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    Matthew Wortham

    TitlePostdoctoral Scholar
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      The role of LSD1 in adaptive insulin secretion
      NIH/NIDDK F32DK102239Sep 18, 2014
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wortham M, Sander M. Mechanisms of ß-cell functional adaptation to changes in workload. Diabetes Obes Metab. 2016 Sep; 18 Suppl 1:78-86. PMID: 27615135; NIHMSID: NIHMS801341 [Available on 09/01/17].
        View in: PubMed
      2. Wortham M, Sander M. High T Gives ß Cells a Boost. Cell Metab. 2016 May 10; 23(5):761-3. PMID: 27166938.
        View in: PubMed
      3. Wortham M, Guo C, Zhang M, Song L, Lee BK, Iyer VR, Furey TS, Crawford GE, Yan H, He Y. Chromatin Accessibility Mapping Identifies Mediators of Basal Transcription and Retinoid-Induced Repression of OTX2 in Medulloblastoma. PLoS One. 2014; 9(9):e107156. PMID: 25198066.
        View in: PubMed
      4. Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17603-8. PMID: 23045699.
        View in: PubMed
      5. Shibata Y, Sheffield NC, Fedrigo O, Babbitt CC, Wortham M, Tewari AK, London D, Song L, Lee BK, Iyer VR, Parker SC, Margulies EH, Wray GA, Furey TS, Crawford GE. Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. PLoS Genet. 2012 Jun; 8(6):e1002789. PMID: 22761590.
        View in: PubMed
      6. Wortham M, Yan H. Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov. 2012 Jun; 2(6):492-4. PMID: 22684456.
        View in: PubMed
      7. Wortham M, Jin G, Sun JL, Bigner DD, He Y, Yan H. Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. PLoS One. 2012; 7(4):e36211. PMID: 22558385.
        View in: PubMed
      8. Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H. OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res. 2010 Jan 1; 70(1):181-91. PMID: 20028867.
        View in: PubMed
      9. Wortham M, He L, Gyamfi M, Copple BL, Wan YJ. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci. 2008 Oct; 53(10):2761-74. PMID: 18299981.
        View in: PubMed
      10. Wortham M, Czerwinski M, He L, Parkinson A, Wan YJ. Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metab Dispos. 2007 Sep; 35(9):1700-10. PMID: 17576804.
        View in: PubMed