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    David Gough

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-822-3446
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      Collapse Research 
      Collapse Research Activities and Funding
      Modeling Mass Transfer to Active Implants for Diabetes
      NIH/NIDDK R01DK077101May 15, 2007 - Mar 31, 2010
      Role: Principal Investigator
      Mass Transfer to Glucose Sensor for Diabetes
      NIH/NIDDK R01DK064570Sep 30, 2002 - Mar 31, 2012
      Role: Principal Investigator
      Validation of Long-Term Glucose Sensor in Tissues
      NIH/NIDDK R56DK064570Sep 30, 2002 - Apr 30, 2008
      Role: Principal Investigator
      INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENT
      NIH/NCRR C06RR017588Sep 15, 2002 - Sep 14, 2004
      Role: Principal Investigator
      KEY PARAMETERS FOR ARTIFICIAL PANCREAS CONTROLLER
      NIH/NIDDK R21DK057109Sep 30, 1999 - Aug 31, 2002
      Role: Principal Investigator
      TISSUE RESPONSE TO IMPLANTED GLUCOSE SENSOR
      NIH/NIDDK R01DK055064Sep 30, 1998 - Sep 29, 2002
      Role: Principal Investigator
      ESSENTIAL ENDOCRINE PANCREAS
      NIH/NIDDK R01DK046307Aug 1, 1995 - Jul 31, 1998
      Role: Principal Investigator
      DEVELOPMENT OF A GLUCOSE SENSOR FOR DIABETES
      NIH/NIDDK R01DK027541Aug 1, 1980 - Mar 31, 1991
      Role: Principal Investigator
      DEVELOPMENT OF A GLUCOSE SENSOR FOR DIABETES
      NIH/NIADDK R01AM027541Aug 1, 1980 - Jan 31, 1987
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lucisano J, Routh T, Lin J, Gough D. Glucose Monitoring in Individuals with Diabetes using a Long-Term Implanted Sensor/Telemetry System and Model. IEEE Trans Biomed Eng. 2016 Oct 19. PMID: 27775510.
        View in: PubMed
      2. Lucisano J, Routh T, Lin J, Gough D. Glucose Monitoring in Individuals with Diabetes using a Long-Term Implanted Sensor/Telemetry System and Model. IEEE Trans Biomed Eng. 2016 Oct 19. PMID: 28026743.
        View in: PubMed
      3. Kumosa LS, Routh TL, Lin JT, Lucisano JY, Gough D. Permeability of subcutaneous tissues surrounding long-term implants to oxygen. Biomaterials. 2014 Sep; 35(29):8287-96. PMID: 24998180.
        View in: PubMed
      4. Bock JR, Maewal A, Gough D. Hitting is contagious in baseball: evidence from long hitting streaks. PLoS One. 2012; 7(12):e51367. PMID: 23251507.
        View in: PubMed
      5. Peng LX, Yu L, Howell SB, Gough D. Effects of solution concentration on the physicochemical properties of a polymeric anticancer therapeutic. Mol Pharm. 2012 Jan 1; 9(1):37-47. PMID: 21988542.
        View in: PubMed
      6. Peng LX, Yu L, Howell SB, Gough D. Aggregation properties of a polymeric anticancer therapeutic: a coarse-grained modeling study. J Chem Inf Model. 2011 Dec 27; 51(12):3030-5. PMID: 21995420.
        View in: PubMed
      7. Peng LX, Das SK, Yu L, Howell SB, Gough D. Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(?-glutamyl-glutamate) paclitaxel conjugates. J Mol Model. 2011 Nov; 17(11):2973-87. PMID: 21360176.
        View in: PubMed
      8. Peng LX, Ivetac A, Chaudhari AS, Van S, Zhao G, Yu L, Howell SB, McCammon JA, Gough D. Characterization of a clinical polymer-drug conjugate using multiscale modeling. Biopolymers. 2010 Nov; 93(11):936-51. PMID: 20564048.
        View in: PubMed
      9. Gough D, Kumosa LS, Routh TL, Lin JT, Lucisano JY. Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Transl Med. 2010 Jul 28; 2(42):42ra53. PMID: 20668297.
        View in: PubMed
      10. Liu C, Zhao G, Liu J, Ma N, Chivukula P, Perelman L, Okada K, Chen Z, Gough D, Yu L. Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J Control Release. 2009 Dec 16; 140(3):277-83. PMID: 19699770.
        View in: PubMed
      11. Feng Z, Zhao G, Yu L, Gough D, Howell SB. Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane. Cancer Chemother Pharmacol. 2010 Apr; 65(5):923-30. PMID: 19685054.
        View in: PubMed
      12. Rahaghi FN, Gough D. Blood glucose dynamics. Diabetes Technol Ther. 2008 Apr; 10(2):81-94. PMID: 18260771.
        View in: PubMed
      13. Mytton J, DiGuiseppi C, Gough D, Taylor R, Logan S. School-based secondary prevention programmes for preventing violence. Cochrane Database Syst Rev. 2006; (3):CD004606. PMID: 16856051.
        View in: PubMed
      14. Bock JR, Gough D. Virtual screen for ligands of orphan G protein-coupled receptors. J Chem Inf Model. 2005 Sep-Oct; 45(5):1402-14. PMID: 16180917.
        View in: PubMed
      15. Makale MT, Chen PC, Gough D. Variants of the tissue-sensor array window chamber. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H57-65. PMID: 15734882.
        View in: PubMed
      16. Makale MT, Jablecki MC, Gough D. Mass transfer and gas-phase calibration of implanted oxygen sensors. Anal Chem. 2004 Mar 15; 76(6):1773-7. PMID: 15018582.
        View in: PubMed
      17. Makale MT, Lin JT, Calou RE, Tsai AG, Chen PC, Gough D. Tissue window chamber system for validation of implanted oxygen sensors. Am J Physiol Heart Circ Physiol. 2003 Jun; 284(6):H2288-94. PMID: 12598234.
        View in: PubMed
      18. Gough D, Kreutz-Delgado K, Bremer TM. Frequency characterization of blood glucose dynamics. Ann Biomed Eng. 2003 Jan; 31(1):91-7. PMID: 12572659.
        View in: PubMed
      19. Bock JR, Gough D. Whole-proteome interaction mining. Bioinformatics. 2003 Jan; 19(1):125-34. PMID: 12499302.
        View in: PubMed
      20. Bock JR, Gough D. A new method to estimate ligand-receptor energetics. Mol Cell Proteomics. 2002 Nov; 1(11):904-10. PMID: 12488466.
        View in: PubMed
      21. Mytton JA, DiGuiseppi C, Gough D, Taylor RS, Logan S. School-based violence prevention programs: systematic review of secondary prevention trials. Arch Pediatr Adolesc Med. 2002 Aug; 156(8):752-62. PMID: 12144364.
        View in: PubMed
      22. Gough D. Employment and career prospects for bioengineers. Nat Biotechnol. 2002 Jun; 20(6):635-6. PMID: 12042874.
        View in: PubMed
      23. Bock JR, Gough D. Predicting protein--protein interactions from primary structure. Bioinformatics. 2001 May; 17(5):455-60. PMID: 11331240.
        View in: PubMed
      24. Bremer TM, Edelman SV, Gough D. Benchmark data from the literature for evaluation of new glucose sensing technologies. Diabetes Technol Ther. 2001; 3(3):409-18. PMID: 11762520.
        View in: PubMed
      25. Jablecki M, Gough D. Simulations of the frequency response of implantable glucose sensors. Anal Chem. 2000 Apr 15; 72(8):1853-9. PMID: 10784153.
        View in: PubMed
      26. Gough D, Bremer T. Immobilized glucose oxidase in implantable glucose sensor technology. Diabetes Technol Ther. 2000; 2(3):377-80. PMID: 11467340.
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      27. Bremer T, Gough D. Is blood glucose predictable from previous values? A solicitation for data. Diabetes. 1999 Mar; 48(3):445-51. PMID: 10078542.
        View in: PubMed
      28. Bock J, Gough D. Toward prediction of physiological state signals in sleep apnea. IEEE Trans Biomed Eng. 1998 Nov; 45(11):1332-41. PMID: 9805832.
        View in: PubMed
      29. Lacy F, Gough D, Schmid-Schönbein GW. Role of xanthine oxidase in hydrogen peroxide production. Free Radic Biol Med. 1998 Oct; 25(6):720-7. PMID: 9801073.
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      30. Gough D, Armour JC, Baker DA. Advances and prospects in glucose assay technology. Diabetologia. 1997 Jul; 40 Suppl 2:S102-7. PMID: 9248710.
        View in: PubMed
      31. Gough D, Botvinick EL. Reservations on the use of error grid analysis for the validation of blood glucose assays. Diabetes Care. 1997 Jun; 20(6):1034-6. PMID: 9167120.
        View in: PubMed
      32. Price JH, Hunter EA, Gough D. Accuracy of least squares designed spatial FIR filters for segmentation of images of fluorescence stained cell nuclei. Cytometry. 1996 Dec 1; 25(4):303-16. PMID: 8946137.
        View in: PubMed
      33. Baker DA, Gough D. Dynamic delay and maximal dynamic error in continuous biosensors. Anal Chem. 1996 Apr 15; 68(8):1292-7. PMID: 8651496.
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      34. Gough D, Armour JC. Development of the implantable glucose sensor. What are the prospects and why is it taking so long? Diabetes. 1995 Sep; 44(9):1005-9. PMID: 7657021.
        View in: PubMed
      35. Price JH, Gough D. Comparison of phase-contrast and fluorescence digital autofocus for scanning microscopy. Cytometry. 1994 Aug 1; 16(4):283-97. PMID: 7988291.
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      36. Baker DA, Gough D. Dynamic concentration challenges for biosensor characterization. Biosens Bioelectron. 1993; 8(9-10):433-41. PMID: 8311939.
        View in: PubMed
      37. Sargent BJ, Gough D. Design and validation of the transparent oxygen sensor array. IEEE Trans Biomed Eng. 1991 May; 38(5):476-82. PMID: 1874530.
        View in: PubMed
      38. Armour JC, Lucisano JY, McKean BD, Gough D. Application of chronic intravascular blood glucose sensor in dogs. Diabetes. 1990 Dec; 39(12):1519-26. PMID: 2245876.
        View in: PubMed
      39. Ertefai S, Gough D. Physiological preparation for studying the response of subcutaneously implanted glucose and oxygen sensors. J Biomed Eng. 1989 Sep; 11(5):362-8. PMID: 2677523.
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      40. McKean BD, Gough D. A telemetry-instrumentation system for chronically implanted glucose and oxygen sensors. IEEE Trans Biomed Eng. 1988 Jul; 35(7):526-32. PMID: 3209214.
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      41. Lucisano JY, Gough D. Transient response of the two-dimensional glucose sensor. Anal Chem. 1988 Jul 1; 60(13):1272-81. PMID: 3213947.
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      42. Gough D. Issues related to in vitro operation of potentially implantable enzyme electrode glucose sensors. Horm Metab Res Suppl. 1988; 20:30-3. PMID: 3074035.
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      43. Tse PH, Gough D. Transient response of an enzyme electrode sensor for glucose. Anal Chem. 1987 Oct 1; 59(19):2339-44. PMID: 3674445.
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      44. Tse PH, Leypoldt JK, Gough D. Determination of the intrinsic kinetic constants of immobilized glucose oxidase and catalase. Biotechnol Bioeng. 1987 Apr; 29(6):696-704. PMID: 18576504.
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      45. Tse PH, Gough D. Time-dependent inactivation of immobilized glucose oxidase and catalase. Biotechnol Bioeng. 1987 Apr; 29(6):705-13. PMID: 18576505.
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      46. Lucisano JY, Armour JC, Gough D. In vitro stability of an oxygen sensor. Anal Chem. 1987 Mar 1; 59(5):736-9. PMID: 3565773.
        View in: PubMed
      47. Gough D, Armour JC, Lucisano JY, McKean BD. Short-term in vivo operation of a glucose sensor. ASAIO Trans. 1986 Jul-Sep; 32(1):148-50. PMID: 3778702.
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      48. Gough D, Sargent BJ, Tse PH. A transparent oxygen sensor array. Ann Biomed Eng. 1986; 14(2):153-61. PMID: 3740567.
        View in: PubMed
      49. Gough D, Lucisano JY, Tse PH. Two-dimensional enzyme electrode sensor for glucose. Anal Chem. 1985 Oct; 57(12):2351-7. PMID: 4061843.
        View in: PubMed
      50. Leypoldt JK, Gough D. Model of a two-substrate enzyme electrode for glucose. Anal Chem. 1984 Dec; 56(14):2896-904. PMID: 6524662.
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      51. Leypoldt JK, Gough D. Diffusion and the limiting substrate in two-substrate immobilized enzyme systems. Biotechnol Bioeng. 1982 Dec; 24(12):2705-19. PMID: 18546248.
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      52. Gough D, Leypoldt JK, Armour JC. Progress toward a potentially implantable, enzyme-based glucose sensor. Diabetes Care. 1982 May-Jun; 5(3):190-8. PMID: 7172982.
        View in: PubMed
      53. Gough D. The composition and optical rotary dispersion of bovine aqueous humor. Diabetes Care. 1982 May-Jun; 5(3):266-70. PMID: 7172993.
        View in: PubMed
      54. Gough D, Aisenberg S, Colton CK, Giner J, Soeldner JS. The status of electrochemical sensors for in vivo glucose monitoring. Horm Metab Res. 1977; Suppl 7:10-22. PMID: 326652.
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      55. Gough D, Andrade JD. Enzyme electrodes. Science. 1973 Apr 27; 180(4084):380-4. PMID: 4573391.
        View in: PubMed
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