Sierra Simpson

Photo of Sierra Simpson
Title(s)Associate Project Scientist, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-1352-0617 Additional info
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    University of California Santa BarbaraBS06/2009Molecular, Cellular, and Developmental Biology
    Scripps Research PhD04/2020Neuroscience / Microbiome / Substance Use Disorders
    University of California San Diego 01/2023Post Doctoral Research

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors. Neuropsychopharmacology. 2026 May; 51(6):1074-1083. Kallupi M, de Guglielmo G, Carrette LLG, Simpson S, Kononoff J, Kimbrough A, Smith LC, Shankar K, Avelar A, Conlisk D, Brennan M, Tieu L, Sedighim S, Boomhower B, Maturin L, Fannon MJ, Martinez A, Crook C, Dirik S, Velarde N, Schweitzer P, Bonnet-Zahedi S, Sneddon E, Plasil S, Morgan AA, Othman DN, Sichel B, Peng B, Chitre AS, Polesskaya O, Lau J, Vang A, Solberg Woods LC, Palmer AA, George O. PMID: 41617925; PMCID: PMC13125645.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention. Commun Biol. 2025 Nov 06; 8(1):1525. Jinich-Diamant A, Simpson S, Zuniga-Hertz JP, Chitteti R, Schilling JM, Bonds JA, Case L, Chernov AV, Dispenza J, Maree J, Amkie Stahl NE, Licamele M, Fazlalipour N, Devulapalli S, Christov-Moore L, Reggente N, Poirier MA, Moeller-Bertram T, Patel HH. PMID: 41198896; PMCID: PMC12592435.
      View in: PubMed   Mentions: Translation:Humans
    3. Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats. bioRxiv. 2025 Jul 28. Lara MK, Carrette LLG, Sanches TM, Polesskaya O, Avelar A, Beeson A, Beldjoud H, Boomhower B, Brennan M, Chen D, China L, Chitre AS, Conlisk DE, Fannon M, Johnson BB, Keung E, Kimbrough A, Kononoff J, Martinez AR, Maturin L, Nguyen KM, Morgan A, Mosquera J, Othman D, Plasil SL, Ramborger J, Schweitzer P, Sedighim S, Seshie O, Shankar K, Sichel B, Simpson S, Smith LC, Sneddon EA, Tieu L, Velarde N, Zahedi S, Woods LCS, Kallupi M, de Guglielmo G, Palmer AA, George O. PMID: 40766591; PMCID: PMC12324211.
      View in: PubMed   Mentions:
    4. Multidimensional Analysis of Twin Sets During an Intensive Week-Long Meditation Retreat: A Pilot Study. Mindfulness (N Y). 2025; 16(6):1634-1655. Zuniga-Hertz JP, Simpson S, Chitetti R, Hsu CF, Huang HP, Jinich-Diamant A, Chernov AV, Onton JA, Cuomo R, Dispenza J, Davis D, Christov-Moore L, Reggente N, Gu W, Kong M, Bonds JA, Maree J, Simonson TS, Ahn AC, Poirier MA, Moeller-Bertram T, Patel HH. PMID: 40535580; PMCID: PMC12170707.
      View in: PubMed   Mentions: 1  
    5. Classification of Surgical Patients Needing Preoperative Cardiac Evaluations: A Comparison of General-Purpose and Domain-Specific Large Language Models. Anesth Analg. 2025 Jul 01; 141(1):223-225. Tully JL, Litake O, Meineke MN, Simpson S, Waterman RS, Gabriel RA. PMID: 39808709; PMCID: PMC12170157.
      View in: PubMed   Mentions:    Fields:    
    6. Associations Between Social Determinants of Health and Opioid-Use Disorder Among Chronic Pain Patients From a Multi-Institutional Dataset. Anesth Analg. 2025 11 01; 141(5):1149-1158. Do VM, Simpson S, Fisch KM, Gabriel RA. PMID: 39715077; PMCID: PMC12183315.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. The Association of Social Determinants of Health With Reported Daily Pain Scores Among Patients With a History of Chronic Pain Using the "All of Us" Research Program. Anesth Analg. 2025 Mar 01; 140(3):732-735. Park BH, Macias AA, Fisch KM, Simpson S, Chen J, Gabriel RA. PMID: 39661558; PMCID: PMC11805467.
      View in: PubMed   Mentions:    Fields:    
    8. On the development and validation of large language model-based classifiers for identifying social determinants of health. Proc Natl Acad Sci U S A. 2024 09 24; 121(39):e2320716121. Gabriel RA, Litake O, Simpson S, Burton BN, Waterman RS, Macias AA. PMID: 39284061; PMCID: PMC11441499.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Classifying High-Risk Patients for Persistent Opioid Use After Major Spine Surgery: A Machine-Learning Approach. Anesth Analg. 2024 10 01; 139(4):690-699. Simpson S, Zhong W, Mehdipour S, Armaneous M, Sathish V, Walker N, Said ET, Gabriel RA. PMID: 39284134; PMCID: PMC11972282.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. A Retrospective Analysis Investigating Whether Case Volume Experience of the Anesthesiologist Correlates with Intraoperative Efficiency for Joint Arthroplasty. J Med Syst. 2023 Nov 16; 47(1):119. Macias AA, Bongbong DN, Waterman RS, Simpson S, Gabriel RA. PMID: 37971577; PMCID: PMC10654185.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. eNeuro. 2021 May-Jun; 8(3). Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 33875455; PMCID: PMC8213442.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    12. The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches. Front Syst Neurosci. 2021; 15:595507. Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. PMID: 33967705; PMCID: PMC8097000.
      View in: PubMed   Mentions: 10  
    13. Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. 2020 May/Jun; 7(3). Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. PMID: 32341122; PMCID: PMC7242819.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    14. Role of corticotropin-releasing factor in alcohol and nicotine addiction. Brain Res. 2020 08 01; 1740:146850. Simpson S, Shankar K, Kimbrough A, George O. PMID: 32330519; PMCID: PMC7869920.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    15. Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology (Berl). 2020 May; 237(5):1545-1555. Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. PMID: 32114633; PMCID: PMC7269712.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    16. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. PMID: 30886240; PMCID: PMC6423296.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    17. Voluntary urination control by brainstem neurons that relax the urethral sphincter. Nat Neurosci. 2018 09; 21(9):1229-1238. Keller JA, Chen J, Simpson S, Wang EH, Lilascharoen V, George O, Lim BK, Stowers L. PMID: 30104734; PMCID: PMC6119086.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    18. A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chem Biol. 2012 Nov 21; 19(11):1460-70. Howery AE, Elvington S, Abraham SJ, Choi KH, Dworschak-Simpson S, Phillips S, Ryan CM, Sanford RL, Almqvist J, Tran K, Chew TA, Zachariae U, Andersen OS, Whitelegge J, Matulef K, Du Bois J, Maduke MC. PMID: 23177200; PMCID: PMC3508466.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
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