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Matthew Wortham

Title(s)Assistant Project Scientist, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    The role of LSD1 in adaptive insulin secretion
    NIH/NIDDK F32DK102239Sep 18, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1ß is associated with changes in expression of beta-cell maturity genes and associated histone modifications. Mol Cell Endocrinol. 2019 10 01; 496:110524. Ibarra Urizar A, Prause M, Wortham M, Sui Y, Thams P, Sander M, Christensen GL, Billestrup N. PMID: 31362031.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Mechanisms of ß-cell functional adaptation to changes in workload. Diabetes Obes Metab. 2016 09; 18 Suppl 1:78-86. Wortham M, Sander M. PMID: 27615135.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. High T Gives ß Cells a Boost. Cell Metab. 2016 May 10; 23(5):761-3. Wortham M, Sander M. PMID: 27166938.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma. PLoS One. 2014; 9(9):e107156. Wortham M, Guo C, Zhang M, Song L, Lee BK, Iyer VR, Furey TS, Crawford GE, Yan H, He Y. PMID: 25198066.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17603-8. Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. PMID: 23045699.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    9. Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. PLoS Genet. 2012 Jun; 8(6):e1002789. Shibata Y, Sheffield NC, Fedrigo O, Babbitt CC, Wortham M, Tewari AK, London D, Song L, Lee BK, Iyer VR, Parker SC, Margulies EH, Wray GA, Furey TS, Crawford GE. PMID: 22761590.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    10. Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov. 2012 Jun; 2(6):492-4. Wortham M, Yan H. PMID: 22684456.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. PLoS One. 2012; 7(4):e36211. Wortham M, Jin G, Sun JL, Bigner DD, He Y, Yan H. PMID: 22558385.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res. 2010 Jan 01; 70(1):181-91. Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H. PMID: 20028867.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    13. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci. 2008 Oct; 53(10):2761-74. Wortham M, He L, Gyamfi M, Copple BL, Wan YJ. PMID: 18299981.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    14. Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metab Dispos. 2007 Sep; 35(9):1700-10. Wortham M, Czerwinski M, He L, Parkinson A, Wan YJ. PMID: 17576804.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
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