Andrew Chisholm

Title(s)Professor, Neurobiology
SchoolAcademic Aff
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Cellular Dynamics of Axon Regeneration
    NIH/NINDS R01NS093588Jul 15, 2015 - Apr 30, 2024
    Role: Principal Investigator
    Development of a C. elegans model for axonal regeneration
    NIH/NINDS R01NS057317Jan 15, 2009 - Dec 31, 2014
    Role: Principal Investigator
    Development of a C.elegans model for axonal regeneration
    NIH/NINDS R56NS057317Dec 1, 2006 - Mar 31, 2015
    Role: Principal Investigator
    Santa Cruz Meetings on Developmental Biology
    NIH/NICHD R13HD048142Jul 1, 2004 - Jun 30, 2005
    Role: Principal Investigator
    Mechanisms of Tissue Morphogenesis in C. elegans
    NIH/NIGMS R01GM054657May 1, 1997 - Mar 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kim KW, Tang NH, Piggott CA, Andrusiak MG, Park S, Zhu M, Kurup N, Cherra SJ, Wu Z, Chisholm AD, Jin Y. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration. Elife. 2018 11 21; 7. PMID: 30461420.
      View in: PubMed
    2. Mulcahy B, Witvliet D, Holmyard D, Mitchell J, Chisholm AD, Samuel ADT, Zhen M. A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. Front Neural Circuits. 2018; 12:94. PMID: 30524248.
      View in: PubMed
    3. Noblett N, Wu Z, Ding ZH, Park S, Roenspies T, Flibotte S, Chisholm AD, Jin Y, Colavita A. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. J Cell Biol. 2019 Jan 07; 218(1):125-133. PMID: 30396999.
      View in: PubMed
    4. Gotenstein JR, Koo CC, Ho TW, Chisholm AD. Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. Genetics. 2018 04; 208(4):1499-1512. PMID: 29440357.
      View in: PubMed
    5. Kim KW, Tang NH, Andrusiak MG, Wu Z, Chisholm AD, Jin Y. A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans. Neuron. 2018 Feb 07; 97(3):511-519.e6. PMID: 29395906.
      View in: PubMed
    6. E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D. An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron. 2018 Jan 03; 97(1):125-138.e5. PMID: 29301098.
      View in: PubMed
    7. Wang S, Tang NH, Lara-Gonzalez P, Zhao Z, Cheerambathur DK, Prevo B, Chisholm AD, Desai A, Oegema K. A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans. Development. 2017 07 15; 144(14):2694-2701. PMID: 28619826.
      View in: PubMed
    8. Knowlton WM, Hubert T, Wu Z, Chisholm AD, Jin Y. A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans. Front Neurosci. 2017; 11:263. PMID: 28539870.
      View in: PubMed
    9. Chen F, Chisholm AD, Jin Y. Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development. Development. 2017 02 15; 144(4):698-707. PMID: 28087624.
      View in: PubMed
    10. Chisholm AD, Hutter H, Jin Y, Wadsworth WG. The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans. Genetics. 2016 Nov; 204(3):849-882. PMID: 28114100.
      View in: PubMed
    11. Chuang M, Hsiao TI, Tong A, Xu S, Chisholm AD. DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. Elife. 2016 09 23; 5. PMID: 27661253.
      View in: PubMed
    12. Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld MG, Fu XD, Chisholm AD, Jin Y. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife. 2016 06 02; 5. PMID: 27253061; PMCID: PMC4946901.
    13. Tang NH, Chisholm AD. Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. F1000Res. 2016; 5. PMID: 27350865; PMCID: PMC4892358.
    14. Xu S, Chisholm AD. Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. Sci Rep. 2016 Feb 10; 6:21271. PMID: 26861262; PMCID: PMC4748272.
    15. Xu S, Wang Z, Kim KW, Jin Y, Chisholm AD. Targeted Mutagenesis of Duplicated Genes in Caenorhabditis elegans Using CRISPR-Cas9. J Genet Genomics. 2016 Feb 20; 43(2):103-6. PMID: 26924693.
      View in: PubMed
    16. Venkatachalam V, Ji N, Wang X, Clark C, Mitchell JK, Klein M, Tabone CJ, Florman J, Ji H, Greenwood J, Chisholm AD, Srinivasan J, Alkema M, Zhen M, Samuel AD. Pan-neuronal imaging in roaming Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1082-8. PMID: 26711989.
      View in: PubMed
    17. Schwieterman AA, Steves AN, Yee V, Donelson CJ, Bentley MR, Santorella EM, Mehlenbacher TV, Pital A, Howard AM, Wilson MR, Ereddia DE, Effrein KS, McMurry JL, Ackley BD, Chisholm AD, Hudson ML. The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching. Genetics. 2016 Feb; 202(2):639-60. PMID: 26645816; PMCID: PMC4788240 [Available on 02/01/17].
    18. Chen L, Chuang M, Koorman T, Boxem M, Jin Y, Chisholm AD. Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase. Elife. 2015 Sep 04; 4. PMID: 26339988; PMCID: PMC4596636.
    19. Chisholm AD. Epidermal Wound Healing in the Nematode Caenorhabditis elegans. Adv Wound Care (New Rochelle). 2015 Apr 01; 4(4):264-271. PMID: 25945288.
      View in: PubMed
    20. Loer CM, Calvo AC, Watschinger K, Werner-Felmayer G, O'Rourke D, Stroud D, Tong A, Gotenstein JR, Chisholm AD, Hodgkin J, Werner ER, Martinez A. Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4). Genetics. 2015 May; 200(1):237-53. PMID: 25808955; PMCID: PMC4423366.
    21. Liu J, Chuang M, Chisholm A, Cosman P. Image registration robust to sparse large errors. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:1975-80. PMID: 26736672.
      View in: PubMed
    22. Chisholm AD. Deep reads: strands in the history of molecular genetics. PLoS Genet. 2014 Dec; 10(12):e1004887. PMID: 25521096; PMCID: PMC4270799.
    23. Xu S, Chisholm AD. Methods for skin wounding and assays for wound responses in C. elegans. J Vis Exp. 2014 Dec 03; (94). PMID: 25548955; PMCID: PMC4396949.
    24. Dejima K, Kang S, Mitani S, Cosman PC, Chisholm AD. Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans. Development. 2014 Nov; 141(22):4354-65. PMID: 25344071.
      View in: PubMed
    25. Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm AD. The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. Cell Rep. 2014 Nov 06; 9(3):874-83. PMID: 25437544; PMCID: PMC4250830.
    26. Xu S, Chisholm AD. C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Dev Cell. 2014 Oct 13; 31(1):48-60. PMID: 25313960; PMCID: PMC4197410.
    27. Kang S, Lee CY, Gonçalves M, Chisholm AD, Cosman PC. Tracking epithelial cell junctions in C. elegans embryogenesis with active contours guided by SIFT flow. IEEE Trans Biomed Eng. 2015 Apr; 62(4):1020-33. PMID: 24771564; PMCID: PMC4418224.
    28. Chuang M, Chisholm AD. Insights into the functions of the death associated protein kinases from C. elegans and other invertebrates. Apoptosis. 2014 Feb; 19(2):392-7. PMID: 24242918; PMCID: PMC3947127.
    29. Hubert T, Wu Z, Chisholm AD, Jin Y. S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans. J Neurosci. 2014 Jan 15; 34(3):758-63. PMID: 24431434; PMCID: PMC3891956.
    30. Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 2013 Sep 04; 79(5):903-16. PMID: 24012004; PMCID: PMC3779136.
    31. Grossman EN, Giurumescu CA, Chisholm AD. Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans. Genetics. 2013 Nov; 195(3):899-913. PMID: 23979582; PMCID: PMC3813872.
    32. Chisholm AD. Cytoskeletal dynamics in Caenorhabditis elegans axon regeneration. Annu Rev Cell Dev Biol. 2013; 29:271-97. PMID: 23844582.
      View in: PubMed
    33. Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P, Chisholm AD. Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos. Development. 2012 Nov; 139(22):4271-9. PMID: 23052905; PMCID: PMC3478691.
    34. Ghosh-Roy A, Goncharov A, Jin Y, Chisholm AD. Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration. Dev Cell. 2012 Oct 16; 23(4):716-28. PMID: 23000142; PMCID: PMC3477258.
    35. Chisholm AD, Hsiao TI. The Caenorhabditis elegans epidermis as a model skin. I: development, patterning, and growth. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; 1(6):861-78. PMID: 23539299; PMCID: PMC3607643.
    36. Chisholm AD, Xu S. The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; 1(6):879-902. PMID: 23539358; PMCID: PMC3607645.
    37. Xu S, Hsiao TI, Chisholm AD. The wounded worm: Using C. elegans to understand the molecular basis of skin wound healing. Worm. 2012 Apr 01; 1(2):134-8. PMID: 24058838; PMCID: PMC3670230.
    38. Xu S, Chisholm AD. A Gaq-Ca²? signaling pathway promotes actin-mediated epidermal wound closure in C. elegans. Curr Biol. 2011 Dec 06; 21(23):1960-7. PMID: 22100061; PMCID: PMC3237753.
    39. Chen L, Wang Z, Ghosh-Roy A, Hubert T, Yan D, O'Rourke S, Bowerman B, Wu Z, Jin Y, Chisholm AD. Axon regeneration pathways identified by systematic genetic screening in C. elegans. Neuron. 2011 Sep 22; 71(6):1043-57. PMID: 21943602; PMCID: PMC3183436.
    40. Chen L, Chisholm AD. Axon regeneration mechanisms: insights from C. elegans. Trends Cell Biol. 2011 Oct; 21(10):577-84. PMID: 21907582; PMCID: PMC3183269.
    41. Giurumescu CA, Chisholm AD. Cell identification and cell lineage analysis. Methods Cell Biol. 2011; 106:325-41. PMID: 22118283; PMCID: PMC4410678.
    42. Gotenstein JR, Swale RE, Fukuda T, Wu Z, Giurumescu CA, Goncharov A, Jin Y, Chisholm AD. The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration. Development. 2010 Nov; 137(21):3603-13. PMID: 20876652; PMCID: PMC2964093.
    43. Fakhouri TH, Stevenson J, Chisholm AD, Mango SE. Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. PLoS Genet. 2010 Aug 12; 6(8). PMID: 20714352; PMCID: PMC2920861.
    44. Ghosh-Roy A, Chisholm AD. Caenorhabditis elegans: a new model organism for studies of axon regeneration. Dev Dyn. 2010 May; 239(5):1460-4. PMID: 20186917; PMCID: PMC3069807.
    45. Ghosh-Roy A, Wu Z, Goncharov A, Jin Y, Chisholm AD. Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase. J Neurosci. 2010 Mar 03; 30(9):3175-83. PMID: 20203177; PMCID: PMC2921707.
    46. Kaminsky R, Denison C, Bening-Abu-Shach U, Chisholm AD, Gygi SP, Broday L. SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans. Dev Cell. 2009 Nov; 17(5):724-35. PMID: 19922876; PMCID: PMC2803632.
    47. Yan D, Wu Z, Chisholm AD, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009 Sep 04; 138(5):1005-18. PMID: 19737525; PMCID: PMC2772821.
    48. Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu YC, Pujol N, Chisholm AD. Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1457-61. PMID: 19164535; PMCID: PMC2629440.
    49. Ding M, King RS, Berry EC, Wang Y, Hardin J, Chisholm AD. The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PLoS One. 2008 Oct 03; 3(10):e3346. PMID: 18833327; PMCID: PMC2553197.
    50. Woo WM, Berry E, Hudson ML, Swale RE, Goncharov A, Chisholm AD. The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues. Development. 2008 Aug; 135(16):2747-2756. PMID: 18614580; PMCID: PMC2633776.
    51. Chisholm AD. Semaphorin signaling in morphogenesis: found in translation. Genes Dev. 2008 Apr 15; 22(8):955-9. PMID: 18413708; PMCID: PMC2732391.
    52. Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, Goncharov A, Jin Y, Chisholm AD, Ewbank JJ. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol. 2008 Apr 08; 18(7):481-9. PMID: 18394898.
      View in: PubMed
    53. Wu Z, Ghosh-Roy A, Yanik MF, Zhang JZ, Jin Y, Chisholm AD. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15132-7. PMID: 17848506; PMCID: PMC1975853.
    54. Nakao F, Hudson ML, Suzuki M, Peckler Z, Kurokawa R, Liu Z, Gengyo-Ando K, Nukazuka A, Fujii T, Suto F, Shibata Y, Shioi G, Fujisawa H, Mitani S, Chisholm AD, Takagi S. The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Genetics. 2007 Jul; 176(3):1591-607. PMID: 17507686; PMCID: PMC1931547.
    55. Chisholm AD. Gastrulation: Wnts signal constriction. Curr Biol. 2006 Oct 24; 16(20):R874-6. PMID: 17055968.
      View in: PubMed
    56. Nicot AS, Fares H, Payrastre B, Chisholm AD, Labouesse M, Laporte J. The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Mol Biol Cell. 2006 Jul; 17(7):3062-74. PMID: 16801682.
      View in: PubMed
    57. Hudson ML, Kinnunen T, Cinar HN, Chisholm AD. C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. Dev Biol. 2006 Jun 15; 294(2):352-65. PMID: 16677626.
      View in: PubMed
    58. Chisholm AD, Hardin J. Epidermal morphogenesis. WormBook. 2005 Dec 01; 1-22. PMID: 18050408.
      View in: PubMed
    59. Chisholm AD, Jin Y. Neuronal differentiation in C. elegans. Curr Opin Cell Biol. 2005 Dec; 17(6):682-9. PMID: 16242313.
      View in: PubMed
    60. Furuya M, Qadota H, Chisholm AD, Sugimoto A. The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6. Dev Biol. 2005 Oct 15; 286(2):452-63. PMID: 16154558.
      View in: PubMed
    61. Ackley BD, Harrington RJ, Hudson ML, Williams L, Kenyon CJ, Chisholm AD, Jin Y. The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation. J Neurosci. 2005 Aug 17; 25(33):7517-28. PMID: 16107639.
      View in: PubMed
    62. Nakata K, Abrams B, Grill B, Goncharov A, Huang X, Chisholm AD, Jin Y. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell. 2005 Feb 11; 120(3):407-20. PMID: 15707898.
      View in: PubMed
    63. Yanik MF, Cinar H, Cinar HN, Chisholm AD, Jin Y, Ben-Yakar A. Neurosurgery: functional regeneration after laser axotomy. Nature. 2004 Dec 16; 432(7019):822. PMID: 15602545.
      View in: PubMed
    64. Ding M, Woo WM, Chisholm AD. The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res. 2004 Nov 15; 301(1):84-90. PMID: 15501449.
      View in: PubMed
    65. Cinar HN, Chisholm AD. Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms. Genetics. 2004 Nov; 168(3):1307-22. PMID: 15579687; PMCID: PMC1448762.
    66. Zahler AM, Tuttle JD, Chisholm AD. Genetic suppression of intronic +1G mutations by compensatory U1 snRNA changes in Caenorhabditis elegans. Genetics. 2004 Aug; 167(4):1689-96. PMID: 15342508; PMCID: PMC1471001.
    67. Woo WM, Goncharov A, Jin Y, Chisholm AD. Intermediate filaments are required for C. elegans epidermal elongation. Dev Biol. 2004 Mar 01; 267(1):216-29. PMID: 14975728.
      View in: PubMed
    68. Ding M, Goncharov A, Jin Y, Chisholm AD. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development. 2003 Dec; 130(23):5791-801. PMID: 14534136.
      View in: PubMed
    69. Huang CC, Hall DH, Hedgecock EM, Kao G, Karantza V, Vogel BE, Hutter H, Chisholm AD, Yurchenco PD, Wadsworth WG. Laminin alpha subunits and their role in C. elegans development. Development. 2003 Jul; 130(14):3343-58. PMID: 12783803.
      View in: PubMed
    70. Bosher JM, Hahn BS, Legouis R, Sookhareea S, Weimer RM, Gansmuller A, Chisholm AD, Rose AM, Bessereau JL, Labouesse M. The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forces. J Cell Biol. 2003 May 26; 161(4):757-68. PMID: 12756232; PMCID: PMC2199363.
    71. Chin-Sang ID, Moseley SL, Ding M, Harrington RJ, George SE, Chisholm AD. The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Development. 2002 Dec; 129(23):5499-510. PMID: 12403719.
      View in: PubMed
    72. Harrington RJ, Gutch MJ, Hengartner MO, Tonks NK, Chisholm AD. The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development. 2002 May; 129(9):2141-53. PMID: 11959824.
      View in: PubMed