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David Gough

Title(s)Professor, Bioengineering
SchoolAcademic Aff
Address9500 Gilman Drive #0412
La Jolla CA 92093
Phone858-822-3446
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    Collapse Research 
    Collapse Research Activities and Funding
    Mass Transfer to Glucose Sensor for Diabetes
    NIH/NIDDK R01DK064570Mar 16, 2010 - Mar 31, 2012
    Role: Principal Investigator
    Modeling Mass Transfer to Active Implants for Diabetes
    NIH/NIDDK R01DK077101May 15, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Validation of Long-Term Glucose Sensor in Tissues
    NIH/NIDDK R56DK064570Sep 30, 2002 - Apr 30, 2008
    Role: Principal Investigator
    INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENT
    NIH/NCRR C06RR017588Sep 15, 2002 - Sep 14, 2004
    Role: Principal Investigator
    KEY PARAMETERS FOR ARTIFICIAL PANCREAS CONTROLLER
    NIH/NIDDK R21DK057109Sep 30, 1999 - Aug 31, 2002
    Role: Principal Investigator
    TISSUE RESPONSE TO IMPLANTED GLUCOSE SENSOR
    NIH/NIDDK R01DK055064Sep 30, 1998 - Sep 29, 2002
    Role: Principal Investigator
    ESSENTIAL ENDOCRINE PANCREAS
    NIH/NIDDK R01DK046307Aug 1, 1995 - Jul 31, 1998
    Role: Principal Investigator
    DEVELOPMENT OF A GLUCOSE SENSOR FOR DIABETES
    NIH/NIDDK R01DK027541Aug 1, 1980 - Mar 31, 1991
    Role: Principal Investigator
    DEVELOPMENT OF A GLUCOSE SENSOR FOR DIABETES
    NIH/NIADDK R01AM027541Aug 1, 1980 - Jan 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Glucose Monitoring in Individuals With Diabetes Using a Long-Term Implanted Sensor/Telemetry System and Model. IEEE Trans Biomed Eng. 2017 09; 64(9):1982-1993. Lucisano JY, Routh TL, Lin JT, Gough DA. PMID: 27775510.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    2. Permeability of subcutaneous tissues surrounding long-term implants to oxygen. Biomaterials. 2014 Sep; 35(29):8287-96. Kumosa LS, Routh TL, Lin JT, Lucisano JY, Gough DA. PMID: 24998180.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Hitting is contagious in baseball: evidence from long hitting streaks. PLoS One. 2012; 7(12):e51367. Bock JR, Maewal A, Gough DA. PMID: 23251507.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Effects of solution concentration on the physicochemical properties of a polymeric anticancer therapeutic. Mol Pharm. 2012 Jan 01; 9(1):37-47. Peng LX, Yu L, Howell SB, Gough DA. PMID: 21988542.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Aggregation properties of a polymeric anticancer therapeutic: a coarse-grained modeling study. J Chem Inf Model. 2011 Dec 27; 51(12):3030-5. Peng LX, Yu L, Howell SB, Gough DA. PMID: 21995420.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(?-glutamyl-glutamate) paclitaxel conjugates. J Mol Model. 2011 Nov; 17(11):2973-87. Peng LX, Das SK, Yu L, Howell SB, Gough DA. PMID: 21360176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Characterization of a clinical polymer-drug conjugate using multiscale modeling. Biopolymers. 2010 Nov; 93(11):936-51. Peng LX, Ivetac A, Chaudhari AS, Van S, Zhao G, Yu L, Howell SB, McCammon JA, Gough DA. PMID: 20564048.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    8. Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Transl Med. 2010 Jul 28; 2(42):42ra53. Gough DA, Kumosa LS, Routh TL, Lin JT, Lucisano JY. PMID: 20668297.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    9. Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J Control Release. 2009 Dec 16; 140(3):277-83. Liu C, Zhao G, Liu J, Ma N, Chivukula P, Perelman L, Okada K, Chen Z, Gough D, Yu L. PMID: 19699770.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    10. Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane. Cancer Chemother Pharmacol. 2010 Apr; 65(5):923-30. Feng Z, Zhao G, Yu L, Gough D, Howell SB. PMID: 19685054.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Blood glucose dynamics. Diabetes Technol Ther. 2008 Apr; 10(2):81-94. Rahaghi FN, Gough DA. PMID: 18260771.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. School-based secondary prevention programmes for preventing violence. Cochrane Database Syst Rev. 2006 Jul 19; (3):CD004606. Mytton J, DiGuiseppi C, Gough D, Taylor R, Logan S. PMID: 16856051.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    13. Virtual screen for ligands of orphan G protein-coupled receptors. J Chem Inf Model. 2005 Sep-Oct; 45(5):1402-14. Bock JR, Gough DA. PMID: 16180917.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    14. Variants of the tissue-sensor array window chamber. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H57-65. Makale MT, Chen PC, Gough DA. PMID: 15734882.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    15. Mass transfer and gas-phase calibration of implanted oxygen sensors. Anal Chem. 2004 Mar 15; 76(6):1773-7. Makale MT, Jablecki MC, Gough DA. PMID: 15018582.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    16. Tissue window chamber system for validation of implanted oxygen sensors. Am J Physiol Heart Circ Physiol. 2003 Jun; 284(6):H2288-94. Makale MT, Lin JT, Calou RE, Tsai AG, Chen PC, Gough DA. PMID: 12598234.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Whole-proteome interaction mining. Bioinformatics. 2003 Jan; 19(1):125-34. Bock JR, Gough DA. PMID: 12499302.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    18. Frequency characterization of blood glucose dynamics. Ann Biomed Eng. 2003 Jan; 31(1):91-7. Gough DA, Kreutz-Delgado K, Bremer TM. PMID: 12572659.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. A new method to estimate ligand-receptor energetics. Mol Cell Proteomics. 2002 Nov; 1(11):904-10. Bock JR, Gough DA. PMID: 12488466.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    20. School-based violence prevention programs: systematic review of secondary prevention trials. Arch Pediatr Adolesc Med. 2002 Aug; 156(8):752-62. Mytton JA, DiGuiseppi C, Gough DA, Taylor RS, Logan S. PMID: 12144364.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. Employment and career prospects for bioengineers. Nat Biotechnol. 2002 Jun; 20(6):635-6. Gough D. PMID: 12042874.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Predicting protein--protein interactions from primary structure. Bioinformatics. 2001 May; 17(5):455-60. Bock JR, Gough DA. PMID: 11331240.
      View in: PubMed   Mentions: 100     Fields:    
    23. Benchmark data from the literature for evaluation of new glucose sensing technologies. Diabetes Technol Ther. 2001; 3(3):409-18. Bremer TM, Edelman SV, Gough DA. PMID: 11762520.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Simulations of the frequency response of implantable glucose sensors. Anal Chem. 2000 Apr 15; 72(8):1853-9. Jablecki M, Gough DA. PMID: 10784153.
      View in: PubMed   Mentions: 11     Fields:    
    25. Immobilized glucose oxidase in implantable glucose sensor technology. Diabetes Technol Ther. 2000; 2(3):377-80. Gough DA, Bremer T. PMID: 11467340.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Is blood glucose predictable from previous values? A solicitation for data. Diabetes. 1999 Mar; 48(3):445-51. Bremer T, Gough DA. PMID: 10078542.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    27. Toward prediction of physiological state signals in sleep apnea. IEEE Trans Biomed Eng. 1998 Nov; 45(11):1332-41. Bock J, Gough DA. PMID: 9805832.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Role of xanthine oxidase in hydrogen peroxide production. Free Radic Biol Med. 1998 Oct; 25(6):720-7. Lacy F, Gough DA, Schmid-Schönbein GW. PMID: 9801073.
      View in: PubMed   Mentions: 13     Fields:    
    29. Advances and prospects in glucose assay technology. Diabetologia. 1997 Jul; 40 Suppl 2:S102-7. Gough DA, Armour JC, Baker DA. PMID: 9248710.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    30. Reservations on the use of error grid analysis for the validation of blood glucose assays. Diabetes Care. 1997 Jun; 20(6):1034-6. Gough DA, Botvinick EL. PMID: 9167120.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Accuracy of least squares designed spatial FIR filters for segmentation of images of fluorescence stained cell nuclei. Cytometry. 1996 Dec 01; 25(4):303-16. Price JH, Hunter EA, Gough DA. PMID: 8946137.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Dynamic delay and maximal dynamic error in continuous biosensors. Anal Chem. 1996 Apr 15; 68(8):1292-7. Baker DA, Gough DA. PMID: 8651496.
      View in: PubMed   Mentions: 5     Fields:    
    33. Development of the implantable glucose sensor. What are the prospects and why is it taking so long? Diabetes. 1995 Sep; 44(9):1005-9. Gough DA, Armour JC. PMID: 7657021.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    34. Comparison of phase-contrast and fluorescence digital autofocus for scanning microscopy. Cytometry. 1994 Aug 01; 16(4):283-97. Price JH, Gough DA. PMID: 7988291.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. Dynamic concentration challenges for biosensor characterization. Biosens Bioelectron. 1993; 8(9-10):433-41. Baker DA, Gough DA. PMID: 8311939.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    36. Design and validation of the transparent oxygen sensor array. IEEE Trans Biomed Eng. 1991 May; 38(5):476-82. Sargent BJ, Gough DA. PMID: 1874530.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    37. Application of chronic intravascular blood glucose sensor in dogs. Diabetes. 1990 Dec; 39(12):1519-26. Armour JC, Lucisano JY, McKean BD, Gough DA. PMID: 2245876.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    38. Physiological preparation for studying the response of subcutaneously implanted glucose and oxygen sensors. J Biomed Eng. 1989 Sep; 11(5):362-8. Ertefai S, Gough DA. PMID: 2677523.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    39. A telemetry-instrumentation system for chronically implanted glucose and oxygen sensors. IEEE Trans Biomed Eng. 1988 Jul; 35(7):526-32. McKean BD, Gough DA. PMID: 3209214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    40. Transient response of the two-dimensional glucose sensor. Anal Chem. 1988 Jul 01; 60(13):1272-81. Lucisano JY, Gough DA. PMID: 3213947.
      View in: PubMed   Mentions: 1     Fields:    
    41. Issues related to in vitro operation of potentially implantable enzyme electrode glucose sensors. Horm Metab Res Suppl. 1988; 20:30-3. Gough DA. PMID: 3074035.
      View in: PubMed   Mentions: 1     Fields:    
    42. Transient response of an enzyme electrode sensor for glucose. Anal Chem. 1987 Oct 01; 59(19):2339-44. Tse PH, Gough DA. PMID: 3674445.
      View in: PubMed   Mentions: 2     Fields:    
    43. Determination of the intrinsic kinetic constants of immobilized glucose oxidase and catalase. Biotechnol Bioeng. 1987 Apr; 29(6):696-704. Tse PH, Leypoldt JK, Gough DA. PMID: 18576504.
      View in: PubMed   Mentions: 2     Fields:    
    44. Time-dependent inactivation of immobilized glucose oxidase and catalase. Biotechnol Bioeng. 1987 Apr; 29(6):705-13. Tse PH, Gough DA. PMID: 18576505.
      View in: PubMed   Mentions: 8     Fields:    
    45. In vitro stability of an oxygen sensor. Anal Chem. 1987 Mar 01; 59(5):736-9. Lucisano JY, Armour JC, Gough DA. PMID: 3565773.
      View in: PubMed   Mentions: 4     Fields:    
    46. Short-term in vivo operation of a glucose sensor. ASAIO Trans. 1986 Jul-Sep; 32(1):148-50. Gough DA, Armour JC, Lucisano JY, McKean BD. PMID: 3778702.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    47. A transparent oxygen sensor array. Ann Biomed Eng. 1986; 14(2):153-61. Gough DA, Sargent BJ, Tse PH. PMID: 3740567.
      View in: PubMed   Mentions:    Fields:    
    48. Two-dimensional enzyme electrode sensor for glucose. Anal Chem. 1985 Oct; 57(12):2351-7. Gough DA, Lucisano JY, Tse PH. PMID: 4061843.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    49. Model of a two-substrate enzyme electrode for glucose. Anal Chem. 1984 Dec; 56(14):2896-904. Leypoldt JK, Gough DA. PMID: 6524662.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    50. Diffusion and the limiting substrate in two-substrate immobilized enzyme systems. Biotechnol Bioeng. 1982 Dec; 24(12):2705-19. Leypoldt JK, Gough DA. PMID: 18546248.
      View in: PubMed   Mentions: 3     Fields:    
    51. Progress toward a potentially implantable, enzyme-based glucose sensor. Diabetes Care. 1982 May-Jun; 5(3):190-8. Gough DA, Leypoldt JK, Armour JC. PMID: 7172982.
      View in: PubMed   Mentions: 3     Fields:    
    52. The composition and optical rotary dispersion of bovine aqueous humor. Diabetes Care. 1982 May-Jun; 5(3):266-70. Gough DA. PMID: 7172993.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    53. The status of electrochemical sensors for in vivo glucose monitoring. Horm Metab Res. 1977; Suppl 7:10-22. Gough DA, Aisenberg S, Colton CK, Giner J, Soeldner JS. PMID: 326652.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    54. Enzyme electrodes. Science. 1973 Apr 27; 180(4084):380-4. Gough DA, Andrade JD. PMID: 4573391.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
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