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Gary Silverman

Title(s)Associate Physician Diplomate, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Null Mutant mig-15(udn323) Shows Touch Receptor Neuron Migration Defects in C. elegans. MicroPubl Biol. 2025; 2025. DaCunha S, Silverman GA, Schedl T, Pak SC, Fielder SM, Penny GM. PMID: 41426950; PMCID: PMC12714349.
      View in: PubMed   Mentions:
    2. ATG-3 limits Orsay virus infection in C. elegans and regulates collagen pathways. PLoS Pathog. 2025 Nov; 21(11):e1012900. Kalugotla G, Marmerstein V, Schriefer LA, Wang L, Morrison SA, Perez LC, Silverman GA, Schedl T, Pak SC, Baldridge MT. PMID: 41252446; PMCID: PMC12646485.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons. bioRxiv. 2025 Oct 02. Klinman E, Kwon JS, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. PMID: 41256562; PMCID: PMC12621752.
      View in: PubMed   Mentions:
    4. Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders. EMBO Mol Med. 2025 Oct; 17(10):2562-2585. Fielder SM, Friederich MW, Hock DH, Zhang JR, Valin LM, Rosenfeld JA, Booth KTA, Brown NJ, Rius R, Sharma T, Semcesen LN, Worley KC, Burrage LC, Treat K, Samson T, Govert S, DaCunha S, Yuan W, Chen J, Lesinski J, Hoang H, Morrison SA, Ladha FA, Van Hove RA, Michel CR, Reisdorph R, Tycksen E, Baldridge D, Silverman GA, Soler-Alfonso C, Conboy E, Vetrini F, Emrick L, Craigen WJ, Undiagnosed Diseases Network, Sykes SM, Stroud DA, Van Hove JLK, Schedl T, Pak SC. PMID: 40859057; PMCID: PMC12514044.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders. medRxiv. 2025 Jul 08. Fielder SM, Friederich MW, Hock DH, Zhang JR, Valin LM, Rosenfeld JA, Booth KTA, Brown NJ, Rius R, Sharma T, Semcesen LN, Worley KC, Burrage LC, Treat K, Samson T, Govert S, DaCunha S, Yuan W, Chen J, Lesinski J, Hoang H, Morrison SA, Ladha FA, Van Hove RA, Michel CR, Reisdorph R, Tycksen E, Baldridge D, Silverman GA, Soler-Alfonso C, Conboy E, Vetrini F, Emrick L, Craigen WJ, Undiagnosed Diseases Network, Sykes SM, Stroud DA, Van Hove JLK, Schedl T, Pak SC. PMID: 40672495; PMCID: PMC12265762.
      View in: PubMed   Mentions:
    6. Brain malformations and seizures by impaired chaperonin function of TRiC. Science. 2024 11; 386(6721):516-525. Kraft F, Rodriguez-Aliaga P, Yuan W, Franken L, Zajt K, Hasan D, Lee TT, Flex E, Hentschel A, Innes AM, Zheng B, Julia Suh DS, Knopp C, Lausberg E, Krause J, Zhang X, Trapane P, Carroll R, McClatchey M, Fry AE, Wang L, Giesselmann S, Hoang H, Baldridge D, Silverman GA, Radio FC, Bertini E, Ciolfi A, Blood KA, de Sainte Agathe JM, Charles P, Bergant G, Cuturilo G, Peterlin B, Diderich K, Streff H, Robak L, Oegema R, van Binsbergen E, Herriges J, Saunders CJ, Maier A, Wolking S, Weber Y, Lochmüller H, Meyer S, Aleman A, Polavarapu K, Nicolas G, Goldenberg A, Guyant L, Pope K, Hehmeyer KN, Monaghan KG, Quade A, Smol T, Caumes R, Duerinckx S, Depondt C, Van Paesschen W, Rieubland C, Poloni C, Guipponi M, Arcioni S, Meuwissen M, Jansen AC, Rosenblum J, Haack TB, Bertrand M, Gerstner L, Magg J, Riess O, Schulz JB, Wagner N, Wiesmann M, Weis J, Eggermann T, Begemann M, Roos A, Häusler M, Schedl T, Tartaglia M, Bremer J, Pak SC, Frydman J, Elbracht M, Kurth I. PMID: 39480921; PMCID: PMC12269548.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors. Nat Commun. 2024 09 10; 15(1):7909. Willim J, Woike D, Greene D, Das S, Pfeifer K, Yuan W, Lindsey A, Itani O, Böhme AL, Tibbe D, Hönck HH, Hassani Nia F, Undiagnosed Diseases Network, Zech M, Brunet T, Faivre L, Sorlin A, Vitobello A, Smol T, Colson C, Baranano K, Schatz K, Bayat A, Schoch K, Spillmann R, Davis EE, Conboy E, Vetrini F, Platzer K, Neuser S, Gburek-Augustat J, Grace AN, Mitchell B, Stegmann A, Sinnema M, Meeks N, Saunders C, Cadieux-Dion M, Hoyer J, Van-Gils J, de Sainte-Agathe JM, Thompson ML, Bebin EM, Weisz-Hubshman M, Tabet AC, Verloes A, Levy J, Latypova X, Harder S, Silverman GA, Pak SC, Schedl T, Freson K, Mumford A, Turro E, Schlein C, Shashi V, Kreienkamp HJ. PMID: 39256359; PMCID: PMC11387733.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy. Autophagy Rep. 2024; 3(1). Dawson ZD, Sundaramoorthi H, Regmi S, Zhang B, Morrison S, Fielder SM, Zhang JR, Hoang H, Perlmutter DH, Luke CJ, Silverman GA, Pak SC. PMID: 39070663; PMCID: PMC11271720.
      View in: PubMed   Mentions: 1  
    9. Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency. Hepatology. 2024 10 01; 80(4):859-871. Tafaleng EN, Li J, Wang Y, Hidvegi T, Soto-Gutierrez A, Locke AE, Nicholas TJ, Wang YC, Pak S, Cho MH, Silverman EK, Silverman GA, Jin SC, Fox IJ, Perlmutter DH. PMID: 38557779; PMCID: PMC11407773.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency. Cell Mol Gastroenterol Hepatol. 2024; 17(6):1007-1024. Li J, Moretti F, Hidvegi T, Sviben S, Fitzpatrick JAJ, Sundaramoorthi H, Pak SC, Silverman GA, Knapp B, Filipuzzi I, Alford J, Reece-Hoyes J, Nigsch F, Murphy LO, Nyfeler B, Perlmutter DH. PMID: 38336172; PMCID: PMC11053228.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration. Nat Aging. 2024 Jan; 4(1):95-109. Lee SW, Oh YM, Victor MB, Yang Y, Chen S, Strunilin I, Dahiya S, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. PMID: 38066314; PMCID: PMC11456361.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    12. Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. PLoS Genet. 2023 11; 19(11):e1011005. Marom R, Zhang B, Washington ME, Song IW, Burrage LC, Rossi VC, Berrier AS, Lindsey A, Lesinski J, Nonet ML, Chen J, Baldridge D, Silverman GA, Sutton VR, Rosenfeld JA, Tran AA, Hicks MJ, Murdock DR, Dai H, Weis M, Jhangiani SN, Muzny DM, Gibbs RA, Caswell R, Pottinger C, Cilliers D, Stals K, Undiagnosed Diseases Network, Eyre D, Krakow D, Schedl T, Pak SC, Lee BH. PMID: 37934770; PMCID: PMC10656020.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Macrocephaly and developmental delay caused by missense variants in RAB5C. Hum Mol Genet. 2023 10 17; 32(21):3063-3077. Koop K, Yuan W, Tessadori F, Rodriguez-Polanco WR, Grubbs J, Zhang B, Osmond M, Graham G, Sawyer S, Conboy E, Vetrini F, Treat K, Ploski R, Pienkowski VM, Klosowska A, Fieg E, Krier J, Mallebranche C, Alban Z, Aldinger KA, Ritter D, Macnamara E, Sullivan B, Herriges J, Alaimo JT, Helbig C, Ellis CA, van Eyk C, Gecz J, Farrugia D, Osei-Owusu I, Adès L, van den Boogaard MJ, Fuchs S, Bakker J, Duran K, Dawson ZD, Lindsey A, Huang H, Baldridge D, Silverman GA, Grant BD, Raizen D, Undiagnosed Diseases Network, van Haaften G, Pak SC, Rehmann H, Schedl T, van Hasselt P. PMID: 37552066; PMCID: PMC10586195.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    14. Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington's disease. Res Sq. 2023 May 09. Lee SW, Oh YM, Victor MB, Strunilin I, Chen S, Dahiya S, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. PMID: 37214956; PMCID: PMC10197783.
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    15. Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy. Nat Neurosci. 2022 11; 25(11):1420-1433. Oh YM, Lee SW, Kim WK, Chen S, Church VA, Cates K, Li T, Zhang B, Dolle RE, Dahiya S, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. PMID: 36303071; PMCID: PMC10162007.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    16. Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay. Mol Genet Metab. 2022 05; 136(1):65-73. Fielder SM, Rosenfeld JA, Burrage LC, Emrick L, Lalani S, Attali R, Bembenek JN, Hoang H, Baldridge D, Silverman GA, Undiagnosed Diseases Network, Schedl T, Pak SC. PMID: 35361529; PMCID: PMC10200280.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    17. Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z. Gastroenterology. 2022 07; 163(1):270-284. Rudnick DA, Huang J, Hidvegi T, Chu AS, Hale P, Munanairi A, Dietzen DJ, Cliften PF, Tycksen E, Lutkewitte AJ, Finck BN, Pak SC, Silverman GA, Perlmutter DH. PMID: 35301011; PMCID: PMC9232923.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Huang H, Pan J, Spielberg DR, Hanchard NA, Scott DA, Burrage LC, Dai H, Murdock D, Rosenfeld JA, Mohammad A, Huang T, Lindsey AG, Kim H, Chen J, Ramu A, Morrison SA, Dawson ZD, Hu AZ, Tycksen E, Silverman GA, Baldridge D, Wambach JA, Undiagnosed Diseases Network, Pak SC, Brody SL, Schedl T. PMID: 35121658; PMCID: PMC8832968.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol. 2022 01 12; 5(1):47. Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM, Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A, Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White FV, Fitzpatrick JAJ, Orvedahl A, Pak SC, Silverman GA. PMID: 35022507; PMCID: PMC8755814.
      View in: PubMed   Mentions: 14  Translation:HumansAnimalsCells
    20. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation. Commun Biol. 2022 01 12; 5(1):46. Wang S, Luke CJ, Pak SC, Shi V, Chen L, Moore J, Andress AP, Jayachandran K, Zhang J, Huang Y, Platik M, Apicelli AA, Schwarz JK, Grigsby PW, Silverman GA, Markovina S. PMID: 35022555; PMCID: PMC8755728.
      View in: PubMed   Mentions: 19  Translation:HumansAnimalsCells
    21. Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA. Mol Genet Metab. 2021 Sep-Oct; 134(1-2):195-202. Boulin T, Itani O, El Mouridi S, Leclercq-Blondel A, Gendrel M, Macnamara E, Soldatos A, Murphy JL, Gorman MP, Lindsey A, Shimada S, Turner D, Silverman GA, Baldridge D, Undiagnosed Diseases Network, Malicdan MC, Schedl T, Pak SC. PMID: 34412939; PMCID: PMC10626981.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    22. Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis. Int J Mol Sci. 2020 Apr 19; 21(8). Shi Q, Pei F, Silverman GA, Pak SC, Perlmutter DH, Liu B, Bahar I. PMID: 32325894; PMCID: PMC7215584.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    23. Functional characterization of four ATP-binding cassette transporter A3 gene (ABCA3) variants. Hum Mutat. 2020 07; 41(7):1298-1307. Hu JY, Yang P, Wegner DJ, Heins HB, Luke CJ, Li F, White FV, Silverman GA, Sessions Cole F, Wambach JA. PMID: 32196812; PMCID: PMC7292786.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    24. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16497-16506. Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW. PMID: 31346084; PMCID: PMC6697821.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    25. CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans. PLoS One. 2019; 14(3):e0214257. Thomas BJ, Wight IE, Chou WYY, Moreno M, Dawson Z, Homayouni A, Huang H, Kim H, Jia H, Buland JR, Wambach JA, Cole FS, Pak SC, Silverman GA, Luke CJ. PMID: 30913273; PMCID: PMC6435234.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z. PLoS One. 2019; 14(1):e0209748. Wang Y, Cobanoglu MC, Li J, Hidvegi T, Hale P, Ewing M, Chu AS, Gong Z, Muzumdar R, Pak SC, Silverman GA, Bahar I, Perlmutter DH. PMID: 30673724; PMCID: PMC6343872.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. Quantitative assessment of cell fate decision between autophagy and apoptosis. Sci Rep. 2017 12 14; 7(1):17605. Liu B, Oltvai ZN, Bayir H, Silverman GA, Pak SC, Perlmutter DH, Bahar I. PMID: 29242632; PMCID: PMC5730598.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    28. Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer. Br J Cancer. 2018 01; 118(1):72-78. Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW. PMID: 29112685; PMCID: PMC5765231.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    29. Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit. J Biol Chem. 2016 Jul 01; 291(27):14012-14022. Shi S, Luke CJ, Miedel MT, Silverman GA, Kleyman TR. PMID: 27189943; PMCID: PMC4933161.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    30. High-Throughput, Liquid-Based Genome-Wide RNAi Screening in C. elegans. Methods Mol Biol. 2016; 1470:151-62. O'Reilly LP, Knoerdel RR, Silverman GA, Pak SC. PMID: 27581291.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    31. SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry. 2015 Nov 17; 54(45):6756-9. Niehaus JZ, Miedel MT, Good M, Wyatt AN, Pak SC, Silverman GA, Luke CJ. PMID: 26497600; PMCID: PMC4900762.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    32. Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency. PLoS One. 2015; 10(10):e0141542. Cummings EE, O'Reilly LP, King DE, Silverman RM, Miedel MT, Luke CJ, Perlmutter DH, Silverman GA, Pak SC. PMID: 26512890; PMCID: PMC4626213.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015 Dec 11; 290(50):29742-57. Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. PMID: 26494620; PMCID: PMC4705969.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    34. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem. 2015 11; 63(11):854-65. Niehaus JZ, Good M, Jackson LE, Ozolek JA, Silverman GA, Luke CJ. PMID: 26220980; PMCID: PMC4812677.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    35. The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Genetics. 2015 May; 200(1):207-19. Silverman RM, Cummings EE, O'Reilly LP, Miedel MT, Silverman GA, Luke CJ, Perlmutter DH, Pak SC. PMID: 25786854; PMCID: PMC4423363.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    36. Expanding the C. elegans toolbox into a toolshed. Methods. 2014 Aug 01; 68(3):379-80. Ghazi A, Yanowitz J, Silverman GA. PMID: 25064639; PMCID: PMC5408735.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    37. Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways. Expert Opin Drug Discov. 2014 Sep; 9(9):1021-32. O'Reilly LP, Benson JA, Cummings EE, Perlmutter DH, Silverman GA, Pak SC. PMID: 24998976.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency. Hum Mol Genet. 2014 Oct 01; 23(19):5123-32. O'Reilly LP, Long OS, Cobanoglu MC, Benson JA, Luke CJ, Miedel MT, Hale P, Perlmutter DH, Bahar I, Silverman GA, Pak SC. PMID: 24838285; PMCID: PMC4159156.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    39. A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Hum Mol Genet. 2014 Oct 01; 23(19):5109-22. Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC. PMID: 24838286; PMCID: PMC4159155.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    40. Isolation of serpin-interacting proteins in C. elegans using protein affinity purification. Methods. 2014 Aug 01; 68(3):536-41. Miedel MT, Zeng X, Yates NA, Silverman GA, Luke CJ. PMID: 24798811; PMCID: PMC4113314.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency. PLoS One. 2014; 9(1):e87260. Li J, Pak SC, O'Reilly LP, Benson JA, Wang Y, Hidvegi T, Hale P, Dippold C, Ewing M, Silverman GA, Perlmutter DH. PMID: 24498058; PMCID: PMC3909079.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    42. α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery. Int J Biochem Cell Biol. 2014 Feb; 47:109-12. O'Reilly LP, Perlmutter DH, Silverman GA, Pak SC. PMID: 24355812; PMCID: PMC3970812.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    43. C. elegans in high-throughput drug discovery. Adv Drug Deliv Rev. 2014 Apr; 69-70:247-53. O'Reilly LP, Luke CJ, Perlmutter DH, Silverman GA, Pak SC. PMID: 24333896; PMCID: PMC4019719.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimals
    44. Update of the human and mouse SERPIN gene superfamily. Hum Genomics. 2013 Oct 30; 7:22. Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V. PMID: 24172014; PMCID: PMC3880077.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    45. A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying. PLoS One. 2013; 8(9):e75869. Chotoo CK, Silverman GA, Devor DC, Luke CJ. PMID: 24040423; PMCID: PMC3769271.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype. J Pediatr. 2013 Aug; 163(2):320-6. Silverman GA, Pak SC, Perlmutter DH. PMID: 23664631; PMCID: PMC3725216.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    47. A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. PLoS One. 2012; 7(7):e40145. Miedel MT, Graf NJ, Stephen KE, Long OS, Pak SC, Perlmutter DH, Silverman GA, Luke CJ. PMID: 22768338; PMCID: PMC3388072.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    48. Simultaneous very late stent thrombosis in multiple coronary arteries. Tex Heart Inst J. 2012; 39(5):630-4. Narasimhan S, Krim NR, Silverman G, Monrad ES. PMID: 23109755; PMCID: PMC3461685.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    49. Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence. Biol Chem. 2011 May; 392(5):483-9. Kantyka T, Plaza K, Koziel J, Florczyk D, Stennicke HR, Thogersen IB, Enghild JJ, Silverman GA, Pak SC, Potempa J. PMID: 21476872; PMCID: PMC4372843.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    50. Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution. Nat Cell Biol. 2011 Mar; 13(3):197-9. Luke CJ, Silverman GA. PMID: 21364568.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    51. Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders. Cold Spring Harb Perspect Biol. 2011 Mar 01; 3(3). Perlmutter DH, Silverman GA. PMID: 21421920; PMCID: PMC3039936.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    52. Using C. elegans to identify the protease targets of serpins in vivo. Methods Enzymol. 2011; 499:283-99. Bhatia SR, Miedel MT, Chotoo CK, Graf NJ, Hood BL, Conrads TP, Silverman GA, Luke CJ. PMID: 21683259; PMCID: PMC4374438.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    53. Using Caenorhabditis elegans to study serpinopathies. Methods Enzymol. 2011; 499:259-81. Long OS, Gosai SJ, Kwak JH, King DE, Perlmutter DH, Silverman GA, Pak SC. PMID: 21683258; PMCID: PMC4374434.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    54. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan; 127(1):254-61, 261.e1-6. Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. PMID: 21126757; PMCID: PMC3058372.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    55. Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One. 2010 Nov 12; 5(11):e15460. Gosai SJ, Kwak JH, Luke CJ, Long OS, King DE, Kovatch KJ, Johnston PA, Shun TY, Lazo JS, Perlmutter DH, Silverman GA, Pak SC. PMID: 21103396; PMCID: PMC2980495.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    56. Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest. 2010 Sep; 120(9):3365-76. Reece ST, Loddenkemper C, Askew DJ, Zedler U, Schommer-Leitner S, Stein M, Mir FA, Dorhoi A, Mollenkopf HJ, Silverman GA, Kaufmann SH. PMID: 20679732; PMCID: PMC2929725.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    57. Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem. 2010 Aug 06; 285(32):24307-12. Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA. PMID: 20498368; PMCID: PMC2915666.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    58. Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem. 2010 Aug 06; 285(32):24299-305. Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI. PMID: 20498369; PMCID: PMC2915665.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    59. Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2. J Oral Microbiol. 2010 May 04; 2. Yin L, Swanson B, An J, Hacker BM, Silverman GA, Dale BA, Chung WO. PMID: 21523231; PMCID: PMC3084571.
      View in: PubMed   Mentions: 16  
    60. Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans. Pediatr Res. 2009 Jan; 65(1):10-8. Silverman GA, Luke CJ, Bhatia SR, Long OS, Vetica AC, Perlmutter DH, Pak SC. PMID: 18852689; PMCID: PMC2731241.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    61. DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem. 2007 Dec 21; 282(51):36980-6. Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN. PMID: 17923478.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    62. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell. 2007 Sep 21; 130(6):1108-19. Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Brömme D, Silverman GA. PMID: 17889653; PMCID: PMC2128786.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    63. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. J Biol Chem. 2007 Aug 24; 282(34):24948-60. Askew DJ, Cataltepe S, Kumar V, Edwards C, Pace SM, Howarth RN, Pak SC, Askew YS, Brömme D, Luke CJ, Whisstock JC, Silverman GA. PMID: 17562709.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    64. An overview of the serpin superfamily. Genome Biol. 2006; 7(5):216. Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, Rosado CJ, Langendorf CG, Pike RN, Bird PI, Whisstock JC. PMID: 16737556; PMCID: PMC1779521.
      View in: PubMed   Mentions: 330     Fields:    Translation:HumansCells
    65. Correlation of serpin-protease expression by comparative analysis of real-time PCR profiling data. Genomics. 2006 Aug; 88(2):173-84. Badola S, Spurling H, Robison K, Fedyk ER, Silverman GA, Strayle J, Kapeller R, Tsu CA. PMID: 16713170.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    66. The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases. Biochemistry. 2006 Apr 11; 45(14):4474-80. Pak SC, Tsu C, Luke CJ, Askew YS, Silverman GA. PMID: 16584183; PMCID: PMC2654365.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    67. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Front Biosci. 2006 Jan 01; 11:581-94. Luke CJ, Pak SC, Askew DJ, Askew YS, Smith JE, Silverman GA. PMID: 16146754.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    68. Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma. Head Neck. 2006 Jan; 28(1):24-30. Nakashima T, Yasumatsu R, Kuratomi Y, Masuda M, Kuwano T, Toh S, Umezaki T, Cataltepe S, Silverman GA, Komune S. PMID: 16155915.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    69. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Blood. 2005 May 15; 105(10):3893-901. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL. PMID: 15701722; PMCID: PMC1895090.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    70. Uteroglobin suppresses SCCA gene expression associated with allergic asthma. J Biol Chem. 2005 Mar 18; 280(11):9761-4. Ray R, Choi M, Zhang Z, Silverman GA, Askew D, Mukherjee AB. PMID: 15677460.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    71. Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Biochemistry. 2004 Sep 21; 43(37):11750-9. Cole EB, Miller D, Rometo D, Greenberg RM, Brömme D, Cataltepe S, Pak SC, Mills DR, Silverman GA, Luke CJ. PMID: 15362859.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    72. The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases. Genomics. 2004 Jul; 84(1):166-75. Askew DJ, Askew YS, Kato Y, Luke CJ, Pak SC, Brömme D, Silverman GA. PMID: 15203214.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    73. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Genomics. 2004 Jul; 84(1):176-84. Askew DJ, Askew YS, Kato Y, Turner RF, Dewar K, Lehoczky J, Silverman GA. PMID: 15203215.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    74. Production of serpins using baculovirus expression systems. Methods. 2004 Feb; 32(2):177-84. Jayakumar A, Cataltepe S, Kang Y, Frederick MJ, Mitsudo K, Henderson Y, Crawford SE, Silverman GA, Clayman GL. PMID: 14698630.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    75. Serpin identification, production, and characterization. Methods. 2004 Feb; 32(2):71-2. Silverman GA, Lomas DA. PMID: 14698620.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    76. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. J Biol Chem. 2004 Apr 09; 279(15):15448-59. Pak SC, Kumar V, Tsu C, Luke CJ, Askew YS, Askew DJ, Mills DR, Brömme D, Silverman GA. PMID: 14739286.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    77. SCCA2-like serpins mediate genetic predisposition to skin tumors. Cancer Res. 2003 Apr 15; 63(8):1871-5. Gariboldi M, Peissel B, Fabbri A, Saran A, Zaffaroni D, Falvella FS, Spinola M, Tanuma J, Pazzaglia S, Mancuso MT, Maurichi A, Bartoli C, Cataltepe S, Silverman GA, Pilotti S, Hayashizaki Y, Okazaki Y, Dragani TA. PMID: 12702576.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    78. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys. 2003 Jan 15; 409(2):367-74. Jayakumar A, Kang Y, Frederick MJ, Pak SC, Henderson Y, Holton PR, Mitsudo K, Silverman GA, EL-Naggar AK, Brömme D, Clayman GL. PMID: 12504904.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    79. Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases. Biochemistry. 2002 Apr 16; 41(15):4998-5004. Irving JA, Pike RN, Dai W, Brömme D, Worrall DM, Silverman GA, Coetzer TH, Dennison C, Bottomley SP, Whisstock JC. PMID: 11939796.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    80. The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry. 2002 Mar 05; 41(9):3189-99. Al-Khunaizi M, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S, Miller D, Mills DR, Tsu C, Brömme D, Irving JA, Whisstock JC, Silverman GA. PMID: 11863458.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    81. Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tract. Cancer. 2002 Jan 01; 94(1):152-8. Yasumatsu R, Nakashima T, Kuratomi Y, Hirakawa N, Azuma K, Tomita K, Cataltepe S, Silverman GA, Clayman GL, Komiyama S. PMID: 11815971.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
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