Ryan Hibbs

Title(s)Professor, Neurobiology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    Ochsner Health2023Alton Ochsner Award Relating Smoking and Disease
    Welch Foundation2022Norman Hackerman Award in Chemical Research
    UC San Diego2019Outstanding Alumnus Award
    Klingenstein Fund2014Klingenstein-Simons Award in the Neurosciences
    McKnight Foundation2014McKnight Scholar Award

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Structural basis of nicotinic acetylcholine receptor gating and toxin inhibition
    NIH R01NS120496Jan 1, 2021 - Dec 31, 2025
    Role: Principal Investigator
    Structure and Function of GABA-A Receptors
    NIH R01DA047325Feb 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Structural biology of the alpha4beta2 nicotinic acetylcholine receptor
    NIH R33DA037492May 1, 2017 - Apr 30, 2020
    Role: Principal Investigator
    Structural studies of heteromeric nicotinic acetylcholine receptors
    NIH R01DA042072Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    3D Structure and mechanism of the alpha7 nicotinic acetylcholine receptor
    NIH R01NS095899Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Structural biology of the alpha4beta2 nicotinic acetylcholine receptor
    NIH R21DA037492Apr 1, 2014 - Mar 31, 2017
    Role: Principal Investigator
    3D Structure and Function of Neuronal Nicotinic Acetylcholine Receptors
    NIH R00NS077983Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    3D Structure and Function of Neuronal Nicotinic Acetylcholine Receptors
    NIH K99NS077983Apr 1, 2012 - Aug 31, 2012
    Role: Principal Investigator
    3D Structure and Function of the Cys-loop Family of Ligand-gated Ion Channels
    NIH F32NS061404Jan 1, 2008 - Dec 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling. Proc Natl Acad Sci U S A. 2025 Feb 18; 122(7):e2420993122. Avstrikova M, Milán Rodríguez P, Burke SM, Hibbs RE, Changeux JP, Cecchini M. PMID: 39946538.
      View in: PubMed   Mentions:    Fields:    
    2. Resolving native GABAA receptor structures from the human brain. Nature. 2025 Jan 22. Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE. PMID: 39843743.
      View in: PubMed   Mentions:    Fields:    
    3. A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules. ACS Chem Neurosci. 2024 Nov 20; 15(22):4171-4184. McCarroll MN, Sisko E, Gong JH, Teng J, Taylor J, Myers-Turnbull D, Young D, Burley G, Pierce LX, Hibbs RE, Kokel D, Sello JK. PMID: 39287508; PMCID: PMC11587515.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Fluorescence-detection size-exclusion chromatography specifically detects autoantibodies targeting the ganglionic acetylcholine receptor in patients with autoimmune autonomic ganglionopathy. J Neuroimmunol. 2024 Nov 15; 396:578454. Baxter L, Hopkins S, O'Connor KC, Pham MC, Nowak RJ, Monson NL, Blackburn K, Hibbs RE, Vernino S, Noviello CM. PMID: 39277987.
      View in: PubMed   Mentions:    Fields:    
    5. Structural switch in acetylcholine receptors in developing muscle. Nature. 2024 Aug; 632(8027):1174-1180. Li H, Teng J, Hibbs RE. PMID: 39085615.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Structural insights into GABAA receptor potentiation by Quaalude. Nat Commun. 2024 Jun 19; 15(1):5244. Chojnacka W, Teng J, Kim JJ, Jensen AA, Hibbs RE. PMID: 38898000; PMCID: PMC11187190.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor. Br J Pharmacol. 2024 Jul; 181(13):1973-1992. Mazzaferro S, Kang G, Natarajan K, Hibbs RE, Sine SM. PMID: 38454578.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. Cell. 2024 Feb 29; 187(5):1160-1176.e21. Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE. PMID: 38382524; PMCID: PMC10950261.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Structural insights into opposing actions of neurosteroids on GABAA receptors. Nat Commun. 2023 08 22; 14(1):5091. Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE. PMID: 37607940; PMCID: PMC10444788.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun. 2023 06 01; 14(1):3169. Goswami U, Rahman MM, Teng J, Hibbs RE. PMID: 37264005; PMCID: PMC10235084.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Structural basis of sensory receptor evolution in octopus. Nature. 2023 04; 616(7956):373-377. Allard CAH, Kang G, Kim JJ, Valencia-Montoya WA, Hibbs RE, Bellono NW. PMID: 37045920; PMCID: PMC10228259.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Sensory specializations drive octopus and squid behaviour. Nature. 2023 04; 616(7956):378-383. Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE. PMID: 37045917; PMCID: PMC10262778.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. A simple flash and freeze system for cryogenic time-resolved electron microscopy. Front Mol Biosci. 2023; 10:1129225. Bhattacharjee B, Rahman MM, Hibbs RE, Stowell MHB. PMID: 36959978; PMCID: PMC10028177.
      View in: PubMed   Mentions: 2  
    14. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2208081119. Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. PMID: 36251999; PMCID: PMC9618078.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities. Nat Commun. 2022 08 06; 13(1):4582. Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE. PMID: 35933426; PMCID: PMC9357065.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    16. Structural mechanisms of GABAA receptor autoimmune encephalitis. Cell. 2022 07 07; 185(14):2469-2477.e13. Noviello CM, Kreye J, Teng J, Prüss H, Hibbs RE. PMID: 35803245; PMCID: PMC9394431.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    17. Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat Struct Mol Biol. 2022 04; 29(4):386-394. Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE. PMID: 35301478; PMCID: PMC9531584.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    18. Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell. 2021 04 15; 184(8):2121-2134.e13. Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE. PMID: 33735609; PMCID: PMC8135066.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    19. Direct Structural Insights into GABAA Receptor Pharmacology. Trends Biochem Sci. 2021 06; 46(6):502-517. Kim JJ, Hibbs RE. PMID: 33674151; PMCID: PMC8122054.
      View in: PubMed   Mentions: 37     Fields:    
    20. Purification of a native nicotinic receptor. Methods Enzymol. 2021; 653:189-206. Rahman MM, Worrell BT, Stowell MHB, Hibbs RE. PMID: 34099171.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. 2020 09; 585(7824):303-308. Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. PMID: 32879488; PMCID: PMC7486282.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    22. Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron. 2020 06 17; 106(6):952-962.e5. Rahman MM, Teng J, Worrell BT, Noviello CM, Lee M, Karlin A, Stowell MHB, Hibbs RE. PMID: 32275860; PMCID: PMC8867384.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    23. Progress in nicotinic receptor structural biology. Neuropharmacology. 2020 07; 171:108086. Gharpure A, Noviello CM, Hibbs RE. PMID: 32272141; PMCID: PMC7255940.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    24. Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site. Elife. 2020 01 28; 9. Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C. PMID: 31990273; PMCID: PMC7015668.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    25. CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations. Am J Hum Genet. 2019 12 05; 105(6):1286-1293. Mann N, Kause F, Henze EK, Gharpure A, Shril S, Connaughton DM, Nakayama M, Klämbt V, Majmundar AJ, Wu CW, Kolvenbach CM, Dai R, Chen J, van der Ven AT, Ityel H, Tooley MJ, Kari JA, Bownass L, El Desoky S, De Franco E, Shalaby M, Tasic V, Bauer SB, Lee RS, Beckel JM, Yu W, Mane SM, Lifton RP, Reutter H, Ellard S, Hibbs RE, Kawate T, Hildebrandt F. PMID: 31708116; PMCID: PMC6904809.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    26. Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon. Proc Natl Acad Sci U S A. 2019 09 24; 116(39):19449-19457. Zoltowski BD, Chelliah Y, Wickramaratne A, Jarocha L, Karki N, Xu W, Mouritsen H, Hore PJ, Hibbs RE, Green CB, Takahashi JS. PMID: 31484780; PMCID: PMC6765304.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    27. Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor. Neuron. 2019 11 06; 104(3):501-511.e6. Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. PMID: 31488329; PMCID: PMC6842111.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    28. Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators. J Pharmacol Exp Ther. 2019 08; 370(2):252-268. Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL. PMID: 31175218; PMCID: PMC6658922.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Bridges between Antimalarials and Synaptic Transmission. Neuron. 2019 02 20; 101(4):546-547. Kim JJ, Hibbs RE. PMID: 30790532.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    30. Structure of a human synaptic GABAA receptor. Nature. 2018 07; 559(7712):67-72. Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE. PMID: 29950725; PMCID: PMC6220708.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansCells
    31. Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. Nature. 2018 05; 557(7704):261-265. Walsh RM, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE. PMID: 29720657; PMCID: PMC6132059.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    32. X-ray structure of the human α4β2 nicotinic receptor. Nature. 2016 Oct 20; 538(7625):411-415. Morales-Perez CL, Noviello CM, Hibbs RE. PMID: 27698419; PMCID: PMC5161573.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    33. Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins. Structure. 2016 05 03; 24(5):797-805. Morales-Perez CL, Noviello CM, Hibbs RE. PMID: 27041595; PMCID: PMC4856541.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    34. X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature. 2014 Aug 21; 512(7514):333-7. Althoff T, Hibbs RE, Banerjee S, Gouaux E. PMID: 25143115; PMCID: PMC4255919.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    35. A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. Structure. 2012 Aug 08; 20(8):1293-9. Hattori M, Hibbs RE, Gouaux E. PMID: 22884106; PMCID: PMC3441139.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    36. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature. 2011 Jun 02; 474(7349):54-60. Hibbs RE, Gouaux E. PMID: 21572436; PMCID: PMC3160419.
      View in: PubMed   Mentions: 516     Fields:    Translation:AnimalsCells
    37. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. EMBO J. 2009 Oct 07; 28(19):3040-51. Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y. PMID: 19696737; PMCID: PMC2760105.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    38. Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7606-11. Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P. PMID: 18477694; PMCID: PMC2396707.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    39. Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes. Biochem Pharmacol. 2007 Oct 15; 74(8):1164-71. Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE, Shi J. PMID: 17826748; PMCID: PMC3341175.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    40. Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein. J Biol Chem. 2006 Dec 22; 281(51):39708-18. Hibbs RE, Radic Z, Taylor P, Johnson DA. PMID: 17068341.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    41. Structural dynamics of the acetylcholine binding protein: hydrodynamic and fluorescence anisotropy decay analyses. J Mol Neurosci. 2006; 30(1-2):73-4. Hibbs RE, Johnson DA, Shi J, Taylor P. PMID: 17192634.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    42. Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: hydrodynamic and fluorescence anisotropy decay analyses. Biochemistry. 2005 Dec 20; 44(50):16602-11. Hibbs RE, Johnson DA, Shi J, Hansen SB, Taylor P. PMID: 16342951.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    43. Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein. J Biol Chem. 2004 Jul 02; 279(27):28483-91. Hibbs RE, Talley TT, Taylor P. PMID: 15117947.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    44. Contemporary paradigms for cholinergic ligand design guided by biological structure. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1875-7. Taylor P, Hansen SB, Talley TT, Hibbs RE, Radic Z. PMID: 15050619; PMCID: PMC3191913.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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