Christina Jamieson

Title(s)	Associate Professor In Residence, Urology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Overview

Dr. Jamieson's research is focused on elucidating mechanisms of therapy resistance in bone metastatic urologic cancers using patient-derived xenograft (PDX) models and 3D in vitro models. She is applying her expertise in genome-wide analyses of prostate cancer tumors and primary patient-derived tumor models to translate next generation genomics on prostate cancers into practical applications and novel therapies that will improve and, she hopes, eventually transform patient care.

Research Overview
Dr. Jamieson's research is focused on elucidating mechanisms of therapy resistance in bone metastatic urologic cancers using patient-derived xenograft (PDX) models and 3D in vitro models. She is applying her expertise in genome-wide analyses of prostate cancer tumors and primary patient-derived tumor models to translate next generation genomics on prostate cancers into practical applications and novel therapies that will improve and, she hopes, eventually transform patient care.

Research Topics
- Cancer
- Cell Biology
- Endocrinology
- Genomics
- Immunology
- Molecular Biology
- Regeneration/Stem Cells
- Translational Research

Current Project Titles
- Novel patient-derived xenograft models of bone metastatic prostate cancer.
- Genomic profiling of castration-resistant prostate cancer in the bone-niche.

Websites

Department of Surgery

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma. Cancer Med. 2024 Apr; 13(7):e7148. Meagher M, Krause H, Elliott A, Farrell A, Antonarakis ES, Bastos B, Heath EI, Jamieson C, Stewart TF, Bagrodia A, Nabhan C, Oberley M, McKay RR, Salmasi A. PMID: 38558536; PMCID: PMC10983807.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Humans Cells
Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase. Cancer Res. 2023 12 15; 83(24):4142-4160. Rawat C, Ben-Salem S, Singh N, Chauhan G, Rabljenovic A, Vaghela V, Venkadakrishnan VB, Macdonald JD, Dahiya UR, Ghanem Y, Bachour S, Su Y, DePriest AD, Lee S, Muldong M, Kim HT, Kumari S, Valenzuela MM, Zhang D, Hu Q, Cortes Gomez E, Dehm SM, Zoubeidi A, Jamieson CAM, Nicolas M, McKenney J, Willard B, Klein EA, Magi-Galluzzi C, Stauffer SR, Liu S, Heemers HV. PMID: 37801613; PMCID: PMC10841833.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Humans Cells
A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE). Mol Cancer Ther. 2023 04 03; 22(4):511-518. Pan E, Xie W, Ajmera A, Araneta A, Jamieson C, Folefac E, Hussain A, Kyriakopoulos CE, Olson A, Parikh M, Parikh R, Saraiya B, Ivy SP, Van Allen EM, Lindeman NI, Kochupurakkal BS, Shapiro GI, McKay RR. PMID: 36780008; PMCID: PMC10769512.

View in: PubMed Mentions: 8 Fields:
Ant Antineoplastic Agents
Translation:Humans CTClinical Trials
A Phase 2, Double-blind, Randomized Controlled Trial of PROSTVAC in Prostate Cancer Patients on Active Surveillance. Eur Urol Focus. 2023 May; 9(3):447-454. Parsons JK, Pinto PA, Pavlovich CP, Uchio E, Nguyen MN, Kim HL, Gulley JL, Sater HA, Jamieson C, Hsu CH, Wojtowicz M, House M, Schlom J, Donahue RN, Dahut WL, Madan RA, Bailey S, Centuori S, Bauman JE, Parnes HL, Chow HS. PMID: 36517408; PMCID: PMC10258223.

View in: PubMed Mentions: Fields:
Uro Urology
Translation:Humans Animals CTClinical Trials
RE: Cancer Stage, Treatment, and Survival Among Transgender Patients in the United States. J Natl Cancer Inst. 2022 08 08; 114(8):1203-1204. Javier-DesLoges J, Salmasi A, Jamieson CA, Anger JT. PMID: 35191502; PMCID: PMC9360451.

View in: PubMed Mentions: 1 Fields:
Neo Neoplasms
Translation:Humans
Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids. Int J Mol Sci. 2022 Mar 16; 23(6). Lee S, Mendoza TR, Burner DN, Muldong MT, Wu CCN, Arreola-Villanueva C, Zuniga A, Greenburg O, Zhu WY, Murtadha J, Koutouan E, Pineda N, Pham H, Kang SG, Kim HT, Pineda G, Lennon KM, Cacalano NA, Jamieson CHM, Kane CJ, Kulidjian AA, Gaasterland T, Jamieson CAM. PMID: 35328625; PMCID: PMC8952299.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Animals Cells
A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand. Sci Adv. 2021 08; 7(33). Lee SC, Ma JSY, Kim MS, Laborda E, Choi SH, Hampton EN, Yun H, Nunez V, Muldong MT, Wu CN, Ma W, Kulidjian AA, Kane CJ, Klyushnichenko V, Woods AK, Joseph SB, Petrassi M, Wisler J, Li J, Jamieson CAM, Schultz PG, Kim CH, Young TS. PMID: 34380625; PMCID: PMC8357232.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Humans Animals Cells
Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Zhou Y, Bastian IN, Long MD, Dow M, Li W, Liu T, Ngu RK, Antonucci L, Huang JY, Phung QT, Zhao XH, Banerjee S, Lin XJ, Wang H, Dang B, Choi S, Karin D, Su H, Ellisman MH, Jamieson C, Bosenberg M, Cheng Z, Haybaeck J, Kenner L, Fisch KM, Bourgon R, Hernandez G, Lill JR, Liu S, Carter H, Mellman I, Karin M, Shalapour S. PMID: 33602823; PMCID: PMC7923353.

View in: PubMed Mentions: 29 Fields:
Sci Science
Translation:Humans Animals Cells
Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 05 28; 18(1):214. Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781; PMCID: PMC7257145.

View in: PubMed Mentions: 16 Fields:
Med Medicine (General)
Translation:Humans Animals Cells CTClinical Trials
The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis. Cancers (Basel). 2020 May 07; 12(5). Crumbaker M, Chan EKF, Gong T, Corcoran N, Jaratlerdsiri W, Lyons RJ, Haynes AM, Kulidjian AA, Kalsbeek AMF, Petersen DC, Stricker PD, Jamieson CAM, Croucher PI, Hovens CM, Joshua AM, Hayes VM. PMID: 32392735; PMCID: PMC7280976.

View in: PubMed Mentions: 6
Establishment and Analysis of Three-Dimensional (3D) Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts. J Vis Exp. 2020 02 03; (156). Lee S, Burner DN, Mendoza TR, Muldong MT, Arreola C, Wu CN, Cacalano NA, Kulidjian AA, Kane CJ, Jamieson CAM. PMID: 32065165.

View in: PubMed Mentions: 7 Fields:
Bio Biology Med Medicine (General)
Translation:Humans
Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC. Am J Clin Exp Urol. 2019; 7(4):297-312. Toth RK, Tran JD, Muldong MT, Nollet EA, Schulz VV, Jensen CC, Hazlehurst LA, Corey E, Durden D, Jamieson C, Miranti CK, Warfel NA. PMID: 31511835; PMCID: PMC6734039.

View in: PubMed Mentions: 16
Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy. Oncogene. 2019 06; 38(23):4496-4511. Venkadakrishnan VB, DePriest AD, Kumari S, Senapati D, Ben-Salem S, Su Y, Mudduluru G, Hu Q, Cortes E, Pop E, Mohler JL, Azabdaftari G, Attwood K, Shah RB, Jamieson C, Dehm SM, Magi-Galluzzi C, Klein E, Sharifi N, Liu S, Heemers HV. PMID: 30742064; PMCID: PMC6771259.

View in: PubMed Mentions: 6 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Humans Animals Cells
A Randomized, Double-blind, Phase II Trial of PSA-TRICOM (PROSTVAC) in Patients with Localized Prostate Cancer: The Immunotherapy to Prevent Progression on Active Surveillance Study. Eur Urol Focus. 2018 09; 4(5):636-638. Parsons JK, Pinto PA, Pavlovich CP, Uchio E, Kim HL, Nguyen MN, Gulley JL, Jamieson C, Hsu P, Wojtowicz M, Parnes H, Schlom J, Dahut WL, Madan RA, Donahue RN, Chow HS. PMID: 30197041; PMCID: PMC7524340.

View in: PubMed Mentions: 10 Fields:
Uro Urology
Translation:Humans CTClinical Trials
Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer. Asian J Urol. 2016 Oct; 3(4):229-239. Hirata T, Park SC, Muldong MT, Wu CN, Yamaguchi T, Strasner A, Raheem O, Kumon H, Sah RL, Cacalano NA, Jamieson CHM, Kane CJ, Masuda K, Kulidjian AA, Jamieson CAM. PMID: 29264191; PMCID: PMC5730873.

View in: PubMed Mentions: 4
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. PMID: 25924065; PMCID: PMC4501632.

View in: PubMed Mentions: 270 Fields:
Sci Science
Translation:Humans Animals Cells
PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche. J Transl Med. 2014 Oct 03; 12:275. Godebu E, Muldong M, Strasner A, Wu CN, Park SC, Woo JR, Ma W, Liss MA, Hirata T, Raheem O, Cacalano NA, Kulidjian AA, Jamieson CA. PMID: 25278011; PMCID: PMC4192441.

View in: PubMed Mentions: 18 Fields:
Med Medicine (General)
Translation:Humans Animals
Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81. Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. PMID: 25267627; PMCID: PMC4205637.

View in: PubMed Mentions: 108 Fields:
Sci Science
Translation:Humans Animals Cells
Tumor infiltrating B-cells are increased in prostate cancer tissue. J Transl Med. 2014 Jan 30; 12:30. Woo JR, Liss MA, Muldong MT, Palazzi K, Strasner A, Ammirante M, Varki N, Shabaik A, Howell S, Kane CJ, Karin M, Jamieson CA. PMID: 24475900; PMCID: PMC3914187.

View in: PubMed Mentions: 90 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. PMID: 23333150; PMCID: PMC3968867.

View in: PubMed Mentions: 107 Fields:
Cel Cell Biology
Translation:Humans Cells
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PMID: 22768113; PMCID: PMC3387267.

View in: PubMed Mentions: 16 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011 Oct 28; 9:185. Raheem O, Kulidjian AA, Wu C, Jeong YB, Yamaguchi T, Smith KM, Goff D, Leu H, Morris SR, Cacalano NA, Masuda K, Jamieson CH, Kane CJ, Jamieson CA. PMID: 22035283; PMCID: PMC3269442.

View in: PubMed Mentions: 25 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation. Neuromuscul Disord. 2010 Feb; 20(2):111-21. Belanto JJ, Diaz-Perez SV, Magyar CE, Maxwell MM, Yilmaz Y, Topp K, Boso G, Jamieson CH, Cacalano NA, Jamieson CA. PMID: 20080405; PMCID: PMC2856642.

View in: PubMed Mentions: 25 Fields:
Neu Neurology
Translation:Animals Cells
Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency. J Gen Virol. 2010 Feb; 91(Pt 2):463-9. Peng L, Wu TT, Tchieu JH, Feng J, Brown HJ, Feng J, Li X, Qi J, Deng H, Vivanco I, Mellinghoff IK, Jamieson C, Sun R. PMID: 19864499; PMCID: PMC2888311.

View in: PubMed Mentions: 32 Fields:
Vir Virology
Translation:Humans Animals Cells
SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal. 2008 Dec; 20(12):2221-30. Sitko JC, Yeh B, Kim M, Zhou H, Takaesu G, Yoshimura A, McBride WH, Jewett A, Jamieson CA, Cacalano NA. PMID: 18793717; PMCID: PMC2676910.

View in: PubMed Mentions: 23 Fields:
Cel Cell Biology
Translation:Animals Cells
Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin Cancer Res. 2007 Apr 15; 13(8):2344-53. Zhou H, Miki R, Eeva M, Fike FM, Seligson D, Yang L, Yoshimura A, Teitell MA, Jamieson CA, Cacalano NA. PMID: 17438093.

View in: PubMed Mentions: 53 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Identification of process-localized mRNAs from cultured rodent hippocampal neurons. J Neurosci. 2006 Dec 20; 26(51):13390-9. Poon MM, Choi SH, Jamieson CA, Geschwind DH, Martin KC. PMID: 17182790; PMCID: PMC6675000.

View in: PubMed Mentions: 125 Fields:
Neu Neurology
Translation:Animals Cells
Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7319-24. Jamieson CA, Yamamoto KR. PMID: 10860997; PMCID: PMC16543.

View in: PubMed Mentions: 24 Fields:
Sci Science
Translation:Animals Cells