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    Chitra Mandyam

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #9151
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      University of Houston, Houston TXPhDNeuropharmacology
      UT Southwestern Medical Center, Dallas TXPostdocNeuroscience
      Scripps Research Institute, La Jolla CAPostdocNeuropsychopharmacology
      Collapse Awards and Honors
      National Institute on Drug Abuse2001National Research Service Award
      University of Houston, Sigma Xi chapter2001Graduate Student Research Achievement Award
      International Narcotics Research Conference 2001Travel Award
      VolkswagenStiftung2002Travel Award (Route28 summits in neurobiology)
      National Institute on Drug Abuse2003National Research Service Award
      National Institute on Drug Abuse2007Career Development Award
      American College of Neuropsychopharmacology2011Young Investigator Travel Award
      American College of Neuropsychopharmacology2018Member

      Collapse Overview 
      Collapse Overview
      Research Goals
      Our laboratory incorporates innovative experiments to elucidate important issues that are of high importance to the addiction and adult neurogenesis fields. The general goal of our laboratory is to understand the relationship between brain structure and function using state-of-the-art molecular and cellular approaches to study high-level mental functions such as drug taking and seeking (which are the purview of behavioral and cognitive neuroscience). We employ genetic, pharmacological and histochemical techniques, and behavioral paradigms for understanding the role of newly born neurons and myelinating oligodendrocytes in drug pathology. The specific research theme of our laboratory is to determine the functional significance of adult neurogenesis and gliogenesis in addiction and addictive disorders. Our research is focused around two areas of inquiry:1) the role of stem cells in drug neuropathology and 2) novel neuroprotective strategies in addictive disorders.

      Collapse Research 
      Collapse Research Activities and Funding
      Caveolins, Striatal Toxicity and Methamphetamine Addiction
      VA I01BX003304Jun 1, 2017 - May 31, 2021
      Role: Principal Investigator
      Methamphetamine and adult hippocampal neurogenesis
      NIH/NIDA R01DA034140Jul 1, 2013 - Mar 31, 2018
      Role: PI
      Medial Prefrontal Cortical Gliogenesis and Alcohol Dependence
      NIH/NIAAA R01AA020098Sep 25, 2012 - Aug 31, 2017
      Role: PI

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Galinato MH, Takashima Y, Fannon MJ, Quach LW, Morales Silva RJ, Mysore KK, Terranova MJ, Dutta RR, Ostrom RW, Somkuwar SS, Mandyam C. Neurogenesis during abstinence is necessary for context-driven methamphetamine-related memory. J Neurosci. 2018 Jan 23. PMID: 29363584.
        View in: PubMed
      2. Mandyam C, Villalpando EG, Steiner NL, Quach LW, Fannon MJ, Somkuwar SS. Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders. Brain Sci. 2017 Oct 16; 7(10). PMID: 29035306.
        View in: PubMed
      3. Somkuwar SS, Fannon MJ, Bao Nguyen T, Mandyam C. Hyper-oligodendrogenesis at the vascular niche and reduced blood-brain barrier integrity in the prefrontal cortex during protracted abstinence. Neuroscience. 2017 Sep 01; 362:265-271. PMID: 28870701.
        View in: PubMed
      4. Schilling JM, Kassan A, Mandyam C, Pearn ML, Voong A, Grogman GG, Risbrough VB, Niesman IR, Patel HH, Patel PM, Head BP. Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice. Br J Anaesth. 2017 Sep 01; 119(3):465-471. PMID: 28969308.
        View in: PubMed
      5. Egawa J, Zemljic-Harpf A, Mandyam C, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2017 Jul 31; 1-12. PMID: 28981594.
        View in: PubMed
      6. Somkuwar SS, Vendruscolo LF, Fannon MJ, Schmeichel BE, Nguyen TB, Guevara J, Sidhu H, Contet C, Zorrilla EP, Mandyam C. Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors. Psychoneuroendocrinology. 2017 Oct; 84:17-31. PMID: 28647675.
        View in: PubMed
      7. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam C, Roth DM, Patel HH, Patel PM, Head BP. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 Apr 27. PMID: 28450301.
        View in: PubMed
      8. Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam C. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Mol Psychiatry. 2017 Mar 28. PMID: 28348387.
        View in: PubMed
      9. Staples MC, Fannon MJ, Mysore KK, Dutta RR, Ongjoco AT, Quach LW, Kharidia KM, Somkuwar SS, Mandyam C. Dietary restriction reduces hippocampal neurogenesis and granule cell neuron density without affecting the density of mossy fibers. Brain Res. 2017 May 15; 1663:59-65. PMID: 28284897.
        View in: PubMed
      10. Staples MC, Mandyam C. Thinking after Drinking: Impaired Hippocampal-Dependent Cognition in Human Alcoholics and Animal Models of Alcohol Dependence. Front Psychiatry. 2016; 7:162. PMID: 27746746.
        View in: PubMed
      11. Somkuwar SS, Fannon-Pavlich MJ, Ghofranian A, Quigley JA, Dutta RR, Galinato MH, Mandyam C. Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex. Brain Behav Immun. 2016 Nov; 58:357-368. PMID: 27542327.
        View in: PubMed
      12. Somkuwar SS, Fannon MJ, Head BP, Mandyam C. Methamphetamine reduces expression of caveolin-1 in the dorsal striatum: Implication for dysregulation of neuronal function. Neuroscience. 2016 Jul 22; 328:147-56. PMID: 27138644.
        View in: PubMed
      13. Somkuwar SS, Fannon MJ, Staples MC, Zamora-Martinez ER, Navarro AI, Kim A, Quigley JA, Edwards S, Mandyam C. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Brain Struct Funct. 2016 Dec; 221(9):4319-4335. PMID: 26659122.
        View in: PubMed
      14. Mandyam C, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2017 Jan 15; 81(2):101-110. PMID: 26592463.
        View in: PubMed
      15. Staples MC, Somkuwar SS, Mandyam C. Developmental effects of wheel running on hippocampal glutamate receptor expression in young and mature adult rats. Neuroscience. 2015 Oct 01; 305:248-56. PMID: 26220171; PMCID: PMC4562394 [Available on 10/01/16].
      16. Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam C, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV. Brain pathways to recovery from alcohol dependence. Alcohol. 2015 Aug; 49(5):435-52. PMID: 26074423; PMCID: PMC4468789.
      17. Staples MC, Kim A, Mandyam C. Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. Mol Cell Neurosci. 2015 Mar; 65:153-62. PMID: 25769285; PMCID: PMC4395499.
      18. Navarro AI, Mandyam C. Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience. 2015 May 07; 293:35-44. PMID: 25732140; PMCID: PMC4385447.
      19. Somkuwar SS, Staples MC, Galinato MH, Fannon MJ, Mandyam C. Role of NG2 expressing cells in addiction: a new approach for an old problem. Front Pharmacol. 2014; 5:279. PMID: 25566075; PMCID: PMC4271769.
      20. Galinato MH, Orio L, Mandyam C. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. 2015 Feb 12; 286:97-108. PMID: 25463524; PMCID: PMC4298458.
      21. Sobieraj JC, Kim A, Fannon MJ, Mandyam C. Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons. Brain Struct Funct. 2016 Jan; 221(1):261-76. PMID: 25273280; PMCID: PMC4383734 [Available on 01/01/17].
      22. Kim A, Mandyam C. Methamphetamine affects cell proliferation in the medial prefrontal cortex: a new niche for toxicity. Pharmacol Biochem Behav. 2014 Nov; 126:90-6. PMID: 25260424; PMCID: PMC4253078.
      23. Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam C. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015 Jan; 232(2):453-63. PMID: 25059540; PMCID: PMC4297709.
      24. Kim A, Zamora-Martinez ER, Edwards S, Mandyam C. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. Brain Struct Funct. 2015; 220(3):1705-20. PMID: 24667898; PMCID: PMC4177030.
      25. Mandyam C. The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence. Front Psychiatry. 2013; 4:61. PMID: 23818882; PMCID: PMC3694261.
      26. García-Fuster MJ, Rhodes JS, Mandyam C. The role of dentate gyrus neurogenesis in neuropsychiatric disorders. Neural Plast. 2013; 2013:584382. PMID: 23864960; PMCID: PMC3706067.
      27. Contet C, Kim A, Le D, Iyengar SK, Kotzebue RW, Yuan CJ, Kieffer BL, Mandyam C. µ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. Addict Biol. 2014 Sep; 19(5):770-80. PMID: 23461397; PMCID: PMC3681911.
      28. Engelmann AJ, Aparicio MB, Kim A, Sobieraj JC, Yuan CJ, Grant Y, Mandyam C. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase. Brain Struct Funct. 2014 Mar; 219(2):657-72. PMID: 23443965; PMCID: PMC3702684.
      29. Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam C. Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014 Jul; 19(4):562-74. PMID: 23278919; PMCID: PMC3620729.
      30. George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam C, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18156-61. PMID: 23071333; PMCID: PMC3497825.
      31. Mandyam C, Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends Neurosci. 2012 Apr; 35(4):250-60. PMID: 22265158; PMCID: PMC3321119.
      32. Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam C. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr; 37(5):1275-87. PMID: 22205547; PMCID: PMC3306889.
      33. Yuan CJ, Quiocho JM, Kim A, Wee S, Mandyam C. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav. 2011 Nov; 100(1):98-108. PMID: 21855565; PMCID: PMC3183122.
      34. Taffe MA, Kotzebue RW, Crean RD, Crawford EF, Edwards S, Mandyam C. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11104-9. PMID: 20534463; PMCID: PMC2890755.
      35. Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam C. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiol Dis. 2009 Oct; 36(1):1-10. PMID: 19501165; PMCID: PMC2742572.
      36. Arguello AA, Harburg GC, Schonborn JR, Mandyam C, Yamaguchi M, Eisch AJ. Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience. 2008 Nov 11; 157(1):70-9. PMID: 18832014; PMCID: PMC3646516.
      37. Mandyam C, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry. 2008 Dec 01; 64(11):958-65. PMID: 18490002; PMCID: PMC2587157.
      38. Mandyam C, Crawford EF, Eisch AJ, Rivier CL, Richardson HN. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev Neurobiol. 2008 Apr; 68(5):575-89. PMID: 18264994; PMCID: PMC3679899.
      39. Bawa-Khalfe T, Altememi GF, Mandyam C, Schwarz LA, Eikenburg DC, Standifer KM. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007 Dec 20; 7:16. PMID: 18096057; PMCID: PMC2234403.
      40. George O, Mandyam C, Wee S, Koob GF. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology. 2008 Sep; 33(10):2474-82. PMID: 18033234; PMCID: PMC2760333.
      41. Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam C, Eisch AJ. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci. 2007 Nov 14; 27(46):12623-9. PMID: 18003841; PMCID: PMC3718551.
      42. Wee S, Mandyam C, Lekic DM, Koob GF. Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. Eur Neuropsychopharmacol. 2008 Apr; 18(4):303-11. PMID: 17920248; PMCID: PMC2376122.
      43. Mandyam C, Wee S, Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci. 2007 Oct 17; 27(42):11442-50. PMID: 17942739; PMCID: PMC2741502.
      44. Eisch AJ, Mandyam C. Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"? Curr Pharm Biotechnol. 2007 Jun; 8(3):147-65. PMID: 17584088.
        View in: PubMed
      45. Mandyam C, Harburg GC, Eisch AJ. Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone. Neuroscience. 2007 Apr 25; 146(1):108-22. PMID: 17307295; PMCID: PMC2230096.
      46. Battiste J, Helms AW, Kim EJ, Savage TK, Lagace DC, Mandyam C, Eisch AJ, Miyoshi G, Johnson JE. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 2007 Jan; 134(2):285-93. PMID: 17166924.
        View in: PubMed
      47. Richardson HN, Zorrilla EP, Mandyam C, Rivier CL. Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology. 2006 May; 147(5):2506-17. PMID: 16455779.
        View in: PubMed
      48. Mandyam C, Norris RD, Eisch AJ. Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone. J Neurosci Res. 2004 Jun 15; 76(6):783-94. PMID: 15160390.
        View in: PubMed
      49. Eisch AJ, Mandyam C. Drug dependence and addiction, II: Adult neurogenesis and drug abuse. Am J Psychiatry. 2004 Mar; 161(3):426. PMID: 14992964.
        View in: PubMed
      50. Mandyam C, Thakker DR, Standifer KM. Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther. 2003 Sep; 306(3):965-72. PMID: 12750434.
        View in: PubMed
      51. Mandyam C, Thakker DR, Christensen JL, Standifer KM. Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002 Aug; 302(2):502-9. PMID: 12130708.
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      52. Mathis JP, Mandyam C, Altememi GF, Pasternak GW, Standifer KM. Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells. Neurosci Lett. 2001 Feb 23; 299(3):173-6. PMID: 11165763.
        View in: PubMed
      53. Mandyam C, Altememi GF, Standifer KM. beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells. Eur J Pharmacol. 2000 Aug 18; 402(1-2):R1-37. PMID: 10940375.
        View in: PubMed
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