George Koob

Title(s)Adjunct Professor, Psychology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Gene Network Perturbations in Alcohol Dependence - A Systems Biology Approach
    NIH/NIAAA R01AA021667Sep 5, 2013 - Jul 31, 2024
    Role: Co-Principal Investigator
    The Role of Brain Stress Systems in the Prefrontal Cortex in Compulsive Drinking
    NIH R01AA020608Aug 1, 2011 - Jun 30, 2017
    Role: Co-Principal Investigator
    Effects of Deep Brain Stimulation on Compulsive Drug Intake
    NIH R21DA029821Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Central mechanisms of nicotine reinforcement and dependence
    NIH R01DA023597Apr 5, 2008 - Jan 31, 2014
    Role: Principal Investigator
    Integrative Neuroscience Initiative on Alcoholism
    NIH U01AA013517Sep 27, 2001 - Aug 31, 2016
    Role: Co-Principal Investigator
    Dopamine Partial Agonists and Psychostimulant Dependence
    NIH R01DA010072Aug 15, 1997 - Mar 31, 2013
    Role: Principal Investigator
    Novel methods to explore mechanisms of cocaine abuse
    NIH R01DA008467Sep 1, 1993 - Jun 30, 2014
    Role: Co-Principal Investigator
    Neuropharmacology of Ethanol Reinforcement
    NIH R01AA008459Apr 1, 1990 - Apr 30, 2015
    Role: Co-Principal Investigator
    NIH R37AA008459Apr 1, 1990 - Mar 31, 2004
    Role: Principal Investigator
    NIH R03DA005843Sep 30, 1989 - Aug 31, 1990
    Role: Principal Investigator
    Neuronal Substrates of Cocaine Reward
    NIH R01DA004398Apr 1, 1987 - Mar 31, 2016
    Role: Co-Principal Investigator
    Central Mechanisms of Opiate Reinforcement and Dependence
    NIH R01DA004043May 1, 1986 - Jun 30, 2010
    Role: Principal Investigator
    CNS Effects of Alcohol: Cellular Neurobiology
    NIH P60AA006420Dec 1, 1983 - Dec 31, 2022
    Role: Co-Principal Investigator
    Neuropsychopharmacology: Multidisciplinary Training
    NIH T32AA007456Dec 1, 1983 - Jun 30, 2022
    Role: Co-Principal Investigator
    NIH P50AA006420Dec 1, 1983 - Feb 28, 2003
    Role: Principal Investigator
    NIH R01NS020912Dec 1, 1983 - Jun 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats. Psychopharmacology (Berl). 2024 Jun 13. Vendruscolo LF, Vendruscolo JCM, Whiting KE, Acri JB, Volkow ND, Koob GF. PMID: 38869515.
      View in: PubMed   Mentions:    Fields:    
    2. Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. Commun Biol. 2024 May 25; 7(1):632. Lékó AH, Gregory-Flores A, Marchette RCN, Gomez JL, Vendruscolo JCM, Repunte-Canonigo V, Choung V, Deschaine SL, Whiting KE, Jackson SN, Cornejo MP, Perello M, You ZB, Eckhaus M, Rasineni K, Janda KD, Zorman B, Sumazin P, Koob GF, Michaelides M, Sanna PP, Vendruscolo LF, Leggio L. PMID: 38796563; PMCID: PMC11127961.
      View in: PubMed   Mentions: 1  Translation:Animals
    3. Indulging Curiosity: Preliminary Evidence of an Anxiolytic-like Effect of Castor Oil and Ricinoleic Acid. Nutrients. 2024 May 18; 16(10). Nisbett KE, Vendruscolo LF, Koob GF. PMID: 38794765; PMCID: PMC11124509.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury. Brain Behav Immun. 2024 Jul; 119:494-506. Wagner J, Park LM, Mukhopadhyay P, Matyas C, Trojnar E, Damadzic R, Jung J, Bell AS, Mavromatis LA, Hamandi AM, Rosoff DB, Vendruscolo LF, Koob GF, Pacher P, Lohoff FW. PMID: 38657842.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice. Transl Psychiatry. 2024 Feb 28; 14(1):125. Nisbett KE, Vendruscolo LF, Koob GF. PMID: 38413576; PMCID: PMC10899625.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Cold nociception as a measure of hyperalgesia during spontaneous heroin withdrawal in mice. Pharmacol Biochem Behav. 2024 Feb; 235:173694. Hastings LE, Frye EV, Carlson ER, Chuong V, Matthews AN, Koob GF, Vendruscolo LF, Marchette RCN. PMID: 38128767; PMCID: PMC10842911.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. Res Sq. 2023 Oct 18. Leggio L, Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, Chuong V, Deschaine S, Whiting K, Jackson S, Cornejo M, Perello M, You ZB, Eckhaus M, Janda K, Zorman B, Sumazin P, Koob G, Michaelides M, Sanna PP, Vendruscolo L. PMID: 37886546; PMCID: PMC10602167.
      View in: PubMed   Mentions:
    8. Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice. Neurobiol Stress. 2023 Sep; 26:100567. Nisbett KE, Gonzalez LA, Teruel M, Carter CS, Vendruscolo LF, Ragozzino ME, Koob GF. PMID: 37706061; PMCID: PMC10495655.
      View in: PubMed   Mentions: 5  
    9. Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder. Curr Top Behav Neurosci. 2023 Jul 09. Koob GF, Vendruscolo L. PMID: 37421551.
      View in: PubMed   Mentions: 4     Fields:    
    10. Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice. Neuropharmacology. 2023 11 01; 238:109643. Richardson RS, Sulima A, Rice KC, Kucharczk JA, Janda KD, Nisbett KE, Koob GF, Vendruscolo LF, Leggio L. PMID: 37369277; PMCID: PMC10513123.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. No time to lose: the current state of research in rapid-acting psychotherapeutics. Neuropsychopharmacology. 2024 Jan; 49(1):10-14. Gordon JA, Volkow ND, Koob GF. PMID: 37349476; PMCID: PMC10700482.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI Insight. 2023 06 22; 8(12). Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R, Marchette RC, Koob GF, Roberto M, Vendruscolo LF, Leggio L. PMID: 37192005; PMCID: PMC10371247.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. NIAAA-Supported Research and the Public Discourse Around Alcohol: A Clarification Regarding Mitchell and McCambridge (2023). J Stud Alcohol Drugs. 2023 03; 84(2):346-347. Koob GF. PMID: 37132578; PMCID: PMC10171253.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Heroin- and Fentanyl-Induced Respiratory Depression in a Rat Plethysmography Model: Potency, Tolerance, and Sex Differences. J Pharmacol Exp Ther. 2023 05; 385(2):117-134. Marchette RCN, Carlson ER, Frye EV, Hastings LE, Vendruscolo JCM, Mejias-Torres G, Lewis SJ, Hampson A, Volkow ND, Vendruscolo LF, Koob GF. PMID: 36828628; PMCID: PMC10108442.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    15. Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor. J Pharmacol Exp Ther. 2023 08; 386(2):117-128. Deschaine SL, Hedegaard MA, Pince CL, Farokhnia M, Moose JE, Stock IA, Adusumalli S, Akhlaghi F, Hougland JL, Sulima A, Rice KC, Koob GF, Vendruscolo LF, Holst B, Leggio L. PMID: 36631279; PMCID: PMC10353127.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Extended access to fentanyl vapor self-administration leads to addiction-like behaviors in mice: Blood chemokine/cytokine levels as potential biomarkers. Addict Neurosci. 2023 Mar; 5. Marchette RCN, Carlson ER, Said N, Koob GF, Vendruscolo LF. PMID: 36683829; PMCID: PMC9851134.
      View in: PubMed   Mentions: 1  
    17. NIAAA 50th Anniversary Festschrift: From the Editor. Alcohol Res. 2022; 42(1):14. Koob GF. PMID: 36420304; PMCID: PMC9678371.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. On the critical need to investigate the effect of alcohol in the older population. Alcohol. 2023 03; 107:2-3. Matthews DB, Koob GF. PMID: 36202275.
      View in: PubMed   Mentions: 2     Fields:    
    19. Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies. Mol Psychiatry. 2022 Nov; 27(11):4642-4652. Farokhnia M, Rentsch CT, Chuong V, McGinn MA, Elvig SK, Douglass EA, Gonzalez LA, Sanfilippo JE, Marchette RCN, Tunstall BJ, Fiellin DA, Koob GF, Justice AC, Leggio L, Vendruscolo LF. PMID: 36123420; PMCID: PMC10231646.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    20. In Memoriam Martin Adler, Ph.D. Neuropsychopharmacology. 2022 Nov; 47(12):2171-2172. Koob GF, Unterwald EM. PMID: 36028754; PMCID: PMC9556644.
      View in: PubMed   Mentions:    Fields:    
    21. Alcohol and aging - An area of increasing concern. Alcohol. 2023 03; 107:19-27. White AM, Orosz A, Powell PA, Koob GF. PMID: 35940508.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats. Addict Neurosci. 2022 Sep; 3. Aldridge GM, Zarin TA, Brandner AJ, George O, Gilpin NW, Repunte-Canonigo V, Sanna PP, Koob GF, Vendruscolo LF, Schmeichel BE. PMID: 35965958; PMCID: PMC9365098.
      View in: PubMed   Mentions: 3  
    23. Effects of Alcohol Withdrawal on Sleep Macroarchitecture and Microarchitecture in Female and Male Rats. Front Neurosci. 2022; 16:838486. Jones MR, Brandner AJ, Vendruscolo LF, Vendruscolo JCM, Koob GF, Schmeichel BE. PMID: 35757544; PMCID: PMC9226367.
      View in: PubMed   Mentions:
    24. Defining Recovery From Alcohol Use Disorder: Development of an NIAAA Research Definition. Am J Psychiatry. 2022 11 01; 179(11):807-813. Hagman BT, Falk D, Litten R, Koob GF. PMID: 35410494.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    25. Corticosteroid sensitization drives opioid addiction. Mol Psychiatry. 2022 05; 27(5):2492-2501. Carmack SA, Vendruscolo JCM, Adrienne McGinn M, Miranda-Barrientos J, Repunte-Canonigo V, Bosse GD, Mercatelli D, Giorgi FM, Fu Y, Hinrich AJ, Jodelka FM, Ling K, Messing RO, Peterson RT, Rigo F, Edwards S, Sanna PP, Morales M, Hastings ML, Koob GF, Vendruscolo LF. PMID: 35296810; PMCID: PMC10406162.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    26. Understanding Hyperkatifeia to Inform Treatment for Alcohol Use Disorder: An Assessment of the National Institute on Alcohol Abuse and Alcoholism Research Portfolio. Biol Psychiatry. 2022 06 15; 91(12):e53-e59. Patterson JT, Koob GF, Anderson RI. PMID: 35469669.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Anhedonia, Hyperkatifeia, and Negative Reinforcement in Substance Use Disorders. Curr Top Behav Neurosci. 2022; 58:147-165. Koob GF. PMID: 35112332.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Nutritional Ketosis as a Potential Treatment for Alcohol Use Disorder. Front Psychiatry. 2021; 12:781668. Mahajan VR, Elvig SK, Vendruscolo LF, Koob GF, Darcey VL, King MT, Kranzler HR, Volkow ND, Wiers CE. PMID: 34916977; PMCID: PMC8670944.
      View in: PubMed   Mentions: 9  
    29. Neurocircuitry basis of the opioid use disorder-post-traumatic stress disorder comorbid state: conceptual analyses using a dimensional framework. Lancet Psychiatry. 2022 01; 9(1):84-96. Upadhyay J, Verrico CD, Cay M, Kodele S, Yammine L, Koob GF, Schreiber R. PMID: 34774203.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration. Addict Neurosci. 2022 Mar; 1. Scarlata MJ, Keeley RJ, Carmack SA, Tsai PJ, Vendruscolo J, Lu H, Koob GF, Vendruscolo LF, Stein EA. PMID: 37323812; PMCID: PMC10270679.
      View in: PubMed   Mentions: 2  
    31. Choosing appropriate language to reduce the stigma around mental illness and substance use disorders. Neuropsychopharmacology. 2021 12; 46(13):2230-2232. Volkow ND, Gordon JA, Koob GF. PMID: 34276051; PMCID: PMC8580983.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    32. Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction. Cereb Cortex. 2021 06 10; 31(7):3254-3265. Tomasi D, Wiers CE, Manza P, Shokri-Kojori E, Michele-Vera Y, Zhang R, Kroll D, Feldman D, McPherson K, Biesecker C, Schwandt M, Diazgranados N, Koob GF, Wang GJ, Volkow ND. PMID: 33629726; PMCID: PMC8196255.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    33. A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data. Addict Biol. 2022 01; 27(1):e13033. Deschaine SL, Farokhnia M, Gregory-Flores A, Zallar LJ, You ZB, Sun H, Harvey DM, Marchette RCN, Tunstall BJ, Mani BK, Moose JE, Lee MR, Gardner E, Akhlaghi F, Roberto M, Hougland JL, Zigman JM, Koob GF, Vendruscolo LF, Leggio L. PMID: 33908131; PMCID: PMC8548413.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats. Neurobiol Stress. 2021 May; 14:100325. Marchette RCN, Gregory-Flores A, Tunstall BJ, Carlson ER, Jackson SN, Sulima A, Rice KC, Koob GF, Vendruscolo LF. PMID: 33997152; PMCID: PMC8095052.
      View in: PubMed   Mentions: 8  
    35. Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. Sci Adv. 2021 04; 7(15). Wiers CE, Vendruscolo LF, van der Veen JW, Manza P, Shokri-Kojori E, Kroll DS, Feldman DE, McPherson KL, Biesecker CL, Zhang R, Herman K, Elvig SK, Vendruscolo JCM, Turner SA, Yang S, Schwandt M, Tomasi D, Cervenka MC, Fink-Jensen A, Benveniste H, Diazgranados N, Wang GJ, Koob GF, Volkow ND. PMID: 33837086; PMCID: PMC8034849.
      View in: PubMed   Mentions: 22     Fields:    
    36. Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction. Sci Adv. 2021 04; 7(15). Pantazis CB, Gonzalez LA, Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF. PMID: 33827822; PMCID: PMC8026136.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    37. Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats. Pharmacol Biochem Behav. 2021 05; 204:173157. Cunningham JI, Todtenkopf MS, Dean RL, Azar MR, Koob GF, Deaver DR, Eyerman DJ. PMID: 33647274.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    38. Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology. 2021 05 01; 188:108510. McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. PMID: 33647278; PMCID: PMC8099171.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    39. Tolerance to alcohol: A critical yet understudied factor in alcohol addiction. Pharmacol Biochem Behav. 2021 05; 204:173155. Elvig SK, McGinn MA, Smith C, Arends MA, Koob GF, Vendruscolo LF. PMID: 33631255; PMCID: PMC8917511.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    40. A Basolateral Amygdala Microcircuit for Drug Craving: Is There a Craving Engram? Biol Psychiatry. 2021 02 15; 89(4):323-325. Koob GF. PMID: 33478679.
      View in: PubMed   Mentions: 1     Fields:    
    41. Drug addiction co-morbidity with alcohol: Neurobiological insights. Int Rev Neurobiol. 2021; 157:409-472. McGinn MA, Pantazis CB, Tunstall BJ, Marchette RCN, Carlson ER, Said N, Koob GF, Vendruscolo LF. PMID: 33648675.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    42. Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development. Pharmacol Rev. 2021 01; 73(1):163-201. Koob GF. PMID: 33318153; PMCID: PMC7770492.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    43. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B. EBioMedicine. 2020 Nov; 61:103066. Liu K, Zhao J, Chen C, Xu J, Bell RL, Hall FS, Koob GF, Volkow ND, Qing H, Lin Z. PMID: 33096475; PMCID: PMC7581882.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Demand for fentanyl becomes inelastic following extended access to fentanyl vapor self-administration. Neuropharmacology. 2021 01; 182:108355. McConnell SA, Brandner AJ, Blank BA, Kearns DN, Koob GF, Vendruscolo LF, Tunstall BJ. PMID: 33091459; PMCID: PMC7747488.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Fentanyl vapor self-administration model in mice to study opioid addiction. Sci Adv. 2020 08; 6(32):eabc0413. Moussawi K, Ortiz MM, Gantz SC, Tunstall BJ, Marchette RCN, Bonci A, Koob GF, Vendruscolo LF. PMID: 32821843; PMCID: PMC7406365.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    46. Converging Structural and Functional Evidence for a Rat Salience Network. Biol Psychiatry. 2020 12 01; 88(11):867-878. Tsai PJ, Keeley RJ, Carmack SA, Vendruscolo JCM, Lu H, Gu H, Vendruscolo LF, Koob GF, Lin CP, Stein EA, Yang Y. PMID: 32981657.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    47. The future of translational research on alcohol use disorder. Addict Biol. 2021 03; 26(2):e12903. Ray LA, Grodin EN, Leggio L, Bechtholt AJ, Becker H, Feldstein Ewing SW, Jentsch JD, King AC, Mason BJ, O'Malley S, MacKillop J, Heilig M, Koob GF. PMID: 32286721; PMCID: PMC7554164.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    48. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    49. Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking. Proc Natl Acad Sci U S A. 2019 12 17; 116(51):25974-25981. Guillot A, Ren T, Jourdan T, Pawlosky RJ, Han E, Kim SJ, Zhang L, Koob GF, Gao B. PMID: 31792171; PMCID: PMC6926021.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    50. PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease. Sci Rep. 2019 11 20; 9(1):17167. Lee JS, Mukhopadhyay P, Matyas C, Trojnar E, Paloczi J, Yang YR, Blank BA, Savage C, Sorokin AV, Mehta NN, Vendruscolo JCM, Koob GF, Vendruscolo LF, Pacher P, Lohoff FW. PMID: 31748600; PMCID: PMC6868240.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    51. Larry Stein: pioneer neuropsychopharmacology researcher, mentor, and friend. Neuropsychopharmacology. 2019 12; 44(13):2294-2295. Koob GF. PMID: 31501525; PMCID: PMC6898304.
      View in: PubMed   Mentions:    Fields:    
    52. Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Front Behav Neurosci. 2019; 13:188. Zorrilla EP, Koob GF. PMID: 31501652; PMCID: PMC6718814.
      View in: PubMed   Mentions: 1  
    53. Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Front Behav Neurosci. 2019; 13:136. Zorrilla EP, Koob GF. PMID: 31293401; PMCID: PMC6603097.
      View in: PubMed   Mentions: 28  
    54. Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework. Neuropsychopharmacology. 2020 01; 45(1):141-165. Koob GF, Colrain IM. PMID: 31234199; PMCID: PMC6879503.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    55. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement. Biol Psychiatry. 2020 01 01; 87(1):44-53. Koob GF. PMID: 31400808.
      View in: PubMed   Mentions: 141     Fields:    Translation:Animals
    56. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol. 2019 04; 17(4):e2006421. Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. PMID: 30990816; PMCID: PMC6467366.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    57. Heroin addiction engages negative emotional learning brain circuits in rats. J Clin Invest. 2019 03 26; 129(6):2480-2484. Carmack SA, Keeley RJ, Vendruscolo JCM, Lowery-Gionta EG, Lu H, Koob GF, Stein EA, Vendruscolo LF. PMID: 30913040; PMCID: PMC6546476.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    58. Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding. Eur J Neurosci. 2019 07; 50(1):1831-1842. Tyler RE, Kim SW, Guo M, Jang YJ, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND. PMID: 30803059; PMCID: PMC10714130.
      View in: PubMed   Mentions: 14  Translation:Animals
    59. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. PMID: 30886240; PMCID: PMC6423296.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    60. Male and female mice develop escalation of heroin intake and dependence following extended access. Neuropharmacology. 2019 06; 151:189-194. Towers EB, Tunstall BJ, McCracken ML, Vendruscolo LF, Koob GF. PMID: 30880124; PMCID: PMC9345532.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    61. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. J Neuroendocrinol. 2019 07; 31(7):e12663. Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L. PMID: 30456835.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    62. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? Alcohol Alcohol. 2019 Jan 09; 54(5):497-502. Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP. PMID: 31535696; PMCID: PMC6751410.
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    63. Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder. Am J Psychiatry. 2019 09 01; 176(9):744-753. Kwako LE, Schwandt ML, Ramchandani VA, Diazgranados N, Koob GF, Volkow ND, Blanco C, Goldman D. PMID: 30606047; PMCID: PMC6609498.
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    64. Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents. Mol Psychiatry. 2020 08; 25(8):1759-1776. Du C, Volkow ND, You J, Park K, Allen CP, Koob GF, Pan Y. PMID: 30283033; PMCID: PMC6447479.
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    65. Addiction and stress: An allostatic view. Neurosci Biobehav Rev. 2019 11; 106:245-262. Koob GF, Schulkin J. PMID: 30227143.
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    66. Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. Brain Sci. 2018 Jun 26; 8(7). Somkuwar SS, Quach LW, Quigley JA, Purohit DC, Fannon MJ, Koob GF, Mandyam CD. PMID: 29949891; PMCID: PMC6070985.
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    67. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Mol Psychiatry. 2018 12; 23(12):2266-2276. Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. PMID: 29880881; PMCID: PMC8276917.
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    68. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents. Neuropsychopharmacology. 2018 08; 43(9):1832-1839. Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral SB, Diazgranados N, Park L, Liow JS, Pike V, Morse C, Vendruscolo LF, Innis RB, Koob GF, Tomasi D, Wang GJ, Volkow ND. PMID: 29777199; PMCID: PMC6046047.
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    69. Promoting Wellness in Older Adults with Mental Illnesses and Substance Use Disorders: Call to Action to All Stakeholders. Am J Geriatr Psychiatry. 2018 06; 26(6):617-630. Jeste DV, Peschin S, Buckwalter K, Blazer DG, McGuire MH, Moutier C, Doederlein A, Niederehe G, Altman B, Borenstein J, Saks E, Norquist G, Koob GF, Compton WM, Sperling A, Bain L, Glorioso D, Paul IH, Reynolds CF. PMID: 29880118.
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    70. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology. 2018 11; 43(12):2373-2382. Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. PMID: 29703996; PMCID: PMC6180106.
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    71. Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats. Addict Biol. 2019 05; 24(3):485-497. Allen CP, Park K, Li A, Volkow ND, Koob GF, Pan Y, Hu XT, Du C. PMID: 29504647; PMCID: PMC6123312.
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    72. Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):940-946. Kenny PJ, Hoyer D, Koob GF. PMID: 29602521.
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    73. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism. Front Psychiatry. 2018; 9:28. Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. PMID: 29497387; PMCID: PMC5818434.
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    74. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. Int J Obes (Lond). 2019 02; 43(2):344-354. Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L. PMID: 29453460; PMCID: PMC6066458.
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    75. Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects. Sci Rep. 2018 01 17; 8(1):882. Tian YH, Ma SX, Lee KW, Wee S, Koob GF, Lee SY, Jang CG. PMID: 29343767; PMCID: PMC5772440.
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    76. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 03 15; 131:96-103. Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. PMID: 29217282; PMCID: PMC5820113.
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    77. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry. 2018 06 15; 83(12):1024-1035. Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. PMID: 29357981; PMCID: PMC5960600.
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    78. Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST). Psychopharmacology (Berl). 2017 Dec; 234(23-24):3485-3498. Francesconi W, Szücs A, Berton F, Koob GF, Vendruscolo LF, Sanna PP. PMID: 28986608; PMCID: PMC5993421.
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    79. Individual differences in the neuropsychopathology of addiction. Dialogues Clin Neurosci. 2017 09; 19(3):217-229. George O, Koob GF. PMID: 29302219; PMCID: PMC5741105.
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    80. Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder. Mol Psychiatry. 2018 09; 23(9):1900-1910. Lohoff FW, Sorcher JL, Rosen AD, Mauro KL, Fanelli RR, Momenan R, Hodgkinson CA, Vendruscolo LF, Koob GF, Schwandt M, George DT, Jones IS, Holmes A, Zhou Z, Xu MJ, Gao B, Sun H, Phillips MJ, Muench C, Kaminsky ZA. PMID: 28848234; PMCID: PMC5832488.
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    81. Neuroscience of Compulsive Eating Behavior. Front Neurosci. 2017; 11:469. Moore CF, Sabino V, Koob GF, Cottone P. PMID: 28883784; PMCID: PMC5573809.
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    82. Compulsive-Like Sufentanil Vapor Self-Administration in Rats. Neuropsychopharmacology. 2018 03; 43(4):801-809. Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater SA, Taffe MA, Koob GF, Vendruscolo LF. PMID: 28812595; PMCID: PMC5809787.
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    83. The future is now: A 2020 view of alcoholism research. Neuropharmacology. 2017 08 01; 122:1-2. Harris RA, Koob GF. PMID: 28633760; PMCID: PMC6135244.
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    84. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Mol Psychiatry. 2018 06; 23(6):1466-1473. Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L. PMID: 28461696; PMCID: PMC5668213.
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    85. The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection. J Nerv Ment Dis. 2017 Apr; 205(4):270-272. Koob GF. PMID: 27356121; PMCID: PMC6135258.
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    86. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Mol Psychiatry. 2018 03; 23(3):629-638. Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD. PMID: 28348387; PMCID: PMC5617764.
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    87. Addictions Neuroclinical Assessment: A reverse translational approach. Neuropharmacology. 2017 Aug 01; 122:254-264. Kwako LE, Momenan R, Grodin EN, Litten RZ, Koob GF, Goldman D. PMID: 28283392; PMCID: PMC5569299.
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    88. Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction. Psychopharmacology (Berl). 2017 05; 234(9-10):1315-1332. Koob GF. PMID: 28050629.
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    89. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 02 01; 37(5):1139-1155. Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. PMID: 27986929; PMCID: PMC5296793.
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    90. Pathological Overeating: Emerging Evidence for a Compulsivity Construct. Neuropsychopharmacology. 2017 Jun; 42(7):1375-1389. Moore CF, Sabino V, Koob GF, Cottone P. PMID: 27922596; PMCID: PMC5436113.
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    91. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859. Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. PMID: 27917870; PMCID: PMC5520777.
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    92. Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking. Curr Opin Behav Sci. 2017 Feb; 13:85-90. Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF. PMID: 28603755; PMCID: PMC5461929.
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    93. A Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence. Neuropsychopharmacology. 2017 Apr; 42(5):1012-1023. Ryan ML, Falk DE, Fertig JB, Rendenbach-Mueller B, Katz DA, Tracy KA, Strain EC, Dunn KE, Kampman K, Mahoney E, Ciraulo DA, Sickles-Colaneri L, Ait-Daoud N, Johnson BA, Ransom J, Scott C, Koob GF, Litten RZ. PMID: 27658483; PMCID: PMC5506792.
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    94. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 09 07; 36(36):9446-53. de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. PMID: 27605618; PMCID: PMC5013191.
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    95. Corticotropin-Releasing Factor From Rodents to Primates: Translational Hope Expresses Itself, Pun Intended. Biol Psychiatry. 2016 09 01; 80(5):340-2. Koob GF. PMID: 27499011; PMCID: PMC6145175.
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    96. Reply to: Neuroclinical Assessment of Addiction Needs to Incorporate Decision-Making Measures and Ecological Validity. Biol Psychiatry. 2017 04 01; 81(7):e55. Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. PMID: 27776735.
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    97. Sex, strain, and estrous cycle influences on alcohol drinking in rats. Pharmacol Biochem Behav. 2017 Jan; 152:61-67. Priddy BM, Carmack SA, Thomas LC, Vendruscolo JC, Koob GF, Vendruscolo LF. PMID: 27498303; PMCID: PMC5755698.
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    98. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 08 03; 36(31):8149-59. Verheij MM, Vendruscolo LF, Caffino L, Giannotti G, Cazorla M, Fumagalli F, Riva MA, Homberg JR, Koob GF, Contet C. PMID: 27488635; PMCID: PMC4971362.
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    99. Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats. Biol Psychiatry. 2017 04 01; 81(7):606-615. Schmeichel BE, Herman MA, Roberto M, Koob GF. PMID: 27567312; PMCID: PMC5161745.
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    100. 11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse. Transl Psychiatry. 2016 Mar 15; 6:e760. Sanna PP, Kawamura T, Chen J, Koob GF, Roberts AJ, Vendruscolo LF, Repunte-Canonigo V. PMID: 26978742; PMCID: PMC4872439.
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    101. Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology. 2016 Jan; 41(1):373-4. Chavkin C, Koob GF. PMID: 26657953; PMCID: PMC4677142.
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    102. Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders. Biol Psychiatry. 2016 08 01; 80(3):179-89. Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. PMID: 26772405; PMCID: PMC4870153.
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    103. Existing and Future Drugs for the Treatment of the Dark Side of Addiction. Annu Rev Pharmacol Toxicol. 2016; 56:299-322. Koob GF, Mason BJ. PMID: 26514207.
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    104. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology. 2016 Apr; 41(5):1210-22. You IJ, Wright SR, Garcia-Garcia AL, Tapper AR, Gardner PD, Koob GF, David Leonardo E, Bohn LM, Wee S. PMID: 26324408; PMCID: PMC4793105.
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    105. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. PMID: 26183165; PMCID: PMC4573833.
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    106. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest. 2015 Aug 03; 125(8):3193-7. Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. PMID: 26121746; PMCID: PMC4563748.
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    107. Brain pathways to recovery from alcohol dependence. Alcohol. 2015 Aug; 49(5):435-52. Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV. PMID: 26074423; PMCID: PMC4468789.
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    108. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015 Apr 15; 35(15):6241-53. Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. PMID: 25878294; PMCID: PMC4397613.
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    109. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology. 2015 Mar 13; 40(5):1123-9. Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. PMID: 25367502; PMCID: PMC4367454.
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    110. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015 Mar 11; 35(10):4296-305. Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. PMID: 25762676; PMCID: PMC4355200.
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    111. Pharmacology, Biochemistry and Behavior: the 2015 transition. Pharmacol Biochem Behav. 2015 Apr; 131:iii. Koob GF, Griebel G. PMID: 25661528.
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    112. Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks. Genome Biol. 2015 Feb 02; 16:68. Repunte-Canonigo V, Shin W, Vendruscolo LF, Lefebvre C, van der Stap L, Kawamura T, Schlosburg JE, Alvarez M, Koob GF, Califano A, Sanna PP. PMID: 25886852; PMCID: PMC4410476.
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    113. The dark side of emotion: the addiction perspective. Eur J Pharmacol. 2015 Apr 15; 753:73-87. Koob GF. PMID: 25583178; PMCID: PMC4380644.
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    114. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8. Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. PMID: 25402857; PMCID: PMC4241147.
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    115. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015 Jan; 232(2):453-63. Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. PMID: 25059540; PMCID: PMC4297709.
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    116. Compulsive-like responding for opioid analgesics in rats with extended access. Neuropsychopharmacology. 2015 Jan; 40(2):421-8. Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF. PMID: 25060491; PMCID: PMC4443956.
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    117. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener. 2014 Jul 01; 9:26. Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. PMID: 24980976; PMCID: PMC4107468.
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    118. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 2014 Jul; 38(7):2148-57. Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. PMID: 24961585; PMCID: PMC4142977.
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    119. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology (Berl). 2014 Oct; 231(19):3911-7. George O, Koob GF, Vendruscolo LF. PMID: 24923982; PMCID: PMC8278497.
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    120. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behav Brain Res. 2014 Sep 01; 271:171-6. Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. PMID: 24914463; PMCID: PMC4216724.
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    121. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS One. 2014; 9(5):e97216. Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. PMID: 24816773; PMCID: PMC4016270.
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    122. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. PLoS One. 2014; 9(4):e95962. Mazei-Robison MS, Appasani R, Edwards S, Wee S, Taylor SR, Picciotto MR, Koob GF, Nestler EJ. PMID: 24755634; PMCID: PMC3995955.
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    123. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology. 2014 Jun; 39(7):1722-31. Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. PMID: 24549104; PMCID: PMC4023146.
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    124. Corticotropin releasing factor: a key role in the neurobiology of addiction. Front Neuroendocrinol. 2014 Apr; 35(2):234-44. Zorrilla EP, Logrip ML, Koob GF. PMID: 24456850; PMCID: PMC4213066.
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    125. Neurocircuitry of alcohol addiction: synthesis from animal models. Handb Clin Neurol. 2014; 125:33-54. Koob GF. PMID: 25307567.
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    126. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addict Biol. 2015 Mar; 20(2):275-84. Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF. PMID: 24330252; PMCID: PMC4057367.
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    127. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. J Neurosci. 2013 Dec 04; 33(49):19384-92. Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. PMID: 24305833; PMCID: PMC3850049.
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    128. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology (Berl). 2014 Mar; 231(5):929-37. Buck CL, Vendruscolo LF, Koob GF, George O. PMID: 24221826; PMCID: PMC3945412.
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    129. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala. Neuropharmacology. 2014 Feb; 77:294-302. Gilpin NW, Roberto M, Koob GF, Schweitzer P. PMID: 24157490; PMCID: PMC3873141.
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    130. The development and maintenance of drug addiction. Neuropsychopharmacology. 2014 Jan; 39(2):254-62. Wise RA, Koob GF. PMID: 24121188; PMCID: PMC3870778.
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    131. Probing the effects of hapten stability on cocaine vaccine immunogenicity. Mol Pharm. 2013 Nov 04; 10(11):4176-84. Cai X, Whitfield T, Moreno AY, Grant Y, Hixon MS, Koob GF, Janda KD. PMID: 23927436; PMCID: PMC3946501.
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    132. Neural mechanisms of pain and alcohol dependence. Pharmacol Biochem Behav. 2013 Nov; 112:34-41. Apkarian AV, Neugebauer V, Koob G, Edwards S, Levine JD, Ferrari L, Egli M, Regunathan S. PMID: 24095683; PMCID: PMC4887744.
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    133. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behav Pharmacol. 2013 Sep; 24(5-6):356-62. Edwards S, Koob GF. PMID: 23839030; PMCID: PMC3866817.
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    134. Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. PLoS One. 2013; 8(8):e63942. Zorrilla EP, Roberts AJ, Rivier JE, Koob GF. PMID: 24015170; PMCID: PMC3756045.
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    135. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Transl Psychiatry. 2013 Aug 27; 3:e296. Edwards S, Baynes BB, Carmichael CY, Zamora-Martinez ER, Barrus M, Koob GF, Gilpin NW. PMID: 23982628; PMCID: PMC3756295.
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    136. Addiction is a Reward Deficit and Stress Surfeit Disorder. Front Psychiatry. 2013; 4:72. Koob GF. PMID: 23914176; PMCID: PMC3730086.
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    137. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addict Biol. 2015 Jan; 20(1):56-68. Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. PMID: 23869743; PMCID: PMC3859819.
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    138. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biol Psychiatry. 2013 Oct 01; 74(7):520-8. Kallupi M, Wee S, Edwards S, Whitfield TW, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. PMID: 23751206; PMCID: PMC3773286.
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    139. Addiction as a stress surfeit disorder. Neuropharmacology. 2014 Jan; 76 Pt B:370-82. Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. PMID: 23747571; PMCID: PMC3830720.
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    140. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology. 2013 Oct; 38(11):2170-8. Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. PMID: 23660705; PMCID: PMC3773666.
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    141. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9036-41. Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. PMID: 23650354; PMCID: PMC3670323.
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    142. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addict Biol. 2014 Sep; 19(5):755-7. Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. PMID: 23639035; PMCID: PMC3872251.
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    143. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. J Med Chem. 2013 May 09; 56(9):3701-9. Cai X, Whitfield T, Hixon MS, Grant Y, Koob GF, Janda KD. PMID: 23627877; PMCID: PMC3691275.
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    144. Negative reinforcement in drug addiction: the darkness within. Curr Opin Neurobiol. 2013 Aug; 23(4):559-63. Koob GF. PMID: 23628232.
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    145. Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. Int J Neuropsychopharmacol. 2013 Sep; 16(8):1867-75. Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF. PMID: 23590881; PMCID: PMC3880138.
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    146. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci. 2013 Mar 06; 33(10):4295-307. Robison AJ, Vialou V, Mazei-Robison M, Feng J, Kourrich S, Collins M, Wee S, Koob G, Turecki G, Neve R, Thomas M, Nestler EJ. PMID: 23467346; PMCID: PMC3658178.
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    147. Control of craving by the prefrontal cortex. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4165-6. George O, Koob GF. PMID: 23483010; PMCID: PMC3600441.
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    148. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci. 2013; 13:3-30. Koob GF. PMID: 21744309; PMCID: PMC3448980.
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    149. Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor. Nat Commun. 2013; 4:1955. Chen J, Repunte-Canonigo V, Kawamura T, Lefebvre C, Shin W, Howell LL, Hemby SE, Harvey BK, Califano A, Morales M, Koob GF, Sanna PP. PMID: 23736082; PMCID: PMC3709481.
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    150. Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014 Jul; 19(4):562-74. Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. PMID: 23278919; PMCID: PMC3620729.
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    151. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology. 2013 May; 38(6):976-84. Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. PMID: 23303056; PMCID: PMC3629386.
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    152. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt A):1932-45. Zorrilla EP, Koob GF. PMID: 23220696; PMCID: PMC3838492.
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    153. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 2013 Apr; 67:337-48. Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. PMID: 23220399; PMCID: PMC3562384.
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    154. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18156-61. George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. PMID: 23071333; PMCID: PMC3497825.
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    155. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology (Berl). 2013 Feb; 225(3):753-63. Jang CG, Whitfield T, Schulteis G, Koob GF, Wee S. PMID: 23007601; PMCID: PMC3547144.
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    156. Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev. 2012 Nov; 36(10):2179-92. Egli M, Koob GF, Edwards S. PMID: 22975446; PMCID: PMC3612891.
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    157. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine. 2012 Oct 19; 30(47):6665-70. Moreno AY, Azar MR, Koob GF, Janda KD. PMID: 22963803.
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    158. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. Sci Transl Med. 2012 Aug 08; 4(146):146ra110. Wee S, Vendruscolo LF, Misra KK, Schlosburg JE, Koob GF. PMID: 22875830; PMCID: PMC3448552.
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    159. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. J Neurosci. 2012 May 30; 32(22):7563-71. Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. PMID: 22649234; PMCID: PMC3375621.
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    160. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology. 2012 Aug; 37(9):2153-60. Cohen A, Koob GF, George O. PMID: 22549121; PMCID: PMC3398720.
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    161. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Hum Gene Ther. 2012 May; 23(5):451-9. Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Tignor N, Mezey JG, Crystal RG. PMID: 22486244; PMCID: PMC3360503.
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    162. Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology (Berl). 2012 Sep; 223(2):159-68. Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. PMID: 22526534; PMCID: PMC3464481.
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    163. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology (Berl). 2012 Sep; 223(1):17-25. Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. PMID: 22418732; PMCID: PMC3464482.
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    164. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends Neurosci. 2012 Apr; 35(4):250-60. Mandyam CD, Koob GF. PMID: 22265158; PMCID: PMC3321119.
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    165. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. Methods Mol Biol. 2012; 829:31-48. Edwards S, Koob GF. PMID: 22231805; PMCID: PMC3285446.
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    166. Animal models of psychiatric disorders. Handb Clin Neurol. 2012; 106:137-66. Koob GF. PMID: 22608620.
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    167. Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology. 2012 Jan; 37(1):308-9. Koob GF, Zorrilla EP. PMID: 22157874; PMCID: PMC3238086.
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    168. Treatment of alcohol dependence with drug antagonists of the stress response. Alcohol Res. 2012; 34(4):516-21. Higley AE, Koob GF, Mason BJ. PMID: 23584117; PMCID: PMC3860394.
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    169. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr; 37(5):1275-87. Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. PMID: 22205547; PMCID: PMC3306889.
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    170. Developing a vaccine against multiple psychoactive targets: a case study of heroin. CNS Neurol Disord Drug Targets. 2011 Dec; 10(8):865-75. Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. PMID: 22229311; PMCID: PMC3327724.
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    171. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus. CNS Neurol Disord Drug Targets. 2011 Dec; 10(8):899-904. Koob G, Hicks MJ, Wee S, Rosenberg JB, De BP, Kaminsky SM, Moreno A, Janda KD, Crystal RG. PMID: 22229312; PMCID: PMC3369545.
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    172. Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. Br J Pharmacol. 2011 Dec; 164(8):1959-75. Fekete EM, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale WW, Koob GF, Zorrilla EP. PMID: 21627635; PMCID: PMC3246660.
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    173. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism. Neuropharmacology. 2012 Feb; 62(2):1142-51. Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. PMID: 22119954; PMCID: PMC3262951.
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    174. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiol Behav. 2012 Apr 12; 106(1):58-64. George O, Le Moal M, Koob GF. PMID: 22108506; PMCID: PMC3288230.
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    175. Drug specificity in extended access cocaine and heroin self-administration. Addict Biol. 2012 Nov; 17(6):964-76. Lenoir M, Guillem K, Koob GF, Ahmed SH. PMID: 21995515.
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    176. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology. 2012 Apr; 37(5):1083-91. Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM, Janda KD, Crystal RG, Koob GF. PMID: 21918504; PMCID: PMC3306868.
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    177. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology. 2012 Feb; 62(2):552-64. Logrip ML, Zorrilla EP, Koob GF. PMID: 21782834; PMCID: PMC3206986.
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    178. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Addict Biol. 2012 Mar; 17(2):300-8. Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. PMID: 21762287; PMCID: PMC3304464.
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    179. A vaccine strategy that induces protective immunity against heroin. J Med Chem. 2011 Jul 28; 54(14):5195-204. Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. PMID: 21692508; PMCID: PMC3142939.
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    180. Preclinical validation of a novel cocaine exposure therapy for relapse prevention. Biol Psychiatry. 2011 Sep 15; 70(6):593-8. Mihindou C, Vouillac C, Koob GF, Ahmed SH. PMID: 21571256; PMCID: PMC3157564.
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    181. The dark side of food addiction. Physiol Behav. 2011 Jul 25; 104(1):149-56. Parylak SL, Koob GF, Zorrilla EP. PMID: 21557958; PMCID: PMC3304465.
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    182. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biol Psychiatry. 2011 Jun 01; 69(11):1091-9. Gilpin NW, Misra K, Herman MA, Cruz MT, Koob GF, Roberto M. PMID: 21459365; PMCID: PMC3090491.
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    183. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. CNS Drugs. 2011 Apr; 25(4):271-87. Logrip ML, Koob GF, Zorrilla EP. PMID: 21425881; PMCID: PMC3273042.
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    184. Craving, context and the cortex. Nat Neurosci. 2011 Apr; 14(4):409-10. George O, Koob GF. PMID: 21445066; PMCID: PMC3829767.
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    185. Escalation patterns of varying periods of heroin access. Pharmacol Biochem Behav. 2011 Jun; 98(4):570-4. Vendruscolo LF, Schlosburg JE, Misra KK, Chen SA, Greenwell TN, Koob GF. PMID: 21406200; PMCID: PMC3081940.
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    186. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence. Addict Biol. 2011 Oct; 16(4):615-9. Contet C, Gardon O, Filliol D, Becker JA, Koob GF, Kieffer BL. PMID: 21392173; PMCID: PMC3139763.
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    187. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology. 2011 May; 36(6):1207-18. Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. PMID: 21346735; PMCID: PMC3079320.
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    188. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain Behav Immun. 2011 Jun; 25 Suppl 1:S50-60. Allen CD, Lee S, Koob GF, Rivier C. PMID: 21300146; PMCID: PMC3098294.
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    189. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addict Biol. 2012 Jan; 17(1):76-85. Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. PMID: 21309953; PMCID: PMC3178679.
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    190. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict Biol. 2012 Jan; 17(1):108-20. Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA. PMID: 21309947; PMCID: PMC3117922.
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    191. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther. 2011 Mar; 19(3):612-9. Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Toth M, Mezey JG, Crystal RG. PMID: 21206484; PMCID: PMC3048190.
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    192. Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addict Biol. 2011 Jan; 16(1):116-9. Walker BM, Zorrilla EP, Koob GF. PMID: 20579007; PMCID: PMC2988980.
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    193. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology (Berl). 2011 Feb; 213(4):715-22. George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. PMID: 20924754; PMCID: PMC3033995.
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    194. Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology (Berl). 2010 Oct; 212(3):431-9. Gilpin NW, Koob GF. PMID: 20676608; PMCID: PMC2966867.
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    195. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Med. 2010 Jul; 11(7):1092-8. Shurman J, Koob GF, Gutstein HB. PMID: 20545871; PMCID: PMC2907890.
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    196. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2010 Nov; 35(2):232-47. George O, Koob GF. PMID: 20493211; PMCID: PMC2955797.
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    197. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol. 2010 May 01; 5(3):393-401. Edwards S, Koob GF. PMID: 20563312; PMCID: PMC2886284.
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    198. The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addict Biol. 2010 Jul; 15(3):312-23. Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. PMID: 20456290; PMCID: PMC2903631.
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    199. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacol Biochem Behav. 2010 Jul; 96(1):104-7. George O, Grieder TE, Cole M, Koob GF. PMID: 20420848; PMCID: PMC2878929.
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    200. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl). 2010 Jun; 210(2):121-35. Wee S, Koob GF. PMID: 20352414; PMCID: PMC2879894.
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    201. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discov Today. 2010 May; 15(9-10):371-83. Zorrilla EP, Koob GF. PMID: 20206287; PMCID: PMC2864802.
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    202. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biol Psychiatry. 2010 May 01; 67(9):831-9. Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. PMID: 20060104; PMCID: PMC2883449.
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    203. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Curr Opin Investig Drugs. 2010 Jan; 11(1):63-71. Koob GF, Zorrilla EP. PMID: 20047160; PMCID: PMC2812895.
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    204. Neurocircuitry of addiction. Neuropsychopharmacology. 2010 Jan; 35(1):217-38. Koob GF, Volkow ND. PMID: 19710631; PMCID: PMC2805560.
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    205. Focus on: Neuroscience and treatment: the potential of neuroscience to inform treatment. Alcohol Res Health. 2010; 33(1-2):144-51. Koob GF. PMID: 23579944; PMCID: PMC3887491.
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    206. The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res. 2010 Feb 16; 1314:3-14. Koob GF. PMID: 19912996; PMCID: PMC2819562.
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    207. CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):20016-20. Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. PMID: 19901333; PMCID: PMC2785284.
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    208. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009 Oct 27; 7:70. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism. PMID: 19874574; PMCID: PMC2777866.
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    209. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcohol Clin Exp Res. 2009 Dec; 33(12):2113-23. Gilpin NW, Smith AD, Cole M, Weiss F, Koob GF, Richardson HN. PMID: 19740131; PMCID: PMC2789881.
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    210. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13; 33(8):1347-55. Francesconi W, Berton F, Koob GF, Sanna PP. PMID: 19683025; PMCID: PMC2935256.
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    211. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiol Dis. 2009 Oct; 36(1):1-10. Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam CD. PMID: 19501165; PMCID: PMC2742572.
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    212. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl). 2009 Sep; 205(4):565-75. Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF. PMID: 19484223; PMCID: PMC2739447.
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    213. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology (Berl). 2009 Aug; 205(2):327-35. Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. PMID: 19440699; PMCID: PMC2748837.
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    214. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry. 2009 May; 42 Suppl 1:S32-41. Koob GF. PMID: 19434554; PMCID: PMC2739305.
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    215. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. J Neurosci. 2009 Apr 29; 29(17):5389-401. Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, Sanna PP. PMID: 19403807; PMCID: PMC2938175.
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    216. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci. 2009 Apr 15; 29(15):4846-57. Orio L, Edwards S, George O, Parsons LH, Koob GF. PMID: 19369553; PMCID: PMC2688678.
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    217. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addict Biol. 2009 Apr; 14(2):130-43. Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. PMID: 19291009; PMCID: PMC2748834.
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    218. Brain stress systems in the amygdala and addiction. Brain Res. 2009 Oct 13; 1293:61-75. Koob GF. PMID: 19332030; PMCID: PMC2774745.
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    219. New dimensions in human laboratory models of addiction. Addict Biol. 2009 Jan; 14(1):1-8. Koob GF. PMID: 19133879.
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    220. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology. 2009 May; 34(6):1482-93. Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. PMID: 18946467; PMCID: PMC2669694.
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    221. Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12; 363(1507):3113-23. Koob GF, Le Moal M. PMID: 18653439; PMCID: PMC2607326.
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    222. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur J Neurosci. 2008 Oct; 28(8):1641-53. Richardson HN, Lee SY, O'Dell LE, Koob GF, Rivier CL. PMID: 18979677; PMCID: PMC2748838.
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    223. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14609-14. Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, Beutler B. PMID: 18794526; PMCID: PMC2567147.
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    224. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 2009; 56 Suppl 1:18-31. Koob GF. PMID: 18725236; PMCID: PMC2637927.
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    225. The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacol Biochem Behav. 2009 Jan; 91(3):295-302. Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. PMID: 18703080; PMCID: PMC2637926.
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    226. Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2008 Sep; 32(9):1535-42. Gilpin NW, Richardson HN, Koob GF. PMID: 18631323; PMCID: PMC2583093.
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    227. A role for brain stress systems in addiction. Neuron. 2008 Jul 10; 59(1):11-34. Koob GF. PMID: 18614026; PMCID: PMC2748830.
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    228. Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake". FASEB J. 2008 Jul; 22(7):2113; author reply 2113-4. Walker BM, Koob GF. PMID: 18593720.
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    229. Vapor inhalation of alcohol in rats. Curr Protoc Neurosci. 2008 Jul; Chapter 9:Unit 9.29. Gilpin NW, Richardson HN, Cole M, Koob GF. PMID: 18634001; PMCID: PMC2583102.
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    230. Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8809-10. Koob GF. PMID: 18583480; PMCID: PMC2449322.
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    231. Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci. 2008 May 28; 28(22):5762-71. Roberto M, Gilpin NW, O'Dell LE, Cruz MT, Morse AC, Siggins GR, Koob GF. PMID: 18509038; PMCID: PMC2493536.
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    232. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry. 2008 Dec 01; 64(11):958-65. Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. PMID: 18490002; PMCID: PMC2587157.
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    233. Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcohol Clin Exp Res. 2008 Sep; 32(9):1688-96. Gilpin NW, Richardson HN, Lumeng L, Koob GF. PMID: 18482158; PMCID: PMC2583092.
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    234. Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacol Biochem Behav. 2008 Sep; 90(3):475-80. Gilpin NW, Misra K, Koob GF. PMID: 18501411; PMCID: PMC2480495.
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    235. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. PMID: 18371494.
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    236. alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol. 2008 Mar; 42(2):91-7. Walker BM, Rasmussen DD, Raskind MA, Koob GF. PMID: 18358987; PMCID: PMC2587143.
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    237. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology. 2008 Nov; 33(12):2878-87. Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A. PMID: 18288089; PMCID: PMC2760329.
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    238. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav Pharmacol. 2008 Feb; 19(1):1-12. Ji D, Gilpin NW, Richardson HN, Rivier CL, Koob GF. PMID: 18195589; PMCID: PMC2586833.
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    239. Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis. Biol Psychiatry. 2008 Jan 15; 63(2):137-8. Koob GF. PMID: 18164903; PMCID: PMC2386996.
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    240. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discov Today Dis Models. 2008; 5(4):207-215. Koob GF. PMID: 20054425; PMCID: PMC2801885.
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    241. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Res Health. 2008; 31(3):185-95. Gilpin NW, Koob GF. PMID: 19881886; PMCID: PMC2770186.
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    242. Addiction and the brain antireward system. Annu Rev Psychol. 2008; 59:29-53. Koob GF, Le Moal M. PMID: 18154498.
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    243. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci. 2007 Nov 28; 27(48):13140-50. Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. PMID: 18045908; PMCID: PMC2747091.
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    244. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology. 2008 Sep; 33(10):2474-82. George O, Mandyam CD, Wee S, Koob GF. PMID: 18033234; PMCID: PMC2760333.
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    245. CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology (Berl). 2008 Feb; 196(3):473-82. Specio SE, Wee S, O'Dell LE, Boutrel B, Zorrilla EP, Koob GF. PMID: 17965976; PMCID: PMC2769571.
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    246. Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. Eur Neuropsychopharmacol. 2008 Apr; 18(4):303-11. Wee S, Mandyam CD, Lekic DM, Koob GF. PMID: 17920248; PMCID: PMC2376122.
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    247. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacol Biochem Behav. 2008 Feb; 88(4):497-510. Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. PMID: 18031798; PMCID: PMC3319109.
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    248. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci. 2007 Oct 17; 27(42):11442-50. Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF. PMID: 17942739; PMCID: PMC2741502.
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    249. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17198-203. George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. PMID: 17921249; PMCID: PMC2040467.
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    250. Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. Eur J Neurosci. 2007 Oct; 26(8):2303-14. Tabarin A, Diz-Chaves Y, Consoli D, Monsaingeon M, Bale TL, Culler MD, Datta R, Drago F, Vale WW, Koob GF, Zorrilla EP, Contarino A. PMID: 17953621; PMCID: PMC2741498.
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    251. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcohol Clin Exp Res. 2007 Nov; 31(11):1811-9. Zhang Z, Morse AC, Koob GF, Schulteis G. PMID: 17877783; PMCID: PMC2367334.
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    252. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007 Aug; 164(8):1149-59. Koob G, Kreek MJ. PMID: 17671276; PMCID: PMC2837343.
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    253. Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion. Biol Psychiatry. 2008 Jan 15; 63(2):158-63. Guillem K, Vouillac C, Koob GF, Cador M, Stinus L. PMID: 17643399.
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    254. A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci. 2007 Aug; 30(8):399-406. Heilig M, Koob GF. PMID: 17629579; PMCID: PMC2747092.
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    255. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11580-4. Treweek J, Wee S, Koob GF, Dickerson TJ, Janda KD. PMID: 17592122; PMCID: PMC1913859.
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    256. Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology. 2008 Feb; 33(3):643-52. Walker BM, Koob GF. PMID: 17473837; PMCID: PMC2739278.
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    257. A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Res. 2007 Jun 25; 1155:172-8. Funk CK, Koob GF. PMID: 17512918; PMCID: PMC2741495.
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    258. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacol Biochem Behav. 2007 Apr; 86(4):813-21. Chu K, Koob GF, Cole M, Zorrilla EP, Roberts AJ. PMID: 17482248; PMCID: PMC2170886.
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    259. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain. 2007 May; 130(Pt 5):1330-7. Thorsell A, Repunte-Canonigo V, O'Dell LE, Chen SA, King AR, Lekic D, Koob GF, Sanna PP. PMID: 17405766; PMCID: PMC2749684.
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    260. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol. J Am Chem Soc. 2007 Mar 28; 129(12):3698-702. Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. PMID: 17335216.
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    261. Inaugural issue of the journal of addiction medicine. J Addict Med. 2007 Mar; 1(1):1. Koob GF, Miller SC, Wunsch MJ. PMID: 21768924.
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    262. Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration. Neuropsychopharmacology. 2007 Oct; 32(10):2238-47. Wee S, Wang Z, Woolverton WL, Pulvirenti L, Koob GF. PMID: 17327886; PMCID: PMC2747088.
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    263. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. Pharmacol Biochem Behav. 2007 Feb; 86(2):346-53. O'Dell LE, Koob GF. PMID: 17292952; PMCID: PMC2386418.
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    264. Effects of dose and session duration on cocaine self-administration in rats. J Pharmacol Exp Ther. 2007 Mar; 320(3):1134-43. Wee S, Specio SE, Koob GF. PMID: 17202405.
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    265. The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcohol Clin Exp Res. 2007 Jan; 31(1):11-8. Walker BM, Koob GF. PMID: 17207096; PMCID: PMC2768469.
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    266. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. Eur J Neurosci. 2006 Dec; 24(12):3532-40. Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. PMID: 17229101.
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    267. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm. 2006 Nov-Dec; 3(6):773-7. Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ, Janda KD. PMID: 17140265; PMCID: PMC2562334.
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    268. New developments in addiction treatment. J Clin Psychiatry. 2006 Nov; 67(11):1801-12. CME Institute of Physicians Postgraduate Press, O'Brien CP, Koob GF, Mee-Lee D, Rosenthal RN. PMID: 17196062.
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    269. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J Neurosci. 2006 Nov 01; 26(44):11324-32. Funk CK, O'Dell LE, Crawford EF, Koob GF. PMID: 17079660; PMCID: PMC6674550.
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    270. Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. Eur J Pharmacol. 2007 Jan 19; 555(1):23-9. Solbrig MV, Adrian R, Wechsler SL, Koob GF. PMID: 17126318; PMCID: PMC2981072.
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    271. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2006 Dec; 189(2):175-86. Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. PMID: 17047935.
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    272. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. J Pharmacol Exp Ther. 2007 Jan; 320(1):180-93. O'Dell LE, Chen SA, Smith RT, Specio SE, Balster RL, Paterson NE, Markou A, Zorrilla EP, Koob GF. PMID: 17050784.
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    273. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology. 2007 May; 32(5):1052-68. Fekete EM, Inoue K, Zhao Y, Rivier JE, Vale WW, Szücs A, Koob GF, Zorrilla EP. PMID: 17019404; PMCID: PMC2748839.
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    274. The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction. 2006 Sep; 101 Suppl 1:23-30. Koob GF. PMID: 16930158.
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    275. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biol Psychiatry. 2007 Jan 01; 61(1):78-86. Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. PMID: 16876134; PMCID: PMC2741496.
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    276. Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons. Exp Neurol. 2006 Nov; 202(1):139-51. Steffensen SC, Stobbs SH, Colago EE, Lee RS, Koob GF, Gallegos RA, Henriksen SJ. PMID: 16814775.
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    277. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. J Neurosci. 2006 May 31; 26(22):5894-900. Kenny PJ, Chen SA, Kitamura O, Markou A, Koob GF. PMID: 16738231; PMCID: PMC6675212.
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    278. Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat. Pharmacol Biochem Behav. 2006 Mar; 83(3):403-9. Hoefer ME, Voskanian SJ, Koob GF, Pulvirenti L. PMID: 16647107.
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    279. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6368-73. Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. PMID: 16618939; PMCID: PMC1458884.
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    280. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology (Berl). 2006 Jul; 186(4):612-9. O'Dell LE, Bruijnzeel AW, Smith RT, Parsons LH, Merves ML, Goldberger BA, Richardson HN, Koob GF, Markou A. PMID: 16598454.
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    281. Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology (Berl). 2006 May; 186(1):48-53. Kitamura O, Wee S, Specio SE, Koob GF, Pulvirenti L. PMID: 16552556.
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    282. Advances in the pharmacotherapy of alcoholism: challenging misconceptions. Alcohol Clin Exp Res. 2006 Feb; 30(2):272-81. Kranzler HR, Koob G, Gastfriend DR, Swift RM, Willenbring ML. PMID: 16441276.
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    283. Application of experimental stressors in laboratory rodents. Curr Protoc Neurosci. 2006 Feb; Chapter 8:Unit8.4. Heinrichs SC, Koob GF. PMID: 18428648.
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    284. Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology. 2006 Dec; 31(12):2692-707. Chen SA, O'Dell LE, Hoefer ME, Greenwell TN, Zorrilla EP, Koob GF. PMID: 16452993.
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    285. Kappa opioid control of seizures produced by a virus in an animal model. Brain. 2006 Mar; 129(Pt 3):642-54. Solbrig MV, Adrian R, Baratta J, Lauterborn JC, Koob GF. PMID: 16399805.
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    286. A role for GABA in alcohol dependence. Adv Pharmacol. 2006; 54:205-29. Koob GF. PMID: 17175816.
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    287. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19168-73. Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. PMID: 16357203; PMCID: PMC1323172.
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    288. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes. 2005 Dec; 54(12):3510-6. Tabarin A, Diz-Chaves Y, Chaves YD, Carmona Mdel C, Catargi B, Zorrilla EP, Roberts AJ, Coscina DV, Rousset S, Redonnet A, Parker GC, Inoue K, Ricquier D, Pénicaud L, Kieffer BL, Koob GF. PMID: 16306369.
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    289. Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol. J Med Chem. 2005 Nov 17; 48(23):7389-99. Qi L, Yamamoto N, Meijler MM, Altobell LJ, Koob GF, Wirsching P, Janda KD. PMID: 16279798.
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    290. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nat Neurosci. 2005 Nov; 8(11):1442-4. Koob GF, Le Moal M. PMID: 16251985.
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    291. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. J Neurosci. 2005 Sep 21; 25(38):8593-600. Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. PMID: 16177026; PMCID: PMC6725504.
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    292. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11533-8. Ahmed SH, Lutjens R, van der Stap LD, Lekic D, Romano-Spica V, Morales M, Koob GF, Repunte-Canonigo V, Sanna PP. PMID: 16076954; PMCID: PMC1183574.
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    293. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor. Pharmacol Biochem Behav. 2005 Aug; 81(4):701-8. Izzo E, Sanna PP, Koob GF. PMID: 16005056.
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    294. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question. Alcohol Clin Exp Res. 2005 Aug; 29(8):1522-7. Sanchis-Segura C, Grisel JE, Olive MF, Ghozland S, Koob GF, Roberts AJ, Cowen MS. PMID: 16156049.
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    295. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacol Biochem Behav. 2005 Jul; 81(3):543-50. O'Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF. PMID: 15950269.
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    296. Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology (Berl). 2005 Jul; 180(3):473-90. Ahmed SH, Koob GF. PMID: 15731896.
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    297. Stress enhancement of craving during sobriety: a risk for relapse. Alcohol Clin Exp Res. 2005 Feb; 29(2):185-95. Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF, Lê DA, O'Dell LE, Overstreet DH, Roberts AJ, Sinha R, Valdez GR, Weiss F. PMID: 15714042; PMCID: PMC2868509.
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    298. Measuring meals: structure of prandial food and water intake of rats. Am J Physiol Regul Integr Comp Physiol. 2005 Jun; 288(6):R1450-67. Zorrilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF. PMID: 15637168.
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    299. Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology. 2005 Jan; 30(1):90-8. Stinus L, Cador M, Zorrilla EP, Koob GF. PMID: 15138444.
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    300. Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action. CNS Drugs. 2005; 19(6):517-37. De Witte P, Littleton J, Parot P, Koob G. PMID: 15963001.
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    301. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl). 2005 Apr; 179(1):247-54. Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A. PMID: 15602687.
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    302. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacol Biochem Behav. 2004 Dec; 79(4):671-89. Valdez GR, Koob GF. PMID: 15582675.
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    303. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol Clin Exp Res. 2004 Nov; 28(11):1676-82. O'Dell LE, Roberts AJ, Smith RT, Koob GF. PMID: 15547454.
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    304. A role for GABA mechanisms in the motivational effects of alcohol. Biochem Pharmacol. 2004 Oct 15; 68(8):1515-25. Koob GF. PMID: 15451394.
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    305. Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats. Eur J Pharmacol. 2004 Oct 06; 501(1-3):235-7. Navarro M, Carrera MR, Del Arco I, Trigo JM, Koob GF, Rodríguez de Fonseca F. PMID: 15464083.
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    306. What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep. 2004 Sep 15; 27(6):1181-94. Boutrel B, Koob GF. PMID: 15532213.
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    307. Neuropeptide S: a novel activating anxiolytic? Neuron. 2004 Aug 19; 43(4):441-2. Koob GF, Greenwell TN. PMID: 15312642.
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    308. Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. J Pharmacol Exp Ther. 2004 Nov; 311(2):427-40. Heinrichs SC, Koob GF. PMID: 15297468.
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    309. Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology (Berl). 2005 Jan; 177(3):324-35. Zorrilla EP, Inoue K, Valdez GR, Tabarin A, Koob GF. PMID: 15609069.
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    310. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. J Pharmacol Exp Ther. 2004 Oct; 311(1):265-73. Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. PMID: 15263066.
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    311. The therapeutic potential of CRF1 antagonists for anxiety. Expert Opin Investig Drugs. 2004 Jul; 13(7):799-828. Zorrilla EP, Koob GF. PMID: 15212620.
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    312. Treating cocaine addiction with viruses. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10416-21. Carrera MR, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. PMID: 15226496; PMCID: PMC478586.
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    313. Reduction of anxiety after restricted feeding in the rat: implication for eating disorders. Biol Psychiatry. 2004 Jun 01; 55(11):1075-81. Inoue K, Zorrilla EP, Tabarin A, Valdez GR, Iwasaki S, Kiriike N, Koob GF. PMID: 15158426.
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    314. Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. Alcohol Clin Exp Res. 2004 Jun; 28(6):865-72. Valdez GR, Sabino V, Koob GF. PMID: 15201629.
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    315. Nicotine withdrawal in adolescent and adult rats. Ann N Y Acad Sci. 2004 Jun; 1021:167-74. O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF. PMID: 15251887.
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    316. A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal. J Neurosci Methods. 2004 May 30; 135(1-2):129-35. Azar MR, Ahmed SH, Lintz R, Gutierrez T, Stinus L, Koob GF. PMID: 15020097.
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    317. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther. 2004 Sep; 310(3):1027-34. Zorrilla EP, Reinhardt LE, Valdez GR, Inoue K, Rivier JE, Vale WW, Koob GF. PMID: 15115804.
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    318. Cocaine's long run. Nat Med. 2004 Apr; 10(4):340-1. Sanna PP, Koob GF. PMID: 15057223.
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    319. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem. 2004 Feb 01; 12(3):563-70. Carrera MR, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda KD. PMID: 14738965.
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    320. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats. Eur J Pharmacol. 2004 Jan 26; 484(2-3):241-7. O'Dell LE, Alomary AA, Vallée M, Koob GF, Fitzgerald RL, Purdy RH. PMID: 14744609.
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    321. The transition from controlled to compulsive drug use is associated with a loss of sensitization. Brain Res. 2004 Jan 02; 995(1):46-54. Ben-Shahar O, Ahmed SH, Koob GF, Ettenberg A. PMID: 14644470.
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    322. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection. AIDS Res Hum Retroviruses. 2004 Jan; 20(1):77-89. Weed MR, Gold LH, Polis I, Koob GF, Fox HS, Taffe MA. PMID: 15000701.
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    323. Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2004 Jan; 27(8):739-49. Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, Parsons LH, Sanna PP. PMID: 15019424.
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    324. Neuroadaptive mechanisms of addiction: studies on the extended amygdala. Eur Neuropsychopharmacol. 2003 Dec; 13(6):442-52. Koob GF. PMID: 14636960.
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    325. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology (Berl). 2004 Apr; 172(4):450-4. Ahmed SH, Koob GF. PMID: 14647962.
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    326. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann N Y Acad Sci. 2003 Nov; 1003:415-8. Kenny PJ, Paterson NE, Boutrel B, Semenova S, Harrison AA, Gasparini F, Koob GF, Skoubis PD, Markou A. PMID: 14684476.
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    327. Conditioned facilitation of brain reward function after repeated cocaine administration. Behav Neurosci. 2003 Oct; 117(5):1103-7. Kenny PJ, Koob GF, Markou A. PMID: 14570559.
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    328. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist. Brain Res. 2003 Aug 08; 980(2):206-12. Valdez GR, Zorrilla EP, Rivier J, Vale WW, Koob GF. PMID: 12867260.
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    329. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends Pharmacol Sci. 2003 Aug; 24(8):421-7. Zorrilla EP, Taché Y, Koob GF. PMID: 12915052.
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    330. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. J Neurochem. 2003 Jul; 86(1):102-13. Ahmed SH, Lin D, Koob GF, Parsons LH. PMID: 12807430.
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    331. Chronic opioid exposure produces increased heroin self-administration in rats. Pharmacol Biochem Behav. 2003 May; 75(2):349-54. Walker JR, Chen SA, Moffitt H, Inturrisi CE, Koob GF. PMID: 12873626.
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    332. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacology. 2003 Aug; 28(8):1463-71. Heyser CJ, Moc K, Koob GF. PMID: 12700689.
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    333. Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat. J Pharmacol Exp Ther. 2003 Apr; 305(1):385-93. Inoue K, Valdez GR, Reyes TM, Reinhardt LE, Tabarin A, Rivier J, Vale WW, Sawchenko PE, Koob GF, Zorrilla EP. PMID: 12649393.
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    334. Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus. Pharmacol Biochem Behav. 2003 Mar; 74(4):777-87. Solbrig MV, Koob GF. PMID: 12667891.
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    335. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol. 2003 Feb; 29(2):55-60. Valdez GR, Zorrilla EP, Roberts AJ, Koob GF. PMID: 12782246.
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    336. Alcoholism: allostasis and beyond. Alcohol Clin Exp Res. 2003 Feb; 27(2):232-43. Koob GF. PMID: 12605072.
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    337. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Dev Alcohol. 2003; 16:263-81. Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R, Weiss F. PMID: 12638642.
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    338. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. Eur J Neurosci. 2003 Jan; 17(1):191-5. Kenny PJ, Polis I, Koob GF, Markou A. PMID: 12534985.
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    339. Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain. Alcohol Clin Exp Res. 2003 Jan; 27(1):38-43. Alomary AA, Vallée M, O'Dell LE, Koob GF, Purdy RH, Fitzgerald RL. PMID: 12544003.
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    340. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nat Neurosci. 2002 Dec; 5(12):1263-4. Izzo E, Martin-Fardon R, Koob GF, Weiss F, Sanna PP. PMID: 12436114.
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    341. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 Oct 18; 952(2):188-99. Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. PMID: 12376179.
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    342. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Res. 2002 Oct 18; 952(2):200-10. Zorrilla EP, Schulteis G, Ormsby A, Klaassen A, Ling N, McCarthy JR, Koob GF, De Souza EB. PMID: 12376180.
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    343. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res. 2002 Oct; 26(10):1494-501. Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, Koob GF. PMID: 12394282.
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    344. ERK regulation in chronic ethanol exposure and withdrawal. Brain Res. 2002 Sep 06; 948(1-2):186-91. Sanna PP, Simpson C, Lutjens R, Koob G. PMID: 12383974.
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    345. Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle. Neuropsychopharmacology. 2002 Aug; 27(2):203-11. Walker JR, Terenius L, Koob GF. PMID: 12093594.
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    346. Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology. 2003 Feb; 28(2):276-83. Caillé S, Stinus L, Espejo EF, De Deurwaerdère P, Spampinato U, Koob GF. PMID: 12589380.
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    347. Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide. Brain Res. 2002 Jul 05; 943(1):142-50. Valdez GR, Inoue K, Koob GF, Rivier J, Vale W, Zorrilla EP. PMID: 12088848.
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    348. Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome. Pharmacol Biochem Behav. 2002 Jul; 72(4):979-86. Caillé S, Espejo EF, Koob GF, Stinus L. PMID: 12062589.
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    349. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nat Neurosci. 2002 Jul; 5(7):625-6. Ahmed SH, Kenny PJ, Koob GF, Markou A. PMID: 12055635.
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    350. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 2002 Aug; 31(4):363-9. Vetter DE, Li C, Zhao L, Contarino A, Liberman MC, Smith GW, Marchuk Y, Koob GF, Heinemann SF, Vale W, Lee KF. PMID: 12091910.
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    351. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. Eur J Pharmacol. 2002 Jun 20; 446(1-3):103-9. Contarino A, Picetti R, Matthes HW, Koob GF, Kieffer BL, Gold LH. PMID: 12098591.
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    352. Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time. Neuropsychopharmacology. 2002 Jun; 26(6):756-64. Smith AD, Amalric M, Koob GF, Zigmond MJ. PMID: 12007746.
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    353. The corticotropin-releasing factor/urocortin system and alcohol. Alcohol Clin Exp Res. 2002 May; 26(5):714-22. Ryabinin AE, Bachtell RK, Heinrichs SC, Lee S, Rivier C, Olive MF, Mehmert KK, Camarini R, Kim JA, Koenig HN, Nannini MA, Hodge CW, Roberts AJ, Koob GF. PMID: 12045481.
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    354. Being partial to psychostimulant addiction therapy. Trends Pharmacol Sci. 2002 Apr; 23(4):151-3. Pulvirenti L, Koob GF. PMID: 11931978.
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    355. Potential neuroprotective effects of acamprosate. Alcohol Clin Exp Res. 2002 Apr; 26(4):586-92. Koob GF, Mason BJ, De Witte P, Littleton J, Siggins GR. PMID: 11981137.
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    356. Ethanol, endocannabinoids, and the cannabinoidergic signaling system. Alcohol Clin Exp Res. 2002 Apr; 26(4):565-74. Hungund BL, Basavarajappa BS, Vadasz C, Kunos G, Rodriguez de Fonseca F, Colombo G, Serra S, Parsons L, Koob GF. PMID: 11981134.
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    357. Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement. Brain Res. 2002 Jan 25; 925(2):133-40. Orsini C, Izzo E, Koob GF, Pulvirenti L. PMID: 11792361.
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    358. Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J Neurosci. 2002 Jan 01; 22(1):193-9. Bale TL, Picetti R, Contarino A, Koob GF, Vale WW, Lee KF. PMID: 11756502; PMCID: PMC6757589.
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    359. Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat. Psychopharmacology (Berl). 2002 Mar; 160(2):113-21. Spina MG, Merlo-Pich E, Akwa Y, Balducci C, Basso AM, Zorrilla EP, Britton KT, Rivier J, Vale WW, Koob GF. PMID: 11875628.
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    360. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. Eur J Neurosci. 2001 Dec; 14(12):2003-10. Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH. PMID: 11860495.
      View in: PubMed   Mentions: 7  Translation:AnimalsCells
    361. Dopamine partial agonist reverses amphetamine withdrawal in rats. Neuropsychopharmacology. 2001 Nov; 25(5):789-92. Orsini C, Koob GF, Pulvirenti L. PMID: 11682262.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    362. Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient. Brain Res. 2001 Oct 19; 916(1-2):222-8. Currie PJ, Coscina DV, Bishop C, Coiro CD, Koob GF, Rivier J, Vale W. PMID: 11597609.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    363. Increased ethanol self-administration in delta-opioid receptor knockout mice. Alcohol Clin Exp Res. 2001 Sep; 25(9):1249-56. Roberts AJ, Gold LH, Polis I, McDonald JS, Filliol D, Kieffer BL, Koob GF. PMID: 11584142.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    364. Functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci. 2001 Jul 15; 21(14):5344-50. Navarro M, Carrera MR, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA, Gomez R, del Arco I, Villanua MA, Maldonado R, Koob GF, Rodriguez de Fonseca F. PMID: 11438610; PMCID: PMC6762870.
      View in: PubMed   Mentions: 120     Fields:    Translation:Animals
    365. Performance-enhancing effects of CRF-BP ligand inhibitors. Neuroreport. 2001 May 08; 12(6):1231-4. Zorrilla EP, Schulteis G, Ling N, Koob GF, De Souza EB. PMID: 11338197.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    366. Neurobiological processes in alcohol addiction. Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):144S-151S. Lê AD, Kiianmaa K, Cunningham CL, Engel JA, Ericson M, Söderpalm B, Koob GF, Roberts AJ, Weiss F, Hyytiä P, Janhunen S, Mikkola J, Bäckström P, Ponomarev I, Crabbe JC. PMID: 11391064.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    367. Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat. Neuropharmacology. 2001 Apr; 40(5):676-85. Macey DJ, Froestl W, Koob GF, Markou A. PMID: 11311895.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    368. A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule. Pharmacol Biochem Behav. 2001 Apr; 68(4):701-8. Izzo E, Orsini C, Koob GF, Pulvirenti L. PMID: 11526967.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    369. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology. 2001 Mar; 24(3):300-18. David V, Gold LH, Koob GF, Cazala P. PMID: 11166520.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    370. A second-generation vaccine protects against the psychoactive effects of cocaine. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1988-92. Carrera MR, Ashley JA, Wirsching P, Koob GF, Janda KD. PMID: 11172063; PMCID: PMC29369.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsPHPublic Health
    371. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology. 2001 Feb; 24(2):97-129. Koob GF, Le Moal M. PMID: 11120394.
      View in: PubMed   Mentions: 1018     Fields:    Translation:HumansAnimals
    372. Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion. Neuropsychopharmacology. 2001 Feb; 24(2):152-60. Gracy KN, Dankiewicz LA, Koob GF. PMID: 11120397.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    373. Drug addiction: functional neurotoxicity of the brain reward systems. Neurotox Res. 2001 Jan; 3(1):145-56. Weiss F, Koob GF. PMID: 15111266.
      View in: PubMed   Mentions: 24     Fields:    
    374. Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry. Anal Biochem. 2000 Dec 01; 287(1):153-66. Vallée M, Rivera JD, Koob GF, Purdy RH, Fitzgerald RL. PMID: 11078595.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    375. Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study. Alcohol Clin Exp Res. 2000 Dec; 24(12):1765-72. Richter RM, Zorrilla EP, Basso AM, Koob GF, Weiss F. PMID: 11141034.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    376. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability. J Neurosci. 2000 Nov 01; 20(21):RC104. Solbrig MV, Koob GF, Parsons LH, Kadota T, Horscroft N, Briese T, Lipkin WI. PMID: 11050146; PMCID: PMC6772732.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    377. Drug addiction. Neurobiol Dis. 2000 Oct; 7(5):543-5. Koob G. PMID: 11042073.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    378. Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat. Alcohol. 2000 Aug; 22(1):19-24. Morse AC, Schulteis G, Holloway FA, Koob GF. PMID: 11109024.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    379. Animal models of craving for ethanol. Addiction. 2000 Aug; 95 Suppl 2:S73-81. Koob GF. PMID: 11002904.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    380. Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. Endocrinology. 2000 Jul; 141(7):2698-702. Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale WW, Gold LH. PMID: 10875276.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    381. Conditioning and opiate withdrawal. Nature. 2000 Jun 29; 405(6790):1013-4. Schulteis G, Ahmed SH, Morse AC, Koob GF, Everitt BJ. PMID: 10890431.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    382. CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist. Brain Res. 2000 Jun 02; 866(1-2):82-91. Macey DJ, Koob GF, Markou A. PMID: 10825483.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    383. Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology. 2000 Jun; 22(6):581-94. Roberts AJ, Heyser CJ, Cole M, Griffin P, Koob GF. PMID: 10788758.
      View in: PubMed   Mentions: 195     Fields:    Translation:Animals
    384. mu-Opioid receptor knockout mice do not self-administer alcohol. J Pharmacol Exp Ther. 2000 Jun; 293(3):1002-8. Roberts AJ, McDonald JS, Heyser CJ, Kieffer BL, Matthes HW, Koob GF, Gold LH. PMID: 10869404.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    385. Cocaine vaccines: antibody protection against relapse in a rat model. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6202-6. Carrera MR, Ashley JA, Zhou B, Wirsching P, Koob GF, Janda KD. PMID: 10823960; PMCID: PMC18582.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsPHPublic Health
    386. Opiate withdrawal-induced place aversion lasts for up to 16 weeks. Psychopharmacology (Berl). 2000 Apr; 149(2):115-20. Stinus L, Caille S, Koob GF. PMID: 10805605.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    387. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet. 2000 Apr; 24(4):410-4. Bale TL, Contarino A, Smith GW, Chan R, Gold LH, Sawchenko PE, Koob GF, Vale WW, Lee KF. PMID: 10742108.
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    388. Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropsychopharmacology. 2000 Apr; 22(4):413-21. Ahmed SH, Walker JR, Koob GF. PMID: 10700660.
      View in: PubMed   Mentions: 152     Fields:    Translation:Animals
    389. Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm. Psychopharmacology (Berl). 2000 Mar; 148(4):355-60. Smith AD, Smith DL, Zigmond MJ, Amalric M, Koob GF. PMID: 10928307.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    390. Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology. 2000 Mar; 22(3):230-9. Spina MG, Basso AM, Zorrilla EP, Heyser CJ, Rivier J, Vale W, Merlo-Pich E, Koob GF. PMID: 10693150.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    391. Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations. Pharmacol Biochem Behav. 2000 Mar; 65(3):407-17. Lin D, Koob GF, Markou A. PMID: 10683480.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    392. Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction. Pharmacol Biochem Behav. 2000 Mar; 65(3):489-94. Gracy KN, Dankiewicz LA, Weiss F, Koob GF. PMID: 10683489.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    393. Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. J Pharmacol Exp Ther. 2000 Mar; 292(3):1053-64. Watkins SS, Stinus L, Koob GF, Markou A. PMID: 10688623.
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    394. Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine Tob Res. 2000 Feb; 2(1):19-37. Watkins SS, Koob GF, Markou A. PMID: 11072438.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimals
    395. Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats. Brain Res. 2000 Jan 31; 854(1-2):85-92. Walker JR, Ahmed SH, Gracy KN, Koob GF. PMID: 10784110.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    396. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiol Learn Mem. 2000 Jan; 73(1):31-48. Dellu F, Contarino A, Simon H, Koob GF, Gold LH. PMID: 10686122.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    397. Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze. Peptides. 2000 Jan; 21(1):37-44. Britton KT, Akwa Y, Spina MG, Koob GF. PMID: 10704717.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    398. Neurobiology of addiction. Toward the development of new therapies. Ann N Y Acad Sci. 2000; 909:170-85. Koob GF. PMID: 10911930.
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    399. Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats. J Neurosci. 1999 Dec 15; 19(24):11017-26. Baldo BA, Koob GF, Markou A. PMID: 10594082; PMCID: PMC6784951.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    400. The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behav Brain Res. 1999 Dec; 106(1-2):119-25. Akwa Y, Purdy RH, Koob GF, Britton KT. PMID: 10595427.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    401. Cocaine reward and dopamine receptors: love at first site. Arch Gen Psychiatry. 1999 Dec; 56(12):1107-8. Koob GF. PMID: 10591287.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    402. Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers. Zhongguo Yao Li Xue Bao. 1999 Dec; 20(12):1109-14. Rodríguez de Fonseca F, Roberts AJ, Bilbao A, Koob GF, Navarro M. PMID: 11189201.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    403. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res. 1999 Nov 27; 848(1-2):141-52. Koob GF, Heinrichs SC. PMID: 10612706.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimals
    404. Corticotropin-releasing factor, norepinephrine, and stress. Biol Psychiatry. 1999 Nov 01; 46(9):1167-80. Koob GF. PMID: 10560023.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimals
    405. Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone. Eur J Pharmacol. 1999 Oct 27; 383(2):115-9. Walker JR, King M, Izzo E, Koob GF, Pasternak GW. PMID: 10585524.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    406. Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance. Brain Res Cogn Brain Res. 1999 Oct 25; 8(3):185-201. Weed MR, Taffe MA, Polis I, Roberts AC, Robbins TW, Koob GF, Bloom FE, Gold LH. PMID: 10556598.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    407. Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens. J Neurosci. 1999 Oct 15; 19(20):9081-9. Martin G, Ahmed SH, Blank T, Spiess J, Koob GF, Siggins GR. PMID: 10516325; PMCID: PMC6782743.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    408. Long-lasting increase in the set point for cocaine self-administration after escalation in rats. Psychopharmacology (Berl). 1999 Oct; 146(3):303-12. Ahmed SH, Koob GF. PMID: 10541731.
      View in: PubMed   Mentions: 131     Fields:    Translation:Animals
    409. Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcohol Clin Exp Res. 1999 Sep; 23(9):1468-76. Heyser CJ, Roberts AJ, Schulteis G, Koob GF. PMID: 10512312.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    410. Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther. 1999 Aug; 290(2):881-92. Caillé S, Espejo EF, Reneric JP, Cador M, Koob GF, Stinus L. PMID: 10411605.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    411. Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs. Psychopharmacology (Berl). 1999 Aug; 145(3):283-94. Lin D, Koob GF, Markou A. PMID: 10494577.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    412. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Res. 1999 Jul 17; 835(1):1-9. Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale W, Gold LH. PMID: 10448190.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    413. Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels. Alcohol Clin Exp Res. 1999 Jul; 23(7):1151-7. Roberts AJ, Heyser CJ, Koob GF. PMID: 10443980.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    414. Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology (Berl). 1999 Jul; 145(1):21-30. Basso AM, Spina M, Rivier J, Vale W, Koob GF. PMID: 10445369.
      View in: PubMed   Mentions: 87     Fields:    Translation:Animals
    415. Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration. Synapse. 1999 Jul; 33(1):49-58. Lee RS, Criado JR, Koob GF, Henriksen SJ. PMID: 10380850.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    416. The role of the striatopallidal and extended amygdala systems in drug addiction. Ann N Y Acad Sci. 1999 Jun 29; 877:445-60. Koob GF. PMID: 10415664.
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    417. Structural and compositional determinants of cortistatin activity. J Neurosci Res. 1999 Jun 15; 56(6):611-9. Criado JR, Li H, Jiang X, Spina M, Huitrón-Reséndiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L. PMID: 10374816.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    418. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May; 32(2):132-5. Parsons LH, Koob GF, Weiss F. PMID: 10231132.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    419. Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone. Psychopharmacology (Berl). 1999 May; 144(2):111-20. Carrera MR, Schulteis G, Koob GF. PMID: 10394991.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    420. Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence. Behav Pharmacol. 1999 May; 10(3):235-42. Schulteis G, Heyser CJ, Koob GF. PMID: 10780239.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    421. A dopamine D1 agonist elevates self-stimulation thresholds: comparison to other dopamine-selective drugs. Pharmacol Biochem Behav. 1999 Apr; 62(4):659-72. Baldo BA, Jain K, Veraldi L, Koob GF, Markou A. PMID: 10208371.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    422. Blockade of nicotine self-administration with nicotinic antagonists in rats. Pharmacol Biochem Behav. 1999 Apr; 62(4):743-51. Watkins SS, Epping-Jordan MP, Koob GF, Markou A. PMID: 10208381.
      View in: PubMed   Mentions: 102     Fields:    Translation:Animals
    423. Stress, corticotropin-releasing factor, and drug addiction. Ann N Y Acad Sci. 1999; 897:27-45. Koob GF. PMID: 10676433.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    424. Animal models of craving: a roundtable discussion. Alcohol Res Health. 1999; 23(3):233-6. Koob GF, Weiss F, Tiffany ST, Zieglgansberger W, Spanagel R. PMID: 10890819; PMCID: PMC6760368.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    425. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology (Berl). 1999 Jan; 141(2):135-44. Baldo BA, Markou A, Koob GF. PMID: 9952037.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    426. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist. Psychopharmacology (Berl). 1999 Jan; 141(3):242-50. Harrison AA, Parsons LH, Koob GF, Markou A. PMID: 10027505.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    427. Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus. Brain Res. 1998 Dec 14; 814(1-2):1-12. Kimes AS, Maldonado R, Ambrosio E, Koob GF, London ED. PMID: 9838021.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    428. Depression and stimulant dependence: neurobiology and pharmacotherapy. J Nerv Ment Dis. 1998 Dec; 186(12):737-45. Kosten TR, Markou A, Koob GF. PMID: 9865811.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    429. Serotonin1B receptor stimulation enhances cocaine reinforcement. J Neurosci. 1998 Dec 01; 18(23):10078-89. Parsons LH, Weiss F, Koob GF. PMID: 9822762; PMCID: PMC6793270.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    430. Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats. Neuropsychopharmacology. 1998 Nov; 19(5):406-16. Schulteis G, Stinus L, Risbrough VB, Koob GF. PMID: 9778662.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    431. CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats. Neuroreport. 1998 Oct 26; 9(15):3397-402. Navarro M, Chowen J, Rocío A Carrera M, del Arco I, Villanúa MA, Martin Y, Roberts AJ, Koob GF, de Fonseca FR. PMID: 9855288.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    432. Transition from moderate to excessive drug intake: change in hedonic set point. Science. 1998 Oct 09; 282(5387):298-300. Ahmed SH, Koob GF. PMID: 9765157.
      View in: PubMed   Mentions: 508     Fields:    Translation:Animals
    433. Estrous cycle effects on operant responding for ethanol in female rats. Alcohol Clin Exp Res. 1998 Oct; 22(7):1564-9. Roberts AJ, Smith AD, Weiss F, Rivier C, Koob GF. PMID: 9802543.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    434. Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat. J Pharmacol Exp Ther. 1998 Sep; 286(3):1231-8. Pulvirenti L, Balducci C, Piercy M, Koob GF. PMID: 9732383.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    435. Neuroscience of addiction. Neuron. 1998 Sep; 21(3):467-76. Koob GF, Sanna PP, Bloom FE. PMID: 9768834.
      View in: PubMed   Mentions: 283     Fields:    Translation:HumansAnimalsCells
    436. Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res. 1998 Aug; 22(5):998-1040. Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL, Kalant H, Koob GF, Li TK, Tabakoff B. PMID: 9726269.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimals
    437. Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat. Brain Res. 1998 Jul 20; 799(2):317-22. Lee RS, Koob GF, Henriksen SJ. PMID: 9675326.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    438. Nociceptin fails to affect heroin self-administration in the rat. Neuroreport. 1998 Jul 13; 9(10):2243-7. Walker JR, Spina M, Terenius L, Koob GF. PMID: 9694207.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    439. Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze. Pharmacol Biochem Behav. 1998 Jul; 60(3):727-31. Schulteis G, Yackey M, Risbrough V, Koob GF. PMID: 9678657.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    440. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 1998 Jun; 20(6):1093-102. Smith GW, Aubry JM, Dellu F, Contarino A, Bilezikjian LM, Gold LH, Chen R, Marchuk Y, Hauser C, Bentley CA, Sawchenko PE, Koob GF, Vale W, Lee KF. PMID: 9655498.
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    441. Drug dependence: stress and dysregulation of brain reward pathways. Drug Alcohol Depend. 1998 Jun-Jul; 51(1-2):23-47. Kreek MJ, Koob GF. PMID: 9716928.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimals
    442. Dramatic decreases in brain reward function during nicotine withdrawal. Nature. 1998 May 07; 393(6680):76-9. Epping-Jordan MP, Watkins SS, Koob GF, Markou A. PMID: 9590692.
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    443. Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function. Brain Res Brain Res Rev. 1998 May; 26(2-3):320-6. Raber J, Sorg O, Horn TF, Yu N, Koob GF, Campbell IL, Bloom FE. PMID: 9651548.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    444. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol. Psychopharmacology (Berl). 1998 May; 137(1):25-32. Roberts AJ, McArthur RA, Hull EE, Post C, Koob GF. PMID: 9631953.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    445. Neuropharmacology. Premenstrual steroids? Nature. 1998 Apr 30; 392(6679):869-70. Britton KT, Koob GF. PMID: 9582066.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    446. Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats. Psychopharmacology (Berl). 1998 Apr; 136(3):247-55. Heinrichs SC, Klaassen A, Koob GF, Schulteis G, Ahmed S, De Souza EB. PMID: 9566810.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    447. Cocaine sensitivity in Borna disease virus-infected rats. Pharmacol Biochem Behav. 1998 Apr; 59(4):1047-52. Solbrig MV, Koob GF, Lipkin WI. PMID: 9586866.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    448. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology. 1998 Mar; 18(3):135-74. Markou A, Kosten TR, Koob GF. PMID: 9471114.
      View in: PubMed   Mentions: 231     Fields:    Translation:Animals
    449. The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat. Brain Res. 1998 Feb 16; 784(1-2):105-15. Epping-Jordan MP, Markou A, Koob GF. PMID: 9518570.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    450. Neurocircuitry targets in ethanol reward and dependence. Alcohol Clin Exp Res. 1998 Feb; 22(1):3-9. Koob GF, Roberts AJ, Schulteis G, Parsons LH, Heyser CJ, Hyytiä P, Merlo-Pich E, Weiss F. PMID: 9514280.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimals
    451. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology. 1998 Feb; 18(2):125-33. Heyser CJ, Schulteis G, Durbin P, Koob GF. PMID: 9430136.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    452. Drug abuse and alcoholism. Overview. Adv Pharmacol. 1998; 42:969-77. Koob GF. PMID: 9328060.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    453. Circuits, drugs, and drug addiction. Adv Pharmacol. 1998; 42:978-82. Koob GF. PMID: 9328061.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    454. Substance dependence as a compulsive behavior. J Psychopharmacol. 1998; 12(1):39-48. Koob GF, Rocio M, Carrera A, Gold LH, Heyser CJ, Maldonado-Irizarry C, Markou A, Parsons LH, Roberts AJ, Schulteis G, Stinus L, Walker JR, Weissenborn R, Weiss F. PMID: 9584967.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    455. Orphan anxiety. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14217-9. Walker JR, Koob GF. PMID: 9405592; PMCID: PMC33793.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    456. Drug abuse: hedonic homeostatic dysregulation. Science. 1997 Oct 03; 278(5335):52-8. Koob GF, Le Moal M. PMID: 9311926.
      View in: PubMed   Mentions: 789     Fields:    Translation:HumansAnimals
    457. Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res. 1997 Aug; 21(5):784-91. Heyser CJ, Schulteis G, Koob GF. PMID: 9267526.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    458. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice. J Neurovirol. 1997 Aug; 3(4):265-73. Brot MD, Rall GF, Oldstone MB, Koob GF, Gold LH. PMID: 9291234.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    459. Cocaine- but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology (Berl). 1997 Aug; 132(3):289-95. Ahmed SH, Koob GF. PMID: 9292629.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    460. D3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport. 1997 Jul 07; 8(9-10):2373-7. Caine SB, Koob GF, Parsons LH, Everitt BJ, Schwartz JC, Sokoloff P. PMID: 9243643.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    461. Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacology (Berl). 1997 Jul; 132(1):6-13. Britton KT, Southerland S, Van Uden E, Kirby D, Rivier J, Koob G. PMID: 9272753.
      View in: PubMed   Mentions: 18     Fields: