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    Maike Sander

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Collapse Overview 
      Collapse Overview
      Our laboratory studies the molecular mechanisms that underlie the differentiation, function and regeneration of cells in the pancreas. We investigate these mechanisms in the context of normal physiology, diabetes and cancer. In our research, we combine of variety experimental systems, including mouse genetics, a human embryonic stem cell-based in vitro differentiation platform, as well as genomic and biochemical approaches.
      In recent studies, we mapped dynamic changes in the transcriptome and epigenome during the progression of pluripotent stem cells toward the pancreatic fate and discovered how chromatin remodeling events prepare developmental precursors to receive and correctly interpret organ-inductive signals. In current work, we are exploring how the cellular environment shapes the epigenome and thereby influences cellular phenotypes in the pancreas. Such knowledge will likely yield an understanding of the mechanisms underlying diseases influenced by both environmental and genetic factors, such as diabetes.

      Research Focus Areas:

    • Developmental Biology

    • Genetics and Genomics

    • Gene Expression and Regulation

    • Stem Cell Biology

    • Collapse Research 
      Collapse Research Activities and Funding
      Fine-mapping and functional analysis of T1D-associated variants
      NIH/NIDDK DP3DK112155Sep 30, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Functional Analysis of T2D Associated Non-coding SNPs
      NIH/NIDDK U01DK105541May 1, 2015 - Apr 30, 2020
      Role: Principal Investigator
      A novel mouse model to identify biomarkers of IPMN formation and progression
      NIH/NCI R21CA194839Apr 1, 2015 - Mar 31, 2017
      Role: Principal Investigator
      A 3-D biomimetic human islet to model beta cell function in health and disease
      NIH/NIDDK UC4DK104202Sep 20, 2014 - Jun 30, 2019
      Role: Principal Investigator
      Epigenetic strategies for the in vitro generation of replacement beta cells
      NIH/NIDDK U01DK089567Sep 17, 2010 - Jun 30, 2014
      Role: Principal Investigator
      Mechanisms of pancreatic endocrine cell differentiation
      NIH/NIDDK R01DK078803Sep 1, 2007 - Jun 30, 2017
      Role: Principal Investigator
      Epigenetic determinants of beta cell development and function
      NIH/NIDDK R01DK068471Jun 1, 2004 - Jul 31, 2021
      Role: Principal Investigator
      Diabetes Research Center (DRC)
      NIH/NIDDK P30DK063491Dec 1, 2002 - Apr 30, 2018
      Role: Co-Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Carrano AC, Mulas F, Zeng C, Sander M. Interrogating islets in health and disease with single-cell technologies. Mol Metab. 2017 Sep; 6(9):991-1001. PMID: 28951823.
        View in: PubMed
      2. Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. PMID: 28467932.
        View in: PubMed
      3. Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ß cells. J Clin Invest. 2017 Jan 03; 127(1):215-229. PMID: 27941246.
        View in: PubMed
      4. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
      5. Shih HP, Panlasigui D, Cirulli V, Sander M. ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis. Cell Rep. 2016 Jan 12; 14(2):169-79. PMID: 26748698; PMCID: PMC4715768.
      6. Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015 Oct 13; 13(2):326-36. PMID: 26440894; PMCID: PMC4607666.
      7. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. PMID: 26276631; PMCID: PMC4545590.
      8. Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M. Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell. 2015 Apr 02; 16(4):386-99. PMID: 25842977; PMCID: PMC4478079.
      9. Xie R, Carrano AC, Sander M. A systems view of epigenetic networks regulating pancreas development and ß-cell function. Wiley Interdiscip Rev Syst Biol Med. 2015 Jan-Feb; 7(1):1-11. PMID: 25644779; PMCID: PMC4339621.
      10. Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M. Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. PLoS One. 2014; 9(10):e109171. PMID: 25285789; PMCID: PMC4186865.
      11. Taylor BL, Benthuysen J, Sander M. Postnatal ß-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1. Diabetes. 2015 Mar; 64(3):897-903. PMID: 25277396; PMCID: PMC4338594.
      12. Shih HP, Sander M. Pancreas development ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional Matrigel™. Methods Mol Biol. 2014; 1210:229-37. PMID: 25173172; PMCID: PMC4423897.
      13. Kopp JL, Sander M. New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions? Gastroenterology. 2014 Jan; 146(1):24-6. PMID: 24275238.
        View in: PubMed
      14. Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4456-64. PMID: 24191021; PMCID: PMC3839746.
      15. Taylor BL, Liu FF, Sander M. Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 2013 Sep 26; 4(6):1262-75. PMID: 24035389; PMCID: PMC4058003.
      16. Shih HP, Wang A, Sander M. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol. 2013; 29:81-105. PMID: 23909279.
        View in: PubMed
      17. Jin L, Feng T, Shih HP, Zerda R, Luo A, Hsu J, Mahdavi A, Sander M, Tirrell DA, Riggs AD, Ku HT. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):3907-12. PMID: 23431132; PMCID: PMC3593860.
      18. Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013; 9(1):e1003274. PMID: 23382704; PMCID: PMC3561089.
      19. Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 2013 Feb 07; 12(2):224-37. PMID: 23318056; PMCID: PMC3619036.
      20. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Dec 11; 22(6):737-50. PMID: 23201164; PMCID: PMC3568632.
      21. Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep; 139(18):3363-72. PMID: 22874919; PMCID: PMC3424044.
      22. Wang A, Sander M. Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells. J Mol Med (Berl). 2012 Jul; 90(7):763-71. PMID: 22714642.
        View in: PubMed
      23. Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin-Botton A, Sander M. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development. 2012 Jul; 139(14):2488-99. PMID: 22675211; PMCID: PMC3383226.
      24. Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M. Transgenic overexpression of the transcription factor Nkx6.1 in ß-cells of mice does not increase ß-cell proliferation, ß-cell mass, or improve glucose clearance. Mol Endocrinol. 2011 Nov; 25(11):1904-14. PMID: 21964593; PMCID: PMC3198960.
      25. Dubois CL, Shih HP, Seymour PA, Patel NA, Behrmann JM, Ngo V, Sander M. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One. 2011; 6(8):e23131. PMID: 21829703; PMCID: PMC3149078.
      26. Kopp JL, Dubois CL, Hao E, Thorel F, Herrera PL, Sander M. Progenitor cell domains in the developing and adult pancreas. Cell Cycle. 2011 Jun 15; 10(12):1921-7. PMID: 21558806; PMCID: PMC3154415.
      27. Seymour PA, Sander M. Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes. 2011 Feb; 60(2):364-76. PMID: 21270248; PMCID: PMC3028333.
      28. Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb; 138(4):653-65. PMID: 21266405; PMCID: PMC3026412.
      29. Schaffer AE, Freude KK, Nelson SB, Sander M. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell. 2010 Jun 15; 18(6):1022-9. PMID: 20627083; PMCID: PMC3133668.
      30. Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 01; 323(1):19-30. PMID: 18723011; PMCID: PMC2879081.
      31. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15; 318(2):224-35. PMID: 18452912; PMCID: PMC2478757.
      32. Nelson SB, Schaffer AE, Sander M. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development. 2007 Jul; 134(13):2491-500. PMID: 17537793.
        View in: PubMed
      33. Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M. NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development. 2005 Jul; 132(13):3139-49. PMID: 15944193.
        View in: PubMed
      34. Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M. Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec; 130(25):6221-31. PMID: 14602683.
        View in: PubMed