury: A Pilot Open-Label Observation Study. Cureus. 2023 Jul; 15(7):e42127. Claure-Del Granado R, Prudencio-Ribera VC, Gupta V, Yang J, Kashani K, Malhotra R. PMID: 37476296; PMCID: PMC10355685.
      View in: PubMed   Mentions:
    4. Risk of de novo proteinuria following hospitalization with acute kidney injury. BMC Nephrol. 2023 06 15; 24(1):176. Bonde SS, Zaman W, Cuomo R, Malhotra R, Macedo E. PMID: 37322414; PMCID: PMC10273748.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Pathways to improve nephrologist comfort in managing patients on in-center or home self-care dialysis. Hemodial Int. 2023 07; 27(3):204-211. Huang M, Vincent Johnson A, Pourafshar N, Malhotra R, Yang J, Shah M, Balogun R, Chopra T. PMID: 37157127.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Associations of Urine Biomarkers of Kidney Tubule Health With Incident Hypertension and Longitudinal Blood Pressure Change in Middle-Aged Adults: The CARDIA Study. Hypertension. 2023 06; 80(6):1353-1362. Khan MB, Scherzer R, Lewis CE, Malhotra R, Ix JH, Shlipak MG, Gutiérrez OM. PMID: 36987923; PMCID: PMC10192098.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. The Impact of a Wearable Activity Tracker and Structured Feedback Program on Physical Activity in Hemodialysis Patients: The Step4Life Pilot Randomized Controlled Trial. Am J Kidney Dis. 2023 07; 82(1):75-83. Malhotra R, Rahimi S, Agarwal U, Katz R, Kumar U, Garimella PS, Gupta V, Chopra T, Kotanko P, Ikizler TA, Larsen B, Cadmus-Bertram L, Ix JH. PMID: 36801430; PMCID: PMC10962931.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. A randomized controlled trial to evaluate outcomes with Aggrenox in patients with SARS-CoV-2 infection. PLoS One. 2023; 18(1):e0274243. Singla A, Dadario NB, Singla A, Greenberg P, Yan R, Nanda A, Boison D, Malhotra R, Patel S, Nipun S, Maninderpal K, Castro D, Bdiiwi S, Boktor H, Kyi HH, Sutherland A, Patrawalla A, Ly K, Xie Y, Sonig A, Khandelwal P, Liu J, Koziol J, Finkle D, Subanna S, Libutti SK. PMID: 36716303; PMCID: PMC9886260.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Biomarkers of kidney tubule injury and dysfunction and risk of incident hypertension in community-living individuals: results from the multi-ethnic study of atherosclerosis. Nephrol Dial Transplant. 2023 Jan 23; 38(1):246-248. Malhotra R, Katz R, Kimmel PL, Vasan RS, Schelling JS, Greenberg JH, Parikh CR, Bonventre JV, Al-Rousan T, Sarnak MJ, Gutierrez OM, Shlipak MG, Ix JH. PMID: 36307927; PMCID: PMC9869850.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Interpreting Estimated GFR Variability and Its Clinical Significance. Kidney Med. 2023 Feb; 5(2):100599. Malhotra R, Chopra T, Ix JH. PMID: 36718188; PMCID: PMC9883260.
      View in: PubMed   Mentions:
    11. Race, Sex, and Kidney Disease Trial Participation. Kidney Med. 2023 Mar; 5(3):100594. Alahamadi Z, Agarwal K, Wen A, Gupta V, Chopra T, Khan A, Malhotra R. PMID: 36960440; PMCID: PMC10028468.
      View in: PubMed   Mentions: 3  
    12. Biphasic Dynamics of Inflammatory Markers Following Hemodialysis Initiation: Results From the International MONitoring Dialysis Outcome Initiative. Kidney Int Rep. 2023 Jan; 8(1):75-80. Yousif DE, Ye X, Stuard S, Berbessi J, Guinsburg AM, Usvyat LA, Raimann JG, Kooman JP, van der Sande FM, Duncan N, Woollard KJ, Bright R, Pusey C, Gupta V, Ix JH, Kotanko P, Malhotra R. PMID: 36644346; PMCID: PMC9831940.
      View in: PubMed   Mentions: 1  
    13. Kidney tubule health, mineral metabolism and adverse events in persons with CKD in SPRINT. Nephrol Dial Transplant. 2022 08 22; 37(9):1637-1646. Ascher SB, Scherzer R, Estrella MM, Berry JD, de Lemos JA, Jotwani VK, Garimella PS, Malhotra R, Bullen AL, Katz R, Ambrosius WT, Cheung AK, Chonchol M, Killeen AA, Ix JH, Shlipak MG, SPRINT Research Group. PMID: 34473302; PMCID: PMC9649818.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    14. Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD. J Am Soc Nephrol. 2022 10; 33(10):1915-1926. Bullen AL, Ascher SB, Scherzer R, Garimella PS, Katz R, Hallan SI, Cheung AK, Raphael KL, Estrella MM, Jotwani VK, Malhotra R, Seegmiller JC, Shlipak MG, Ix JH. PMID: 35973732; PMCID: PMC9528325.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Physical activity in hemodialysis patients on nondialysis and dialysis days: Prospective observational study. Hemodial Int. 2021 04; 25(2):240-248. Malhotra R, Kumar U, Virgen P, Magallon B, Garimella PS, Chopra T, Kotanko P, Ikizler TA, Trzebinska D, Cadmus-Bertram L, Ix JH. PMID: 33650200.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    16. Estimated GFR Variability and Risk of Cardiovascular Events and Mortality in SPRINT (Systolic Blood Pressure Intervention Trial). Am J Kidney Dis. 2021 07; 78(1):48-56. Malhotra R, Katz R, Jotwani V, Agarwal A, Cohen DL, Cushman WC, Ishani A, Killeen AA, Kitzman DW, Oparil S, Papademetriou V, Parikh CR, Raphael KL, Rocco MV, Tamariz LJ, Whelton PK, Wright JT, Shlipak MG, Ix JH. PMID: 33333147; PMCID: PMC8200370.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. Urinary Phosphate Excretion and Microvascular Function in a Population-Based Cohort. Kidney Med. 2020 Nov-Dec; 2(6):812-815. Ginsberg C, Houben AJHM, Malhotra R, Berendschot TTJM, Kooman JP, Webers CAB, Stehouwer CDA, Ix JH. PMID: 33319206; PMCID: PMC7729221.
      View in: PubMed   Mentions:
    18. Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants. Am J Nephrol. 2020; 51(10):797-805. Jotwani V, Garimella PS, Katz R, Malhotra R, Bates J, Cheung AK, Chonchol M, Drawz PE, Freedman BI, Haley WE, Killeen AA, Punzi H, Sarnak MJ, Segal MS, Shlipak MG, Ix JH, SPRINT Research Group. PMID: 32906135; PMCID: PMC7606644.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Urine Markers of Kidney Tubule Cell Injury and Kidney Function Decline in SPRINT Trial Participants with CKD. Clin J Am Soc Nephrol. 2020 03 06; 15(3):349-358. Malhotra R, Katz R, Jotwani V, Ambrosius WT, Raphael KL, Haley W, Rastogi A, Cheung AK, Freedman BI, Punzi H, Rocco MV, Ix JH, Shlipak MG. PMID: 32111704; PMCID: PMC7057300.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    20. Exclusion of Persons with Kidney Disease in Trials of Peripheral Artery Disease: A Systematic Review of Randomized Trials. Clin J Am Soc Nephrol. 2020 01 07; 15(1):117-119. Wen Y, Potok OA, Wei X, Paranjpe I, Chan L, Malhotra R, Coca S, Narula J, Olin JW, Nadkarni GN, Garimella PS. PMID: 31888921; PMCID: PMC6946068.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Serum Phosphate and Microvascular Function in a Population-Based Cohort. Clin J Am Soc Nephrol. 2019 11 07; 14(11):1626-1633. Ginsberg C, Houben AJHM, Malhotra R, Berendschot TTJM, Dagnelie PC, Kooman JP, Webers CA, Stehouwer CDA, Ix JH. PMID: 31540930; PMCID: PMC6832044.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    22. Dialysate Calcium: A Lot More Than 'Set It and Forget It'. Kidney Med. 2019 Sep-Oct; 1(5):238-241. Garimella PS, Malhotra R. PMID: 32939451; PMCID: PMC7477722.
      View in: PubMed   Mentions: 3  
    23. Blood Pressure, Chronic Kidney Disease Progression, and Kidney Allograft Failure in Kidney Transplant Recipients: A Secondary Analysis of the FAVORIT Trial. Am J Hypertens. 2019 08 14; 32(9):816-823. Malhotra R, Katz R, Weiner DE, Levey AS, Cheung AK, Bostom AG, Ix JH. PMID: 31179500; PMCID: PMC6694012.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. The SPRINT trial suggests that markers of tubule cell function in the urine associate with risk of subsequent acute kidney injury while injury markers elevate after the injury. Kidney Int. 2019 08; 96(2):470-479. Bullen AL, Katz R, Lee AK, Anderson CAM, Cheung AK, Garimella PS, Jotwani V, Haley WE, Ishani A, Lash JP, Neyra JA, Punzi H, Rastogi A, Riessen E, Malhotra R, Parikh CR, Rocco MV, Wall BM, Bhatt UY, Shlipak MG, Ix JH, Estrella MM. PMID: 31262489; PMCID: PMC6650383.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    25. Urinary Biomarkers of Tubular Damage Are Associated with Mortality but Not Cardiovascular Risk among Systolic Blood Pressure Intervention Trial Participants with Chronic Kidney Disease. Am J Nephrol. 2019; 49(5):346-355. Jotwani VK, Lee AK, Estrella MM, Katz R, Garimella PS, Malhotra R, Rifkin DE, Ambrosius W, Freedman BI, Cheung AK, Raphael KL, Drawz P, Neyra JA, Oparil S, Punzi H, Shlipak MG, Ix JH, for the SPRINT Research Group. PMID: 30939472; PMCID: PMC6491265.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    26. Blood Pressure Goals in Patients with CKD: A Review of Evidence and Guidelines. Clin J Am Soc Nephrol. 2019 01 07; 14(1):161-169. Chang AR, Lóser M, Malhotra R, Appel LJ. PMID: 30455322; PMCID: PMC6364532.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    27. Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study. Ann Intern Med. 2018 11 06; 169(9):610-618. Zhang WR, Craven TE, Malhotra R, Cheung AK, Chonchol M, Drawz P, Sarnak MJ, Parikh CR, Shlipak MG, Ix JH, SPRINT Research Group. PMID: 30357395; PMCID: PMC6953744.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    28. Effects of Intensive Blood Pressure Lowering on Kidney Tubule Injury in CKD: A Longitudinal Subgroup Analysis in SPRINT. Am J Kidney Dis. 2019 01; 73(1):21-30. Malhotra R, Craven T, Ambrosius WT, Killeen AA, Haley WE, Cheung AK, Chonchol M, Sarnak M, Parikh CR, Shlipak MG, Ix JH, SPRINT Research Group. PMID: 30291012; PMCID: PMC7325694.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    29. Protein Intake and Long-term Change in Glomerular Filtration Rate in the Jackson Heart Study. J Ren Nutr. 2018 07; 28(4):245-250. Malhotra R, Lipworth L, Cavanaugh KL, Young BA, Tucker KL, Carithers TC, Taylor HA, Correa A, Kabagambe EK, Ikizler TA. PMID: 29452887.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    30. The Role of Renal Angiography in Hepatitis B-related Polyarteritis Nodosa. Indian J Nephrol. 2018 Jan-Feb; 28(1):81-82. Malhotra R, Al Nimri O. PMID: 29515309; PMCID: PMC5830817.
      View in: PubMed   Mentions:
    31. The Effect of Extended Release Niacin on Markers of Mineral Metabolism in CKD. Clin J Am Soc Nephrol. 2018 01 06; 13(1):36-44. Malhotra R, Katz R, Hoofnagle A, Bostom A, Rifkin DE, Mcbride R, Probstfield J, Block G, Ix JH. PMID: 29208626; PMCID: PMC5753310.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    32. Performance of the Surprise Question Compared to Prediction Models in Hemodialysis Patients: A Prospective Study. Am J Nephrol. 2017; 46(5):390-396. Malhotra R, Tao X, Wang Y, Chen Y, Apruzzese RH, Balter P, Xiao Q, Usvyat LA, Kotanko P, Thijssen S. PMID: 29130949.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Marchiafava Bignami disease. Neurol India. 2017 Nov-Dec; 65(6):1440-1441. Malhotra R, Chopra T, Al Nimri O. PMID: 29133740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis. JAMA Intern Med. 2017 10 01; 177(10):1498-1505. Malhotra R, Nguyen HA, Benavente O, Mete M, Howard BV, Mant J, Odden MC, Peralta CA, Cheung AK, Nadkarni GN, Coleman RL, Holman RR, Zanchetti A, Peters R, Beckett N, Staessen JA, Ix JH. PMID: 28873137; PMCID: PMC5704908.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    35. Higher defibrillation threshold in methamphetamine cardiomyopathy patients with implantable cardioverter-defibrillator. Indian Pacing Electrophysiol J. 2017 Nov - Dec; 17(6):167-170. Malhotra R, Patel S, Ramchand T, Al Nimri O. PMID: 29231820; PMCID: PMC5784601.
      View in: PubMed   Mentions: 4  
    36. A risk prediction score for acute kidney injury in the intensive care unit. Nephrol Dial Transplant. 2017 May 01; 32(5):814-822. Malhotra R, Kashani KB, Macedo E, Kim J, Bouchard J, Wynn S, Li G, Ohno-Machado L, Mehta R. PMID: 28402551.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    37. Tryptophan and Kynurenine Levels and Its Association With Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients. J Ren Nutr. 2017 07; 27(4):260-266. Malhotra R, Persic V, Zhang W, Brown J, Tao X, Rosales L, Thijssen S, Finkelstein FO, Unruh ML, Ikizler A, Garimella PS, Ix JH, Kooman J, Levin NW, Handelman GJ, Kotanko P. PMID: 28366444.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    38. Reliability and Utility of the Surprise Question in CKD Stages 4 to 5. Am J Kidney Dis. 2017 Jul; 70(1):93-101. Javier AD, Figueroa R, Siew ED, Salat H, Morse J, Stewart TG, Malhotra R, Jhamb M, Schell JO, Cardona CY, Maxwell CA, Ikizler TA, Abdel-Kader K. PMID: 28215946; PMCID: PMC5771496.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    39. Sarcopenic Obesity Definitions by Body Composition and Mortality in the Hemodialysis Patients. J Ren Nutr. 2017 03; 27(2):84-90. Malhotra R, Deger SM, Salat H, Bian A, Stewart TG, Booker C, Vincz A, Pouliot B, Ikizler TA. PMID: 27876469; PMCID: PMC5318243.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    40. Biomarkers for the Early Detection and Prognosis of Acute Kidney Injury. Clin J Am Soc Nephrol. 2017 01 06; 12(1):149-173. Malhotra R, Siew ED. PMID: 27827308; PMCID: PMC5220647.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    41. Dietary polyunsaturated fatty acids and incidence of end-stage renal disease in the Southern Community Cohort Study. BMC Nephrol. 2016 10 18; 17(1):152. Malhotra R, Cavanaugh KL, Blot WJ, Ikizler TA, Lipworth L, Kabagambe EK. PMID: 27756237; PMCID: PMC5070154.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    42. Neutrophil-lymphocyte ratio as a novel predictor of survival in chronic hemodialysis patients. Clin Nephrol. 2016 Apr; 85(4):191-8. Ouellet G, Malhotra R, Penne EL, Usvya L, Levin NW, Kotanko P. PMID: 26951970.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    43. Understanding migraine: Potential role of neurogenic inflammation. Ann Indian Acad Neurol. 2016 Apr-Jun; 19(2):175-82. Malhotra R. PMID: 27293326; PMCID: PMC4888678.
      View in: PubMed   Mentions: 70  
    44. Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive Protein in Hemodialysis Patients: Results from 2 International Cohort Studies. Nephron. 2015; 130(4):263-70. Malhotra R, Marcelli D, von Gersdorff G, Grassmann A, Schaller M, Bayh I, Scatizzi L, Etter M, Guinsburg A, Barth C, Marelli C, Carioni P, van der Sande F, Kooman JP, Liu E, Toffelmire T, Wang Y, Thijssen S, Usvyat LA, Kotanko P. PMID: 26182958.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    45. Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study. PLoS One. 2015; 10(3):e0120770. Bouchard J, Malhotra R, Shah S, Kao YT, Vaida F, Gupta A, Berg DT, Grinnell BW, Stofan B, Tolwani AJ, Mehta RL. PMID: 25790110; PMCID: PMC4366245.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. Oliguria is an early predictor of higher mortality in critically ill patients. Kidney Int. 2011 Oct; 80(7):760-7. Macedo E, Malhotra R, Bouchard J, Wynn SK, Mehta RL. PMID: 21716258.
      View in: PubMed   Mentions: 117     Fields:    Translation:Humans
    47. Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16; 12:27. Kang SW, Shih PA, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, O'Connor DT. PMID: 21679467; PMCID: PMC3154145.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    48. Defining urine output criterion for acute kidney injury in critically ill patients. Nephrol Dial Transplant. 2011 Feb; 26(2):509-15. Macedo E, Malhotra R, Claure-Del Granado R, Fedullo P, Mehta RL. PMID: 20562094; PMCID: PMC3108356.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    49. Multiple myeloma bone marrow niche. Curr Pharm Biotechnol. 2009 Apr; 10(3):345-6. Basak GW, Srivastava AS, Malhotra R, Carrier E. PMID: 19355944.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    50. Potentials of ES cell therapy in neurodegenerative diseases. Curr Pharm Des. 2008; 14(36):3873-9. Srivastava AS, Malhotra R, Sharp J, Berggren T. PMID: 19128238.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    51. Ovarian recovery after stem cell transplantation. Bone Marrow Transplant. 2008 Feb; 41(3):275-8. Liu J, Malhotra R, Voltarelli J, Stracieri AB, Oliveira L, Simoes BP, Ball ED, Carrier E. PMID: 17952128.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    52. Prospects of embryonic stem cells in treatment of hematopoietic disorders. Curr Pharm Biotechnol. 2007 Oct; 8(5):305-17. Srivastava AS, Malhotra R, Esmaeli-Azad B, Lane T, Carrier E. PMID: 17979728.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    53. Embryonic stem cells ameliorate piroxicam-induced colitis in IL10-/- KO mice. Biochem Biophys Res Commun. 2007 Oct 05; 361(4):953-9. Srivastava AS, Feng Z, Mishra R, Malhotra R, Kim HS, Carrier E. PMID: 17692287.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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