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    Nigel Calcutt

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-534-5331
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      Collapse Research 
      Collapse Research Activities and Funding
      Muscarinic receptor antagonists as a therapy for diabetic neuropathy
      NIH/NIDDK R21DK102032Aug 1, 2014 - Jul 31, 2016
      Role: Principal Investigator
      Cholinergic constraint and diabetic neuropathy
      NIH/NINDS R01NS081082Jul 1, 2013 - Jun 30, 2018
      Role: Principal Investigator
      Non Phamacologic Treatments for Diabetic Neuropathy
      NIH/NINDS R21NS062346Feb 1, 2009 - Jan 31, 2012
      Role: Principal Investigator
      Near Infra Red Energy To Treat Diabetic Neuropathy
      NIH/NINDS R21NS050232Jul 1, 2005 - Jun 30, 2007
      Role: Principal Investigator
      Mechanisms of Spinally-Mediated Hyperalgesia in Diabetes
      NIH/NIDDK R01DK057629Apr 1, 2000 - Jul 31, 2014
      Role: Principal Investigator
      PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
      NIH/NINDS R01NS038855Sep 30, 1999 - Aug 31, 2004
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Aghanoori MR, Smith DR, Roy Chowdhury S, Sabbir MG, Calcutt N, Fernyhough P. Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats. Exp Neurol. 2017 Nov; 297:148-157. PMID: 28803751.
        View in: PubMed
      2. Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, Frizzi K, Tavakoli M, Jeziorska M, Jolivalt CG, Boulton AJM, Efron N, Calcutt N, Malik RA. Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Diabetes. 2017 May; 66(5):1380-1390. PMID: 28202580.
        View in: PubMed
      3. Calcutt N, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J Clin Invest. 2017 Feb 01; 127(2):608-622. PMID: 28094765.
        View in: PubMed
      4. Jolivalt CG, Frizzi KE, Guernsey L, Marquez A, Ochoa J, Rodriguez M, Calcutt N. Peripheral Neuropathy in Mouse Models of Diabetes. Curr Protoc Mouse Biol. 2016 Sep 01; 6(3):223-55. PMID: 27584552; PMCID: PMC5023323 [Available on 09/01/17].
      5. Calcutt N, Fernyhough P. A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:3-8. PMID: 27133141.
        View in: PubMed
      6. Calcutt N, Fernyhough P. An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:45-52. PMID: 27133144.
        View in: PubMed
      7. Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt N, Delgado-Lezama R, Marsala M, Granados-Soto V. The a5 subunit containing GABAA receptors contribute to chronic pain. Pain. 2016 Mar; 157(3):613-26. PMID: 26545088; PMCID: PMC4950669 [Available on 03/01/17].
      8. Rocca CJ, Kreymerman A, Ur SN, Frizzi KE, Naphade S, Lau A, Tran T, Calcutt N, Goldberg JL, Cherqui S. Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7214-23. PMID: 26540660; PMCID: PMC4640476.
      9. Hollis ER, Ishiko N, Pessian M, Tolentino K, Lee-Kubli CA, Calcutt N, Zou Y. Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery. Nat Commun. 2015 Jan 19; 6:6079. PMID: 25597627; PMCID: PMC4831586.
      10. Hollis ER, Ishiko N, Tolentino K, Doherty E, Rodriguez MJ, Calcutt N, Zou Y. A novel and robust conditioning lesion induced by ethidium bromide. Exp Neurol. 2015 Mar; 265:30-9. PMID: 25541322; PMCID: PMC4346483.
      11. Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt N, Fernyhough P. Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents. Cell Mol Neurobiol. 2014 Jul; 34(5):643-9. PMID: 24682898.
        View in: PubMed
      12. Lee-Kubli CA, Mixcoatl-Zecuatl T, Jolivalt CG, Calcutt N. Animal models of diabetes-induced neuropathic pain. Curr Top Behav Neurosci. 2014; 20:147-70. PMID: 24510303.
        View in: PubMed
      13. Lee-Kubli CA, Calcutt N. Painful neuropathy: Mechanisms. Handb Clin Neurol. 2014; 126:533-57. PMID: 25410243.
        View in: PubMed
      14. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt N. Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst. 2013 Dec; 18(4):306-15. PMID: 24147903; PMCID: PMC3981941.
      15. Calcutt N. Location, location, location?: is the pain of diabetic neuropathy generated by hyperactive sensory neurons? Diabetes. 2013 Nov; 62(11):3658-60. PMID: 24158992; PMCID: PMC3806595.
      16. Lee-Kubli CA, Calcutt N. Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain. Pain. 2014 Feb; 155(2):250-60. PMID: 24103402; PMCID: PMC3946970.
      17. Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt N, Fernyhough P, Kotra LP. Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy. J Med Chem. 2013 Jun 27; 56(12):5071-8. PMID: 23758573.
        View in: PubMed
      18. Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi KE, Calcutt N, Fernyhough P. Ciliary neurotrophic factor activates NF-?B to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents. Neuropharmacology. 2013 Feb; 65:65-73. PMID: 23022047; PMCID: PMC3521091.
      19. Gregory JA, Jolivalt CG, Goor J, Mizisin AP, Calcutt N. Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats. Acta Neuropathol. 2012 Oct; 124(4):561-73. PMID: 22791295.
        View in: PubMed
      20. Roy Chowdhury SK, Smith DR, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt N, Fernyhough P. Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes. Brain. 2012 Jun; 135(Pt 6):1751-66. PMID: 22561641; PMCID: PMC3359752.
      21. Landgraf RR, Garrett TJ, Conaway MC, Calcutt N, Stacpoole PW, Yost RA. Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging. Rapid Commun Mass Spectrom. 2011 Oct 30; 25(20):3178-84. PMID: 21953974; PMCID: PMC3926214.
      22. Li W, James MO, McKenzie SC, Calcutt N, Liu C, Stacpoole PW. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther. 2011 Jan; 336(1):87-94. PMID: 20884751; PMCID: PMC3014303.
      23. Calcutt N. Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy. ASN Neuro. 2010 Sep 09; 2(4):e00042. PMID: 20842208; PMCID: PMC2936743.
      24. Davidson EP, Coppey LJ, Calcutt N, Oltman CL, Yorek MA. Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction. Diabetes Metab Res Rev. 2010 May; 26(4):306-18. PMID: 20503263; PMCID: PMC2878284.
      25. Davidson E, Coppey L, Lu B, Arballo V, Calcutt N, Gerard C, Yorek M. The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy. Exp Diabetes Res. 2009; 2009:431980. PMID: 20148083; PMCID: PMC2817866.
      26. Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt N, Fernyhough P. Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes. 2010 Apr; 59(4):1082-91. PMID: 20103706; PMCID: PMC2844817.
      27. Fernyhough P, Calcutt N. Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium. 2010 Feb; 47(2):130-9. PMID: 20034667; PMCID: PMC2834846.
      28. Calcutt N, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin AP, Stacpoole PW. Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol. 2009 Sep; 68(9):985-93. PMID: 19680144; PMCID: PMC2741559.
      29. Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt N. Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. J Magn Reson Imaging. 2009 Aug; 30(2):271-6. PMID: 19629995; PMCID: PMC2742673.
      30. Calcutt N, Cooper ME, Kern TS, Schmidt AM. Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov. 2009 May; 8(5):417-29. PMID: 19404313.
        View in: PubMed
      31. Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt N. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol. 2009 Jun 10; 612(1-3):41-7. PMID: 19393643.
        View in: PubMed
      32. Jolivalt CG, Lee CA, Ramos KM, Calcutt N. Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain. 2008 Nov 15; 140(1):48-57. PMID: 18755547; PMCID: PMC2593464.
      33. Beiswenger KK, Calcutt N, Mizisin AP. Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neurosci Lett. 2008 Sep 19; 442(3):267-72. PMID: 18619518; PMCID: PMC2610845.
      34. Cunha JM, Jolivalt CG, Ramos KM, Gregory JA, Calcutt N, Mizisin AP. Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism. 2008 Jul; 57(7):873-81. PMID: 18555826; PMCID: PMC2518323.
      35. Jolivalt CG, Vu Y, Mizisin LM, Mizisin AP, Calcutt N. Impaired prosaposin secretion during nerve regeneration in diabetic rats and protection of nerve regeneration by a prosaposin-derived peptide. J Neuropathol Exp Neurol. 2008 Jul; 67(7):702-10. PMID: 18596543; PMCID: PMC2748883.
      36. Beiswenger KK, Calcutt N, Mizisin AP. Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochem. 2008; 110(5):351-62. PMID: 18384843; PMCID: PMC2561960.
      37. Calcutt N, Jolivalt CG, Fernyhough P. Growth factors as therapeutics for diabetic neuropathy. Curr Drug Targets. 2008 Jan; 9(1):47-59. PMID: 18220712.
        View in: PubMed
      38. Calcutt N, Backonja MM. Pathogenesis of pain in peripheral diabetic neuropathy. Curr Diab Rep. 2007 Dec; 7(6):429-34. PMID: 18255005.
        View in: PubMed
      39. Landgraf RR, Garrett TJ, Calcutt N, Stacpoole PW, Yost RA. MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue. Anal Chem. 2007 Nov 01; 79(21):8170-5. PMID: 17894472.
        View in: PubMed
      40. Jolivalt CG, Dacunha JM, Esch FS, Calcutt N. Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. 2008 Jan; 12(1):76-81. PMID: 17466547.
        View in: PubMed
      41. Ramos KM, Jiang Y, Svensson CI, Calcutt N. Pathogenesis of spinally mediated hyperalgesia in diabetes. Diabetes. 2007 Jun; 56(6):1569-76. PMID: 17287466.
        View in: PubMed
      42. Jiang Y, Calcutt N, Ramos KM, Rames KM, Mizisin AP. Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats. J Peripher Nerv Syst. 2006 Dec; 11(4):274-85. PMID: 17117935.
        View in: PubMed
      43. Malmberg AB, O'Connor WT, Glennon JC, Ceseña R, Calcutt N. Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats. Brain Res. 2006 Oct 18; 1115(1):48-53. PMID: 16920081.
        View in: PubMed
      44. Calcutt N, Freshwater JD, Hauptmann N, Taylor EM, Mizisin AP. Protection of sensory function in diabetic rats by Neotrofin. Eur J Pharmacol. 2006 Mar 18; 534(1-3):187-93. PMID: 16507305.
        View in: PubMed
      45. Jolivalt CG, Ramos KM, Herbetsson K, Esch FS, Calcutt N. Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia. Pain. 2006 Mar; 121(1-2):14-21. PMID: 16480831.
        View in: PubMed
      46. Malmberg AB, Mizisin AP, Calcutt N, von Stein T, Robbins WR, Bley KR. Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain. 2004 Oct; 111(3):360-7. PMID: 15363880.
        View in: PubMed
      47. Mizisin AP, Vu Y, Shuff M, Calcutt N. Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats. Diabetes. 2004 Jul; 53(7):1807-12. PMID: 15220205.
        View in: PubMed
      48. Calcutt N. Experimental models of painful diabetic neuropathy. J Neurol Sci. 2004 May 15; 220(1-2):137-9. PMID: 15140623.
        View in: PubMed
      49. Calcutt N, Freshwater JD, Mizisin AP. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr; 47(4):718-24. PMID: 15298349.
        View in: PubMed
      50. Calcutt N. Modeling diabetic sensory neuropathy in rats. Methods Mol Med. 2004; 99:55-65. PMID: 15131329.
        View in: PubMed
      51. Garcia ML, Lobsiger CS, Shah SB, Deerinck TJ, Crum J, Young D, Ward CM, Crawford TO, Gotow T, Uchiyama Y, Ellisman MH, Calcutt N, Cleveland DW. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol. 2003 Dec 08; 163(5):1011-20. PMID: 14662745; PMCID: PMC2173620.
      52. Sayers NM, Beswick LJ, Middlemas A, Calcutt N, Mizisin AP, Tomlinson DR, Fernyhough P. Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Diabetes. 2003 Sep; 52(9):2372-80. PMID: 12941778.
        View in: PubMed
      53. Svensson CI, Marsala M, Westerlund A, Calcutt N, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. PMID: 12950462.
        View in: PubMed
      54. Huang TJ, Price SA, Chilton L, Calcutt N, Tomlinson DR, Verkhratsky A, Fernyhough P. Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes. 2003 Aug; 52(8):2129-36. PMID: 12882932.
        View in: PubMed
      55. Calcutt N, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14. PMID: 12588889; PMCID: PMC151919.
      56. Calcutt N. Future treatments for diabetic neuropathy: clues from experimental neuropathy. Curr Diab Rep. 2002 Dec; 2(6):482-8. PMID: 12643154.
        View in: PubMed
      57. Freshwater JD, Svensson CI, Malmberg AB, Calcutt N. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Diabetes. 2002 Jul; 51(7):2249-55. PMID: 12086957.
        View in: PubMed
      58. Calcutt N. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol. 2002; 50:205-28. PMID: 12198811.
        View in: PubMed
      59. Calcutt N, Freshwater JD, O'Brien JS. Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiology. 2000 Nov; 93(5):1271-8. PMID: 11046216.
        View in: PubMed
      60. Calcutt N, Stiller C, Gustafsson H, Malmberg AB. Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats. Brain Res. 2000 Feb 21; 856(1-2):20-7. PMID: 10677607.
        View in: PubMed
      61. Calcutt N, Chen P, Hua XY. Effects of diabetes on tissue content and evoked release of calcitonin gene-related peptide-like immunoreactivity from rat sensory nerves. Neurosci Lett. 1998 Oct 02; 254(3):129-32. PMID: 10214974.
        View in: PubMed