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David Gough

Title(s)Professor, Bioengineering
SchoolAcademic Aff
Phone858-822-3446
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    Collapse Research 
    Collapse Research Activities and Funding
    Modeling Mass Transfer to Active Implants for Diabetes
    NIH/NIDDK R01DK077101May 15, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Mass Transfer to Glucose Sensor for Diabetes
    NIH/NIDDK R01DK064570Sep 30, 2002 - Mar 31, 2012
    Role: Principal Investigator
    Validation of Long-Term Glucose Sensor in Tissues
    NIH/NIDDK R56DK064570Sep 30, 2002 - Apr 30, 2008
    Role: Principal Investigator
    INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENT
    NIH/NCRR C06RR017588Sep 15, 2002 - Sep 14, 2004
    Role: Principal Investigator
    KEY PARAMETERS FOR ARTIFICIAL PANCREAS CONTROLLER
    NIH/NIDDK R21DK057109Sep 30, 1999 - Aug 31, 2002
    Role: Principal Investigator
    TISSUE RESPONSE TO IMPLANTED GLUCOSE SENSOR
    NIH/NIDDK R01DK055064Sep 30, 1998 - Sep 29, 2002
    Role: Principal Investigator
    ESSENTIAL ENDOCRINE PANCREAS
    NIH/NIDDK R01DK046307Aug 1, 1995 - Jul 31, 1998
    Role: Principal Investigator
    DEVELOPMENT OF A GLUCOSE SENSOR FOR DIABETES
    NIH/NIDDK R01DK027541Aug 1, 1980 - Mar 31, 1991
    Role: Principal Investigator
    DEVELOPMENT OF A GLUCOSE SENSOR FOR DIABETES
    NIH/NIADDK R01AM027541Aug 1, 1980 - Jan 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lucisano JY, Routh TL, Lin JT, Gough DA. Glucose Monitoring in Individuals With Diabetes Using a Long-Term Implanted Sensor/Telemetry System and Model. IEEE Trans Biomed Eng. 2017 09; 64(9):1982-1993. PMID: 27775510.
      View in: PubMed
    2. Kumosa LS, Routh TL, Lin JT, Lucisano JY, Gough DA. Permeability of subcutaneous tissues surrounding long-term implants to oxygen. Biomaterials. 2014 Sep; 35(29):8287-96. PMID: 24998180; PMCID: PMC4527688.
    3. Bock JR, Maewal A, Gough DA. Hitting is contagious in baseball: evidence from long hitting streaks. PLoS One. 2012; 7(12):e51367. PMID: 23251507; PMCID: PMC3520861.
    4. Peng LX, Yu L, Howell SB, Gough DA. Effects of solution concentration on the physicochemical properties of a polymeric anticancer therapeutic. Mol Pharm. 2012 Jan 01; 9(1):37-47. PMID: 21988542.
      View in: PubMed
    5. Peng LX, Yu L, Howell SB, Gough DA. Aggregation properties of a polymeric anticancer therapeutic: a coarse-grained modeling study. J Chem Inf Model. 2011 Dec 27; 51(12):3030-5. PMID: 21995420.
      View in: PubMed
    6. Peng LX, Das SK, Yu L, Howell SB, Gough DA. Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(?-glutamyl-glutamate) paclitaxel conjugates. J Mol Model. 2011 Nov; 17(11):2973-87. PMID: 21360176.
      View in: PubMed
    7. Peng LX, Ivetac A, Chaudhari AS, Van S, Zhao G, Yu L, Howell SB, McCammon JA, Gough DA. Characterization of a clinical polymer-drug conjugate using multiscale modeling. Biopolymers. 2010 Nov; 93(11):936-51. PMID: 20564048; PMCID: PMC3099131.
    8. Gough DA, Kumosa LS, Routh TL, Lin JT, Lucisano JY. Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Transl Med. 2010 Jul 28; 2(42):42ra53. PMID: 20668297; PMCID: PMC4528300.
    9. Liu C, Zhao G, Liu J, Ma N, Chivukula P, Perelman L, Okada K, Chen Z, Gough D, Yu L. Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J Control Release. 2009 Dec 16; 140(3):277-83. PMID: 19699770.
      View in: PubMed
    10. Feng Z, Zhao G, Yu L, Gough D, Howell SB. Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane. Cancer Chemother Pharmacol. 2010 Apr; 65(5):923-30. PMID: 19685054; PMCID: PMC2824123.
    11. Rahaghi FN, Gough DA. Blood glucose dynamics. Diabetes Technol Ther. 2008 Apr; 10(2):81-94. PMID: 18260771.
      View in: PubMed
    12. Mytton J, DiGuiseppi C, Gough D, Taylor R, Logan S. School-based secondary prevention programmes for preventing violence. Cochrane Database Syst Rev. 2006 Jul 19; (3):CD004606. PMID: 16856051.
      View in: PubMed
    13. Bock JR, Gough DA. Virtual screen for ligands of orphan G protein-coupled receptors. J Chem Inf Model. 2005 Sep-Oct; 45(5):1402-14. PMID: 16180917.
      View in: PubMed
    14. Makale MT, Chen PC, Gough DA. Variants of the tissue-sensor array window chamber. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H57-65. PMID: 15734882.
      View in: PubMed
    15. Makale MT, Jablecki MC, Gough DA. Mass transfer and gas-phase calibration of implanted oxygen sensors. Anal Chem. 2004 Mar 15; 76(6):1773-7. PMID: 15018582.
      View in: PubMed
    16. Makale MT, Lin JT, Calou RE, Tsai AG, Chen PC, Gough DA. Tissue window chamber system for validation of implanted oxygen sensors. Am J Physiol Heart Circ Physiol. 2003 Jun; 284(6):H2288-94. PMID: 12598234.
      View in: PubMed
    17. Bock JR, Gough DA. Whole-proteome interaction mining. Bioinformatics. 2003 Jan; 19(1):125-34. PMID: 12499302.
      View in: PubMed
    18. Gough DA, Kreutz-Delgado K, Bremer TM. Frequency characterization of blood glucose dynamics. Ann Biomed Eng. 2003 Jan; 31(1):91-7. PMID: 12572659.
      View in: PubMed
    19. Bock JR, Gough DA. A new method to estimate ligand-receptor energetics. Mol Cell Proteomics. 2002 Nov; 1(11):904-10. PMID: 12488466.
      View in: PubMed
    20. Mytton JA, DiGuiseppi C, Gough DA, Taylor RS, Logan S. School-based violence prevention programs: systematic review of secondary prevention trials. Arch Pediatr Adolesc Med. 2002 Aug; 156(8):752-62. PMID: 12144364.
      View in: PubMed
    21. Gough D. Employment and career prospects for bioengineers. Nat Biotechnol. 2002 Jun; 20(6):635-6. PMID: 12042874.
      View in: PubMed
    22. Bock JR, Gough DA. Predicting protein--protein interactions from primary structure. Bioinformatics. 2001 May; 17(5):455-60. PMID: 11331240.
      View in: PubMed
    23. Bremer TM, Edelman SV, Gough DA. Benchmark data from the literature for evaluation of new glucose sensing technologies. Diabetes Technol Ther. 2001; 3(3):409-18. PMID: 11762520.
      View in: PubMed
    24. Jablecki M, Gough DA. Simulations of the frequency response of implantable glucose sensors. Anal Chem. 2000 Apr 15; 72(8):1853-9. PMID: 10784153.
      View in: PubMed
    25. Gough DA, Bremer T. Immobilized glucose oxidase in implantable glucose sensor technology. Diabetes Technol Ther. 2000; 2(3):377-80. PMID: 11467340.
      View in: PubMed
    26. Bremer T, Gough DA. Is blood glucose predictable from previous values? A solicitation for data. Diabetes. 1999 Mar; 48(3):445-51. PMID: 10078542.
      View in: PubMed
    27. Bock J, Gough DA. Toward prediction of physiological state signals in sleep apnea. IEEE Trans Biomed Eng. 1998 Nov; 45(11):1332-41. PMID: 9805832.
      View in: PubMed
    28. Lacy F, Gough DA, Schmid-Schönbein GW. Role of xanthine oxidase in hydrogen peroxide production. Free Radic Biol Med. 1998 Oct; 25(6):720-7. PMID: 9801073.
      View in: PubMed
    29. Gough DA, Armour JC, Baker DA. Advances and prospects in glucose assay technology. Diabetologia. 1997 Jul; 40 Suppl 2:S102-7. PMID: 9248710.
      View in: PubMed
    30. Gough DA, Botvinick EL. Reservations on the use of error grid analysis for the validation of blood glucose assays. Diabetes Care. 1997 Jun; 20(6):1034-6. PMID: 9167120.
      View in: PubMed
    31. Price JH, Hunter EA, Gough DA. Accuracy of least squares designed spatial FIR filters for segmentation of images of fluorescence stained cell nuclei. Cytometry. 1996 Dec 01; 25(4):303-16. PMID: 8946137.
      View in: PubMed
    32. Baker DA, Gough DA. Dynamic delay and maximal dynamic error in continuous biosensors. Anal Chem. 1996 Apr 15; 68(8):1292-7. PMID: 8651496.
      View in: PubMed
    33. Gough DA, Armour JC. Development of the implantable glucose sensor. What are the prospects and why is it taking so long? Diabetes. 1995 Sep; 44(9):1005-9. PMID: 7657021.
      View in: PubMed
    34. Price JH, Gough DA. Comparison of phase-contrast and fluorescence digital autofocus for scanning microscopy. Cytometry. 1994 Aug 01; 16(4):283-97. PMID: 7988291.
      View in: PubMed
    35. Baker DA, Gough DA. Dynamic concentration challenges for biosensor characterization. Biosens Bioelectron. 1993; 8(9-10):433-41. PMID: 8311939.
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    36. Sargent BJ, Gough DA. Design and validation of the transparent oxygen sensor array. IEEE Trans Biomed Eng. 1991 May; 38(5):476-82. PMID: 1874530.
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    37. Armour JC, Lucisano JY, McKean BD, Gough DA. Application of chronic intravascular blood glucose sensor in dogs. Diabetes. 1990 Dec; 39(12):1519-26. PMID: 2245876.
      View in: PubMed
    38. Ertefai S, Gough DA. Physiological preparation for studying the response of subcutaneously implanted glucose and oxygen sensors. J Biomed Eng. 1989 Sep; 11(5):362-8. PMID: 2677523.
      View in: PubMed
    39. McKean BD, Gough DA. A telemetry-instrumentation system for chronically implanted glucose and oxygen sensors. IEEE Trans Biomed Eng. 1988 Jul; 35(7):526-32. PMID: 3209214.
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    40. Lucisano JY, Gough DA. Transient response of the two-dimensional glucose sensor. Anal Chem. 1988 Jul 01; 60(13):1272-81. PMID: 3213947.
      View in: PubMed
    41. Gough DA. Issues related to in vitro operation of potentially implantable enzyme electrode glucose sensors. Horm Metab Res Suppl. 1988; 20:30-3. PMID: 3074035.
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    42. Tse PH, Gough DA. Transient response of an enzyme electrode sensor for glucose. Anal Chem. 1987 Oct 01; 59(19):2339-44. PMID: 3674445.
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    43. Tse PH, Leypoldt JK, Gough DA. Determination of the intrinsic kinetic constants of immobilized glucose oxidase and catalase. Biotechnol Bioeng. 1987 Apr; 29(6):696-704. PMID: 18576504.
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    44. Tse PH, Gough DA. Time-dependent inactivation of immobilized glucose oxidase and catalase. Biotechnol Bioeng. 1987 Apr; 29(6):705-13. PMID: 18576505.
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    45. Lucisano JY, Armour JC, Gough DA. In vitro stability of an oxygen sensor. Anal Chem. 1987 Mar 01; 59(5):736-9. PMID: 3565773.
      View in: PubMed
    46. Gough DA, Armour JC, Lucisano JY, McKean BD. Short-term in vivo operation of a glucose sensor. ASAIO Trans. 1986 Jul-Sep; 32(1):148-50. PMID: 3778702.
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    47. Gough DA, Sargent BJ, Tse PH. A transparent oxygen sensor array. Ann Biomed Eng. 1986; 14(2):153-61. PMID: 3740567.
      View in: PubMed
    48. Gough DA, Lucisano JY, Tse PH. Two-dimensional enzyme electrode sensor for glucose. Anal Chem. 1985 Oct; 57(12):2351-7. PMID: 4061843.
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    49. Leypoldt JK, Gough DA. Model of a two-substrate enzyme electrode for glucose. Anal Chem. 1984 Dec; 56(14):2896-904. PMID: 6524662.
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    50. Leypoldt JK, Gough DA. Diffusion and the limiting substrate in two-substrate immobilized enzyme systems. Biotechnol Bioeng. 1982 Dec; 24(12):2705-19. PMID: 18546248.
      View in: PubMed
    51. Gough DA. The composition and optical rotary dispersion of bovine aqueous humor. Diabetes Care. 1982 May-Jun; 5(3):266-70. PMID: 7172993.
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    52. Gough DA, Leypoldt JK, Armour JC. Progress toward a potentially implantable, enzyme-based glucose sensor. Diabetes Care. 1982 May-Jun; 5(3):190-8. PMID: 7172982.
      View in: PubMed
    53. Gough DA, Aisenberg S, Colton CK, Giner J, Soeldner JS. The status of electrochemical sensors for in vivo glucose monitoring. Horm Metab Res. 1977; Suppl 7:10-22. PMID: 326652.
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    54. Gough DA, Andrade JD. Enzyme electrodes. Science. 1973 Apr 27; 180(4084):380-4. PMID: 4573391.
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