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    Dan Kaufman

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-822-1777
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kidwai F, Edwards J, Zou L, Kaufman D. Fibrinogen Induces RUNX2 Activity and Osteogenic Development from Human Pluripotent Stem Cells. Stem Cells. 2016 Aug; 34(8):2079-89. PMID: 27331788.
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      2. Zou L, Chen Q, Quanbeck Z, Bechtold JE, Kaufman D. Angiogenic activity mediates bone repair from human pluripotent stem cell-derived osteogenic cells. Sci Rep. 2016; 6:22868. PMID: 26980556.
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      3. Hermanson DL, Bendzick L, Kaufman D. Mouse Xenograft Model for Intraperitoneal Administration of NK Cell Immunotherapy for Ovarian Cancer. Methods Mol Biol. 2016; 1441:277-84. PMID: 27177674.
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      4. Hermanson DL, Bendzick L, Pribyl L, McCullar V, Vogel RI, Miller JS, Geller MA, Kaufman D. Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer. Stem Cells. 2016 Jan; 34(1):93-101. PMID: 26503833.
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      5. Angelos MG, Kaufman D. Pluripotent stem cell applications for regenerative medicine. Curr Opin Organ Transplant. 2015 Dec; 20(6):663-70. PMID: 26536430.
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      6. Song W, Kaufman D, Shen W. Efficient generation of endothelial cells from human pluripotent stem cells and characterization of their functional properties. J Biomed Mater Res A. 2015 Oct 31. PMID: 26519950.
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      7. Li LB, Ma C, Awong G, Kennedy M, Gornalusse G, Keller G, Kaufman D, Russell DW. Silent IL2RG Gene Editing in Human Pluripotent Stem Cells. Mol Ther. 2016 Mar; 24(3):582-91. PMID: 26444081.
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      8. Hermanson DL, Kaufman D. Utilizing chimeric antigen receptors to direct natural killer cell activity. Front Immunol. 2015; 6:195. PMID: 25972867.
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      9. Ferrell PI, Xi J, Ma C, Adlakha M, Kaufman D. The RUNX1 +24 Enhancer and P1 Promoter Identify a Unique Subpopulation of Hematopoietic Progenitor Cells Derived from Human Pluripotent Stem Cells. Stem Cells. 2015 Apr; 33(4):1130-41. PMID: 25546363.
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      10. Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman D, Walcheck B. Identification of an ADAM17 Cleavage Region in Human CD16 (Fc?RIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells. PLoS One. 2015; 10(3):e0121788. PMID: 25816339.
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      11. Zou L, Kidwai FK, Kopher RA, Motl J, Kellum CA, Westendorf JJ, Kaufman D. Use of RUNX2 Expression to Identify Osteogenic Progenitor Cells Derived from Human Embryonic Stem Cells. Stem Cell Reports. 2015 Feb 10; 4(2):190-8. PMID: 25680477.
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      12. Ye L, Chang YH, Xiong Q, Zhang P, Zhang L, Somasundaram P, Lepley M, Swingen C, Su L, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang J, Kamp TJ, Kaufman D, Ge Y, Zhang J. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell. 2014 Dec 4; 15(6):750-61. PMID: 25479750.
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      13. Ni Z, Knorr DA, Bendzick L, Allred J, Kaufman D. Expression of chimeric receptor CD4? by natural killer cells derived from human pluripotent stem cells improves in vitro activity but does not enhance suppression of HIV infection in vivo. Stem Cells. 2014 Apr; 32(4):1021-31. PMID: 24307574; NIHMSID: NIHMS548658 [Available on 04/01/15].
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      14. Ferrell PI, Hexum MK, Kopher RA, Lepley MA, Gussiaas A, Kaufman D. Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev. 2014 Jun 15; 23(12):1355-63. PMID: 24517837; PMCID: PMC4046207 [Available on 06/15/15].
      15. Geller MA, Knorr DA, Hermanson DA, Pribyl L, Bendzick L, McCullar V, Miller JS, Kaufman D. Intraperitoneal delivery of human natural killer cells for treatment of ovarian cancer in a mouse xenograft model. Cytotherapy. 2013 Oct; 15(10):1297-306. PMID: 23993303; NIHMSID: NIHMS492882.
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      16. Ran D, Lam K, Shia WJ, Lo MC, Fan JB, Knorr DA, Ferrell PI, Ye Z, Yan M, Cheng L, Kaufman D, Zhang DE. Response: the role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells. Blood. 2013 Jun 27; 121(26):5252-3. PMID: 23813938; PMCID: PMC3695367.
      17. Bock AM, Knorr D, Kaufman D. Development, expansion, and in vivo monitoring of human NK cells from human embryonic stem cells (hESCs) and and induced pluripotent stem cells (iPSCs). J Vis Exp. 2013; (74):e50337. PMID: 23644738.
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      18. Vallera DA, Zhang B, Gleason MK, Oh S, Weiner LM, Kaufman D, McCullar V, Miller JS, Verneris MR. Heterodimeric bispecific single-chain variable-fragment antibodies against EpCAM and CD16 induce effective antibody-dependent cellular cytotoxicity against human carcinoma cells. Cancer Biother Radiopharm. 2013 May; 28(4):274-82. PMID: 23611188; PMCID: PMC4209492.
      19. Knorr DA, Bock A, Brentjens RJ, Kaufman D. Engineered human embryonic stem cell-derived lymphocytes to study in vivo trafficking and immunotherapy. Stem Cells Dev. 2013 Jul 1; 22(13):1861-9. PMID: 23421330; PMCID: PMC3685314.
      20. Knorr DA, Ni Z, Hermanson D, Hexum MK, Bendzick L, Cooper LJ, Lee DA, Kaufman D. Clinical-scale derivation of natural killer cells from human pluripotent stem cells for cancer therapy. Stem Cells Transl Med. 2013 Apr; 2(4):274-83. PMID: 23515118; PMCID: PMC3659832.
      21. Kaufman D. Tu-mor(e) blood cells from human pluripotent stem cells. Blood. 2013 Feb 21; 121(8):1245-6. PMID: 23429981.
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      22. Xiong Q, Ye L, Zhang P, Lepley M, Tian J, Li J, Zhang L, Swingen C, Vaughan JT, Kaufman D, Zhang J. Functional consequences of human induced pluripotent stem cell therapy: myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling. Circulation. 2013 Mar 5; 127(9):997-1008. PMID: 23371930; NIHMSID: NIHMS563761.
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      23. Ran D, Shia WJ, Lo MC, Fan JB, Knorr DA, Ferrell PI, Ye Z, Yan M, Cheng L, Kaufman D, Zhang DE. RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood. 2013 Apr 11; 121(15):2882-90. PMID: 23372166.
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      24. Simara P, Motl JA, Kaufman D. Pluripotent stem cells and gene therapy. Transl Res. 2013 Apr; 161(4):284-92. PMID: 23353080; NIHMSID: NIHMS434129.
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      25. Ni Z, Knorr DA, Kaufman D. Hematopoietic and nature killer cell development from human pluripotent stem cells. Methods Mol Biol. 2013; 1029:33-41. PMID: 23756940.
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      26. Xiong Q, Ye L, Zhang P, Lepley M, Swingen C, Zhang L, Kaufman D, Zhang J. Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells. Circ Res. 2012 Aug 3; 111(4):455-68. PMID: 22723295; NIHMSID: NIHMS459911.
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      27. Rao M, Ahrlund-Richter L, Kaufman D. Concise review: Cord blood banking, transplantation and induced pluripotent stem cell: success and opportunities. Stem Cells. 2012 Jan; 30(1):55-60. PMID: 22069231.
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      28. Sjeklocha LM, Park CW, Wong PY, Roney MJ, Belcher JD, Kaufman D, Vercellotti GM, Hebbel RP, Steer CJ. Erythroid-specific expression of ß-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells. PLoS One. 2011; 6(12):e29110. PMID: 22216176; PMCID: PMC3247234.
      29. Waldron NN, Kaufman D, Oh S, Inde Z, Hexum MK, Ohlfest JR, Vallera DA. Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer. Mol Cancer Ther. 2011 Oct; 10(10):1829-38. PMID: 21862685; NIHMSID: NIHMS317817.
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      30. Liu Y, Wang X, Kaufman D, Shen W. A synthetic substrate to support early mesodermal differentiation of human embryonic stem cells. Biomaterials. 2011 Nov; 32(32):8058-66. PMID: 21821284; NIHMSID: NIHMS318158.
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      31. Undale A, Fraser D, Hefferan T, Kopher RA, Herrick J, Evans GL, Li X, Kakar S, Hayes M, Atkinson E, Yaszemski MJ, Kaufman D, Westendorf JJ, Khosla S. Induction of fracture repair by mesenchymal cells derived from human embryonic stem cells or bone marrow. J Orthop Res. 2011 Dec; 29(12):1804-11. PMID: 21674605; NIHMSID: NIHMS301697.
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      32. Solh M, DeFor TE, Weisdorf DJ, Kaufman D. Extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation: better prognosis than systemic relapse. Biol Blood Marrow Transplant. 2012 Jan; 18(1):106-12. PMID: 21703975.
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      33. Xiong Q, Hill KL, Li Q, Suntharalingam P, Mansoor A, Wang X, Jameel MN, Zhang P, Swingen C, Kaufman D, Zhang J. A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling. Stem Cells. 2011 Feb; 29(2):367-75. PMID: 21732493; NIHMSID: NIHMS392526.
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      34. Hexum MK, Tian X, Kaufman D. In vivo evaluation of putative hematopoietic stem cells derived from human pluripotent stem cells. Methods Mol Biol. 2011; 767:433-47. PMID: 21822894.
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      35. Gori JL, McIvor RS, Kaufman D. Methotrexate supports in vivo selection of human embryonic stem cell derived-hematopoietic cells expressing dihydrofolate reductase. Bioeng Bugs. 2010 Nov-Dec; 1(6):434-6. PMID: 21468213; PMCID: PMC3056096.
      36. Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman D. Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms. J Virol. 2011 Jan; 85(1):43-50. PMID: 20962093; PMCID: PMC3014194.
      37. Kaufman D. HIF hits Wnt in the stem cell niche. Nat Cell Biol. 2010 Oct; 12(10):926-7. PMID: 20885419.
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      38. Islam MS, Ni Z, Kaufman D. Use of human embryonic stem cells to understand hematopoiesis and hematopoietic stem cell niche. Curr Stem Cell Res Ther. 2010 Sep; 5(3):245-50. PMID: 20214557.
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      39. Knorr DA, Kaufman D. Pluripotent stem cell-derived natural killer cells for cancer therapy. Transl Res. 2010 Sep; 156(3):147-54. PMID: 20801411; NIHMSID: NIHMS230241.
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      40. Kopher RA, Penchev VR, Islam MS, Hill KL, Khosla S, Kaufman D. Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells. Bone. 2010 Oct; 47(4):718-28. PMID: 20601304; NIHMSID: NIHMS225291.
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      41. Hill KL, Obrtlikova P, Alvarez DF, King JA, Keirstead SA, Allred JR, Kaufman D. Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function. Exp Hematol. 2010 Mar; 38(3):246-257.e1. PMID: 20067819; NIHMSID: NIHMS174937.
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      42. Tian X, Hexum MK, Penchev VR, Taylor RJ, Shultz LD, Kaufman D. Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells. 2009 Nov; 27(11):2675-85. PMID: 19711457; NIHMSID: NIHMS192108.
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      43. Gori JL, Tian X, Swanson D, Gunther R, Shultz LD, McIvor RS, Kaufman D. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther. 2010 Feb; 17(2):238-49. PMID: 19829316; NIHMSID: NIHMS145529.
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      44. Kaufman D. Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells. Blood. 2009 Oct 22; 114(17):3513-23. PMID: 19652198; PMCID: PMC2766673.
      45. Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman D, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ. Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome. J Clin Oncol. 2009 Aug 1; 27(22):3634-41. PMID: 19581540; PMCID: PMC2720079.
      46. Woll PS, Grzywacz B, Tian X, Marcus RK, Knorr DA, Verneris MR, Kaufman D. Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity. Blood. 2009 Jun 11; 113(24):6094-101. PMID: 19365083; PMCID: PMC2699231.
      47. Hill KL, Kaufman D. Hematopoietic differentiation of human embryonic stem cells by cocultivation with stromal layers. Curr Protoc Stem Cell Biol. 2008 Sep; Chapter 1:Unit 1F.6. PMID: 18819084.
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      48. Martin CH, Woll PS, Ni Z, Zúñiga-Pflücker JC, Kaufman D. Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells. Blood. 2008 Oct 1; 112(7):2730-7. PMID: 18621931; PMCID: PMC2556609.
      49. Tian X, Kaufman D. Differentiation of embryonic stem cells towards hematopoietic cells: progress and pitfalls. Curr Opin Hematol. 2008 Jul; 15(4):312-8. PMID: 18536568.
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      50. Cameron CM, Harding F, Hu WS, Kaufman D. Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies. Exp Biol Med (Maywood). 2008 Aug; 233(8):1044-57. PMID: 18535160.
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      51. Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman D, Pera M, Pastan I. Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. Stem Cells Dev. 2008 Apr; 17(2):325-32. PMID: 18447647.
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      52. Majhail NS, Brunstein CG, Tomblyn M, Thomas AJ, Miller JS, Arora M, Kaufman D, Burns LJ, Slungaard A, McGlave PB, Wagner JE, Weisdorf DJ. Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor. Biol Blood Marrow Transplant. 2008 Mar; 14(3):282-9. PMID: 18275894; NIHMSID: NIHMS41246.
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      53. Tian X, Kaufman D. Hematopoietic development of human embryonic stem cells in culture. Methods Mol Biol. 2008; 430:119-33. PMID: 18370295.
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      54. Woll PS, Morris JK, Painschab MS, Marcus RK, Kohn AD, Biechele TL, Moon RT, Kaufman D. Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood. 2008 Jan 1; 111(1):122-31. PMID: 17875805; PMCID: PMC2200802.
      55. Wilber A, Linehan JL, Tian X, Woll PS, Morris JK, Belur LR, McIvor RS, Kaufman D. Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer. Stem Cells. 2007 Nov; 25(11):2919-27. PMID: 17673526.
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      56. Flynn CM, Kaufman D. Donor cell leukemia: insight into cancer stem cells and the stem cell niche. Blood. 2007 Apr 1; 109(7):2688-92. PMID: 17132724.
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      57. Cameron CM, Hu WS, Kaufman D. Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnol Bioeng. 2006 Aug 5; 94(5):938-48. PMID: 16547998.
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      58. Anderson JS, Bandi S, Kaufman D, Akkina R. Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy. Retrovirology. 2006; 3:24. PMID: 16623949; PMCID: PMC1462997.
      59. Tian X, Woll PS, Morris JK, Linehan JL, Kaufman D. Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells. 2006 May; 24(5):1370-80. PMID: 16456127.
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      60. Qiu C, Hanson E, Olivier E, Inada M, Kaufman D, Gupta S, Bouhassira EE. Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol. 2005 Dec; 33(12):1450-8. PMID: 16338487.
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      61. Schwartz RE, Linehan JL, Painschab MS, Hu WS, Verfaillie CM, Kaufman D. Defined conditions for development of functional hepatic cells from human embryonic stem cells. Stem Cells Dev. 2005 Dec; 14(6):643-55. PMID: 16433619.
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      62. Narayan AD, Chase JL, Lewis RL, Tian X, Kaufman D, Thomson JA, Zanjani ED. Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood. 2006 Mar 1; 107(5):2180-3. PMID: 16278307; PMCID: PMC1895718.
      63. Woll PS, Martin CH, Miller JS, Kaufman D. Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity. J Immunol. 2005 Oct 15; 175(8):5095-103. PMID: 16210613.
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      64. Martin CH, Kaufman D. Synergistic use of adult and embryonic stem cells to study human hematopoiesis. Curr Opin Biotechnol. 2005 Oct; 16(5):510-5. PMID: 16095900.
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      65. Hematti P, Obrtlikova P, Kaufman D. Nonhuman primate embryonic stem cells as a preclinical model for hematopoietic and vascular repair. Exp Hematol. 2005 Sep; 33(9):980-6. PMID: 16140145.
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      66. Kaufman D, Winter KA, Shipley WU, Althausen AF, Hug EB, Toonkel LM, Sandler HM. Muscle-invading bladder cancer, RTOG Protocol 99-06: Initial report of a phase I/II trial of selective bladder-conservation employing TURBT, accelerated irradiation sensitized with cisplatin and paclitaxel followed by adjuvant cisplatin and gemcitabine chemotherapy. J Clin Oncol. 2005 Jun; 23(16_suppl):4506. PMID: 27946525.
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      67. Tian X, Kaufman D. Hematopoietic development of human embryonic stem cells in culture. Methods Mol Biol. 2005; 290:149-62. PMID: 15361661.
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      68. Tian X, Kaufman D. Hematopoietic development of human embryonic stem cells in culture. Methods Mol Med. 2005; 105:425-36. PMID: 15492412.
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      69. Tian X, Morris JK, Linehan JL, Kaufman D. Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells. Exp Hematol. 2004 Oct; 32(10):1000-9. PMID: 15504555.
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      70. Lakshmipathy U, Pelacho B, Sudo K, Linehan JL, Coucouvanis E, Kaufman D, Verfaillie CM. Efficient transfection of embryonic and adult stem cells. Stem Cells. 2004; 22(4):531-43. PMID: 15277699.
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      71. Chen D, Lewis RL, Kaufman D. Mouse and human embryonic stem cell models of hematopoiesis: past, present, and future. Biotechniques. 2003 Dec; 35(6):1253-61. PMID: 14682061.
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      72. Kaufman D, Lewis RL, Hanson ET, Auerbach R, Plendl J, Thomson JA. Functional endothelial cells derived from rhesus monkey embryonic stem cells. Blood. 2004 Feb 15; 103(4):1325-32. PMID: 14563647.
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      73. Kaufman D, Thomson JA. Human ES cells--haematopoiesis and transplantation strategies. J Anat. 2002 Mar; 200(Pt 3):243-8. PMID: 12033728; PMCID: PMC1570686.
      74. Kaufman D, Hanson ET, Lewis RL, Auerbach R, Thomson JA. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10716-21. PMID: 11535826; PMCID: PMC58532.
      75. Kaufman D. A scientific rationale for human embryonic stem cell research. Yale J Health Policy Law Ethics. 2001; 2(1):109, 177-87. PMID: 12664943.
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      76. Odorico JS, Kaufman D, Thomson JA. Multilineage differentiation from human embryonic stem cell lines. Stem Cells. 2001; 19(3):193-204. PMID: 11359944.
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      77. Kaufman D, Schoon RA, Robertson MJ, Leibson PJ. Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I. Proc Natl Acad Sci U S A. 1995 Jul 3; 92(14):6484-8. PMID: 7604018; PMCID: PMC41542.
      78. Kaufman D, Schoon RA, Leibson PJ. MHC class I expression on tumor targets inhibits natural killer cell-mediated cytotoxicity without interfering with target recognition. J Immunol. 1993 Feb 15; 150(4):1429-36. PMID: 8432986.
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      79. Kaufman D, Schoon RA, Leibson PJ. Role for major histocompatibility complex class I in regulating natural killer cell-mediated killing of virus-infected cells. Proc Natl Acad Sci U S A. 1992 Sep 1; 89(17):8337-41. PMID: 1325654; PMCID: PMC49913.
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