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    Constance Benson

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address200 W. Arbor Drive #8208
    CA San Diego 92103
    Phone619-543-4727
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      A Novel Wireless Ingestible Sensor System for Measurement of Medication Adherence in HIV Treatment and Prevention
      NIH R01MH110057Sep 20, 2015 - Jul 31, 2020
      Role: Principal Investigator
      The UCSD CD4 Collaborative Clinical Trial Unit
      NIH UM1AI069432Feb 1, 2007 - Nov 30, 2020
      Role: Principal Investigator
      UCSD Department of Medicine HIV/AIDS Clinical Trials Unit
      NIH U01AI069432Feb 1, 2007 - Nov 30, 2013
      Role: Principal Investigator
      AIDS Clinical Trials Group Network
      NIH U01AI068636Jun 29, 2006 - May 31, 2013
      Role: Principal Investigator
      ADULT ACTG CENTRAL GROUP
      NIH U01AI038858Jan 1, 1996 - Dec 31, 2008
      Role: Principal Investigator
      SAN DIEGO AIDS CLINICAL TRIAL UNIT
      NIH U01AI027670Jun 30, 1986 - Dec 31, 2006
      Role: Principal Investigator
      General Clinical Research Center
      NIH M01RR000051Dec 1, 1978 - Mar 31, 2010
      Role: Co-Investigator
      General Clinical Research Center
      NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Jenks JD, Benson C. Early cerebritis resulting in a first-time seizure in an otherwise healthy young man. Infect Dis Clin Pract (Baltim Md). 2016 Nov; 24(6):e66-e68. PMID: 27840566.
        View in: PubMed
      2. Logan C, Todorof K, Fiorillo SP, Campbell TB, Elder JH, Borok M, Gudza I, Gwanzura L, Ndemera B, Lochhead MJ, Benson C, Schooley RT. Rapid Multiplexed Immunoassay for Detection of Antibodies to Kaposi's Sarcoma-Associated Herpesvirus. PLoS One. 2016; 11(9):e0163616. PMID: 27669509.
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      3. Günthard HF, Saag MS, Benson C, del Rio C, Eron JJ, Gallant JE, Hoy JF, Mugavero MJ, Sax PE, Thompson MA, Gandhi RT, Landovitz RJ, Smith DM, Jacobsen DM, Volberding PA. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2016 Jul 12; 316(2):191-210. PMID: 27404187.
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      4. Sterling TR, Scott NA, Miro JM, Calvet G, La Rosa A, Infante R, Chen MP, Benator DA, Gordin F, Benson C, Chaisson RE, Villarino ME. Three months of weekly rifapentine and isoniazid for treatment of Mycobacterium tuberculosis infection in HIV-coinfected persons. AIDS. 2016 Jun 19; 30(10):1607-15. PMID: 27243774.
        View in: PubMed
      5. Massanella M, Gianella S, Schrier R, Dan JM, Pérez-Santiago J, Oliveira MF, Richman DD, Little SJ, Benson C, Daar ES, Dube MP, Haubrich RH, Smith DM, Morris SR. Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy. Sci Rep. 2015; 5:13179. PMID: 26299251.
        View in: PubMed
      6. Labo N, Miley W, Benson C, Campbell TB, Whitby D. Epidemiology of Kaposi's sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy. AIDS. 2015 Jun 19; 29(10):1217-25. PMID: 26035321.
        View in: PubMed
      7. Podany AT, Bao Y, Swindells S, Chaisson RE, Andersen JW, Mwelase T, Supparatpinyo K, Mohapi L, Gupta A, Benson C, Kim P, Fletcher CV. Efavirenz Pharmacokinetics and Pharmacodynamics in HIV-Infected Persons Receiving Rifapentine and Isoniazid for Tuberculosis Prevention. Clin Infect Dis. 2015 Oct 15; 61(8):1322-7. PMID: 26082504.
        View in: PubMed
      8. Lennox JL, Landovitz RJ, Ribaudo HJ, Ofotokun I, Na LH, Godfrey C, Kuritzkes DR, Sagar M, Brown TT, Cohn SE, McComsey GA, Aweeka F, Fichtenbaum CJ, Presti RM, Koletar SL, Haas DW, Patterson KB, Benson C, Baugh BP, Leavitt RY, Rooney JF, Seekins D, Currier JS. Efficacy and Tolerability of 3 Nonnucleoside Reverse Transcriptase Inhibitor-Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1: A Randomized, Controlled Equivalence Trial. Ann Intern Med. 2014 Oct 7; 161(7):461-71. PMID: 25285539.
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      9. Noormahomed EV, Nhacupe N, Mascaró-Lazcano C, Mauaie MN, Buene T, Funzamo CA, Benson C. A cross-sectional serological study of cysticercosis, schistosomiasis, toxocariasis and echinococcosis in HIV-1 infected people in Beira, Mozambique. PLoS Negl Trop Dis. 2014 Sep; 8(9):e3121. PMID: 25188395.
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      10. Jacobson JM, Wang H, Bordi R, Zheng L, Gross BH, Landay AL, Spritzler J, Routy JP, Benson C, Aberg J, Tebas P, Haas DW, Tiu J, Coughlin K, Purdue L, Sekaly RP. A Randomized Controlled Trial of Palifermin (Recombinant Human Keratinocyte Growth Factor) for the Treatment of Inadequate CD4+ T-Lymphocyte Recovery in Patients with HIV-1 Infection on Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2014 Aug 1; 66(4):399-406. PMID: 24815851.
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      11. Mocumbi AO, Carrilho C, Aronoff-Spencer E, Funzamo C, Patel S, Preziosi M, Lederer P, Tilghman W, Benson C, Badaró R, Nguenha A, Schooley RT, Noormahomed EV. Innovative strategies for transforming internal medicine residency training in resource-limited settings: the mozambique experience. Acad Med. 2014 Aug; 89(8 Suppl):S78-82. PMID: 25072585.
        View in: PubMed
      12. Günthard HF, Aberg JA, Eron JJ, Hoy JF, Telenti A, Benson C, Burger DM, Cahn P, Gallant JE, Glesby MJ, Reiss P, Saag MS, Thomas DL, Jacobsen DM, Volberding PA. Antiretroviral Treatment of Adult HIV Infection: 2014 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2014 Jul 23; 312(4):410-25. PMID: 25038359.
        View in: PubMed
      13. Marrazzo JM, Del Rio C, Holtgrave DR, Cohen MS, Kalichman SC, Mayer KH, Montaner JS, Wheeler DP, Grant RM, Grinsztejn B, Kumarasamy N, Shoptaw S, Walensky RP, Dabis F, Sugarman J, Benson C. HIV Prevention in Clinical Care Settings: 2014 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2014 Jul 23; 312(4):390-409. PMID: 25038358.
        View in: PubMed
      14. Zheng Y, Hughes MD, Lockman S, Benson C, Hosseinipour MC, Campbell TB, Gulick RM, Daar ES, Sax PE, Riddler SA, Haubrich R, Salata RA, Currier JS. Antiretroviral Therapy and Efficacy After Virologic Failure on First-line Boosted Protease Inhibitor Regimens. Clin Infect Dis. 2014 Sep 15; 59(6):888-96. PMID: 24842909.
        View in: PubMed
      15. Weinberg A, Bosch R, Bennett K, Tovar-Salazar A, Benson C, Collier AC, Zolopa A, Gulick RM, Wohl D, Polsky B, Erice A, Jacobson MA. Regulatory T cells and the risk of CMV end-organ disease in patients with AIDS. J Acquir Immune Defic Syndr. 2014 May 1; 66(1):25-32. PMID: 24378728.
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      16. Luetkemeyer AF, Kendall MA, Nyirenda M, Wu X, Ive P, Benson C, Andersen JW, Swindells S, Sanne IM, Havlir DV, Kumwenda J. Tuberculosis Immune Reconstitution Inflammatory Syndrome in A5221 STRIDE: Timing, Severity, and Implications for HIV-TB Programs. J Acquir Immune Defic Syndr. 2014 Apr 1; 65(4):423-8. PMID: 24226057.
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      17. Masur H, Brooks JT, Benson C, Holmes KK, Pau AK, Kaplan JE. Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents: Updated Guidelines From the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2014 May; 58(9):1308-11. PMID: 24585567.
        View in: PubMed
      18. Vignesh R, Kumarasamy N, Lim A, Solomon S, Murugavel KG, Balakrishnan P, Solomon SS, Mayer KH, Swathirajan CR, Chandrasekaran E, Pradeep A, Poongulali S, Benson C, French MA. TB-IRIS after initiation of antiretroviral therapy is associated with expansion of preexistent Th1 responses against Mycobacterium tuberculosis antigens. J Acquir Immune Defic Syndr. 2013 Nov 1; 64(3):241-8. PMID: 23774879.
        View in: PubMed
      19. Lok JJ, Hunt PW, Collier AC, Benson C, Witt MD, Luque AE, Deeks SG, Bosch RJ. The impact of age on the prognostic capacity of CD8+ T-cell activation during suppressive antiretroviral therapy. AIDS. 2013 Aug 24; 27(13):2101-10. PMID: 24326304.
        View in: PubMed
      20. Luetkemeyer AF, Rosenkranz SL, Lu D, Marzan F, Ive P, Hogg E, Swindells S, Benson C, Grinsztejn B, Sanne IM, Havlir DV, Aweeka F. Relationship between weight, efavirenz exposure, and virologic suppression in HIV-infected patients on rifampin-based tuberculosis treatment in the AIDS Clinical Trials Group A5221 STRIDE Study. Clin Infect Dis. 2013 Aug; 57(4):586-93. PMID: 23592830.
        View in: PubMed
      21. Wang R, Bosch RJ, Benson C, Lederman MM. Drug-resistant virus has reduced ability to induce immune activation. J Acquir Immune Defic Syndr. 2012 Dec 1; 61(4):e60-3. PMID: 23138731.
        View in: PubMed
      22. Logan C, Givens M, Ives JT, Delaney M, Lochhead MJ, Schooley RT, Benson C. Performance evaluation of the MBio Diagnostics point-of-care CD4 counter. J Immunol Methods. 2013 Jan 31; 387(1-2):107-13. PMID: 23063690.
        View in: PubMed
      23. Thompson MA, Aberg JA, Hoy JF, Telenti A, Benson C, Cahn P, Eron JJ, Günthard HF, Hammer SM, Reiss P, Richman DD, Rizzardini G, Thomas DL, Jacobsen DM, Volberding PA. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA. 2012 Jul 25; 308(4):387-402. PMID: 22820792.
        View in: PubMed
      24. Abraham AG, Lau B, Deeks S, Moore RD, Zhang J, Eron J, Harrigan R, Gill MJ, Kitahata M, Klein M, Napravnik S, Rachlis A, Rodriguez B, Rourke S, Benson C, Bosch R, Collier A, Gebo K, Goedert J, Hogg R, Horberg M, Jacobson L, Justice A, Kirk G, Martin J, McKaig R, Silverberg M, Sterling T, Thorne J, Willig J, Gange SJ. Missing data on the estimation of the prevalence of accumulated human immunodeficiency virus drug resistance in patients treated with antiretroviral drugs in north america. Am J Epidemiol. 2011 Sep 15; 174(6):727-35. PMID: 21813792.
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      25. Krishnan S, Schouten JT, Jacobson DL, Benson C, Collier AC, Koletar SL, Santana J, Sattler FR, Mitsuyasu R. Incidence of non-AIDS-defining cancer in antiretroviral treatment-naïve subjects after antiretroviral treatment initiation: an ACTG longitudinal linked randomized trials analysis. Oncology. 2011; 80(1-2):42-9. PMID: 21606663.
        View in: PubMed
      26. Ribaudo HJ, Benson C, Zheng Y, Koletar SL, Collier AC, Lok JJ, Smurzynski M, Bosch RJ, Bastow B, Schouten JT. No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001/ALLRT. Clin Infect Dis. 2011 Apr 1; 52(7):929-40. PMID: 21427402.
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      27. Daar ES, Tierney C, Fischl MA, Sax PE, Mollan K, Budhathoki C, Godfrey C, Jahed NC, Myers L, Katzenstein D, Farajallah A, Rooney JF, Pappa KA, Woodward WC, Patterson K, Bolivar H, Benson C, Collier AC. Atazanavir plus ritonavir or efavirenz as part of a 3-drug regimen for initial treatment of HIV-1. Ann Intern Med. 2011 Apr 5; 154(7):445-56. PMID: 21320923.
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      28. Smurzynski M, Wu K, Benson C, Bosch RJ, Collier AC, Koletar SL. Relationship between CD4+ T-cell counts/HIV-1 RNA plasma viral load and AIDS-defining events among persons followed in the ACTG longitudinal linked randomized trials study. J Acquir Immune Defic Syndr. 2010 Sep; 55(1):117-27. PMID: 20622677.
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      29. Lok JJ, Bosch RJ, Benson C, Collier AC, Robbins GK, Shafer RW, Hughes MD. Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection. AIDS. 2010 Jul 31; 24(12):1867-76. PMID: 20467286.
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      30. May S, Gamst A, Haubrich R, Benson C, Smith DM. Pooled nucleic acid testing to identify antiretroviral treatment failure during HIV infection. J Acquir Immune Defic Syndr. 2010 Feb; 53(2):194-201. PMID: 19770802.
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      31. Deeks SG, Gange SJ, Kitahata MM, Saag MS, Justice AC, Hogg RS, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Benson C, Collier AC, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Kushel MB, Goedert JJ, McKaig RG, Moore RD. Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America. Clin Infect Dis. 2009 Nov 15; 49(10):1582-90. PMID: 19845473.
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      32. Smith DM, May SJ, Pérez-Santiago J, Strain MC, Ignacio CC, Haubrich RH, Richman DD, Benson C, Little SJ. The use of pooled viral load testing to identify antiretroviral treatment failure. AIDS. 2009 Oct 23; 23(16):2151-8. PMID: 19730348.
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      33. Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep. 2009 Apr 10; 58(RR-4):1-207; quiz CE1-4. PMID: 19357635.
        View in: PubMed
      34. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Hogg RS, Deeks SG, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Goedert JJ, Benson C, Collier AC, Van Rompaey SE, Crane HM, McKaig RG, Lau B, Freeman AM, Moore RD. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009 Apr 30; 360(18):1815-26. PMID: 19339714.
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      35. Brooks JT, Kaplan JE, Holmes KK, Benson C, Pau A, Masur H. HIV-associated opportunistic infections--going, going, but not gone: the continued need for prevention and treatment guidelines. Clin Infect Dis. 2009 Mar 1; 48(5):609-11. PMID: 19191648.
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      36. Smurzynski M, Collier AC, Koletar SL, Bosch RJ, Wu K, Bastow B, Benson C. AIDS clinical trials group longitudinal linked randomized trials (ALLRT): rationale, design, and baseline characteristics. HIV Clin Trials. 2008 Jul-Aug; 9(4):269-82. PMID: 18753121.
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      37. Wilson CC, Newman MJ, Livingston BD, MaWhinney S, Forster JE, Scott J, Schooley RT, Benson C. Clinical phase 1 testing of the safety and immunogenicity of an epitope-based DNA vaccine in human immunodeficiency virus type 1-infected subjects receiving highly active antiretroviral therapy. Clin Vaccine Immunol. 2008 Jun; 15(6):986-94. PMID: 18400976.
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      38. Gerber JG, Kitch DW, Fichtenbaum CJ, Zackin RA, Charles S, Hogg E, Acosta EP, Connick E, Wohl D, Kojic EM, Benson C, Aberg JA. Fish oil and fenofibrate for the treatment of hypertriglyceridemia in HIV-infected subjects on antiretroviral therapy: results of ACTG A5186. J Acquir Immune Defic Syndr. 2008 Apr 1; 47(4):459-66. PMID: 17971707.
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      39. Andrade AC, Ladeia AM, Netto EM, Mascarenhas A, Cotter B, Benson C, Badaró R. Cross-sectional study of endothelial function in HIV-infected patients in Brazil. AIDS Res Hum Retroviruses. 2008 Jan; 24(1):27-33. PMID: 18275345.
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      40. Bosch RJ, Bennett K, Collier AC, Zackin R, Benson C. Pretreatment factors associated with 3-year (144-week) virologic and immunologic responses to potent antiretroviral therapy. J Acquir Immune Defic Syndr. 2007 Mar 1; 44(3):268-77. PMID: 17146370.
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      41. Landay A, da Silva BA, King MS, Albrecht M, Benson C, Eron J, Glesby M, Gulick R, Hicks C, Kessler H, Murphy R, Thompson M, White AC, Wolfe P, McMillan FI, Hanna GJ. Evidence of ongoing immune reconstitution in subjects with sustained viral suppression following 6 years of lopinavir-ritonavir treatment. Clin Infect Dis. 2007 Mar 1; 44(5):749-54. PMID: 17278071.
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      42. Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson C, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. J Infect Dis. 2007 Mar 1; 195(5):734-8. PMID: 17262717.
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      43. Mulligan K, Zackin R, Von Roenn JH, Chesney MA, Egorin MJ, Sattler FR, Benson C, Liu T, Umbleja T, Shriver S, Auchus RJ, Schambelan M. Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. J Clin Endocrinol Metab. 2007 Feb; 92(2):563-70. PMID: 17090640.
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      44. Benson C, Vaida F, Havlir DV, Downey GF, Lederman MM, Gulick RM, Glesby MJ, Wantman M, Bixby CJ, Rinehart AR, Snyder S, Wang R, Patel S, Mellors JW. A randomized trial of treatment interruption before optimized antiretroviral therapy for persons with drug-resistant HIV: 48-week virologic results of ACTG A5086. J Infect Dis. 2006 Nov 1; 194(9):1309-18. PMID: 17041858.
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      45. Haas DW, Geraghty DE, Andersen J, Mar J, Motsinger AA, D'Aquila RT, Unutmaz D, Benson C, Ritchie MD, Landay A. Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. J Infect Dis. 2006 Oct 15; 194(8):1098-107. PMID: 16991084.
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      46. Benson C. Structured treatment interruptions--new findings. Top HIV Med. 2006 Aug-Sep; 14(3):107-11. PMID: 16946455.
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      47. Ellis RJ, Evans SR, Clifford DB, Moo LR, McArthur JC, Collier AC, Benson C, Bosch R, Simpson D, Yiannoutsos CT, Yang Y, Robertson K. Clinical validation of the NeuroScreen. J Neurovirol. 2005 Dec; 11(6):503-11. PMID: 16338744.
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      48. Benson C, Kaplan JE, Masur H, Pau A, Holmes KK. Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America. MMWR Recomm Rep. 2004 Dec 17; 53(RR-15):1-112. PMID: 15841069.
        View in: PubMed
      49. Benson C, van der Horst C, Lamarca A, Haas DW, McDonald CK, Steinhart CR, Rublein J, Quinn JB, Mondou E, Rousseau F. A randomized study of emtricitabine and lamivudine in stably suppressed patients with HIV. AIDS. 2004 Nov 19; 18(17):2269-76. PMID: 15577539.
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      50. Hicks C, King MS, Gulick RM, White AC, Eron JJ, Kessler HA, Benson C, King KR, Murphy RL, Brun SC. Long-term safety and durable antiretroviral activity of lopinavir/ritonavir in treatment-naive patients: 4 year follow-up study. AIDS. 2004 Mar 26; 18(5):775-9. PMID: 15075512.
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      51. Haas DW, Wu H, Li H, Bosch RJ, Lederman MM, Kuritzkes D, Landay A, Connick E, Benson C, Wilkinson GR, Kessler H, Kim RB. MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J Acquir Immune Defic Syndr. 2003 Nov 1; 34(3):295-8. PMID: 14600574.
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      52. Benson C, Williams PL, Currier JS, Holland F, Mahon LF, MacGregor RR, Inderlied CB, Flexner C, Neidig J, Chaisson R, Notario GF, Hafner R. A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome. Clin Infect Dis. 2003 Nov 1; 37(9):1234-43. PMID: 14557969.
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      53. Schambelan M, Benson C, Carr A, Currier JS, Dubé MP, Gerber JG, Grinspoon SK, Grunfeld C, Kotler DP, Mulligan K, Powderly WG, Saag MS. Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel. J Acquir Immune Defic Syndr. 2002 Nov 1; 31(3):257-75. PMID: 12439201.
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      54. Benson C, Deeks SG, Brun SC, Gulick RM, Eron JJ, Kessler HA, Murphy RL, Hicks C, King M, Wheeler D, Feinberg J, Stryker R, Sax PE, Riddler S, Thompson M, Real K, Hsu A, Kempf D, Japour AJ, Sun E. Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients. J Infect Dis. 2002 Mar 1; 185(5):599-607. PMID: 11865416.
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