Theodore Welling

Title(s)Professor Of Clinical, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. BASECAMP-1 screening study: a model for efficient enrolment in precision oncology clinical trials. BMJ Oncol. 2026; 5(1):e001033. Hecht JR, Molina JR, Liechty K, Welling TH, Grierson PM, Patel SP, Kirtane K, Morelli MP, Locke FL, Maloney DG, Punekar SR, Nikiforow S, Lin Y, Ulrickson M, Specht JM, Lozac'hmeur A, Osterman CK, Garde RJ, Rangel GA, Ng EW, Welch JS, Tebbets JC, Go WY, Simeone DM. PMID: 41918932; PMCID: PMC13034198.
      View in: PubMed   Mentions:
    2. Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression. bioRxiv. 2025 Feb 15. Kalfakakou D, Cameron DC, Kawaler EA, Tsuda M, Wang L, Jing X, Hajdu C, Tamayo DL, Shim Y, Ackermann A, Weissinger D, Zimny H, Hernandez R, Beier M, Dimartino D, Meyn P, Rice K, Selvaraj S, Loomis C, Heguy A, Lund AW, Sears RC, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. PMID: 39990481; PMCID: PMC11844494.
      View in: PubMed   Mentions:
    3. Longitudinal assessment of disparities in pancreatic cancer care: A retrospective analysis of the National Cancer Database. World J Surg. 2025 01; 49(1):262-269. Grewal M, Kroon VJ, Kaslow SR, Sorrentino AM, Winner MD, Allendorf JD, Shah PC, Simeone DM, Welling TH, Berman RS, Cohen SM, Wolfgang CL, Sacks GD, Javed AA. PMID: 39653505.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment. Ann Surg. 2024 Aug 01; 280(2):317-324. Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA. PMID: 37870253; PMCID: PMC11259998.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    5. Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nat Commun. 2023 Jul 03; 14(1):3912. Werba G, Weissinger D, Kawaler EA, Zhao E, Kalfakakou D, Dhara S, Wang L, Lim HB, Oh G, Jing X, Beri N, Khanna L, Gonda T, Oberstein P, Hajdu C, Loomis C, Heguy A, Sherman MH, Lund AW, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. PMID: 37400453; PMCID: PMC10317973.
      View in: PubMed   Mentions: 4     Fields:    
    6. POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling. J Clin Invest. 2023 06 01; 133(11). Oh G, Wang A, Wang L, Li J, Werba G, Weissinger D, Zhao E, Dhara S, Hernandez RE, Ackermann A, Porcella S, Kalfakakou D, Dolgalev I, Kawaler E, Golan T, Welling TH, Sfeir A, Simeone DM. PMID: 36976649; PMCID: PMC10232002.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    7. Corrigendum: Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies. Front Immunol. 2023; 14:1177713. Wan S, Zhao E, Freeman D, Weissinger D, Krantz BA, Werba G, Khanna LG, Siolas D, Oberstein PE, Chattopadhyay PK, Simeone DM, Welling TH. PMID: 37033968; PMCID: PMC10078804.
      View in: PubMed   Mentions:    Fields:    
    8. Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nat Commun. 2023 02 13; 14(1):797. Werba G, Weissinger D, Kawaler EA, Zhao E, Kalfakakou D, Dhara S, Wang L, Lim HB, Oh G, Jing X, Beri N, Khanna L, Gonda T, Oberstein P, Hajdu C, Loomis C, Heguy A, Sherman MH, Lund AW, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. PMID: 36781852; PMCID: PMC9925748.
      View in: PubMed   Mentions: 140     Fields:    Translation:Humans
    9. Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies. Front Immunol. 2023; 14:1067352. Wan S, Zhao E, Weissinger D, Krantz BA, Werba G, Freeman D, Khanna LG, Siolas D, Oberstein PE, Chattopadhyay PK, Simeone DM, Welling TH. PMID: 36798126; PMCID: PMC9927010.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. A pan-cancer organoid platform for precision medicine. Cell Rep. 2021 07 27; 36(4):109429. Larsen BM, Kannan M, Langer LF, Leibowitz BD, Bentaieb A, Cancino A, Dolgalev I, Drummond BE, Dry JR, Ho CS, Khullar G, Krantz BA, Mapes B, McKinnon KE, Metti J, Perera JF, Rand TA, Sanchez-Freire V, Shaxted JM, Stein MM, Streit MA, Tan YC, Zhang Y, Zhao E, Venkataraman J, Stumpe MC, Borgia JA, Masood A, Catenacci DVT, Mathews JV, Gursel DB, Wei JJ, Welling TH, Simeone DM, White KP, Khan AA, Igartua C, Salahudeen AA. PMID: 34320344.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    11. New Labyrinth Microfluidic Device Detects Circulating Tumor Cells Expressing Cancer Stem Cell Marker and Circulating Tumor Microemboli in Hepatocellular Carcinoma. Sci Rep. 2019 12 09; 9(1):18575. Wan S, Kim TH, Smith KJ, Delaney R, Park GS, Guo H, Lin E, Plegue T, Kuo N, Steffes J, Leu C, Simeone DM, Razimulava N, Parikh ND, Nagrath S, Welling TH. PMID: 31819089; PMCID: PMC6901480.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    12. Safety of Combined Yttrium-90 Radioembolization and Immune Checkpoint Inhibitor Immunotherapy for Hepatocellular Carcinoma. J Vasc Interv Radiol. 2020 Jan; 31(1):25-34. Zhan C, Ruohoniemi D, Shanbhogue KP, Wei J, Welling TH, Gu P, Park JS, Dagher NN, Taslakian B, Hickey RM. PMID: 31422022.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    13. Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma. Hepatol Commun. 2019 Oct; 3(10):1400-1414. Alcedo KP, Guerrero A, Basrur V, Fu D, Richardson ML, McLane JS, Tsou CC, Nesvizhskii AI, Welling TH, Lebrilla CB, Otey CA, Kim HJ, Omary MB, Snider NT. PMID: 31592495; PMCID: PMC6771166.
      View in: PubMed   Mentions: 23     Fields:    
    14. Multicenter Study of Staging and Therapeutic Predictors of Hepatocellular Carcinoma Recurrence Following Transplantation. Liver Transpl. 2018 09; 24(9):1233-1242. Welling TH, Eddinger K, Carrier K, Zhu D, Kleaveland T, Moore DE, Schaubel DE, Abt PL. PMID: 29729113; PMCID: PMC6153067.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    15. Histotripsy for Non-Invasive Ablation of Hepatocellular Carcinoma (HCC) Tumor in a Subcutaneous Xenograft Murine Model. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:6064-6067. Worlikar T, Vlaisavljevich E, Gerhardson T, Greve J, Wan S, Kuruvilla S, Lundt J, Ives K, Hall T, Welling TH, Lee F, Xu Z. PMID: 30441719.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    16. Individualized Adaptive Stereotactic Body Radiotherapy for Liver Tumors in Patients at High Risk for Liver Damage: A Phase 2 Clinical Trial. JAMA Oncol. 2018 Jan 01; 4(1):40-47. Feng M, Suresh K, Schipper MJ, Bazzi L, Ben-Josef E, Matuszak MM, Parikh ND, Welling TH, Normolle D, Ten Haken RK, Lawrence TS. PMID: 28796864; PMCID: PMC5766368.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    17. Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency. Oncotarget. 2017 Sep 12; 8(39):65090-65099. Dosch J, Ziemke E, Wan S, Luker K, Welling T, Hardiman K, Fearon E, Thomas S, Flynn M, Rios-Doria J, Hollingsworth R, Herbst R, Hurt E, Sebolt-Leopold J. PMID: 29029414; PMCID: PMC5630314.
      View in: PubMed   Mentions: 29     Fields:    
    18. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 2017 Jun 24; 389(10088):2492-2502. El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I. PMID: 28434648; PMCID: PMC7539326.
      View in: PubMed   Mentions: 2421     Fields:    Translation:HumansCTClinical Trials
    19. Non-Invasive Liver Ablation Using Histotripsy: Preclinical Safety Study in an In Vivo Porcine Model. Ultrasound Med Biol. 2017 06; 43(6):1237-1251. Vlaisavljevich E, Owens G, Lundt J, Teofilovic D, Ives K, Duryea A, Bertolina J, Welling TH, Xu Z. PMID: 28318889.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    20. GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer. Cancer Discov. 2016 08; 6(8):886-99. Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Pasca Di Magliano M, Welling TH, Palmbos PL, Abel EV, Sahai V, Nagrath S, Wang L, Simeone DM. PMID: 27184426; PMCID: PMC5549011.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    21. Non-Invasive Ultrasound Liver Ablation Using Histotripsy: Chronic Study in an In Vivo Rodent Model. Ultrasound Med Biol. 2016 08; 42(8):1890-902. Vlaisavljevich E, Greve J, Cheng X, Ives K, Shi J, Jin L, Arvidson A, Hall T, Welling TH, Owens G, Roberts W, Xu Z. PMID: 27140521; PMCID: PMC4912895.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    22. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol. 2016 Jan; 17(1):95-103. Zhao E, Maj T, Kryczek I, Li W, Wu K, Zhao L, Wei S, Crespo J, Wan S, Vatan L, Szeliga W, Shao I, Wang Y, Liu Y, Varambally S, Chinnaiyan AM, Welling TH, Marquez V, Kotarski J, Wang H, Wang Z, Zhang Y, Liu R, Wang G, Zou W. PMID: 26523864; PMCID: PMC4684796.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimalsCells
    23. Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6. Clin Cancer Res. 2016 Jan 15; 22(2):405-14. Ziemke EK, Dosch JS, Maust JD, Shettigar A, Sen A, Welling TH, Hardiman KM, Sebolt-Leopold JS. PMID: 26369631; PMCID: PMC4715945.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    24. Myeloid cells in hepatocellular carcinoma. Hepatology. 2015 Oct; 62(4):1304-12. Wan S, Kuo N, Kryczek I, Zou W, Welling TH. PMID: 25914264; PMCID: PMC4589430.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    25. Internal biliary stenting during orthotopic liver transplantation: anastomotic complications, post-transplant biliary interventions, and survival. Clin Transplant. 2015 Apr; 29(4):327-35. Mathur AK, Nadig SN, Kingman S, Lee D, Kinkade K, Sonnenday CJ, Welling TH. PMID: 25604635.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    26. Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73). Mol Biol Cell. 2014 Dec 15; 25(25):4024-33. Snider NT, Altshuler PJ, Wan S, Welling TH, Cavalcoli J, Omary MB. PMID: 25298403; PMCID: PMC4263446.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    27. Heterogeneity of The CD90+ Population in Different Stages of Hepatocarcinogenesis. J Proteomics Bioinform. 2014 Sep 12; 7(10):296-302. Thakolwiboon S, Zhu J, Liang Q, Welling TH, Zhang M, Lubman DM. PMID: 25580065; PMCID: PMC4285360.
      View in: PubMed   Mentions: 8  
    28. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology. 2014 Dec; 147(6):1393-404. Wan S, Zhao E, Kryczek I, Vatan L, Sadovskaya A, Ludema G, Simeone DM, Zou W, Welling TH. PMID: 25181692; PMCID: PMC4253315.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansAnimalsCells
    29. CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunol Res. 2014 May; 2(5):423-35. Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins MA, Evans RA, Welling TH, Vonderheide RH, di Magliano MP. PMID: 24795355; PMCID: PMC4160804.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    30. Neoadjuvant stereotactic body radiation therapy, capecitabine, and liver transplantation for unresectable hilar cholangiocarcinoma. Liver Transpl. 2014 Jan; 20(1):81-8. Welling TH, Feng M, Wan S, Hwang SY, Volk ML, Lawrence TS, Zalupski MM, Sonnenday CJ. PMID: 24115315; PMCID: PMC4185427.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    31. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Curr Opin Immunol. 2013 Apr; 25(2):214-21. Crespo J, Sun H, Welling TH, Tian Z, Zou W. PMID: 23298609; PMCID: PMC3636159.
      View in: PubMed   Mentions: 455     Fields:    Translation:HumansAnimalsCells
    32. Elevated serum IL-8 is associated with the presence of hepatocellular carcinoma and independently predicts survival. Cancer Invest. 2012 Dec; 30(10):689-97. Welling TH, Fu S, Wan S, Zou W, Marrero JA. PMID: 23072563.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    33. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology. 2011 Dec; 141(6):2218-2227.e5. Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M, Simeone DM. PMID: 21864475.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansAnimalsCells
    34. The effect of smoking on biliary complications following liver transplantation. Transpl Int. 2011 Jan; 24(1):58-66. Mathur AK, Ranney DN, Patel SP, Lee DS, Bednar F, Lynch RJ, Welling TH, Englesbe MJ. PMID: 20735768.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    35. Body mass index and adverse perioperative outcomes following hepatic resection. J Gastrointest Surg. 2010 Aug; 14(8):1285-91. Mathur AK, Ghaferi AA, Osborne NH, Pawlik TM, Campbell DA, Englesbe MJ, Welling TH. PMID: 20532666; PMCID: PMC2925640.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    36. Influence of body mass index on complications and oncologic outcomes following hepatectomy for malignancy. J Gastrointest Surg. 2010 May; 14(5):849-57. Mathur AK, Ghaferi AA, Sell K, Sonnenday CJ, Englesbe MJ, Welling TH. PMID: 20140536.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    37. Portal vein thrombosis and survival in patients with cirrhosis. Liver Transpl. 2010 Jan; 16(1):83-90. Englesbe MJ, Kubus J, Muhammad W, Sonnenday CJ, Welling T, Punch JD, Lynch RJ, Marrero JA, Pelletier SJ. PMID: 20035521.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    38. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res. 2009 Oct 15; 69(20):8067-75. Wu K, Kryczek I, Chen L, Zou W, Welling TH. PMID: 19826049; PMCID: PMC4397483.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    39. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood. 2009 Aug 06; 114(6):1141-9. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W. PMID: 19470694; PMCID: PMC2723011.
      View in: PubMed   Mentions: 411     Fields:    Translation:HumansCells
    40. Modern diagnosis and management of hepatocellular carcinoma. Clin Liver Dis. 2009 May; 13(2):233-47. Marrero JA, Welling T. PMID: 19442916.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    41. FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res. 2009 May 01; 69(9):3995-4000. Kryczek I, Liu R, Wang G, Wu K, Shu X, Szeliga W, Vatan L, Finlayson E, Huang E, Simeone D, Redman B, Welling TH, Chang A, Zou W. PMID: 19383912.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    42. Role of liver transplantation in the treatment of cholangiocarcinoma. Expert Rev Anticancer Ther. 2009 Apr; 9(4):491-502. Singal A, Welling TH, Marrero JA. PMID: 19374602.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol. 2008 Oct 01; 181(7):4733-41. Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L, Szeliga W, Wang Y, Liu Y, Welling TH, Elder JT, Zou W. PMID: 18802076; PMCID: PMC2677162.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansCells
    44. Hepatopulmonary syndrome: use of extracorporeal life support for life-threatening hypoxia following liver transplantation. Liver Transpl. 2008 Jul; 14(7):966-70. Fleming GM, Cornell TT, Welling TH, Magee JC, Annich GM. PMID: 18581508; PMCID: PMC4414403.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    45. Biliary complications following liver transplantation in the model for end-stage liver disease era: effect of donor, recipient, and technical factors. Liver Transpl. 2008 Jan; 14(1):73-80. Welling TH, Heidt DG, Englesbe MJ, Magee JC, Sung RS, Campbell DA, Punch JD, Pelletier SJ. PMID: 18161843.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    46. Regulation of alloimmune Th1 responses by the cyclin-dependent kinase inhibitor p21 following transplantation. Surgery. 2008 Mar; 143(3):394-403. Welling TH, Lu G, Csencsits K, Wood SC, Jarvinen L, Bishop DK. PMID: 18291261; PMCID: PMC2423232.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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